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Integration and Restructuring Plans (Tables)
9 Months Ended
Sep. 30, 2023
Allergan integration plan  
Restructuring charges  
Summary of charges associated with integration plan The following table summarizes the charges (benefits) associated with the Allergan acquisition integration plan:
Three months ended
September 30,
Nine months ended
September 30,
(in millions)2023202220232022
Cost of products sold$20 $24 $66 $81 
Research and development14 
Selling, general and administrative39 88 134 234 
Total charges$60 $116 $202 $329 
Summary of cash activity in the restructuring reserve The following table summarizes the cash activity in the recorded liability associated with the Allergan integration plan for the nine months ended September 30, 2023:
(in millions)
Accrued balance as of December 31, 2022
$107 
Charges192 
Payments and other adjustments(258)
Accrued balance as of September 30, 2023$41 
Other restructuring  
Restructuring charges  
Summary of cash activity in the restructuring reserve The following table summarizes the cash activity in the restructuring reserve for the nine months ended September 30, 2023:
(in millions)
Accrued balance as of December 31, 2022$176 
Restructuring charges31 
Payments and other adjustments(64)
Accrued balance as of September 30, 2023$143