Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (No. 333-258448) and FormS-8 (Nos. 333-240065, 333-253159 and 333-262406) of Nurix Therapeutics, Inc. of our report dated February 9, 2023 relating to the financial statements, which appears in this Form 10-K.

/s/ PricewaterhouseCoopers LLP

San Jose, CaliforniaFebruary 9, 2023

1