X0306 4 2021-12-10 0 0001549595 Nurix Therapeutics, Inc. NRIX 0001817199 Ring Christine C/O NURIX THERAPEUTICS, INC. 1700 OWENS STREET, SUITE 205 SAN FRANCISCO CA 94158 0 1 0 0 General Counsel Common Stock 2021-12-10 4 M 0 1200 1.86 A 2486 D Common Stock 2021-12-10 4 S 0 1200 29.04 D 1286 D Employee Stock Option (right to buy) 1.86 2021-12-10 4 M 0 1200 0.00 D 2029-09-30 Common Stock 1200 101266 D This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person. The option vests as to 1/4 of the total shares on September 9, 2020, and then 1/48 of the total shares will vest monthly thereafter until the option is fully vested on August 9, 2023, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The option contains an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase. /s/ Christine Ring 2021-12-13