Integration and Restructuring Plans (Tables)

12 Months Ended

Dec. 31, 2021

Allergan integration plan

Restructuring charges

Summary of charges associated with integration plan

The following table summarizes the charges associated with the Allergan acquisition integration plan:

	Severance and employee benefits				Other integration
year ended December 31 (in millions)	2021		2020		2021		2020
Cost of products sold	$	5	$	109	$	127	$	21
Research and development	—		199		102		177
Selling, general and administrative	64		388		289		237
Total charges	$	69	$	696	$	518	$	435

Summary of cash activity in the restructuring reserve

The following table summarizes the cash activity in the recorded liability associated with the integration plan:

year ended December 31 (in millions)	Severance and employee benefits		Other integration
Charges	$	594	$	435
Payments and other adjustments	(227)		(415)
Accrued balance as of December 31, 2020	$	367	$	20
Charges	65		461
Payments and other adjustments	(210)		(448)
Accrued balance as of December 31, 2021	$	222	$	33

Other restructuring

Restructuring charges

Summary of cash activity in the restructuring reserve

The following table summarizes the cash activity in the restructuring reserve for 2021, 2020 and 2019:

(in millions)
Accrued balance as of December 31, 2018	$	99
Restructuring charges	219
Payments and other adjustments	(178)
Accrued balance as of December 31, 2019	140
Restructuring charges	58
Payments and other adjustments	(108)
Accrued balance as of December 31, 2020	90
Restructuring charges	54
Payments and other adjustments	(111)
Accrued balance as of December 31, 2021	$	33