X0306 4 2022-03-25 0 0001659323 Iterum Therapeutics plc ITRM 0001553593 Dunne Michael W. C/O ITERUM THERAPEUTICS PLC FITZWILLIAM COURT, FL. 1, LEESON CLOSE DUBLIN 2 L2 IRELAND 1 0 0 0 Ordinary Shares 2022-03-25 4 M 0 10494 0.00 A 346849 D Restricted Share Units 2022-03-25 4 M 0 10494 0.00 D Ordinary Shares 10494 0 D Restricted Share Units 2022-03-25 4 A 0 11426 0.00 A Ordinary Shares 11426 11426 D Restricted share units ("2021 RSUs") converted into ordinary shares on a one-for-one basis upon vesting of the 2021 RSUs. On March 25, 2021, the reporting person was granted an award of 10,494 2021 RSUs, which vested on March 25, 2022. Each restricted share unit ("2022 RSU") represents the contingent right to receive one ordinary share upon vesting of a 2022 RSU. Subject to the reporting person providing continuous service to the Issuer and the other terms and conditions of the Issuer's 2018 Amended and Restated Equity Incentive Plan, as amended, the 2022 RSUs shall vest in full on January 1, 2023. /s/ Michael W. Dunne 2022-03-29