SCHEDULE 13G 0001463928 XXXXXXXX LIVE American Depositary Shares 12/19/2025 0001553846 RedHill Biopharma Ltd. 757468301 21 Ha'arba'a Street Tel Aviv L3 647392 Rule 13d-1(c) YA II PN, Ltd. a E9 0.00 508723.00 0.00 508723.00 508723.00 N 9.9 OO Pursuant to the Standby Equity Distribution Agreement (the "SEPA") entered into on December 19, 2025 between YA II PN, Ltd. ("YA II") and RedHill Biopharma Ltd. (the "Issuer"), YA II received 508,723 American Depositary Shares (the "ADSs") representing ordinary shares (the "Shares") of the Issuer, and received a warrant (the "Warrant") to purchase an additional 590,446 ADSs. YA II is prohibited from acquiring any ADSs pursuant to the SEPA or the Warrant which when aggregated with all other ADSs then owned by YA II and its affiliates, would result in the beneficial ownership by YA II and its affiliates to exceed 9.99% of the ADSs outstanding. Calculation based on 5,092,326 ADSs, consisting of 4,583,603 ADSs outstanding as of December 19, 2025, plus an additional 508,723 ADSs received by YA II pursuant to the SEPA. YA Global Investments II (U.S.), LP a DE 0.00 508723.00 0.00 508723.00 508723.00 N 9.9 OO Pursuant to the SEPA, YA II received 508,723 ADSs representing Shares of the Issuer and received the Warrant to purchase an additional 590,446 ADSs. YA II is prohibited from acquiring any ADSs pursuant to the SEPA or the Warrant which when aggregated with all other ADSs then owned by YA II and its affiliates, would result in the beneficial ownership by YA II and its affiliates to exceed 9.99% of the ADSs outstanding. Calculation based on 5,092,326 ADSs, consisting of 4,583,603 ADSs outstanding as of December 19, 2025, plus an additional 508,723 ADSs received by YA II pursuant to the SEPA. Yorkville Advisors Global, LP a DE 0.00 508723.00 0.00 508723.00 508723.00 N 9.9 OO Pursuant to the SEPA, YA II received 508,723 ADSs representing Shares of the Issuer and received the Warrant to purchase an additional 590,446 ADSs. YA II is prohibited from acquiring any ADSs pursuant to the SEPA or the Warrant which when aggregated with all other ADSs then owned by YA II and its affiliates, would result in the beneficial ownership by YA II and its affiliates to exceed 9.99% of the ADSs outstanding. Calculation based on 5,092,326 ADSs, consisting of 4,583,603 ADSs outstanding as of December 19, 2025, plus an additional 508,723 ADSs received by YA II pursuant to the SEPA. Yorkville Advisors Global II, LLC a DE 0.00 508723.00 0.00 508723.00 508723.00 N 9.9 OO Pursuant to the SEPA, YA II received 508,723 ADSs representing Shares of the Issuer and received the Warrant to purchase an additional 590,446 ADSs. YA II is prohibited from acquiring any ADSs pursuant to the SEPA or the Warrant which when aggregated with all other ADSs then owned by YA II and its affiliates, would result in the beneficial ownership by YA II and its affiliates to exceed 9.99% of the ADSs outstanding. Calculation based on 5,092,326 ADSs, consisting of 4,583,603 ADSs outstanding as of December 19, 2025, plus an additional 508,723 ADSs received by YA II pursuant to the SEPA. YAII GP, LP a DE 0.00 508723.00 0.00 508723.00 508723.00 N 9.9 OO Pursuant to the SEPA, YA II received 508,723 ADSs representing Shares of the Issuer and received the Warrant to purchase an additional 590,446 ADSs. YA II is prohibited from acquiring any ADSs pursuant to the SEPA or the Warrant which when aggregated with all other ADSs then owned by YA II and its affiliates, would result in the beneficial ownership by YA II and its affiliates to exceed 9.99% of the ADSs outstanding. Calculation based on 5,092,326 ADSs, consisting of 4,583,603 ADSs outstanding as of December 19, 2025, plus an additional 508,723 ADSs received by YA II pursuant to the SEPA. YAII GP II, LLC a DE 0.00 508723.00 0.00 508723.00 508723.00 N 9.9 OO Pursuant to the SEPA, YA II received 508,723 ADSs representing Shares of the Issuer and received the Warrant to purchase an additional 590,446 ADSs. YA II is prohibited from acquiring any ADSs pursuant to the SEPA or the Warrant which when aggregated with all other ADSs then owned by YA II and its affiliates, would result in the beneficial ownership by YA II and its affiliates to exceed 9.99% of the ADSs outstanding. Calculation based on 5,092,326 ADSs, consisting of 4,583,603 ADSs outstanding as of December 19, 2025, plus an additional 508,723 ADSs received by YA II pursuant to the SEPA. Mark Angelo a NJ 0.00 508723.00 0.00 508723.00 508723.00 N 9.9 OO Pursuant to the SEPA, YA II received 508,723 ADSs representing Shares of the Issuer and received the Warrant to purchase an additional 590,446 ADSs. YA II is prohibited from acquiring any ADSs pursuant to the SEPA or the Warrant which when aggregated with all other ADSs then owned by YA II and its affiliates, would result in the beneficial ownership by YA II and its affiliates to exceed 9.99% of the ADSs outstanding. Calculation based on 5,092,326 ADSs, consisting of 4,583,603 ADSs outstanding as of December 19, 2025, plus an additional 508,723 ADSs received by YA II pursuant to the SEPA. SC-Sigma Global Partners, LP a DE 0.00 508723.00 0.00 508723.00 508723.00 N 9.9 OO Pursuant to the SEPA, YA II received 508,723 ADSs representing Shares of the Issuer and received the Warrant to purchase an additional 590,446 ADSs. YA II is prohibited from acquiring any ADSs pursuant to the SEPA or the Warrant which when aggregated with all other ADSs then owned by YA II and its affiliates, would result in the beneficial ownership by YA II and its affiliates to exceed 9.99% of the ADSs outstanding. Calculation based on 5,092,326 ADSs, consisting of 4,583,603 ADSs outstanding as of December 19, 2025, plus an additional 508,723 ADSs received by YA II pursuant to the SEPA. RedHill Biopharma Ltd. 21 Ha'arba'a Street Tel Aviv, L3, 647392 YA II PN, Ltd. 1012 Springfield Ave., Mountainside, NJ 07092 Cayman Islands N OO 508,723 9.9 0 508,723 0 508,723 Y Y Y N YA II is beneficially owned by YA Global Investments II (U.S.), LP (the "YA Feeder"). Yorkville Advisors Global, LP (the "YA Advisor") is the investment manager to YA II. Yorkville Advisors Global II, LLC (the "YA Advisor GP") is the general partner to the YA Advisor. YAII GP, LP (the "YA GP") is the general partner to the YA Feeder. YAII GP II, LLC (the "Yorkville GP") is the general partner to the YA GP. Mark Angelo makes the investment decisions on behalf of YA II. Accordingly, each of YA II, YA Feeder, the YA Advisor, the YA Advisor GP, the YA GP, the Yorkville GP and Mark Angelo may be deemed affiliates and therefore may be deemed to beneficially own the same number of ADSs. YAII GP, LP is the general partner of SC-Sigma Global Partners, LP ("SC-Sigma"), which is an investor in YA II. YAII GP II, LLC is the general partner of YAII GP, LP. The YA Advisor is the investment manager to SC-Sigma. Accordingly, SC-Sigma, the YA GP, the Yorkville GP, the YA Advisor, and Mark Angelo may be deemed affiliates and therefore may be deemed to beneficially own the same number of ADSs. For purposes of this filing, each of the reporting persons is deemed an affiliate of each other reporting person. Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. YA II PN, Ltd. /s/ David Gonzalez 12/23/2025 YA Global Investments II (U.S.), LP /s/ David Gonzalez 12/23/2025 Yorkville Advisors Global, LP /s/ David Gonzalez 12/23/2025 Yorkville Advisors Global II, LLC /s/ David Gonzalez 12/23/2025 YAII GP, LP /s/ David Gonzalez 12/23/2025 YAII GP II, LLC /s/ David Gonzalez 12/23/2025 Mark Angelo /s/ Mark Angelo 12/23/2025 SC-Sigma Global Partners, LP /s/ David Gonzalez 12/23/2025