<?xml version="1.0" encoding="UTF-8"?>
<edgarSubmission xmlns:ns1="http://www.sec.gov/edgar/common" xmlns="http://www.sec.gov/edgar/thirteenffiler">
  <schemaVersion>X0202</schemaVersion>
  <headerData>
    <submissionType>13F-NT</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>false</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0001542162</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>09-30-2024</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>09-30-2024</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>Signature Financial Management, Inc.</name>
        <address>
          <ns1:street1>101 WEST MAIN STREET, SUITE 700</ns1:street1>
          <ns1:city>NORFOLK</ns1:city>
          <ns1:stateOrCountry>VA</ns1:stateOrCountry>
          <ns1:zipCode>23510</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F NOTICE</reportType>
      <form13FFileNumber>028-14797</form13FFileNumber>
      <crdNumber>000106375</crdNumber>
      <secFileNumber>801-47290</secFileNumber>
      <otherManagersInfo>
        <otherManager>
          <cik>0001345929</cik>
          <form13FFileNumber>028-13997</form13FFileNumber>
          <crdNumber>000017501</crdNumber>
          <secFileNumber>8-38904</secFileNumber>
          <name>BROWN ADVISORY INC</name>
        </otherManager>
      </otherManagersInfo>
      <provideInfoForInstruction5>N</provideInfoForInstruction5>
    </coverPage>
    <signatureBlock>
      <name>Julie P. Coleman</name>
      <title>Deputy General Counsel &amp; Chief Compliance Officer</title>
      <phone>443-873-5209</phone>
      <signature>/s/Julie P. Coleman</signature>
      <city>Baltimore</city>
      <stateOrCountry>MD</stateOrCountry>
      <signatureDate>11-13-2024</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
      <tableEntryTotal>0</tableEntryTotal>
      <tableValueTotal>0</tableValueTotal>
      <isConfidentialOmitted>false</isConfidentialOmitted>
    </summaryPage>
  </formData>
</edgarSubmission>
