NPORT-EX 2 edgar.htm ETF VI 3/31 FYE N-PORT PART F 12.31.21
First Trust Nasdaq Bank ETF (FTXO)
Portfolio of Investments
December 31, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.8%
    Banks – 91.5%    
248,071   Bank of America Corp.   $11,036,679
346,363   Citigroup, Inc.   20,916,862
466,753   Citizens Financial Group, Inc.   22,054,079
67,703   Comerica, Inc.   5,890,161
37,030   Cullen/Frost Bankers, Inc.   4,668,372
60,542   East West Bancorp, Inc.   4,763,445
261,725   Fifth Third Bancorp   11,398,124
5,798   First Citizens BancShares, Inc., Class A   4,811,412
683,924   First Horizon Corp.   11,168,479
22,236   First Republic Bank   4,591,956
314,134   Huntington Bancshares, Inc.   4,843,946
138,912   JPMorgan Chase & Co.   21,996,715
491,608   KeyCorp   11,370,893
31,797   M&T Bank Corp.   4,883,383
55,998   PNC Financial Services Group (The), Inc.   11,228,719
283,519   Popular, Inc.   23,259,899
969,820   Regions Financial Corp.   21,142,076
15,420   Signature Bank   4,987,907
22,798   Silvergate Capital Corp., Class A (a)   3,378,664
6,734   SVB Financial Group (a)   4,567,268
102,931   Synovus Financial Corp.   4,927,307
78,599   Truist Financial Corp.   4,601,972
84,237   US Bancorp   4,731,592
230,885   Wells Fargo & Co.   11,077,862
42,464   Western Alliance Bancorp   4,571,250
174,884   Zions Bancorp N.A.   11,045,673
        253,914,695
    Consumer Finance – 4.3%    
102,287   Discover Financial Services   11,820,286
    Thrifts & Mortgage Finance – 4.0%    
920,843   New York Community Bancorp, Inc.   11,243,493
    Total Investments – 99.8%   276,978,474
    (Cost $260,816,799) (b)    
    Net Other Assets and Liabilities – 0.2%   436,956
    Net Assets – 100.0%   $277,415,430
    

(a) Non-income producing security.
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of December 31, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $19,579,053 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $3,417,378. The net unrealized appreciation was $16,161,675.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of December 31, 2021 is as follows (see Valuation Inputs in the Additional Information section):
  Total
Value at
12/31/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $276,978,474 $276,978,474 $$
    
* See Portfolio of Investments for industry breakout.
 

First Trust Nasdaq Food & Beverage ETF (FTXG)
Portfolio of Investments
December 31, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.6%
    Beverages – 20.0%    
88   Boston Beer (The) Co., Inc., Class A (a)   $44,449
563   Brown-Forman Corp., Class B   41,020
4,534   Coca-Cola (The) Co.   268,458
176   Constellation Brands, Inc., Class A   44,171
6,997   Keurig Dr. Pepper, Inc.   257,909
892   Molson Coors Beverage Co., Class B   41,344
473   Monster Beverage Corp. (a)   45,427
763   National Beverage Corp. (a)   34,587
2,977   PepsiCo, Inc.   517,135
        1,294,500
    Chemicals – 3.9%    
5,285   Corteva, Inc.   249,875
    Food & Staples Retailing – 0.7%    
1,262   US Foods Holding Corp. (a)   43,955
    Food Products – 74.5%    
7,646   Archer-Daniels-Midland Co.   516,793
7,894   B&G Foods, Inc.   242,583
564   Beyond Meat, Inc. (a)   36,750
5,495   Bunge Ltd.   513,013
5,897   Campbell Soup Co.   256,284
7,785   Conagra Brands, Inc.   265,858
587   Darling Ingredients, Inc. (a)   40,673
3,850   General Mills, Inc.   259,413
1,340   Hershey (The) Co.   259,250
957   Hormel Foods Corp.   46,711
2,554   Ingredion, Inc.   246,819
3,761   JM Smucker (The) Co.   510,819
3,887   Kellogg Co.   250,400
7,076   Kraft Heinz (The) Co.   254,028
763   Lamb Weston Holdings, Inc.   48,359
2,771   McCormick & Co., Inc.   267,706
4,035   Mondelez International, Inc., Class A   267,561
6,024   Tyson Foods, Inc., Class A   525,052
        4,808,072
    Specialty Retail – 0.5%    
2,432   GrowGeneration Corp. (a)   31,738
    Total Investments – 99.6%   6,428,140
    (Cost $6,172,810) (b)    
    Net Other Assets and Liabilities – 0.4%   23,638
    Net Assets – 100.0%   $6,451,778
    

(a) Non-income producing security.
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of December 31, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $428,446 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $173,116. The net unrealized appreciation was $255,330.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of December 31, 2021 is as follows (see Valuation Inputs in the Additional Information section):
  Total
Value at
12/31/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $6,428,140 $6,428,140 $$
    
* See Portfolio of Investments for industry breakout.
 

First Trust Nasdaq Oil & Gas ETF (FTXN)
Portfolio of Investments
December 31, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 100.0%
    Energy Equipment &
Services – 6.7%
   
323,923   Baker Hughes Co.   $7,793,588
370,442   ChampionX Corp. (a)   7,486,633
350,199   Halliburton Co.   8,009,051
336,783   Helmerich & Payne, Inc.   7,981,757
92,824   Nabors Industries Ltd. (a)   7,527,098
634,292   NOV, Inc.   8,594,657
263,633   Schlumberger N.V.   7,895,808
2,503,533   Transocean Ltd. (a)   6,909,751
        62,198,343
    Oil, Gas & Consumable Fuels – 93.3%    
1,581,711   Antero Midstream Corp.   15,310,962
430,576   Antero Resources Corp. (a)   7,535,080
1,163,945   APA Corp.   31,298,481
148,717   Callon Petroleum Co. (a)   7,026,878
3,256,107   Centennial Resource Development, Inc./DE, Class A (a)   19,471,520
351,142   Cheniere Energy, Inc.   35,612,822
534,013   Chevron Corp.   62,666,426
554,289   CNX Resources Corp. (a)   7,621,474
934,582   Comstock Resources, Inc. (a)   7,560,768
524,786   ConocoPhillips   37,879,054
632,536   Coterra Energy, Inc.   12,018,184
482,177   Delek US Holdings, Inc. (a)   7,227,833
830,845   Devon Energy Corp.   36,598,722
70,845   Diamondback Energy, Inc.   7,640,633
309,417   EOG Resources, Inc.   27,485,512
389,113   EQT Corp. (a)   8,486,555
3,581,597   Equitrans Midstream Corp.   37,033,713
276,275   Exxon Mobil Corp.   16,905,267
101,467   Hess Corp.   7,511,602
362,462   HollyFrontier Corp.   11,881,504
3,480,717   Kinder Morgan, Inc.   55,204,172
3,447,168   Kosmos Energy Ltd. (a)   11,927,201
1,532,869   Magnolia Oil & Gas Corp., Class A   28,925,238
2,618,756   Marathon Oil Corp.   42,999,974
414,221   Marathon Petroleum Corp.   26,506,002
351,092   Matador Resources, Co.   12,962,317
284,440   Murphy Oil Corp.   7,426,728
255,008   Occidental Petroleum Corp.   7,392,682
615,026   ONEOK, Inc.   36,138,928
217,523   Ovintiv, Inc.   7,330,525
603,418   PBF Energy, Inc., Class A (a)   7,826,331
481,028   PDC Energy, Inc.   23,464,546
109,309   Phillips 66   7,920,530
58,918   Pioneer Natural Resources Co.   10,716,006
386,547   Range Resources Corp. (a)   6,892,133
1,269,055   SM Energy Co.   37,411,741
1,687,648   Southwestern Energy Co. (a)   7,864,440
883,653   Targa Resources Corp.   46,162,033
2,319,224   Tellurian, Inc. (a)   7,143,210
Shares   Description   Value
    Oil, Gas & Consumable
Fuels (Continued)
   
112,957   Valero Energy Corp.   $8,484,200
2,433,711   Williams (The) Cos., Inc.   63,373,834
        868,845,761
    Total Investments – 100.0%   931,044,104
    (Cost $920,465,937) (b)    
    Net Other Assets and Liabilities – 0.0%   93,742
    Net Assets – 100.0%   $931,137,846
    

(a) Non-income producing security.
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of December 31, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $19,603,935 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $9,025,768. The net unrealized appreciation was $10,578,167.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of December 31, 2021 is as follows (see Valuation Inputs in the Additional Information section):
  Total
Value at
12/31/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $931,044,104 $931,044,104 $$
    
* See Portfolio of Investments for industry breakout.
 

First Trust Nasdaq Pharmaceuticals ETF (FTXH)
Portfolio of Investments
December 31, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.9%
    Biotechnology – 32.6%    
5,744   AbbVie, Inc.   $777,738
9,069   Alkermes PLC (a)   210,945
7,674   BioMarin Pharmaceutical, Inc. (a)   677,998
2,066   Blueprint Medicines Corp. (a)   221,289
19,213   Gilead Sciences, Inc.   1,395,056
6,382   Horizon Therapeutics PLC (a)   687,724
7,502   Ionis Pharmaceuticals, Inc. (a)   228,286
3,494   United Therapeutics Corp. (a)   754,983
3,542   Vertex Pharmaceuticals, Inc. (a)   777,823
        5,731,842
    Health Care Providers &
Services – 4.2%
   
14,324   Cardinal Health, Inc.   737,543
    Pharmaceuticals – 63.1%    
12,347   Bristol-Myers Squibb Co.   769,835
5,147   Catalent, Inc. (a)   658,970
22,003   Corcept Therapeutics, Inc. (a)   435,659
6,917   Elanco Animal Health, Inc. (a)   196,305
2,670   Eli Lilly & Co.   737,507
118,248   Endo International PLC (a)   444,613
22,771   Esperion Therapeutics, Inc. (a)   113,855
1,658   Jazz Pharmaceuticals PLC (a)   211,229
8,493   Johnson & Johnson   1,452,898
8,840   Merck & Co., Inc.   677,498
29,063   Ocular Therapeutix, Inc. (a)   202,569
3,778   Pacira BioSciences, Inc. (a)   227,322
5,415   Perrigo Co. PLC   210,644
24,649   Pfizer, Inc.   1,455,523
23,671   Prestige Consumer Healthcare, Inc. (a)   1,435,646
401,600   TherapeuticsMD, Inc. (a)   142,769
5,965   Zoetis, Inc.   1,455,639
17,670   Zogenix, Inc. (a)   287,138
        11,115,619
    Total Investments – 99.9%   17,585,004
    (Cost $16,178,148) (b)    
    Net Other Assets and Liabilities – 0.1%   20,165
    Net Assets – 100.0%   $17,605,169
    

(a) Non-income producing security.
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of December 31, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $2,797,477 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $1,390,621. The net unrealized appreciation was $1,406,856.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of December 31, 2021 is as follows (see Valuation Inputs in the Additional Information section):
  Total
Value at
12/31/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $17,585,004 $17,585,004 $$
    
* See Portfolio of Investments for industry breakout.
 

First Trust Nasdaq Retail ETF (FTXD) (a)
Portfolio of Investments
December 31, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.7%
    Commercial Services &
Supplies – 1.0%
   
1,998   Copart, Inc. (b)   $302,936
    Diversified Consumer
Services – 0.3%
   
2,736   Chegg, Inc. (b)   83,995
    Food & Staples Retailing – 19.5%    
3,171   Costco Wholesale Corp.   1,800,177
42,639   Kroger (The) Co.   1,929,841
1,088   Sysco Corp.   85,462
19,649   Walgreens Boots Alliance, Inc.   1,024,892
8,175   Walmart, Inc.   1,182,841
        6,023,213
    Health Care Providers &
Services – 7.1%
   
658   AmerisourceBergen Corp.   87,442
19,489   CVS Health Corp.   2,010,485
351   McKesson Corp.   87,248
        2,185,175
    Internet & Direct Marketing
Retail – 5.4%
   
68   Amazon.com, Inc. (b)   226,735
1,116   Chewy, Inc., Class A (b)   65,811
17,043   eBay, Inc.   1,133,359
278   Etsy, Inc. (b)   60,865
854   Overstock.com, Inc. (b)   50,395
3,061   Stitch Fix, Inc., Class A (b)   57,914
308   Wayfair, Inc., Class A (b)   58,511
        1,653,590
    Multiline Retail – 20.3%    
5,194   Dollar General Corp.   1,224,901
8,520   Dollar Tree, Inc. (b)   1,197,230
19,599   Kohl’s Corp.   967,995
62,558   Macy’s, Inc.   1,637,769
3,599   Nordstrom, Inc. (b)   81,409
1,232   Ollie’s Bargain Outlet Holdings, Inc. (b)   63,066
4,716   Target Corp.   1,091,471
        6,263,841
    Oil, Gas & Consumable Fuels – 0.2%    
10,629   Clean Energy Fuels Corp. (b)   65,156
    Road & Rail – 0.5%    
1,877   Lyft, Inc., Class A (b)   80,204
2,005   Uber Technologies, Inc. (b)   84,070
        164,274
    Specialty Retail – 45.4%    
5,210   Advance Auto Parts, Inc.   1,249,775
Shares   Description   Value
    Specialty Retail (Continued)    
2,944   American Eagle Outfitters, Inc.   $74,542
633   AutoZone, Inc. (b)   1,327,015
15,303   Bath & Body Works, Inc.   1,067,996
4,157   Bed Bath & Beyond, Inc. (b)   60,609
10,123   Best Buy Co., Inc.   1,028,497
261   Burlington Stores, Inc. (b)   76,084
1,684   CarMax, Inc. (b)   219,307
272   Carvana Co. (b)   63,047
9,780   Dick’s Sporting Goods, Inc.   1,124,602
375   Five Below, Inc. (b)   77,584
10,950   GameStop Corp., Class A (b)   1,624,871
4,611   Gap (The), Inc.   81,384
2,869   Home Depot (The), Inc.   1,190,664
262   Lithia Motors, Inc.   77,801
4,701   Lowe’s Cos., Inc.   1,215,115
1,802   O’Reilly Automotive, Inc. (b)   1,272,626
130   RH (b)   69,672
699   Ross Stores, Inc.   79,882
1,520   TJX (The) Cos., Inc.   115,398
4,183   Tractor Supply Co.   998,064
198   Ulta Beauty, Inc. (b)   81,643
1,403   Victoria’s Secret & Co. (b)   77,923
4,433   Williams-Sonoma, Inc.   749,753
        14,003,854
    Total Investments – 99.7%   30,746,034
    (Cost $29,409,583) (c)    
    Net Other Assets and Liabilities – 0.3%   77,213
    Net Assets – 100.0%   $30,823,247
    

(a) As of January 26, 2022, the Fund changed its name to First Trust S-Network E-Commerce ETF.
(b) Non-income producing security.
(c) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of December 31, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $2,426,135 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $1,089,684. The net unrealized appreciation was $1,336,451.
 

First Trust Nasdaq Retail ETF (FTXD) (a)
Portfolio of Investments (Continued)
December 31, 2021 (Unaudited)

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of December 31, 2021 is as follows (see Valuation Inputs in the Additional Information section):
  Total
Value at
12/31/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $30,746,034 $30,746,034 $$
    
* See Portfolio of Investments for industry breakout.

First Trust Nasdaq Semiconductor ETF (FTXL)
Portfolio of Investments
December 31, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.8%
    Electronic Equipment,
Instruments & Components – 4.0%
   
34,886   II-VI, Inc. (a)   $2,383,760
13,286   IPG Photonics Corp. (a)   2,287,052
        4,670,812
    Semiconductors &
Semiconductor Equipment – 95.8%
   
28,415   Advanced Micro Devices, Inc. (a)   4,088,918
12,151   Ambarella, Inc. (a)   2,465,316
101,178   Amkor Technology, Inc.   2,508,203
24,965   Analog Devices, Inc.   4,388,098
14,820   Applied Materials, Inc.   2,332,075
19,287   Azenta, Inc.   1,988,683
16,256   Broadcom, Inc.   10,816,905
27,206   Cirrus Logic, Inc. (a)   2,503,496
14,933   Entegris, Inc.   2,069,415
182,926   Intel Corp.   9,420,689
8,705   KLA Corp.   3,744,108
3,209   Lam Research Corp.   2,307,752
28,730   Lattice Semiconductor Corp. (a)   2,213,934
30,651   Marvell Technology, Inc.   2,681,656
26,147   Microchip Technology, Inc.   2,276,358
53,571   Micron Technology, Inc.   4,990,139
3,942   Monolithic Power Systems, Inc.   1,944,707
13,772   NVIDIA Corp.   4,050,483
9,767   NXP Semiconductors N.V.   2,224,727
73,254   ON Semiconductor Corp. (a)   4,975,412
14,917   Qorvo, Inc. (a)   2,332,870
49,845   QUALCOMM, Inc.   9,115,155
11,114   Silicon Laboratories, Inc. (a)   2,294,152
14,384   Skyworks Solutions, Inc.   2,231,534
31,888   Synaptics, Inc. (a)   9,231,895
14,270   Teradyne, Inc.   2,333,573
46,784   Texas Instruments, Inc.   8,817,380
17,789   Wolfspeed, Inc. (a)   1,988,276
        112,335,909
    Total Investments – 99.8%   117,006,721
    (Cost $99,991,107) (b)    
    Net Other Assets and Liabilities – 0.2%   178,997
    Net Assets – 100.0%   $117,185,718
    

(a) Non-income producing security.
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of December 31, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $17,941,833 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $926,219. The net unrealized appreciation was $17,015,614.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of December 31, 2021 is as follows (see Valuation Inputs in the Additional Information section):
  Total
Value at
12/31/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $117,006,721 $117,006,721 $$
    
* See Portfolio of Investments for industry breakout.
 

First Trust Nasdaq Transportation ETF (FTXR)
Portfolio of Investments
December 31, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 100.0%
    Air Freight & Logistics – 20.3%    
501,945   CH Robinson Worldwide, Inc.   $54,024,340
575,581   Expeditors International of Washington, Inc.   77,294,773
187,524   FedEx Corp.   48,501,207
233,404   GXO Logistics, Inc. (a)   21,200,085
240,611   United Parcel Service, Inc., Class B   51,572,562
        252,592,967
    Airlines – 13.1%    
461,569   Alaska Air Group, Inc. (a)   24,047,745
1,267,292   American Airlines Group, Inc. (a)   22,760,564
619,292   Delta Air Lines, Inc. (a)   24,201,932
1,670,521   JetBlue Airways Corp. (a)   23,788,219
504,919   Southwest Airlines Co. (a)   21,630,730
1,072,138   Spirit Airlines, Inc. (a)   23,426,215
530,487   United Airlines Holdings, Inc. (a)   23,224,721
        163,080,126
    Auto Components – 5.1%    
139,809   Aptiv PLC (a)   23,061,495
894,773   BorgWarner, Inc.   40,327,419
        63,388,914
    Automobiles – 17.1%    
4,974,458   Ford Motor Co.   103,319,493
824,778   General Motors Co. (a)   48,356,734
41,261   Tesla, Inc. (a)   43,603,799
3,838,766   Workhorse Group, Inc. (a) (b)   16,737,020
        212,017,046
    Electrical Equipment – 1.3%    
583,356   Blink Charging Co. (a) (b)   15,464,768
    Machinery – 9.7%    
2,193,580   Nikola Corp. (a) (b)   21,650,634
572,164   PACCAR, Inc.   50,499,195
519,606   Westinghouse Air Brake Technologies Corp.   47,860,909
        120,010,738
    Road & Rail – 30.1%    
2,029,894   CSX Corp.   76,324,014
249,685   JB Hunt Transport Services, Inc.   51,035,614
179,929   Norfolk Southern Corp.   53,566,663
245,106   Old Dominion Freight Line, Inc.   87,841,088
321,722   Union Pacific Corp.   81,051,423
309,476   XPO Logistics, Inc. (a)   23,962,727
        373,781,529
Shares   Description   Value
    Trading Companies &
Distributors – 3.3%
   
122,401   United Rentals, Inc. (a)   $40,672,628
    Total Common Stocks   1,241,008,716
    (Cost $1,111,002,601)    
MONEY MARKET FUNDS – 2.3%
28,502,647   Goldman Sachs Financial Square Treasury Obligations Fund - Institutional Class - 0.01% (c) (d)   28,502,647
    (Cost $28,502,647)    
Principal
Value
  Description   Value
REPURCHASE AGREEMENTS – 1.0%
$12,655,667   BNP Paribas S.A., 0.03% (c), dated 12/31/21, due 1/3/22, with a maturity value of $12,655,699. Collateralized by U.S. Treasury Note, interest rate of 1.50%, due 11/30/28. The value of the collateral including accrued interest is $12,903,223. (d)   12,655,667
    (Cost $12,655,667)    
    Total Investments – 103.3%   1,282,167,030
    (Cost $1,152,160,915) (e)    
    Net Other Assets and Liabilities – (3.3)%   (40,456,672)
    Net Assets – 100.0%   $1,241,710,358
    

(a) Non-income producing security.
(b) All or a portion of this security is on loan for securities lending. The remaining contractual maturity of all of the securities lending transactions is overnight and continuous. The aggregate value of such securities is $34,395,581 and the total value of the collateral held by the Fund is $41,158,314.
(c) Rate shown reflects yield as of December 31, 2021.
(d) This security serves as collateral for securities on loan.
(e) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of December 31, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $184,283,941 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $54,277,826. The net unrealized appreciation was $130,006,115.
 

First Trust Nasdaq Transportation ETF (FTXR)
Portfolio of Investments (Continued)
December 31, 2021 (Unaudited)

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of December 31, 2021 is as follows (see Valuation Inputs in the Additional Information section):
  Total
Value at
12/31/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $1,241,008,716 $1,241,008,716 $$
Money Market Funds 28,502,647 28,502,647
Repurchase Agreements 12,655,667 12,655,667
Total Investments $1,282,167,030 $1,269,511,363 $12,655,667 $
    
* See Portfolio of Investments for industry breakout.

First Trust Indxx Medical Devices ETF (MDEV)
Portfolio of Investments
December 31, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.6%
    Biotechnology – 1.6%    
2,421   Exact Sciences Corp. (a)   $188,427
    Health Care Equipment &
Supplies – 73.6%
   
1,917   Abbott Laboratories   269,799
667   ABIOMED, Inc. (a)   239,566
2,881   Alcon, Inc.   255,281
352   Align Technology, Inc. (a)   231,327
8,461   Ambu A.S., Class B   224,088
2,827   Baxter International, Inc.   242,670
946   Becton Dickinson and Co.   237,900
1,998   BioMerieux   284,113
5,257   Boston Scientific Corp. (a)   223,317
1,207   Carl Zeiss Meditec AG   254,015
1,468   Coloplast A.S., Class B   258,673
550   Cooper (The) Cos., Inc.   230,417
4,951   Demant A.S. (a)   253,991
3,907   DENTSPLY SIRONA, Inc.   217,972
424   DexCom, Inc. (a)   227,667
2,088   Edwards Lifesciences Corp. (a)   270,500
10,809   Fisher & Paykel Healthcare Corp., Ltd.   242,525
3,178   Hologic, Inc. (a)   243,308
1,494   Hoya Corp.   222,223
775   Insulet Corp. (a)   206,204
685   Intuitive Surgical, Inc. (a)   246,120
5,257   Koninklijke Philips N.V.   196,102
837   Masimo Corp. (a)   245,057
1,810   Medtronic PLC   187,244
2,034   Novocure Ltd. (a)   152,713
10,840   Olympus Corp.   249,679
892   ResMed, Inc.   232,348
3,529   Siemens Healthineers AG (b) (c)   264,449
13,249   Smith & Nephew PLC   231,966
613   Sonova Holding AG   240,706
1,035   STERIS PLC   251,929
126   Straumann Holding AG   267,847
856   Stryker Corp.   228,912
1,878   Sysmex Corp.   253,872
622   Teleflex, Inc.   204,315
5,030   Terumo Corp.   212,517
1,548   Zimmer Biomet Holdings, Inc.   196,658
        8,697,990
    Health Care Providers &
Services – 1.8%
   
2,170   Guardant Health, Inc. (a)   217,043
    Life Sciences Tools &
Services – 22.6%
   
1,459   10X Genomics, Inc., Class A (a)   217,333
1,486   Agilent Technologies, Inc.   237,240
315   Bio-Rad Laboratories, Inc., Class A (a)   238,004
756   Danaher Corp.   248,731
Shares   Description   Value
    Life Sciences Tools &
Services (Continued)
   
163   Mettler-Toledo International, Inc. (a)   $276,645
1,333   PerkinElmer, Inc.   268,013
451   Sartorius Stedim Biotech   247,695
388   Thermo Fisher Scientific, Inc.   258,889
658   Waters Corp. (a)   245,171
558   West Pharmaceutical Services, Inc.   261,708
10,134   WuXi AppTec Co., Ltd., Class H (b) (c)   175,451
        2,674,880
    Total Investments – 99.6%   11,778,340
    (Cost $11,768,918) (d)    
    Net Other Assets and Liabilities – 0.4%   41,818
    Net Assets – 100.0%   $11,820,158
    

(a) Non-income producing security.
(b) This security may be resold to qualified foreign investors and foreign institutional buyers under Regulation S of the Securities Act of 1933, as amended (the “1933 Act”).
(c) This security is exempt from registration upon resale under Rule 144A of the 1933 Act and may be resold in transactions exempt from registration, normally to qualified institutional buyers. This security is not restricted on the foreign exchange where it trades freely without any additional registration. As such, it does not require the additional disclosure required of restricted securities.
(d) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of December 31, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $357,343 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $347,921. The net unrealized appreciation was $9,422.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of December 31, 2021 is as follows (see Valuation Inputs in the Additional Information section):
  Total
Value at
12/31/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $11,778,340 $11,778,340 $$
    
* See Portfolio of Investments for industry breakout.
 

Additional Information
First Trust Exchange-Traded Fund VI
December 31, 2021 (Unaudited)
Valuation Inputs
The Funds are subject to fair value accounting standards that define fair value, establish the framework for measuring fair value and provide a three-level hierarchy for fair valuation based upon the inputs to the valuation as of the measurement date. The three levels of the fair value hierarchy are as follows:
Level 1 – Level 1 inputs are quoted prices in active markets for identical investments.
Level 2 – Level 2 inputs are observable inputs, either directly or indirectly. (Quoted prices for similar investments, valuations based on interest rates and yield curves, or valuations derived from observable market data.)
Level 3 – Level 3 inputs are unobservable inputs that may reflect the reporting entity’s own assumptions about the assumptions that market participants would use in pricing the investment.
The inputs or methodologies used for valuing investments are not necessarily an indication of the risk associated with investing in those investments.
Licensing Information
Nasdaq®, Nasdaq US Smart Banks IndexTM, Nasdaq US Smart Food & Beverage IndexTM, Nasdaq US Smart Oil & Gas IndexTM, Nasdaq US Smart Pharmaceuticals IndexTM, Nasdaq US Smart Retail IndexTM, Nasdaq US Smart Semiconductor IndexTM and Nasdaq US Smart Transportation IndexTM are registered trademarks and service marks of Nasdaq, Inc. (which with its affiliates herein after referred to as the “Corporations”) and are licensed for use by First Trust. The Funds have not been passed on by the Corporations as to their legality or suitability. The Funds are not issued, endorsed, sold, or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUNDS.
Indxx and Indxx Global Medical Equipment Index (“Index”) are trademarks of Indxx, LLC (“Indxx”) and have been licensed for use for certain purposes by First Trust. The Fund is not sponsored, endorsed, sold or promoted by Indxx and Indxx makes no representation regarding the advisability of trading in such product. The Index is determined, composed and calculated by Indxx without regard to First Trust or the Fund.