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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merck &amp; Co., Inc</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK &amp; CO. INC.</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
          <ticker value="MRK"/>
          <other otherDesc="SEDOL" value="2778844"/>
        </identifiers>
        <balance>8380.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>762161.00</valUSD>
        <pctVal>8.1111883164</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pacira Biosciences Inc</name>
        <lei>549300P56LERYBDHCF69</lei>
        <title>PACIRA BIOSCIENCES INC</title>
        <cusip>695127100</cusip>
        <identifiers>
          <isin value="US6951271005"/>
          <ticker value="PCRX"/>
          <other otherDesc="SEDOL" value="B3X26D8"/>
        </identifiers>
        <balance>3458.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>156647.40</valUSD>
        <pctVal>1.6670973202</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pfizer Inc.</name>
        <lei>765LHXWGK1KXCLTFYQ30</lei>
        <title>PFIZER INC</title>
        <cusip>717081103</cusip>
        <identifiers>
          <isin value="US7170811035"/>
          <ticker value="PFE"/>
          <other otherDesc="SEDOL" value="2684703"/>
        </identifiers>
        <balance>18967.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>743127.06</valUSD>
        <pctVal>7.9086223602</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics Inc</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
          <ticker value="SAGE"/>
          <other otherDesc="SEDOL" value="BP4GNK9"/>
        </identifiers>
        <balance>1033.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>74572.27</valUSD>
        <pctVal>0.7936246084</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Supernus Pharmaceuticals, Inc</name>
        <lei>549300GRM36VBKISYJ58</lei>
        <title>SUPERNUS PHARMACEUTICALS INC</title>
        <cusip>868459108</cusip>
        <identifiers>
          <isin value="US8684591089"/>
          <ticker value="SUPN"/>
          <other otherDesc="SEDOL" value="B72ZBG4"/>
        </identifiers>
        <balance>6836.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>162149.92</valUSD>
        <pctVal>1.7256570943</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vanda Pharmace Inc</name>
        <lei>529900AY8VOOQBKJ0O70</lei>
        <title>VANDA PHARMACEUTICALS INC</title>
        <cusip>921659108</cusip>
        <identifiers>
          <isin value="US9216591084"/>
          <ticker value="VNDA"/>
          <other otherDesc="SEDOL" value="B12W3P6"/>
        </identifiers>
        <balance>9553.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>156764.73</valUSD>
        <pctVal>1.6683459878</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zogenix Inc</name>
        <lei>54930089H3HF4C32SK78</lei>
        <title>ZOGENIX INC</title>
        <cusip>98978L204</cusip>
        <identifiers>
          <isin value="US98978L2043"/>
          <ticker value="ZGNX"/>
          <other otherDesc="SEDOL" value="BYTJZL1"/>
        </identifiers>
        <balance>3345.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>174374.85</valUSD>
        <pctVal>1.8557591454</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zoetis Inc.</name>
        <lei>549300HD9Q1LOC9KLJ48</lei>
        <title>ZOETIS INC</title>
        <cusip>98978V103</cusip>
        <identifiers>
          <isin value="US98978V1035"/>
          <ticker value="ZTS"/>
          <other otherDesc="SEDOL" value="B95WG16"/>
        </identifiers>
        <balance>3031.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>401152.85</valUSD>
        <pctVal>4.2692112428</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mylan NV</name>
        <lei>549300A0CD4KNFGIIS89</lei>
        <title>MYLAN NV</title>
        <cusip>N59465109</cusip>
        <identifiers>
          <isin value="NL0011031208"/>
          <ticker value="MYL"/>
          <other otherDesc="SEDOL" value="BVFMFG8"/>
        </identifiers>
        <balance>8510.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>171051.00</valUSD>
        <pctVal>1.8203855520</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Perrigo Company Plc</name>
        <lei>549300IFOQS6R1QLY196</lei>
        <title>PERRIGO COMPANY PLC</title>
        <cusip>G97822103</cusip>
        <identifiers>
          <isin value="IE00BGH1M568"/>
          <ticker value="PRGO"/>
          <other otherDesc="SEDOL" value="BGH1M56"/>
        </identifiers>
        <balance>3120.0000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>161179.20</valUSD>
        <pctVal>1.7153263469</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2020-01-30</ncom:dateSigned>
      <ncom:nameOfApplicant>First Trust Exchange-Traded Fund VI</ncom:nameOfApplicant>
      <ncom:signature>Donald P. Swade</ncom:signature>
      <ncom:signerName>First Trust Exchange-Traded Fund VI </ncom:signerName>
      <ncom:title>Treasurer, Chief Financial Officer and Chief Accounting Officer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
