<?xml version="1.0" encoding="UTF-8"?>
<edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns="http://www.sec.gov/edgar/npx">
  <headerData>
    <submissionType>N-PX</submissionType>
    <filerInfo>
      <registrantType>IM</registrantType>
      <liveTestFlag>LIVE</liveTestFlag>
      <filer>
        <issuerCredentials>
          <cik>0001542339</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>
      <periodOfReport>06/30/2025</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <yearOrQuarter>YEAR</yearOrQuarter>
      <reportCalendarYear>2025</reportCalendarYear>
      <reportingPerson>
        <name>Essex Woodlands Management, Inc.</name>
        <phoneNumber>281-364-1555</phoneNumber>
        <address>
          <com:street1>21 Waterway Avenue Suite 150</com:street1>
          <com:city>The Woodlands</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77380</com:zipCode>
        </address>
      </reportingPerson>
      <reportInfo>
        <reportType>INSTITUTIONAL MANAGER VOTING REPORT</reportType>
        <confidentialTreatment>N</confidentialTreatment>
      </reportInfo>
      <fileNumber>028-14839</fileNumber>
      <reportingCrdNumber>000158263</reportingCrdNumber>
      <reportingSecFileNumber>801-73888</reportingSecFileNumber>
      <explanatoryInformation>
        <explanatoryChoice>Y</explanatoryChoice>
        <explanatoryNotes>Voting authority for CUSIP 602496101 is held by EW Healthcare Partners Fund 2-UGP, LLC on behalf of Falcon Fund 2 Holding Company, L.P., owned by EW Healthcare Partners Fund 2, L.P, EW Healthcare Partners Fund 2-A, L.P. and Falcon Co-Investment Fund 2, L.P. Voting authority for CUSIP 872381108 is held by EW Healthcare Partners Fund 2-GP, L.P. and its general partner EW Healthcare Partners Fund 2-UGP, LLC on behalf of EW Healthcare Partners Fund 2, L.P. and EW Healthcare Partners Fund 2-A, L.P. Voting authority for CUSIP 58468P206 is held by Essex Woodlands Health Ventures VI, L.P. and its general partner Essex Woodlands Health Ventures VI, LLC on behalf of EW Fund VI SPV, LP. Essex Woodlands Management, Inc. has assumed the obligations and services of the management company of the investment funds. Consistent with past practice, Essex Woodlands Management, Inc. is filing this Form N-PX as the reporting person as of June 30, 2025. Essex Woodlands Management, Inc. expects that Form N-PX disclosure for future periods will reflect investment discretion over such securities is maintained by one or more affiliated entities of Essex Woodlands Management, Inc. for such investment funds.</explanatoryNotes>
      </explanatoryInformation>
    </coverPage>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
    </summaryPage>
    <signaturePage>
      <reportingPerson>Essex Woodlands Management, Inc.</reportingPerson>
      <txSignature>Gregory Hill</txSignature>
      <txPrintedSignature>Gregory Hill</txPrintedSignature>
      <txTitle>Chief Compliance Officer and Chief Financial Officer</txTitle>
      <txAsOfDate>10/15/2025</txAsOfDate>
    </signaturePage>
  </formData>
</edgarSubmission>
