<?xml version="1.0" encoding="UTF-8"?>
<edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns="http://www.sec.gov/edgar/thirteenffiler">
  <schemaVersion>X0202</schemaVersion>
  <headerData>
    <submissionType>13F-HR</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <filer>
        <credentials>
          <cik>0001542339</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>12-31-2024</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>12-31-2024</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>Essex Woodlands Management, Inc.</name>
        <address>
          <com:street1>21 WATERWAY AVE</com:street1>
          <com:street2>STE 225</com:street2>
          <com:city>THE WOODLANDS</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77380</com:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-14839</form13FFileNumber>
      <crdNumber>000158263</crdNumber>
      <secFileNumber>801-73888</secFileNumber>
      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation>Consistent with past practice, Essex Woodlands Management, Inc. ("EWM") is filing this Form 13F-HR as the reporting manager with respect to Section 13(f) securities held by affiliated investment funds of EWM as of December 31, 2024. EWM expects that Form 13F disclosure for future periods will reflect that investment discretion over such Section 13(f) securities is maintained by one or more affiliated entities of EWM for such investment funds.</additionalInformation>
    </coverPage>
    <signatureBlock>
      <name>Gregory Hill</name>
      <title>Chief Compliance Officer and Chief Financial Officer</title>
      <phone>281-364-1555</phone>
      <signature>/s/ Gregory Hill</signature>
      <city>The Woodlands</city>
      <stateOrCountry>TX</stateOrCountry>
      <signatureDate>02-13-2025</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
      <tableEntryTotal>7</tableEntryTotal>
      <tableValueTotal>433218148</tableValueTotal>
    </summaryPage>
  </formData>
</edgarSubmission>
