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      <repPdEnd>2022-03-31</repPdEnd>
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      <totLiabs>1676368.650000000000</totLiabs>
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      <assetsInvested>0.000000000000</assetsInvested>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SVB Financial Group</name>
        <lei>549300D2KJ20JMXE7542</lei>
        <title>SVB FINANCIAL GROUP</title>
        <cusip>78486Q101</cusip>
        <identifiers>
          <isin value="US78486Q1013"/>
          <ticker value="SIVB"/>
          <other otherDesc="SEDOL" value="2808053"/>
        </identifiers>
        <balance>6734.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4567268.16</valUSD>
        <pctVal>1.6463641592</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Signature Bank</name>
        <lei>VLP5AP0XK2GM6GKD1007</lei>
        <title>SIGNATURE BANK</title>
        <cusip>82669G104</cusip>
        <identifiers>
          <isin value="US82669G1040"/>
          <ticker value="SBNY"/>
          <other otherDesc="SEDOL" value="B00JQL9"/>
        </identifiers>
        <balance>15420.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4987907.40</valUSD>
        <pctVal>1.7979920787</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Silvergate Capital Corporation</name>
        <lei>BPE6FTXDZEBNAGIT2T19</lei>
        <title>SILVERGATE CAPITAL CORP-CL A</title>
        <cusip>82837P408</cusip>
        <identifiers>
          <isin value="US82837P4081"/>
          <ticker value="SI"/>
          <other otherDesc="SEDOL" value="BJ1DBR4"/>
        </identifiers>
        <balance>22798.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3378663.60</valUSD>
        <pctVal>1.2179076118</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Synovus Financial Corp.</name>
        <lei>549300EIUS8UN5JTLE54</lei>
        <title>SYNOVUS FINANCIAL CORP</title>
        <cusip>87161C501</cusip>
        <identifiers>
          <isin value="US87161C5013"/>
          <ticker value="SNV"/>
          <other otherDesc="SEDOL" value="BMH4NJ8"/>
        </identifiers>
        <balance>102931.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4927306.97</valUSD>
        <pctVal>1.7761474283</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Truist Financial Corporation</name>
        <lei>549300DRQQI75D2JP341</lei>
        <title>TRUIST FINANCIAL CORP</title>
        <cusip>89832Q109</cusip>
        <identifiers>
          <isin value="US89832Q1094"/>
          <ticker value="TFC"/>
          <other otherDesc="SEDOL" value="BKP7287"/>
        </identifiers>
        <balance>78599.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4601971.45</valUSD>
        <pctVal>1.6588736618</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>U.S. Bancorp</name>
        <lei>N1GZ7BBF3NP8GI976H15</lei>
        <title>US BANCORP</title>
        <cusip>902973304</cusip>
        <identifiers>
          <isin value="US9029733048"/>
          <ticker value="USB"/>
          <other otherDesc="SEDOL" value="2736035"/>
        </identifiers>
        <balance>84237.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4731592.29</valUSD>
        <pctVal>1.7055981146</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Wells Fargo &amp; Company</name>
        <lei>PBLD0EJDB5FWOLXP3B76</lei>
        <title>WELLS FARGO &amp; CO</title>
        <cusip>949746101</cusip>
        <identifiers>
          <isin value="US9497461015"/>
          <ticker value="WFC"/>
          <other otherDesc="SEDOL" value="2649100"/>
        </identifiers>
        <balance>230885.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11077862.30</valUSD>
        <pctVal>3.9932394623</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Western Alliance Bancorporation</name>
        <lei>5493003VJXZ5JXT9S762</lei>
        <title>WESTERN ALLIANCE BANCORP</title>
        <cusip>957638109</cusip>
        <identifiers>
          <isin value="US9576381092"/>
          <ticker value="WAL"/>
          <other otherDesc="SEDOL" value="B0CCGJ4"/>
        </identifiers>
        <balance>42464.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4571249.60</valUSD>
        <pctVal>1.6477993498</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zions Bancorporation Natl Assn Global Bank</name>
        <lei>8WH0EE09O9V05QJZ3V89</lei>
        <title>ZIONS BANCORP NA</title>
        <cusip>989701107</cusip>
        <identifiers>
          <isin value="US9897011071"/>
          <ticker value="ZION"/>
          <other otherDesc="SEDOL" value="2989828"/>
        </identifiers>
        <balance>174884.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11045673.44</valUSD>
        <pctVal>3.9816363369</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2022-01-30</ncom:dateSigned>
      <ncom:nameOfApplicant>First Trust Exchange-Traded Fund VI</ncom:nameOfApplicant>
      <ncom:signature>Donald P. Swade</ncom:signature>
      <ncom:signerName>First Trust Exchange-Traded Fund VI </ncom:signerName>
      <ncom:title>Treasurer, Chief Financial Officer and Chief Accounting Officer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
