<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0000950170-25-021396</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Huh Hoyoung -->
          <cik>0001401267</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Ordinary shares, $0.000000005 par value</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/02/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001541157</issuerCik>
        <issuerName>Akari Therapeutics Plc</issuerName>
        <issuerCusip>00972G207</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>401 East Jackson Street,</com:street1>
          <com:street2>Suite 3300,</com:street2>
          <com:city>Tampa</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33602</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Hoyoung Huh, M.D., Ph.D.</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>18199697667.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>18199697667.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>18199697667.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>18.4</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>1) Comprised of the Registrant's ordinary shares, $0.000000005 par value per share ("Ordinary Shares"), represented by American Depositary Shares ("ADSs"). Each ADS represents 2,000 Ordinary Shares.

(2) Includes (i) 9,391,708,000 shares held of record by Reporting Person, (ii) 1,061,691,667 shares underlying options exercisable within 60 days of March 1, 2026 granted to Reporting Person, (iii) 103,482,000 shares underlying warrants exercisable within 60 days of March 1, 2026 (iv) 7,423,902,000 shares underlying prefunded warrants exercisable within 60 days of March 1, 2026, and (v) 218,914,000 shares held of record by Hannol Ventures LLC. Excludes up to 10,995,330,000 shares underlying warrants exercisable within 60 days of March 1, 2026 issued to Reporting Person which are subject to a 9.99% beneficial ownership limitation and with respect to which Reporting Person disclaims beneficial ownership to the extent that any exercise of such warrants would exceed such percentage.

(3) The percentage of ownership is based on 91,567,009,533 ordinary shares issued and outstanding on March 1, 2026, as per information provided to the Reporting Person by the Issuer.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Akari Therapeutics Plc</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>401 East Jackson Street, Suite 3300, Tampa, FL 33602</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Hoyoung Huh, M.D., Ph.D.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>c/o Akari Therapeutics Plc

401 East Jackson Street, Suite 3300, Tampa, FL 33602</principalBusinessOfficeOrResidenceAddress>
        <citizenship>U.S.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>18,199,697,667</amountBeneficiallyOwned>
        <classPercent>18.4%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>18,199,697,667</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>18,199,697,667</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>Y</notApplicableFlag>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Hoyoung Huh, M.D., Ph.D.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hoyoung Huh, M.D., Ph.D.</signature>
        <title>Hoyoung Huh, Authorized Person</title>
        <date>03/04/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
