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  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0001552740</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000046116</seriesId>
        <classId>C000144324</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>First Trust Exchange-Traded Fund VI</regName>
      <regFileNumber>811-22717</regFileNumber>
      <regCik>0001552740</regCik>
      <regLei>549300ZLB3EUU3H8NE60</regLei>
      <regStreet1>120 East Liberty Drive, Suite 400</regStreet1>
      <regCity>Wheaton</regCity>
      <regStateConditional regCountry="US" regState="US-IL"/>
      <regZipOrPostalCode>60187</regZipOrPostalCode>
      <regPhone>630-765-8000</regPhone>
      <seriesName>First Trust Dorsey Wright International Focus 5 ETF</seriesName>
      <seriesId>S000046116</seriesId>
      <seriesLei>549300BQPNWGKE23QP35</seriesLei>
      <repPdEnd>2022-09-30</repPdEnd>
      <repPdDate>2021-12-31</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>228720709.630000000000</totAssets>
      <totLiabs>1403720.560000000000</totLiabs>
      <netAssets>227316989.070000000000</netAssets>
      <assetsAttrMiscSec>0.000000000000</assetsAttrMiscSec>
      <assetsInvested>0.000000000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.000000000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.000000000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.000000000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.000000000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.000000000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.000000000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.000000000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.000000000000</amtPayAftOneYrOther>
      <delayDeliv>0.000000000000</delayDeliv>
      <standByCommit>0.000000000000</standByCommit>
      <liquidPref>0.000000000000</liquidPref>
      <cshNotRptdInCorD>147470.340000000000</cshNotRptdInCorD>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000144324" rtn1="2.95" rtn2="-3.97" rtn3="3.8"/>
        </monthlyTotReturns>
        <othMon1 netRealizedGain="9847709.3" netUnrealizedAppr="-2133564.71"/>
        <othMon2 netRealizedGain="2890179.94" netUnrealizedAppr="-12772632.53"/>
        <othMon3 netRealizedGain="1242121.67" netUnrealizedAppr="5809383.6"/>
      </returnInfo>
      <mon1Flow redemption="-3407707" reinvestment="0" sales="0"/>
      <mon2Flow redemption="-25443103.5" reinvestment="0" sales="0"/>
      <mon3Flow redemption="-13649168" reinvestment="0" sales="0"/>
    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>First Trust Germany AlphaDEX Fund</name>
        <lei>549300HROUDUV84QFV64</lei>
        <title>FIRST TRUST GERMANY</title>
        <cusip>33737J190</cusip>
        <identifiers>
          <isin value="US33737J1907"/>
          <ticker value="FGM"/>
          <other otherDesc="SEDOL" value="B57LLC9"/>
        </identifiers>
        <balance>826006.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44333394.03</valUSD>
        <pctVal>19.5028951472</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust United Kingdom AlphaDEX Fund</name>
        <lei>549300HROUDUV84QFV64</lei>
        <title>FIRST TRUST UNITED KINGDOM</title>
        <cusip>33737J224</cusip>
        <identifiers>
          <isin value="US33737J2244"/>
          <ticker value="FKU"/>
          <other otherDesc="SEDOL" value="B7PF2W4"/>
        </identifiers>
        <balance>1069612.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47282198.46</valUSD>
        <pctVal>20.8001164600</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Switzerland AlphaDEX Fund</name>
        <lei>549300HROUDUV84QFV64</lei>
        <title>FIRST TRUST SWITZERLAND</title>
        <cusip>33737J232</cusip>
        <identifiers>
          <isin value="US33737J2327"/>
          <ticker value="FSZ"/>
          <other otherDesc="SEDOL" value="B7PF3H6"/>
        </identifiers>
        <balance>671988.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47946343.80</valUSD>
        <pctVal>21.0922835095</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust Eurozone AlphaDEX ETF</name>
        <lei>549300HROUDUV84QFV64</lei>
        <title>FIRST TRUST EUROZONE ALPHADE</title>
        <cusip>33737J505</cusip>
        <identifiers>
          <isin value="US33737J5056"/>
          <ticker value="FEUZ"/>
          <other otherDesc="SEDOL" value="BRS6752"/>
        </identifiers>
        <balance>976218.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44981196.79</valUSD>
        <pctVal>19.7878728616</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First Trust India NIFTY 50 Equal Weight ETF</name>
        <lei>549300HROUDUV84QFV64</lei>
        <title>FIRST TRUST INDIA NIFTY 50 E</title>
        <cusip>33737J802</cusip>
        <identifiers>
          <isin value="US33737J8027"/>
          <ticker value="NFTY"/>
          <other otherDesc="SEDOL" value="BZ57FP0"/>
        </identifiers>
        <balance>898949.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42529277.19</valUSD>
        <pctVal>18.7092383037</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2022-01-30</ncom:dateSigned>
      <ncom:nameOfApplicant>First Trust Exchange-Traded Fund VI</ncom:nameOfApplicant>
      <ncom:signature>Donald P. Swade</ncom:signature>
      <ncom:signerName>First Trust Exchange-Traded Fund VI </ncom:signerName>
      <ncom:title>Treasurer, Chief Financial Officer and Chief Accounting Officer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
