144 0001551778 XXXXXXXX LIVE 0001061983 CYTOKINETICS, INCORPORATED 000-50633 350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 6506243000 FADY MALIK Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

22000 1428680.00 123162807 04/07/2026 NASDAQ Common 04/07/2026 Exercise of Stock Options Issuer N 22000 04/07/2026 Cash N FADY MALIK

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/17/2026 12033 747850.95 FADY MALIK

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 03/09/2026 2907 176513.04 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 04/07/2026 12/23/2025 /s/ Fady Malik