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        <name>Sartorius Stedim Biotech SA</name>
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        <name>Olympus Corp.</name>
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        <name>Sysmex Corp.</name>
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        <name>Straumann Holding AG</name>
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        <name>Waters Corporation</name>
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        <name>Globus Med Inc</name>
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        <name>Abbott Laboratories</name>
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        <name>Intuitive Surgical Inc.</name>
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        <name>WuXi AppTec Co Ltd.</name>
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        <name>Koninklijke Philips NV</name>
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        <pctVal>2.266191767774</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NZ</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Carl Zeiss Meditec AG</name>
        <lei>529900GRL4MZ8NMOOK95</lei>
        <title>Carl Zeiss Meditec AG NPV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="DE0005313704"/>
          <ticker value="AFX"/>
          <other otherDesc="SEDOL" value="5922961"/>
        </identifiers>
        <balance>837.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.86516000"/>
        <valUSD>24057.90000000</valUSD>
        <pctVal>1.262222962996</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Revvity Inc</name>
        <lei>549300IKL1SDPFI7N655</lei>
        <title>Revvity Inc COM</title>
        <cusip>714046109</cusip>
        <identifiers>
          <isin value="US7140461093"/>
          <ticker value="RVTY"/>
        </identifiers>
        <balance>470.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41176.70000000</valUSD>
        <pctVal>2.160378764580</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amplifon S.p.A.</name>
        <lei>ZYXJDNVM2JI3VBM8G556</lei>
        <title>Amplifon S.p.A. EUR0.02</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IT0004056880"/>
          <ticker value="AMP"/>
          <other otherDesc="SEDOL" value="B14NJ71"/>
        </identifiers>
        <balance>2423.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.86516000"/>
        <valUSD>26732.60000000</valUSD>
        <pctVal>1.402553904563</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IT</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>West Pharmaceutical Services Incorporated</name>
        <lei>5493007NKRGM1RJQ1P16</lei>
        <title>West Pharmaceutical Services Incorporated COM</title>
        <cusip>955306105</cusip>
        <identifiers>
          <isin value="US9553061055"/>
          <ticker value="WST"/>
        </identifiers>
        <balance>158.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39601.12000000</valUSD>
        <pctVal>2.077714306916</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Teleflex Incorporated</name>
        <lei>UUL85LWXB4NGSWWXIQ25</lei>
        <title>Teleflex Incorporated COM</title>
        <cusip>879369106</cusip>
        <identifiers>
          <isin value="US8793691069"/>
          <ticker value="TFX"/>
        </identifiers>
        <balance>347.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41504.67000000</valUSD>
        <pctVal>2.177586054708</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Baxter International, Inc.</name>
        <lei>J5OIVXX3P24RJRW5CK77</lei>
        <title>Baxter International, Inc. COM</title>
        <cusip>071813109</cusip>
        <identifiers>
          <isin value="US0718131099"/>
          <ticker value="BAX"/>
        </identifiers>
        <balance>1889.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31735.20000000</valUSD>
        <pctVal>1.665020561864</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Edwards Lifesciences Corporation</name>
        <lei>YA13X31F3V31L8TMPR58</lei>
        <title>Edwards Lifesciences Corporation COM</title>
        <cusip>28176E108</cusip>
        <identifiers>
          <isin value="US28176E1082"/>
          <ticker value="EW"/>
        </identifiers>
        <balance>561.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44924.88000000</valUSD>
        <pctVal>2.357030960551</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Smith &amp; Nephew PLC</name>
        <lei>213800ZTMDN8S67S1H61</lei>
        <title>Smith &amp; Nephew PLC ORD USD0.20</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="GB0009223206"/>
          <ticker value="SN/"/>
          <other otherDesc="SEDOL" value="0922320"/>
        </identifiers>
        <balance>2352.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.75552000"/>
        <valUSD>37264.89000000</valUSD>
        <pctVal>1.955141548993</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Medtronic PLC</name>
        <lei>549300GX3ZBSQWUXY261</lei>
        <title>Medtronic PLC SHS</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00BTN1Y115"/>
          <ticker value="MDT"/>
        </identifiers>
        <balance>434.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37606.10000000</valUSD>
        <pctVal>1.973043489611</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioMerieux SA</name>
        <lei>549300AK8Y0LBIQ4T071</lei>
        <title>BioMerieux SA NPV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="FR0013280286"/>
          <ticker value="BIM"/>
          <other otherDesc="SEDOL" value="BF0LBX7"/>
        </identifiers>
        <balance>312.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.86516000"/>
        <valUSD>33332.31000000</valUSD>
        <pctVal>1.748814613565</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HOYA Corp.</name>
        <lei>353800X4VR3BHEUCJB42</lei>
        <title>HOYA Corp. NPV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="JP3837800006"/>
          <ticker value="7741"/>
          <other otherDesc="SEDOL" value="6441506"/>
        </identifiers>
        <balance>294.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="158.70500000"/>
        <valUSD>50967.97000000</valUSD>
        <pctVal>2.674088017295</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bio-Rad Laboratories, Inc.</name>
        <lei>549300ZC1GPV35XYDK53</lei>
        <title>Bio-Rad Laboratories, Inc. CL A</title>
        <cusip>090572207</cusip>
        <identifiers>
          <isin value="US0905722072"/>
          <ticker value="BIO"/>
        </identifiers>
        <balance>139.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38746.25000000</valUSD>
        <pctVal>2.032862655509</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Coloplast AS</name>
        <lei>529900NN7SOJ5QG82X67</lei>
        <title>Coloplast AS SER'B'DKK1</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="DK0060448595"/>
          <ticker value="COLOB"/>
          <other otherDesc="SEDOL" value="B8FMRX8"/>
        </identifiers>
        <balance>473.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="DKK" exchangeRt="6.46520000"/>
        <valUSD>32220.26000000</valUSD>
        <pctVal>1.690469743647</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alcon AG</name>
        <lei>549300LDT5AP8S0NBM78</lei>
        <title>Alcon AG CHF0.04</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="CH0432492467"/>
          <ticker value="ALC"/>
          <other otherDesc="SEDOL" value="BJT1GR5"/>
        </identifiers>
        <balance>574.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.79960000"/>
        <valUSD>43388.79000000</valUSD>
        <pctVal>2.276438387166</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>Stryker Corporation COM</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
          <ticker value="SYK"/>
        </identifiers>
        <balance>114.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37459.26000000</valUSD>
        <pctVal>1.965339374959</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Hologic Inc</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>Hologic Inc COM</title>
        <cusip>436440101</cusip>
        <identifiers>
          <isin value="US4364401012"/>
          <ticker value="HOLX"/>
        </identifiers>
        <balance>612.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46261.08000000</valUSD>
        <pctVal>2.427136095378</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agilent Technologies Inc.</name>
        <lei>QUIX8Y7A2WP0XRMW7G29</lei>
        <title>Agilent Technologies Inc. COM</title>
        <cusip>00846U101</cusip>
        <identifiers>
          <isin value="US00846U1016"/>
          <ticker value="A"/>
        </identifiers>
        <balance>303.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34535.94000000</valUSD>
        <pctVal>1.811964324261</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mettler-Toledo International Inc</name>
        <lei>5493000BD5GJNUDIUG10</lei>
        <title>Mettler-Toledo International Inc COM</title>
        <cusip>592688105</cusip>
        <identifiers>
          <isin value="US5926881054"/>
          <ticker value="MTD"/>
        </identifiers>
        <balance>33.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41619.60000000</valUSD>
        <pctVal>2.183615977733</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>The Cooper Companies, Inc.</name>
        <lei>QJKMVPIGLH7530PCUE20</lei>
        <title>The Cooper Companies, Inc. COM</title>
        <cusip>216648501</cusip>
        <identifiers>
          <isin value="US2166485019"/>
          <ticker value="COO"/>
        </identifiers>
        <balance>606.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43329.00000000</valUSD>
        <pctVal>2.273301442090</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GE Healthcare Technologies Inc.</name>
        <lei>549300OI9J7XOWZMUN85</lei>
        <title>GE Healthcare Technologies Inc. COMMON STOCK</title>
        <cusip>36266G107</cusip>
        <identifiers>
          <isin value="US36266G1076"/>
          <ticker value="GEHC"/>
        </identifiers>
        <balance>584.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41569.12000000</valUSD>
        <pctVal>2.180967491574</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Terumo Corp.</name>
        <lei>353800JX1R4582QVK932</lei>
        <title>Terumo Corp. NPV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="JP3546800008"/>
          <ticker value="4543"/>
          <other otherDesc="SEDOL" value="6885074"/>
        </identifiers>
        <balance>2560.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="158.70500000"/>
        <valUSD>34392.98000000</valUSD>
        <pctVal>1.804463777880</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2026-05-21</ncom:dateSigned>
      <ncom:nameOfApplicant>First Trust Exchange-Traded Fund VI</ncom:nameOfApplicant>
      <ncom:signature>Derek Maltbie</ncom:signature>
      <ncom:signerName>Derek Maltbie</ncom:signerName>
      <ncom:title>Treasurer, Chief Financial Officer and Chief Accounting Officer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
