ABIOMED INC COM 003654100 186441 1450000 SH SOLE 1450000 0 0 ACURA PHARMACEUTICALS INC COM PAR 00509L802 3130 1956397 SH SOLE 1956397 0 0 AXOGEN INC COM 05463X106 43896 4861111 SH SOLE 4861111 0 0 CATALYST BIOSCIENCES INC COM 14888D109 1448 1179352 SH SOLE 1179352 0 0 CORIUM INTL INC COM 21887L107 52659 9353304 SH SOLE 9353304 0 0 ENDOLOGIX INC COM 29266S106 22855 1257468 SH SOLE 1257468 0 0 ENTELLUS MED INC COM 29363K105 84577 3813197 SH SOLE 3813197 0 0 LIGAND PHARMACEUTICALS INC COM NEW 53220K504 2400 32893 SH SOLE 32893 0 0 MEDICINOVA INC COM NEW 58468P206 8766 1170370 SH SOLE 1170370 0 0 REVANCE THERAPEUTICS INC COM 761330109 74437 4592047 SH SOLE 4592047 0 0