EX-4.21 8 exh_421.htm EXHIBIT 4.21

Exhibit 4.21

CONFIDENTIAL

THE SYMBOL "[****]" DENOTES PLACES WHERE PORTIONS OF THIS DOCUMENT HAVE BEEN OMIITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT. SUCH MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION

MASTER AGREEMENT WORK ORDER

AMENDMENT #1

Protocol # RHB-104-01 (MAP and Other Analysis)

Effective Date: date of last signature below

RedHill Biopharma

21 Ha’arba’a St.

Tel-Aviv Israel 64739

WHEREAS, RedhIll Biopharma Ltd. and Quest Diagnostics Clinical Laboratories, Inc. are parties (together the “Parties”) to a Clinical Trials Global Master Services Agreement dated 27-December-2015 (the “Agreement”) and have also entered into a Work Order on 10-Oct-2013 pursuant to Protocol RHB-104-01 (the “Work Order”).

WHEREAS, Quintiles Laboratories and Quest Diagnostics have formed the company Q Squared Solutions (Quest) LLC, to provide certain laboratory services (including central and bio-analytical laboratory services).

WHEREAS, pursuant to the joint venture described in the above recital, Q Squared Solutions (Quest) LLC will hereinafter perform the Services under the Agreement, and all references to Quest Diagnostics Clinical Laboratories, Inc. in the Agreement, the Work Order and this Amendment #1 shall reflect Q Squared Solutions (Quest) LLC (hereinafter “Q Squared”) following the effective date of this Amendment.

NOW THEREFORE, the Parties agree as follows:

1. The purpose of this Amendment #1 to the Work Order is to revise the budget, update the project term and to provide services by Q Squared Solutions.

2. The Term of the Agreement shall now be as follows:

Effective Date: 10-Oct-2013 End Date: [****]

The Budget has been updated to reflect :

the addition of Australia and New Zealand;

an estimate for optional [****]use in the US only;

the addition of [****];

updated [****], [****], [****]

that Israel and [****]shipping costs from sites direct [****]have been line itemed until Quest is notified to begin shipping directly and the budget will be updated with these costs at that time;

outbound shipping of [****]is included - estimating [****]per site;

the inclusion of[****];

the addition of [****]: [****], [****], [****], [****], [****], [****];

additional updates made to [****], [****] per client request;

the addition of [****]

RedHill Biopharma Limited

Protocol # RHB-104-01

Master Agreement Work Order, Amendment #1

Page 1 of 3

and a revised [****] sample volume;

add [****]([****] sites/[****] screen/[****] randomized);

remove [****] patients from [****] to move to [****];

update visit names;

study amendment fee;

update to [****];

[****];

Add [****], [****] to be sent to [****];

change to [****];

New kit for [****];

costs added for [****];

extend DNA storage length to 10 years.

4. The revised Estimated Central Laboratory Budget is attached hereto as Attachment #1, is incorporated herein by reference, and shall replace the Attachment #1 of the Work Order.

5. The study value is revised as follows:

Document

Change Value

Total Study

Contracted Value*

Original Work Order

$0.00

$[****]

Amendment #1

$[****]

*RedHill shall be invoiced for actual tests performed and services rendered.

6. All other terms and conditions of the Work Order and the Clinical Trials Global Master Services Agreement (the “Agreement”) shall remain in full force and effect. In the event of any conflict between the terms of the Agreement, the Work Order, and this Amendment, the terms of this Amendment shall control.

7. The parties hereto agree to this Amendment #1 as of the effective date by authorized signature below.

REDHILL BIOPHARMA LIMITED		Q Squared Solutions (Quest) LLC


/s/ Dror Ben Asher /s/ Ori Shilo		/s/ Terrence D. Burke
Authorized Signature		Terrence D Burke
		Authorized Person
Dror Ben-Asher Ori Shilo
Name Printed

CEO Deputy CEO
Title

December 29, 2015		December 30, 2015
Date		Date

RedHill Biopharma Limited

Protocol # RHB-104-01

Master Agreement Work Order, Amendment #1

Page 2 of 3

Attachment # 1

Protocol # RHB-104-01 (MAP and Other Analysis)

[The Quest Diagnostics Budget Version #16, dated 2-Sep-2015, is attached hereto, is incorporated herein, contains 27 printed pages, and shall be printed in full for contract signature]

RedHill Biopharma Limited

Protocol # RHB-104-01

Master Agreement Work Order, Amendment #1

Page 3 of 3

CONFIDENTIAL

Q² Solutions, a Quintiles Quest Joint Venture

Central Laboratory Services Budget

Q² Solutions, a Quintiles Quest Joint Venture (JV), brings together the clinical trials laboratory operations of the two parent organizations to provide biopharmaceutical customers with the diverse capabilities and end-to-end services required in the rapidly evolving biopharmaceutical industry. The new organization creates a global laboratory network that combines Quintiles’ scale, clinical trial expertise, and diverse therapeutic experience with Quest Diagnostics’ operational, scientific and quality excellence, supply-chain network and informatics to promote greater innovation, quality and value for biopharmaceutical customers.

RedHill Biopharma Limited

RHB-104-01 (CR)

Version 16

2-Sep-15



Prepared for:	[****]	by:	[****]
	[****]		[****]
	[****]		[****]
	[****]		[****]
	[****]		[****]
			[****]


Tel:	[****]	Tel:	[****]
		Fax:	[****]
Email:	[****]	Email:	[****]

2-Sep-15

Patrick L. McLean
Product Manager
RedHill Biopharma Limited
21 Ha’arba’a St.
Tel-Aviv Israel 64739


Regarding:	Centralized Clinical Laboratory and Related Support Services for Protocol
	RHB-104-01 (CR)

Dear Patrick :

Thank you for the opportunity to submit a revised budget for your study. This budget includes the following changes.

	version16: - add [**] ([] sites/[] screen/[] randomized) - remove [] patients from US to move to [] - update visit names - study amendment fee: update to [], Initial [] receiving reported as []. Remaining [] to be [], add [], AUS/NZ MAP to be sent to [],[], New kit for [] collection - costs added for [**] - extend DNA storage length to 10 years

Q²Solutions, a Quintiles Quest Joint Venture has a commitment to peak performance, superior value for our customers, teamwork, innovation and integrity. We look forward to the opportunity to work with you to demonstrate our dedication to these values.

If you have any questions or require further assistance, please feel free to call me.

Yours sincerely,

[****]

Senior Strategic Account Executive

Q² Solutions, a Quintiles Quest Joint Venture

RedHill Biopharma Limited

Quote for Services

Assumptions

Protocol: RHB-104-01 (CR)

Assumptions:

Global Phase III trial

[****] countries, [****] sites: Israel: [****] sites, US/Canada: [****] sites, AUS: [****], NZ: [****], respectively, [****]: [****] sites, [****]: [****] sites
[****] screened , [****] baseline to visit [****], and decreasing number of patients from visit [****] to visit [****]

Recommended couriers:
Israel- sites to [****], sites to Quest ([****],[****] and [****]and [****]),
[****]- sites to [****] ([****],[****]), sites to Quest [****] ([****], [****] and [****] and [****]),
[****]- sites to [****] ([****], [****]), sites to Quest [****] ([****], [****]and [****] and [****]),
Canada - sites to [****] ([****] and [****]), sites to Quest [****] ([****] and [****]),
US- sites to [****] ([****]), sites to Quest [****] ([****]),
Quest [****]
[****] to Quest US- [****] ([****])
Courier mapping- [****],[****],[****]:
Sites to Quest [****],
Sites to Quest [****], [****], [****].
Sites to Quest [****], [****].
Sites to [****]
Quest UK to [****], [****]
Courier mapping- [****] /Australia/New Zealand
Sites to Quest [****]
Sites to Quest [****], [****], [****].
Sites to [****]
Sites to [****], [****].
[****] to Quest [****]

Inbound budget (shipments from sites to Quest Diagnostics): [****], [****]

[****], [****].

PK [****]
PK [****], [****].
Worst case scenario: we assume [****] to be revised in accordance to validation data.
PK [****]

HIV Western Blot- we assume [****]

[****]:
1- [****],
2- [****],
3- [****],
4- [****],
5- [****].

[****]

Stored specimen:
For bidding purpose, we assume average storage of [****]. [****].
DNA extraction samples are due to be stored for 10 years.
Note: RedHill Biopharma is charged for rendered services only.

[****]-
[****] ([****], [****]) [****].
[****].
[****]
[****]
[****]
[****]

Week-end shipments from sites - [****]
EWP(extreme weather packaging)- [****].

Australia and New Zealand supplies are sourced from the US, these quantities are reflected in US region.

- [****]:
- [****] sites ([****] Aust, [****] NZ)
- [****] total visits plus ET
- [****] Enrolled ([****] total patient visits)
- supplies are sourced locally

Forceps can only be shipped in US; remaining countries will be sourced locally by RHB.

RedHill Biopharma Limited

Quote for Services

Change In Scope History

Protocol: RHB-104-01 (CR)

Category	Updated Study Value	Previous Study Value *	Difference	Comments
Laboratory Testing	$[****]	$[****]	$[****]	Addition of [**] patients ([] screened/[] randomized/[] completed): total of [**] additional patient visits
Supplies	$[****]	$[****]	$[****]	EU supplies increase of [**]% to account for [**] patients.
Additional Pass-Through Services	$[****]	$[****]	$[****]	Reduction in US weekend shipments for patients that moved under [**]:-$[] []budget: $[] [] outbound sample shipping: $[] [] weekend shipments: $[**]
Study Management	$[****]	$[****]	$[****]	Capture all amendment charges: - update to [**] - add [] - change to AUS/NZ [] to [] - change to [] - New kit for [] Per visit quantities updated to capture [**] patients
Storage & Services	$[****]	$[****]	$[****]	[****]
Inbound Transportation	$[****]	$[****]	$[****]	Adjustment to account for [****] shipping
Batched Inbound	$[****]	$[****]	$[****]	Adjustment to account for [****] shipping
Outbound Transportation	$[****]	$[****]	$[****]	Adjustment to account for [****] shipping
Outbound Transportation - Shipping Containers	$[****]	$[****]	$[****]	Adjustment to account for [****] shipping
Estimated Central Laboratory Budget:	$[****]	$[****]	$[****]

* Budget taken from RedHill Biopharma Limited: RHB-104-01 (CR).v15

Date	Reason	Total Value	Difference
31-Oct-11	Original	$[****]	$[****]
14-Nov-11	Version2 reflects the amended protocol (28October 2011)- MAP testing and Chemistry/Hematology/Inflammatory markers/Urinalysis/Other AP markers	$[****]	$[****]
24-Nov-11	version3: updated MAP testing processes/pricing, increasing number of MAP tests, expanded stool culture COP panel (addition of [**] agents: [**])	$[****]	$[****]
21-Dec-11	version4: MAP validations/testing and other analysis [**]: revised countries:patients distribution for USA, Canada versus Israel resulting in a grand total of [] screned/ week26-week[] patients in North America and [] patients in Europe Combined shipments(ambient/frozen) at screening, [] and [] Updated selection of couriers in Canada and US for ambient shipments with [**] and Quest courier respectively	$[****]	$[****]
11-Jan-12	Version 5: Updated discounting in testing and study management section.	$[****]	$[****]
29-Aug-12	version6 reflects Protocol dated 22-Aug-2012 Updated country:site:visit:patient distribution. 3 countries, [**] sites, [] screened/other visits patients Routine clinical laboratory tests (hematology, biochemistry, inflammatory markers and stool tests performed at Quest Diagnostics. Viral serology performed at screening visit. Urine pregnancy kits and urinalysis dipsticks to be supplies by Quest to sites []assay performed at Quest Diagnostics (frozen whole blood), Additional samples of []blood([]) collected and frozen at weeks []. These samples will be retained at Quest Diagnostics during the course of the study for future MAP assessment. PK specimens management Courier model as follow: (1) Combined shipments (ambient and frozen) at screening, [**] only.	$[****]	$[****]
7-Mar-13	version 7 reflects FINAL protocol dated 20Feb2013 All testing managed by Quest Diagnostics: safety, MAP testing and PK analysis.	$[****]	$[****]
20-Mar-13	version8 captures study specs discussed on 20-March with RHB.	$[****]	$[****]
15-Apr-13	version9: PK analysis ([**]) done by a 3rd party located in Canada (confirmed by RHB 5-April); PK analysis ([]) to be confirmed soon by RHB: testing AND validation fees as line items into this budget (zero quantity) - budget to be updated if QDCT eventually perform PK tissue analysis; validation fees( removed and to be included into the existing fully separate contract relating to MAP validations; no changes into the transportation budget ([]s collected at the same time than other [**]samples).	$[****]	$[****]
2-Sep-13	version10 captures the most recent decisions/information including notably the protocol amendment, approved [**], [**]for v, updated samples processes for Israel, US/Canada, special supplies.	$[****]	$[****]
25-Sep-13	version11- adjusted testing/aliquoting/storage mapping.	$[****]	$[****]
8-Oct-13	version 12: Updated patients:visits distribution based on info dated 9-October (decreasing grand total number of patient-visits)	$[****]	$[****]
5-Jun-14	version13: add Australia and New Zealand; add estimate for optional [****]use in US only.	$[****]	$[****]
14-Nov-14	version14: add [**]; update site numbers; []kits, starter packs and resupplies have been updated based on study amendments; Israel and [] shipping costs from sites direct []have been line itemed until Quest is notified to begin shipping directly- budget to be updated with these costs at that time; outbound shipping of cooled [] has also been included- estimate [] shipments per site; []charge included as line item; add [**]	$[****]	$[****]
15-Jan-15	version15: - update site/visit/patient numbers per Patrick 19 Jan 2015, - addition of [**], - revised [**]volume of samples	$[****]	$[****]
18-Jun-15	version16: [**] ([] sites/[] screen/[] randomized) - remove [] patients from US to move to [] - update visit names - study amendment fee: update to []results, []reported as[]. []Remaining [] related results to be [], add [], AUS/NZ MAP to be sent to [], change to PK, New kit for calprotectin collection - costs added for [**] - extend DNA storage length to 10 years	$[****]	$[****]

RedHill Biopharma Limited

Quote for Services

Budget Summary

Protocol: RHB-104-01 (CR)

Study Duration:	[****]	Total Investigators:	[****]
Quote Date:	[****]	Total Countries:	[****]
Quote Expiration Date:	[****]	Total Visits:	[****]
		Total Patient-Visits:	[****]

Estimated Grand Total Amount	$[****]
Average Cost Per Patient-Visit	$[****]
Average Cost Per Patient	$[****]

Budget Summary ¹

Sub-Totals	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
* See Budget Summary_EU	Israel, [**], [**]	$[****]	1.0000	$[****]
	Australia, New Zealand	$[****]	1.0000	$[****]
	Study Set-up Fees	$[****]	1.0000	$[****]
				$[****]
Average Cost Per Patient-Visit	Region	Estimated Total Amount	Patient Visits	Average Cost
	USA, Canada	$[****]	[****]	$[****]
	Israel, [**], [**]	$[****]	[****]	$[****]
	Australia, New Zealand	$[****]	[****]	$[****]
	Study Set-up Fees	$[****]
		$[****]	[****]	$[****]
Average Cost Per Patient	Region	Estimated Total Amount	Patients	Average Cost
	USA, Canada	$[****]	[****]	$[****]
	Israel, [**], [**]	$[****]	[****]	$[****]
	Australia, New Zealand	$[****]	[****]	$[****]
	Study Set-up Fees	$[****]
		$[****]	270	$[****]

Detailed Budget Summary

Laboratory Testing	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
	Israel, [**], [**]	$[****]	1.0000	$[****]
	Australia, New Zealand	$[****]	1.0000	$[****]
Laboratory Testing Total ^{1LT,3LT,5LT,6LT,7LT,8LT,9LT}				$[****]
Supplies	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
	Israel, [**], [**]	$[****]	1.0000	$[****]
	Australia, New Zealand	$[****]	1.0000	$[****]
Supplies Total *^SL**				$[****]
Additional Pass-Through Services	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
	Israel, [**], [**]	$[****]	1.0000	$[****]
	Australia, New Zealand	$[****]	1.0000	$[****]
Additional Pass-Through Services Total				$[****]
Storage	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
	Israel, [**], [**]	$[****]	1.0000	$[****]
	Australia, New Zealand	$[****]	1.0000	$[****]
Storage Total ^1ST,2ST,3ST				$[****]
Study Management	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
	Israel, [**], [**]	$[****]	1.0000	$[****]
	Australia, New Zealand	$[****]	1.0000	$[****]
	Study Set-up Fees	$[****]	1.0000	$[****]
Study Management Total ^{1SM,2SM,3SM,4SM,5SM,6SM,7SM,8SM}				$[****]
Inbound Transportation	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
	Israel, [**], [**]	$[****]	1.0000	$[****]
	Australia, New Zealand	$[****]	1.0000	$[****]
Inbound Transportation Total ^{1IT,2IT,3IT,}**				$[****]
Inbound Batched Shipments	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
	Israel, [**], [**]	$[****]	1.0000	$[****]
	Australia, New Zealand	$[****]	1.0000	$[****]
Inbound Batched Shipments Total ^{1IT,2IT,3IT,}*				$[****]
Outbound Transportation	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
	Israel,[**], [**]	$[****]	1.0000	$[****]
	Australia, New Zealand	$[****]	1.0000	$[****]
Outbound Transportation Total ^{1OT,2OT,3OT,4OT,5OT,6OT,7OT}				$[****]
Shipping Container Transportation	Region	Billing Amount	Conversion Rate	Estimated Total Amount
	USA, Canada	$[****]	1.0000	$[****]
	Israel, [**], [**]	$[****]	1.0000	$[****]
Shipping Container Transportation Total ^5OT,6OT,7OT				$[****]

Fee Type	Israel	[****]	[****]	Total EU
Laboratory Testing	$[****]	$[****]	$[****]	$[****]
Supplies	$[****]	$[****]	$[****]	$[****]
Special Services	$[****]	$[****]	$[****]	$[****]
Study Management	$[****]	$[****]	$[****]	$[****]
Storage & Services	$[****]	$[****]	$[****]	$[****]
Inbound Transportation	$[****]	$[****]	$[****]	$[****]
Batched Inbound	$[****]	$[****]	$[****]	$[****]
Outbound Transportation	$[****]	$[****]	$[****]	$[****]
Outbound Transportation - Shipping Containers	$[****]	$[****]	$[****]	$[****]
Estimated Central Laboratory Budget:	$[****]	$[****]	$[****]	$[****]

RedHill Biopharma Limited

Quote for Services

Detail Summary

Protocol: RHB-104-01 (CR)

Laboratory Testing	Region	Time Points	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	TBD	TBD	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Laboratory Testing Total							$[****]			$[****]	$[****]
Supplies	Region	Unit	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	USA, Canada	CASE	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	CASE	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	BOX	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	CASE	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	PACK	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Supplies Total							$[****]			$[****]	$[****]
Additional Pass-Through Services	Region	Unit	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Additional Pass-Through Services	Region	Unit	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]			[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Additional Pass-Through Services Total							$[****]			$[****]	$[****]
Storage	Region	Aliquots	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Storage	Region	Aliquots	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	Israel, [**], [**]	[****]	413	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	9,499	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	413	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	Line Item	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	Line Item	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	Line Item	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	1,219	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	6,307	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	6,307	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	15,387	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	79,611	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	79,611	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	31,178	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	31,178	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	931	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	931	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	931	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Storage	Region	Aliquots	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Storage Total							$[****]			$[****]	$[****]
Study Management	Region	Unit	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Study Set-up Fees		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Study Set-up Fees		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Study Set-up Fees		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Study Set-up Fees		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Study Management Total							$[****]			$[****]	$[****]
Inbound Transportation	Region	Unit	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Inbound Transportation Total							$[****]			$[****]	$[****]
Inbound Batched Shipments	Region	Unit	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Inbound Batched Shipments Total							$[****]			$[****]	$[****]
Outbound Transportation	Region	Unit	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	USA, Canada		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Australia, New Zealand		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Outbound Transportation Total							$[****]			$[****]	$[****]
Shipping Container Transportation	Region	Unit	Quantity	Billing Currency Unit Price	Billing Amount	Conversion Rate	Estimated Total Amount	Previous Quantity	Previous Billing Currency Unit Price	Previous Estimated Total Amount	Estimated Total Variance
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	USA, Canada		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
[****]	Israel, [**], [**]		[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
Shipping Container Transportation Total							$[****]			$[****]	$[****]

RedHill Biopharma Limited

Quote for Services

Test Visit Schedule

All Locations

Protocol: RHB-104-01 (CR)

[****]

RedHill Biopharma Limited

Quote for Services

Patient Visit Schedule

All Locations

Protocol: RHB-104-01 (CR)

Country

[****]

Calculated Totals:

[****]

Canada (Toronto)

[****]

United States (New York)

[****]

Israel (Tel Aviv)

[****]

Israel (Tel Aviv) - sites direct to [****]

[****]

Canada (Toronto) - sites direct to [****]

[****]

United States (New York) - sites direct to [****]

[****]

Australia ([****])

[****]

Australia ([****]) - sites direct to [****]

[****]

New Zealand ([****])

[****]

New Zealand ([****]) - [****]

[****]

RedHill Biopharma Limited

Quote for Services

End Notes

Protocol: RHB-104-01 (CR)

Global Summary
¹	See Study Specific Assumptions and Pricing Model, herein. Budget excludes any “TBD” (To Be Determined) items.
Global Summary - Laboratory Testing (LT)
^1LT	Quoted fees reflect Q² Solutions', a Quintiles Quest Joint Venture, Year 2011 Fee Schedule.
^2LT	Referral test to be performed by UFC. Fee includes the referral laboratory charge plus a referral fee for sample handling, data entry and result reporting. Any fee increase imposed by the Referral laboratory will be passed on to Client.
^3LT	Fees quoted for testing services performed are exclusive of any applicable added Taxes (including Value Added Tax (VAT)).
^4LT	Test to be performed by our alliance partner laboratory, Tan Tock Seng, in Singapore.
^5LT	The sample testing fees include the receipt of samples into a Q² Solutions, a Quintiles Quest Joint Venture, -owned, affiliate or alliance partner laboratory, the direct costs associated with the laboratory testing of the samples, retention of the unused samples for a maximum of fourteen (14) days, laboratory quality control and global standardisation of equipment, processes, controls and calibrators.
^6LT	The sample testing fees also include the distribution of interim result reports (per patient visit) and final result reports to Investigator(s) and/or Clients/CROs as applicable and agreed in the Central Laboratory Worksheet. Any final result reports issued in hard copy will be sent via standard postal service or (within the continental United States only) Q² Solutions, a Quintiles Quest Joint Venture, -US proprietary courier.
^7LT	It is Q² Solutions', a Quintiles Quest Joint Venture, experience that investigator sites experience significant challenges producing a peripheral blood smear ( PBS ) of sufficient quality for an appropriate hematology laboratory PBS review. Therefore, it is standard Q² Solutions', a Quintiles Quest Joint Venture, practice to not provide glass slides and to not require the sites to make PBS slides . The performance by Q² Solutions, a Quintiles Quest Joint Venture, of a routine safety CBC analysis (hematology) does involve the occasional review of PBS slides for the white blood cell morphology and differential, red blood cell morphology and platelet evaluation if the instrument or the SOP flags the specimen for a PBS slide review. The PBS slide can be appropriately created and reviewed in the majority of cases by the laboratory from the submitted CBC sample if a review is required.
^8LT	If the protocol requires a PBS slide review then glass microscope slides will be provided to the site(s) for each appropriate visit so that the site can create and provide a PBS to the central laboratory. Protocols where in our experience peripheral blood smears are recommended include significant hematological/bone marrow abnormalities (white or red cell, platelet abnormalities), leukaemia's, HIV clinical trials, sepsis, or other severe illnesses that would be impacting the hematological system. Our scientific affairs and medical affairs teams are available to further discuss the needs of your protocol regarding any requirements for PBS creation by the site or by the laboratory and PBS slide review by the Quest laboratory. Please could you confirm if this protocol requires a peripheral blood smear review or if subjects in this study are expected to have hematological abnormalities where we would recommend the preparation of peripheral blood smears at the investigator site.
^9LT	CBC and Peripheral blood smear pricing are based on assumptions received at the point of preparing this quotation. Q² Solutions, a Quintiles Quest Joint Venture, reserves the right to adjust these pertinent to further discussion with the customer.
Global Summary - Supplies (SL)
*	The Supplies total for shipping containers is based on one separate shipment for each patient visit and reflects a “worst case scenario.” Shipper container costs may be dramatically reduced when sites batch specimens prior to shipment to the laboratory.
Global Summary - Storage (ST)
^1ST	The “In” fee includes receipt, preparation, storage and entry of specimens into Q² Solutions, a Quintiles Quest Joint Venture storage facility and computer system.
^2ST	The “Monthly Maintenance” fee includes inventory, storage, temperature monitoring and continuous security coverage at Q² Solutions, a Quintiles Quest Joint Venture storage facility.
^3ST	The “Pull” fee includes the removal of requested specimens from storage, sorting of specimens prior to shipment (in a manner requested by client, e.g. - by patient, by visit) and the generation of a manifest.
Global Summary - Study Management (SM)
^1SM	The Study Management set-up fees quoted include provision for our standard toxicity and exclusions flagging; and cumulative data transmissions sent weekly via email zip file or SFTP or portals in our standard data file format. The fees do not include any set-up related to storage samples, new testing method set-up's, algorithms, microbiology testing or referral lab data entry. If client requires Q² Solutions, a Quintiles Quest Joint Venture, to add any of these elements or set up additional flagging options and use data files which differ to our standard format, we reserve the right to adjust our set-up fees accordingly.
^2SM	The Project Management Study Set-Up fee includes an internal review of the protocol in conjunction with the client's study team and formulation of an agreed Central Laboratory Worksheet signed off by Client and Q2 Solutions, a Quintiles Quest Joint Venture, which lays out detailed specifications for the set-up and management of the study. Q² Solutions, a Quintiles Quest Joint Venture, will design study documents, which include Investigator Manuals in the languages specified in the budget, a Lab Requirement Summary and pictogram, and study specific test Requistion forms in accordance with these specifications, as part of this fee. The design of visit specific specimen collection kits and set-up of Investigator site information is included as part of Project Management set-up.
^3SM	The fee Per Visit for Project Management covers ongoing Project Management support, 24/7 investigator assistance/support by Q² Solutions, a Quintiles Quest Joint Venture, CRC Support Team, including the use of toll-free phone lines. Auto faxing of supply expiry details and inclusion of alerts and delta flagging are also covered by this fee.
^4SM	The fee Per Visit for Data Management covers ongoing Data Management support, maintenance of the results database and the actioning and documentation of all necessary data revisions and data transfers up to once per week.
^5SM	The fee Per Visit for Logistics covers the expertise and management of the ongoing study logistics, shipment tracking, processing and auditing of courier invoices and the performance management of the courier companies.
^6SM	Q² Solutions, a Quintiles Quest Joint Venture, proprietary software Result/ViewTM – web-based version shall be included for the two users per study at no additional charge, more than two users will be charged. This includes training and support by telephone.
^7SM	Q² Solutions, a Quintiles Quest Joint Venture will charge a per work order fee associated with each pull order. The purpose of this is to maximize the batching of samples whenever they are pulled for regular or ad hoc shipments from sample storage in order to create operational efficiency.
^8SM	Q² Solutions, a Quintiles Quest Joint Venture will charge a STAT per work order fee associated with each STAT pull order request. The purpose of this charge is for STAT pull order requests needed in 5 business days or less.
Global Summary - Inbound Transportation (IT)
**	The Inbound Transportation total is representative of individual patient specimen shipments and reflects a “worst case scenario”. Transportation totals may be dramatically reduced when sites batch specimens prior to shipment to the laboratory. Please note if India, Russia and the Ukraine are participating in the study those countries dry ice and packaging fees are included in the inbound charges.
***	The Total Batched Inbound Transportation is representative of 24 batched shipments per site for frozen samples. Please note if India, Russia and the Ukraine are participating in the study those countries dry ice and packaging fees are included in the inbound charges.
^1IT	The inbound specimen transportation fees are based on typical volumetric weight, and vary by city. Q² Solutions, a Quintiles Quest Joint Venture will bill client actual transport costs, per the invoice of the transport company. Any change to the fee imposed by the courier will be passed on to client. Additional charges for secondary cities, holidays and weekend service may apply.
^2IT	The USD ($) Inbound Diagnostic Transportation fees quoted are based on an estimated exchange rate of £1 GBP = $ 1.6022. However, all Inbound Diagnostic Transportation will be billed at the actual £GBP to USD ($) rate ruling in the applicable month as published by UK Customs and Excise. Thus the Inbound Transportation fees may vary from those quoted in this budget in any given month depending on what the actual exchange rate is.
^3IT	The Logistics estimates included represent our best recommendations based on recent experience. We welcome the opportunity to discuss carrier performance and recommendations since the decision on courier selection ultimately resides with the sponsor.
Global Summary - Outbound Transportation (OT)
^1OT	Initial Supply Shipments: Initial shipments will be distributed within ten (10) working days from Client’s approval of the (a) requisition form, (b) Investigator Manual, and (c) receipt of Client’s final Investigator list. Q² Solutions, a Quintiles Quest Joint Venture, must also receive Client’s approval of Q² Solutions', a Quintiles Quest Joint Venture, verification report (without changes) at least 2 days prior to shipment.
^2OT	Please note that Q² Solutions, a Quintiles Quest Joint Venture does charge an additional fee for expedited/priority starter pack shipments.
^3OT	Shipment of Re-supplies: Re-supply orders will be distributed within five (5) working days of Q² Solutions', a Quintiles Quest Joint Venture, receipt of the Request for Supplies form from the Investigator or Client. Any re-supply orders containing special supplies shall be shipped upon supply availability and may require more than a five (5) working day turnaround.
^4OT	Q² Solutions, a Quintiles Quest Joint Venture, will use commercially-reasonable efforts to provide re-supply orders with less than five (5) working-days prior notification from Client or the Investigator (“STAT re-orders”). However, Client will be responsible for all additional labor and transportation charges associated with STAT re-orders.
^5OT	The Outbound transportation fees are based on typical volumetric weight. Q² Solutions, a Quintiles Quest Joint Venture will bill client actual transport costs per the invoice of the transport company. Any change to the fee imposed by the courier will be passed on to client. Priority shipments, e.g. next-day air are additional. Fees for outbound supply shipments do not include any imposed tariffs.
^6OT	The USD ($) Outbound transportation fees quoted are based on an estimated exchange rate of £1 GBP = $ 1.6022. However, all Outbound Transportation will be billed at the actual £GBP to USD ($) rate ruling in the applicable month as published by UK Customs and Excise. Thus the actual Outbound Transportation fees may vary from those quoted in this budget in any given month depending on what the actual exchange rate is.
^7OT	The Logistics estimates included represent our best recommendations based on recent experience. We welcome the opportunity to discuss carrier performance and recommendations since the decision on courier selection ultimately resides with the sponsor.