X0206 3 2022-01-06 0 0001658551 Amylyx Pharmaceuticals, Inc. AMLX 0001543031 Quimi Daphne C/O AMYLYX PHARMACEUTICALS, INC. 43 THORNDIKE STREET CAMBRIDGE MA 02142 1 0 0 0 Stock Option (Right to Buy) 7.09 2031-06-21 Common Stock 81100 D 20,296 of the shares subject to such option shall vest and become exercisable on June 21, 2022 and the remainder of the shares vest in monthly installments of 1,689 shares thereafter. /s/ Joshua B. Cohen, as Attorney-in-Fact for Daphne Quimi 2022-01-06