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Summary of Significant Accounting Policies (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Summary of Significant Accounting Policies                        
Net loss $ (8,073) $ (9,963) $ (10,193) $ (11,937) $ (28,250) $ (6,604) $ (2,992) $ (3,384) $ (40,166) $ (41,230) $ (5,811)  
Cash provided by (used in) operations                 (34,430) (18,184) 450  
Accumulated deficit 215,442       175,276       215,442 175,276    
Cash and cash equivalents $ 67,212       $ 112,801       $ 67,212 $ 112,801 $ 96,729 $ 9,722