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Equity - Stock-Based Compensation (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Shares reserved for issuance (in shares) 144,000,000    
Retirement-eligible employees' age 55 years    
Minimum number of years of services 10 years    
Pre-tax compensation expense $ 692 $ 753 $ 430
Tax benefit 126 131 80
After-tax compensation expense 566 622 350
Realized excess tax benefits from the exercise of stock options 50 34 15
Cost of products sold      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Pre-tax compensation expense 46 47 29
Research and development      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Pre-tax compensation expense 226 247 171
Selling, general and administrative      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Pre-tax compensation expense $ 420 $ 459 $ 230