X0306 4 2022-09-25 0 0001659323 Iterum Therapeutics plc ITRM 0001553593 Dunne Michael W. C/O ITERUM THERAPEUTICS PLC FITZWILLIAM COURT, FL. 1, LEESON CLOSE DUBLIN 2 L2 IRELAND 1 0 0 0 Restricted Share Units 2022-09-25 4 A 0 1779 0.00 A Ordinary Shares 1779 1779 D Each restricted share unit ("RSU") represents the contingent right to receive one ordinary share upon vesting of the RSU. Subject to the reporting person providing continuous service to the Issuer and the other terms and conditions of the Issuer's 2018 Amended and Restated 2018 Equity Incentive Plan, as amended, the RSUs shall vest in full on July 1, 2023. /s/ Michael W. Dunne 2022-09-27