The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AMPLIPHI BIOSCIENCES CORP COM NEW 03211P202 1,580 400,000 SH   SOLE   400,000 0 0
AMPLIPHI BIOSCIENCES CORP COM NEW 03211P202 2,997 758,788 SH   DFND   758,788 0 0
CRESTWOOD MIDSTREAM PARTNERS UNIT LTD PARTNER 226378107 1,759 284,620 SH   SOLE   284,620 0 0
ENERGY TRANSFER PRTNRS L P UNIT LTD PARTN 29273R109 3,188 77,635 SH   SOLE   77,635 0 0
ENERGY TRANSFER EQUITY L P COM UT LTD PTN 29273V100 15,657 752,400 SH   SOLE   752,400 0 0
ENTERPRISE PRODS PARTNERS L COM 293792107 25,792 1,035,834 SH   SOLE   1,035,834 0 0
FIBROCELL SCIENCE INC COM NEW 315721209 39,346 10,219,631 SH   SOLE   10,219,631 0 0
FIBROCELL SCIENCE INC COM NEW 315721209 24,643 6,400,783 SH   DFND   6,400,783 0 0
GENESIS ENERGY L P UNIT LTD PARTN 371927104 8,320 217,000 SH   SOLE   217,000 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 266,308 19,829,337 SH   SOLE   19,829,337 0 0
HISTOGENICS CORP COM 43358V109 10,708 2,690,570 SH   DFND   2,690,570 0 0
INTREXON CORP COM 46122T102 1,962,845 61,724,682 SH   SOLE   61,724,682 0 0
MARTIN MIDSTREAM PRTNRS L P UNIT L P INT 573331105 3,460 141,800 SH   SOLE   141,800 0 0
NUSTAR ENERGY LP UNIT COM 67058H102 5,222 116,500 SH   SOLE   116,500 0 0
ORAGENICS INC COM NEW 684023203 1,641 1,000,555 SH   SOLE   1,000,555 0 0
ORAGENICS INC COM NEW 684023203 14,495 8,838,666 SH   DFND   8,838,666 0 0
OVASCIENCE INC COM 69014Q101 849 100,000 SH   SOLE   100,000 0 0
OVASCIENCE INC COM 69014Q101 2,320 273,224 SH   DFND   273,224 0 0
SYNTHETIC BIOLOGICS INC COM 87164U102 21,822 9,613,268 SH   DFND   9,613,268 0 0
SYNTHETIC BIOLOGICS INC COM 87164U102 8,229 3,625,000 SH   SOLE   3,625,000 0 0
TC PIPELINES LP UT COM LTD PRT 87233Q108 4,618 97,000 SH   SOLE   97,000 0 0
TRANSGENOMIC INC COM NEW 89365K305 709 770,490 SH   SOLE   770,490 0 0
ZIOPHARM ONCOLOGY INC COM 98973P101 87,088 9,665,742 SH   SOLE   9,665,742 0 0