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Integration and Restructuring Plans (Tables)
 6 Months Ended
Jun. 30, 2023
Allergan integration plan  
Restructuring charges  
Summary of charges associated with integration plan The following table summarizes the charges (benefits) associated with the Allergan acquisition integration plan:
Three months ended
June 30,		Six months ended
June 30,
(in millions)2023202220232022
Cost of products sold$32 $26 $46 $57 
Research and development1 1 1 10 
Selling, general and administrative51 76 95 146 
Total charges$84 $103 $142 $213 
Summary of cash activity in the restructuring reserve The following table summarizes the cash activity in the recorded liability associated with the Allergan integration plan for the six months ended June 30, 2023:
(in millions)
Accrued balance as of December 31, 2022
$107 
Charges135 
Payments and other adjustments(195)
Accrued balance as of June 30, 2023$47 
Other restructuring  
Restructuring charges  
Summary of cash activity in the restructuring reserve The following table summarizes the cash activity in the restructuring reserve for the six months ended June 30, 2023:
(in millions)
Accrued balance as of December 31, 2022$176 
Restructuring charges24 
Payments and other adjustments(51)
Accrued balance as of June 30, 2023$149