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Stock Compensation (Tables)
 3 Months Ended
Mar. 31, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Schedule of Stock Based Compensation Expense Company’s condensed consolidated statement of operations for the three months ended March 31, 2022:
Three Months Ended March 31,
20222021
Research and development$102 $77 
General and administrative226 43 
Total$328 $120 
Summary of Information About Stock Options Outstanding
The following table summarizes information about stock options outstanding at March 31, 2022:

SharesWeighted Average Remaining Contractual Life (In Years)Weighted Average Exercise PriceAggregate Intrinsic Value
Options outstanding1,076,5608.72$25.75$—
Vested and expected to vest1,076,5608.72$25.75$—
Exercisable376,8067.90$55.41$—
Summary of Stock Options
Total Options OutstandingWeighted-Average Exercise Price
Balance—December 31, 2021790,637 $32.82 
Granted303,125 5.26 
Exercised— 
Cancelled and forfeited(17,202)7.49 
Balance—March 31, 20221,076,560 25.75 
Balance—December 31, 2020452,165 $5.35 
Granted62,468 10.25 
Exercised(4,368)4.66 
Cancelled and forfeited(5,667)5.90 
Balance—March 31, 2021504,598 5.96 
Share-based Payment Arrangement, Employee  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Summary of Grant Date Fair Value The fair value of employee stock options was estimated using the following assumptions for the three months ended March 31, 2022 and 2021:
20222021
Expected term (in years)66
Expected volatility68 %67 %
Risk-free interest rate
1.5% - 1.7%
1.0 %
Dividends— %— %