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    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0001552740</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000044369</seriesId>
        <classId>C000138164</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
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      <regName>First Trust Exchange-Traded Fund VI</regName>
      <regFileNumber>811-22717</regFileNumber>
      <regCik>0001552740</regCik>
      <regLei>549300ZLB3EUU3H8NE60</regLei>
      <regStreet1>120 East Liberty Drive, Suite 400</regStreet1>
      <regCity>Wheaton</regCity>
      <regStateConditional regCountry="US" regState="US-IL"/>
      <regZipOrPostalCode>60187</regZipOrPostalCode>
      <regPhone>630-765-8000</regPhone>
      <seriesName>First Trust Dorsey Wright Focus 5 ETF</seriesName>
      <seriesId>S000044369</seriesId>
      <seriesLei>549300JOTP3OPVVFZL06</seriesLei>
      <repPdEnd>2022-09-30</repPdEnd>
      <repPdDate>2021-12-31</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>2922305474.890000000000</totAssets>
      <totLiabs>2695763.430000000000</totLiabs>
      <netAssets>2919609711.460000000000</netAssets>
      <assetsAttrMiscSec>0.000000000000</assetsAttrMiscSec>
      <assetsInvested>0.000000000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.000000000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.000000000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.000000000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.000000000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.000000000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.000000000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.000000000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.000000000000</amtPayAftOneYrOther>
      <delayDeliv>0.000000000000</delayDeliv>
      <standByCommit>0.000000000000</standByCommit>
      <liquidPref>0.000000000000</liquidPref>
      <cshNotRptdInCorD>672215.370000000000</cshNotRptdInCorD>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000138164" rtn1="7.08" rtn2="-0.98" rtn3="1.41"/>
        </monthlyTotReturns>
        <othMon1 netRealizedGain="0" netUnrealizedAppr="191537625.27"/>
        <othMon2 netRealizedGain="3340832.76" netUnrealizedAppr="-31294526"/>
        <othMon3 netRealizedGain="344535598.59" netUnrealizedAppr="-304674544.65"/>
      </returnInfo>
      <mon1Flow redemption="0" reinvestment="0" sales="9594940"/>
      <mon2Flow redemption="-7554240.5" reinvestment="0" sales="17800538"/>
      <mon3Flow redemption="-628092538.5" reinvestment="0" sales="630259676.5"/>
    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>First Trust Exchange-Traded Fund</name>
        <lei>549300MZB4XDLRWOC672</lei>
        <title>FIRST TRUST NASDQ 100 TECH I</title>
        <cusip>337345102</cusip>
        <identifiers>
          <isin value="US3373451026"/>
          <ticker value="QTEC"/>
          <other otherDesc="SEDOL" value="B13HMB9"/>
        </identifiers>
        <balance>3335573.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>584258966.68</valUSD>
        <pctVal>20.0115434740</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Exchange-Traded AlphaDEX Fund</name>
        <lei>549300PGRVU1P76W4537</lei>
        <title>FIRST TRUST CONSUMER DISCRET</title>
        <cusip>33734X101</cusip>
        <identifiers>
          <isin value="US33734X1019"/>
          <ticker value="FXD"/>
          <other otherDesc="SEDOL" value="B1X2ZK4"/>
        </identifiers>
        <balance>9427573.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>584886628.92</valUSD>
        <pctVal>20.0330416296</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Exchange-Traded AlphaDEX Fund</name>
        <lei>549300PGRVU1P76W4537</lei>
        <title>FIRST TRUST INDST/PRODUCERS</title>
        <cusip>33734X150</cusip>
        <identifiers>
          <isin value="US33734X1506"/>
          <ticker value="FXR"/>
          <other otherDesc="SEDOL" value="B1X2ZX7"/>
        </identifiers>
        <balance>9533223.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>594968447.43</valUSD>
        <pctVal>20.3783555417</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Exchange-Traded Fund VI</name>
        <lei>549300ZLB3EUU3H8NE60</lei>
        <title>FIRST TRUST NASDAQ TRANSPORT</title>
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        <identifiers>
          <isin value="US33738R7952"/>
          <ticker value="FTXR"/>
          <other otherDesc="SEDOL" value="BZB1341"/>
        </identifiers>
        <balance>16969084.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>586281852.20</valUSD>
        <pctVal>20.0808296362</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Exchange-Traded Fund VI</name>
        <lei>549300ZLB3EUU3H8NE60</lei>
        <title>FIRST TRUST NASDAQ OIL &amp; GAS</title>
        <cusip>33738R845</cusip>
        <identifiers>
          <isin value="US33738R8455"/>
          <ticker value="FTXN"/>
          <other otherDesc="SEDOL" value="BZB1299"/>
        </identifiers>
        <balance>29172991.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>567122945.04</valUSD>
        <pctVal>19.4246149687</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2022-01-30</ncom:dateSigned>
      <ncom:nameOfApplicant>First Trust Exchange-Traded Fund VI</ncom:nameOfApplicant>
      <ncom:signature>Donald P. Swade</ncom:signature>
      <ncom:signerName>First Trust Exchange-Traded Fund VI </ncom:signerName>
      <ncom:title>Treasurer, Chief Financial Officer and Chief Accounting Officer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
