Shareholders' (Deficit) Equity - outstanding warrants (Details) - American Depositary Shares - $ / shares	3 Months Ended	12 Months Ended
	Mar. 31, 2024	Dec. 31, 2023
Class of Warrant or Right [Line Items]
Equity-classified Warrants	790,671	658,610
Liability-classified Warrants	1,510,000	1,510,000
Warrants exercised	2,300,671	2,168,610
2019 Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	59,211	59,211
Weighted-Average Exercise Price	$ 60
2019 Placement Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	8,881	8,881
Weighted-Average Exercise Price	$ 57
2020 Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	139,882	139,882
Weighted-Average Exercise Price	$ 44
2020 Placement Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	22,481	22,481
Weighted-Average Exercise Price	$ 51
July 2021 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	19,919	19,919
Weighted-Average Exercise Price	$ 46.4
December 2021 Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	107,775	107,775
Weighted-Average Exercise Price	$ 33
December 2021 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	8,622	8,622
Weighted-Average Exercise Price	$ 35
March 2022 Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	186,020	186,020
Weighted-Average Exercise Price	$ 28
March 2022 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	14,882	14,882
Weighted-Average Exercise Price	$ 30
October 2023 Investor Prefunded Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	48,387	48,387
Weighted-Average Exercise Price	$ 0.2
October 2023 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	42,550	42,550
Weighted-Average Exercise Price	$ 4.13
March 2024 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	132,061
Weighted-Average Exercise Price	$ 1.85
Series A warrants | September 2022 Investor Warrants
Class of Warrant or Right [Line Items]
Liability-classified Warrants	755,000	755,000
Weighted-Average Exercise Price	$ 17
Series B warrants | September 2022 Investor Warrants
Class of Warrant or Right [Line Items]
Liability-classified Warrants	755,000	755,000
Weighted-Average Exercise Price	$ 17