SCHEDULE 13G 0002050194 XXXXXXXX LIVE Common Stock, par value $0.001 per share 12/31/2025 0001553643 RELMADA THERAPEUTICS, INC. 75955J402 2222 PONCE DE LEON BLVD. 3RD FLOOR CORAL GABLES FL 33134 Rule 13d-1(b) Spruce Street Capital LP DE 0.00 4086181.00 0.00 4086181.00 4086181.00 N 5.57 IA PN Alex R. Rosen X1 0.00 4086181.00 0.00 4086181.00 4086181.00 N 5.57 HC IN Simon Basseyn X1 0.00 4086181.00 0.00 4086181.00 4086181.00 N 5.57 HC IN RELMADA THERAPEUTICS, INC. 2222 Ponce de Leon Blvd., Floor 3, Coral Gables, FL 33134 This statement is filed by: (i) Spruce Street Capital LP (the "Investment Manager"), the investment manager to certain investment funds and/or accounts (collectively, the "Spruce Street Funds"), with respect to the shares of common stock, par value $0.001 per share (the "Common Stock") of Relmada Therapeutics, Inc. (the "Company") held by the Spruce Street Funds; (ii) Alex R. Ryan, co-Managing Member of Spruce Street Capital GP LLC, the general partner of the Investment Manager, and the co-Managing Partner of the Investment Manager, with respect to the shares of Common Stock held by the Spruce Street Funds; and (iii) Simon Basseyn, co-Managing Member of Spruce Street Capital GP LLC, the general partner of the Investment Manager, and the co-Managing Partner of the Investment Manager, with respect to the shares of Common Stock held by the Spruce Street Funds. The filing of this statement should not be construed as an admission that any of the forgoing persons or any Reporting Person is, for the purposes of Section 13 of the Act, the beneficial owner of the shares of Common Stock reported herein. The address of the business office of each of the Reporting Persons is: 777 Third Avenue, Suite 1704 New York, New York 10017 Citizenship is set forth in Row (4) of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person. N IA HC The information required by Item 4(a) is set forth in Row (9) of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentage set forth in this Schedule 13G is calculated based upon an aggregate of 73,333,622 shares of Common Stock outstanding as of November 10, 2025, as reported in the Company's Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2025, filed with the Securities and Exchange Commission on November 13, 2025. 5.57% The information required by Item 4(c)(i) is set forth in Row (5) of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(ii) is set forth in Row (6) of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iii) is set forth in Row (7) of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iv) is set forth in Row (8) of the cover page for each of the Reporting Persons and is incorporated herein by reference. Y N See Item 2(a). Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1: Joint Filing Agreement Spruce Street Capital LP /s/ Alex R. Rosen 02/17/2026 Alex R. Rosen /s/ Alex R. Rosen 02/17/2026 Simon Basseyn /s/ Simon Basseyn 02/17/2026