INCOME TAXES (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Deferred Tax Assets and Liabilities

	December 31,
	2022		2021
Domestic tax loss and contribution carryforwards	$	21,419,800	$	18,656,500
Foreign tax loss carryforwards	4,531,900		5,134,700
Tax credits	3,718,100		2,534,600
Share-based compensation	3,908,000		3,647,100
Intangible assets	2,957,100		3,096,800
Accrued expenses	114,300		371,200
Section 174 - capitalized research and development	5,940,400		—
Research and development expenses	—		20,500
Other	19,200		5,900
Valuation allowance	(42,608,800)		(33,467,300)
Total deferred tax assets, noncurrent	$	—	$	—

Schedule of Effective Income Tax Rate Reconciliation

The reasons for the difference between actual income tax expense (benefit) for the years ended December 31, 2022 and 2021, and the amount computed by applying the statutory federal income tax rate to losses before income tax (benefit) are as follows:

	2022				2021
	Amount		% of Pretax Earnings		Amount		% of Pretax Earnings
Income tax benefit at statutory rate	$	(9,190,900)	21.0	%	$	(7,726,800)	21.0	%
State income taxes, net of federal tax benefit	(41,000)		0.1	%	(27,900)		0.1	%
Non-deductible expenses	314,900		(0.7)	%	4,500		—	%
Credits	(1,210,000)		2.7	%	(1,176,500)		3.2	%
Foreign rate differential	3,100		—	%	2,400		—	%
Change in state tax rate	(8,500)		—	%	1,764,100		(4.8)	%
Other	367,500		(0.8)	%	894,600		(2.5)	%
Change in valuation allowance	9,764,900		(22.3)	%	6,265,600		(17.0)	%
Income tax benefit	$	—	—	%	$	—	—	%