X0609 4 2026-08-06 0001100682 CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CRL 0001543779 Knell Michael Gunnar false C/O CHARLES RIVER LABORATORIES 251 BALLARDVALE STREET WILMINGTON MA 01887 1 SVP, Finance and CAO 0 Common Stock 2026-08-06 4 S 0 1274 259.07 D 14878 D Common Stock 2026-08-06 4 S 0 901 260.63 D 13977 D Common Stock 2026-08-06 4 S 0 810 261.45 D 13167 D Common Stock 2026-08-06 4 S 0 213 262.37 D 12954 D Common Stock 2026-08-06 4 S 0 620 263.94 D 12334 D Common Stock 2026-08-06 4 S 0 482 265.17 D 11852 D Common Stock 2026-08-06 4 M 0 404 179.66 A 12256 D Common Stock 2026-08-06 4 M 0 1205 194.12 A 13461 D Common Stock 2026-08-06 4 M 0 736 208.44 A 14197 D Common Stock 2026-08-06 4 S 0 404 258.53 D 13793 D Common Stock 2026-08-06 4 S 0 1205 258.53 D 12588 D Common Stock 2026-08-06 4 S 0 736 258.53 D 11852 D Stock Options (Right to Buy) 179.66 2026-08-06 4 M 0 404 0 D 2021-05-29 2030-05-29 Common Stock 404 0 D Stock Options (Right to Buy) 194.12 2026-08-06 4 M 0 1205 0 D 2024-05-26 2033-05-26 Common Stock 1205 402 D Stock Options (Right to Buy) 208.44 2026-08-06 4 M 0 736 0 D 2025-05-31 2034-05-31 Common Stock 736 736 D This transaction was executed in multiple trades at prices ranging from $258.77 to $259.43. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $259.97 to $260.94. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $261.00 to $261.84. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $262.26 to $262.50. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $263.39 to $264.29. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $264.91 to $265.60. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. /s/ Michael G. Knell 2026-08-10