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Licensing, Acquisitions, and Other Arrangements - Other Licensing & Acquisitions Activity (Details) - USD ($)
$ in Millions
1 Months Ended 3 Months Ended 12 Months Ended
Sep. 30, 2020
Oct. 31, 2019
Dec. 31, 2021
Sep. 30, 2021
Dec. 31, 2020
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Jun. 30, 2020
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Cash outflows related to other acquisitions and investments           $ 1,377 $ 1,350 $ 1,135  
Acquired in-process research and development           962 1,198 385  
Other operating expense (income), net           432 0 (890)  
Calico Life Sciences LLC                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Additional contribution to collaboration by partner       $ 500          
Calico Life Sciences LLC | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Additional contribution to collaboration       500          
Other operating expense (income), net       500          
TeneoOne | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Potential additional milestone payments     $ 250     250      
REGENXBIO Inc. | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Potential additional milestone payments     1,400     1,400      
I-Mab Biopharma | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Potential additional milestone payments $ 1,700                
Genmab A/S | Maximum | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Potential additional milestone payments                 $ 3,200
Reata Pharmaceuticals Inc                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Other operating expense (income), net               (330)  
Consideration received for acquired rights             250    
Consideration receivable for acquired rights     80     80      
Other individually insignificant arrangements | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Acquired in-process research and development           192 248 $ 385  
Other individually insignificant arrangements | Maximum | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Potential additional milestone payments     5,500     $ 5,500      
In-process research and development | TeneoOne | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Acquired in-process research and development       $ 400          
In-process research and development | REGENXBIO Inc. | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Upfront payment     $ 370            
In-process research and development | I-Mab Biopharma | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Acquired in-process research and development         $ 200        
Upfront payment 180                
Milestone payment $ 20                
In-process research and development | Genmab A/S | Collaborative arrangement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Acquired in-process research and development             $ 750    
Other operating income | Reata Pharmaceuticals Inc                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions                  
Total consideration for acquired rights   $ 330