ABIOMED INC COM 003654100 119889 3150000 SH SOLE 3150000 0 0 ACURA PHARMACEUTICALS INC COM NEW 00509L703 4402 10284886 SH SOLE 10284886 0 0 CORIUM INTL INC COM 21887L107 57055 9353304 SH SOLE 9353304 0 0 CURIS INC COM 231269101 350 233797 SH SOLE 233797 0 0 ECHO THERAPEUTICS INC COM NEW 27876L206 17 12319 SH SOLE 12319 0 0 ENDOLOGIX INC COM 29266S106 43633 2514936 SH SOLE 2514936 0 0 MEDICINOVA INC COM NEW 58468P206 3558 1170370 SH SOLE 1170370 0 0 PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 17 23928 SH SOLE 23928 0 0 REVANCE THERAPEUTICS INC COM 761330109 77789 4592047 SH SOLE 4592047 0 0 ZIOPHARM ONCOLOGY INC COM 98973P101 13691 2700408 SH SOLE 2700408 0 0