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			<nameOfIssuer>AQUABOUNTY TECHNOLOGIES INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>03842K200</cusip>
			<value>1834</value>
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			<nameOfIssuer>AQUABOUNTY TECHNOLOGIES INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>03842K200</cusip>
			<value>18044</value>
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			<nameOfIssuer>ENERGY TRANSFER L P</nameOfIssuer>
			<titleOfClass>COM UT LTD PTN</titleOfClass>
			<cusip>29273V100</cusip>
			<value>16507</value>
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		<infoTable>
			<nameOfIssuer>ENTERPRISE PRODS PARTNERS L</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>293792107</cusip>
			<value>33050</value>
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			<nameOfIssuer>FIBROCELL SCIENCE INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>315721407</cusip>
			<value>2368</value>
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		<infoTable>
			<nameOfIssuer>FIBROCELL SCIENCE INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>315721407</cusip>
			<value>824</value>
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			<investmentDiscretion>DFND</investmentDiscretion>
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			<nameOfIssuer>HALOZYME THERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>40637H109</cusip>
			<value>226894</value>
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				<sshPrnamt>14092771</sshPrnamt>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>14092771</Sole>
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		<infoTable>
			<nameOfIssuer>INTREXON CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>46122T102</cusip>
			<value>356582</value>
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				<sshPrnamt>67791169</sshPrnamt>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>67791169</Sole>
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				<None>0</None>
			</votingAuthority>
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			<nameOfIssuer>NUSTAR ENERGY LP</nameOfIssuer>
			<titleOfClass>UNIT COM</titleOfClass>
			<cusip>67058H102</cusip>
			<value>3904</value>
			<shrsOrPrnAmt>
				<sshPrnamt>145200</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>145200</Sole>
				<Shared>0</Shared>
				<None>0</None>
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			<nameOfIssuer>ORAGENICS INC</nameOfIssuer>
			<titleOfClass>COM PAR</titleOfClass>
			<cusip>684023302</cusip>
			<value>59</value>
			<shrsOrPrnAmt>
				<sshPrnamt>100056</sshPrnamt>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>100056</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>ORAGENICS INC</nameOfIssuer>
			<titleOfClass>COM PAR</titleOfClass>
			<cusip>684023302</cusip>
			<value>847</value>
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				<sshPrnamt>1448110</sshPrnamt>
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			<investmentDiscretion>DFND</investmentDiscretion>
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				<None>0</None>
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			<nameOfIssuer>PTC THERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>69366J200</cusip>
			<value>5177</value>
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				<sshPrnamt>137551</sshPrnamt>
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			<investmentDiscretion>SOLE</investmentDiscretion>
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				<Sole>137551</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>QUAKER CHEM CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>747316107</cusip>
			<value>258</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1290</sshPrnamt>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>1290</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
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		<infoTable>
			<nameOfIssuer>SYNTHETIC BIOLOGICS INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>87164U201</cusip>
			<value>70</value>
			<shrsOrPrnAmt>
				<sshPrnamt>103572</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>103572</Sole>
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				<None>0</None>
			</votingAuthority>
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		<infoTable>
			<nameOfIssuer>SYNTHETIC BIOLOGICS INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>87164U201</cusip>
			<value>186</value>
			<shrsOrPrnAmt>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
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				<None>0</None>
			</votingAuthority>
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		<infoTable>
			<nameOfIssuer>TC PIPELINES LP</nameOfIssuer>
			<titleOfClass>UT COM LTD PRT</titleOfClass>
			<cusip>87233Q108</cusip>
			<value>3624</value>
			<shrsOrPrnAmt>
				<sshPrnamt>97000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>97000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
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</informationTable>
