<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
    <submissionType>NPORT-P/A</submissionType>
    <isConfidential>false</isConfidential>
    <accessionNumber>0001145549-23-049473</accessionNumber>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0001552740</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000044369</seriesId>
        <classId>C000138164</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>First Trust Exchange-Traded Fund VI</regName>
      <regFileNumber>811-22717</regFileNumber>
      <regCik>0001552740</regCik>
      <regLei>549300ZLB3EUU3H8NE60</regLei>
      <regStreet1>120 East Liberty Drive, Suite 400</regStreet1>
      <regCity>Wheaton</regCity>
      <regStateConditional regCountry="US" regState="US-IL"/>
      <regZipOrPostalCode>60187</regZipOrPostalCode>
      <regPhone>630-765-8000</regPhone>
      <seriesName>First Trust Dorsey Wright Focus 5 ETF</seriesName>
      <seriesId>S000044369</seriesId>
      <seriesLei>549300JOTP3OPVVFZL06</seriesLei>
      <repPdEnd>2023-09-30</repPdEnd>
      <repPdDate>2023-06-30</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>3356226541.960000000000</totAssets>
      <totLiabs>11011112.150000000000</totLiabs>
      <netAssets>3345215429.810000000000</netAssets>
      <assetsAttrMiscSec>0.000000000000</assetsAttrMiscSec>
      <assetsInvested>0.000000000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.000000000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.000000000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.000000000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.000000000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.000000000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.000000000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.000000000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.000000000000</amtPayAftOneYrOther>
      <delayDeliv>0.000000000000</delayDeliv>
      <standByCommit>0.000000000000</standByCommit>
      <liquidPref>0.000000000000</liquidPref>
      <cshNotRptdInCorD>6189436.170000000000</cshNotRptdInCorD>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000138164" rtn1="-1.77" rtn2="-2.55" rtn3="8.58"/>
        </monthlyTotReturns>
        <othMon1 netRealizedGain="1412990.8" netUnrealizedAppr="-57133966.68"/>
        <othMon2 netRealizedGain="1599075.08" netUnrealizedAppr="-80811818.39"/>
        <othMon3 netRealizedGain="-52493271.76" netUnrealizedAppr="311305000.64"/>
      </returnInfo>
      <mon1Flow redemption="-28790716" reinvestment="0" sales="6705634.5"/>
      <mon2Flow redemption="-56974833" reinvestment="0" sales="35235848"/>
      <mon3Flow redemption="-9093649.5" reinvestment="0" sales="73197500"/>
    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>First Trust Dow Jones Internet Index Fund</name>
        <lei>549300MZB4XDLRWOC672</lei>
        <title>FIRST TRUST DJ INTERNET IND</title>
        <cusip>33733E302</cusip>
        <identifiers>
          <isin value="US33733E3027"/>
          <ticker value="FDN"/>
          <other otherDesc="SEDOL" value="B17NS93"/>
        </identifiers>
        <balance>3995359.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>651203563.41</valUSD>
        <pctVal>19.4667152856</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Consumer Discretionary AlphaDEX Fund</name>
        <lei>549300PGRVU1P76W4537</lei>
        <title>FIRST TRUST CONSUMER DISCRET</title>
        <cusip>33734X101</cusip>
        <identifiers>
          <isin value="US33734X1019"/>
          <ticker value="FXD"/>
          <other otherDesc="SEDOL" value="B1X2ZK4"/>
        </identifiers>
        <balance>12333560.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>680935847.60</valUSD>
        <pctVal>20.3555155681</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Industrials/Producer Durables AlphaDEX Fund</name>
        <lei>549300PGRVU1P76W4537</lei>
        <title>FIRST TRUST INDST/PRODUCERS</title>
        <cusip>33734X150</cusip>
        <identifiers>
          <isin value="US33734X1506"/>
          <ticker value="FXR"/>
          <other otherDesc="SEDOL" value="B1X2ZX7"/>
        </identifiers>
        <balance>11429289.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>686785976.01</valUSD>
        <pctVal>20.5303960364</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Nasdaq Semiconductor ETF</name>
        <lei>549300ZLB3EUU3H8NE60</lei>
        <title>FIRST TRUST NASDAQ SEMICONDU</title>
        <cusip>33738R811</cusip>
        <identifiers>
          <isin value="US33738R8117"/>
          <ticker value="FTXL"/>
          <other otherDesc="SEDOL" value="BZB1374"/>
        </identifiers>
        <balance>9679925.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>689113860.75</valUSD>
        <pctVal>20.5999845214</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Nasdaq Food &amp; Beverage ETF</name>
        <lei>549300ZLB3EUU3H8NE60</lei>
        <title>FIRST TRUST NASDAQ FOOD &amp; BE</title>
        <cusip>33738R852</cusip>
        <identifiers>
          <isin value="US33738R8521"/>
          <ticker value="FTXG"/>
          <other otherDesc="SEDOL" value="BZB12G6"/>
        </identifiers>
        <balance>24276466.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>636528938.52</valUSD>
        <pctVal>19.0280402526</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2023-07-28</ncom:dateSigned>
      <ncom:nameOfApplicant>First Trust Exchange-Traded Fund VI</ncom:nameOfApplicant>
      <ncom:signature>Derek D. Maltbie</ncom:signature>
      <ncom:signerName>First Trust Exchange-Traded Fund VI </ncom:signerName>
      <ncom:title>Treasurer, Chief Financial Officer and Chief Accounting Officer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
