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SHARE-BASED COMPENSATION (Tables)
 12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Share-based Compensation, Activity
The following table summarizes stock option activity under the Private Innovate Plan:
 Number of
Options		Weighted-Average
Exercise Price		Aggregate
Intrinsic
Value		Weighted-Average
Remaining
Contractual Life
(in years)
Outstanding at December 31, 2021265,067 $33.80 $837,459 2.7
Options granted— — — 
Options forfeited(85,437)41.76 — 
Options exercised— — — 
Outstanding at December 31, 2022179,630 29.88 — 2.7
Exercisable at December 31, 2022179,630 29.88 — 2.7
Vested and expected to vest at December 31, 2022179,630 $29.88 $— 2.7
The following table summarizes stock option activity under the Omnibus Plan:
 Number of
Options		Weighted-Average
Exercise Price		Aggregate
Intrinsic
Value		Weighted-Average
Remaining
Contractual Life
(in years)
Outstanding at December 31, 2021730,377 $23.70 $2,296,720 8.5
Options granted470,631 14.71 
Options forfeited(8,775)14.80 
Options exercised— — 
Outstanding at December 31, 20221,192,233 20.22 — 8.1
Exercisable at December 31, 2022519,256 23.78 — 7.4
Vested and expected to vest at December 31, 20221,153,870 $20.32 $— 8.1
The following table summarizes stock option activity under the 2022 Plan:
 Number of
Options		Weighted-Average
Exercise Price		Aggregate
Intrinsic
Value		Weighted-Average
Remaining
Contractual Life
(in years)
Outstanding at December 31, 2021— $— $— —
Options granted36,880 5.27 
Options forfeited— — 
Options exercised— — 
Outstanding at December 31, 202236,880 $5.27 $— 9.5
Exercisable at December 31, 20225,940 $5.29 $— 9.5
Vested and expected to vest at December 31, 202234,927 $5.27 $— 9.5
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions
The range of assumptions used in estimating the fair value of the options granted under the Omnibus Plan using the Black-Scholes option pricing model for the periods presented were as follows:
 Year Ended December 31,
 20222021
Expected dividend yield0%0%
Expected stock-price volatility
79%
68% - 85%
Risk-free interest rate
1.4% - 1.9%
0.1% - 1.1%
Expected term of options (in years)
6.1
2.3 - 6.1
The range of assumptions used in estimating the fair value of the options granted under the 2022 Plan using the Black-Scholes option pricing model for the periods presented were as follows:
 Year Ended December 31,
 20222021
Expected dividend yield—%—
Expected stock-price volatility
79% - 81%
—
Risk-free interest rate
3.0% - 3.2%
—
Expected term of options (in years)
5.8 - 6.0
—
Share-based Payment Arrangement, Option, Activity
The following table summarizes stock option activity for the RDD Options:
 Number of
Options		Weighted-Average
Exercise Price		Aggregate
Intrinsic
Value		Weighted-Average
Remaining
Contractual Life
(in years)
Outstanding at December 31, 202149,295 $12.60 $343,486 3.3
Options granted— 
Options forfeited— 
Options exercised— 
Outstanding at December 31, 202249,295 $12.60 $8,269 2.3
Exercisable at December 31, 202249,295 $12.60 $8,269 2.3
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs
Total share-based compensation expense recognized in the accompanying consolidated statements of operations and comprehensive loss was as follows:
 Year Ended December 31,
 20222021
Research and development$950,000 $773,000 
General and administrative2,988,000 1,640,000 
Total share-based compensation$3,938,000 $2,413,000