The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALPHABET INC CAP STK CL C 02079K107 BBG009S3NB21 356,313 1,871 SH   SOLE   0 0 1,871
ALVOTECH ORDINARY SHARES L01800108 BBG014MBMZZ1 184,770 13,966 SH   SOLE   0 0 13,966
AMAZON COM INC COM 023135106 BBG001S5PQL7 208,639 951 SH   SOLE   0 0 951
APPLE INC COM 037833100 BBG001S5N8V8 27,045 108 SH   SOLE 1 0 0 108
APPLE INC COM 037833100 BBG001S5N8V8 4,133,140 16,506 SH   SOLE   0 0 16,506
ARK ETF TR INNOVATION ETF 00214Q104 BBG007FJMV49 207,849 3,662 SH   SOLE   0 0 3,662
ARK ETF TR INNOVATION ETF 00214Q104 BBG007FJMV49 12 0 SH   SOLE 1 0 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 BBG001S90346 3,681,034 8,121 SH   SOLE   0 0 8,121
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 BBG001S90346 250,253 552 SH   SOLE 1 0 0 552
DURECT CORP COM NEW 266605500 BBG001SG3GG5 960,883 1,281,176 SH   SOLE   0 0 1,281,176
GUGGENHEIM STRATEGIC OPPORTU COM SBI 40167F101 BBG001STTSL7 110,115 7,216 SH   SOLE 1 0 0 7,216
GUGGENHEIM STRATEGIC OPPORTU COM SBI 40167F101 BBG001STTSL7 3,526,905 231,122 SH   SOLE   0 0 231,122
HERON THERAPEUTICS INC COM 427746102 BBG001SB92D4 982,779 642,339 SH   SOLE   0 0 642,339
INVESCO QQQ TR UNIT SER 1 46090E103 BBG001S9GN63 12,051,788 23,574 SH   SOLE   0 0 23,574
INVESCO QQQ TR UNIT SER 1 46090E103 BBG001S9GN63 26,961,470 52,738 SH   SOLE 1 0 0 52,738
ISHARES TR CORE S&P500 ETF 464287200 BBG001SFB7R6 476,242 809 SH   SOLE   0 0 809
ISHARES TR ISHARES BIOTECH 464287556 BBG001SGYSW7 427,513 3,234 SH   SOLE   0 0 3,234
ISHARES TR ISHARES BIOTECH 464287556 BBG001SGYSW7 71,790 543 SH   SOLE 1 0 0 543
MICROSOFT CORP COM 594918104 BBG001S5TD05 1,331,739 3,160 SH   SOLE   0 0 3,160
MIMEDX GROUP INC COM 602496101 BBG001STPW96 1,832,746 190,514 SH   SOLE   0 0 190,514
MIMEDX GROUP INC COM 602496101 BBG001STPW96 3 0 SH   SOLE 1 0 0 0
NUVEEN AMT FREE MUN CR INC F COM 67071L106 BBG001SHZCF8 473,113 38,589 SH   SOLE   0 0 38,589
PROSHARES TR ULTRAPRO QQQ 74347X831 BBG001T6S396 697,649 8,817 SH   SOLE   0 0 8,817
ROCKWELL MED INC COM NEW 774374300 BBG001S8R2Y8 66,670 32,682 SH   SOLE   0 0 32,682
SPDR SER TR BLOOMBERG 1-3 MO 78468R663 BBG001STKCW9 9,949,152 108,817 SH   SOLE 1 0 0 108,817
VANGUARD BD INDEX FDS INTERMED TERM 921937819 BBG001ST39R1 5,270,346 70,526 SH   SOLE 1 0 0 70,526
VANGUARD BD INDEX FDS SHORT TRM BOND 921937827 BBG001ST39Q2 83,491 1,081 SH   SOLE   0 0 1,081
VANGUARD BD INDEX FDS SHORT TRM BOND 921937827 BBG001ST39Q2 5,338,906 69,094 SH   SOLE 1 0 0 69,094
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 BBG001SMD2X3 7,282 82 SH   SOLE   0 0 82
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 BBG001SMD2X3 7,185,889 80,668 SH   SOLE 1 0 0 80,668
VANGUARD MALVERN FDS STRM INFPROIDX 922020805 BBG003H12XS7 4,675,111 96,553 SH   SOLE 1 0 0 96,553
VANGUARD WORLD FD COMM SRVC ETF 92204A884 BBG001SHTV72 19,370 125 SH   SOLE   0 0 125
VANGUARD WORLD FD COMM SRVC ETF 92204A884 BBG001SHTV72 8,036,791 51,863 SH   SOLE 1 0 0 51,863
VANGUARD WORLD FD CONSUM DIS ETF 92204A108 BBG001SHVTQ3 8,011,019 21,343 SH   SOLE 1 0 0 21,343
VANGUARD WORLD FD CONSUM DIS ETF 92204A108 BBG001SHVTQ3 17,455 47 SH   SOLE   0 0 47
VANGUARD WORLD FD CONSUM STP ETF 92204A207 BBG001SHVR41 7,609 37 SH   SOLE   0 0 37
VANGUARD WORLD FD CONSUM STP ETF 92204A207 BBG001SHVR41 7,163,722 33,891 SH   SOLE 1 0 0 33,891
VANGUARD WORLD FD ENERGY ETF 92204A306 BBG001SHTV45 13,648 113 SH   SOLE   0 0 113
VANGUARD WORLD FD ENERGY ETF 92204A306 BBG001SHTV45 3,532,320 29,119 SH   SOLE 1 0 0 29,119
VANGUARD WORLD FD FINANCIALS ETF 92204A405 BBG001SHTTM0 17,976 152 SH   SOLE   0 0 152
VANGUARD WORLD FD FINANCIALS ETF 92204A405 BBG001SHTTM0 7,896,354 66,879 SH   SOLE 1 0 0 66,879
VANGUARD WORLD FD HEALTH CAR ETF 92204A504 BBG001SHVR32 3,420,186 13,483 SH   SOLE 1 0 0 13,483
VANGUARD WORLD FD HEALTH CAR ETF 92204A504 BBG001SHVR32 7,230 29 SH   SOLE   0 0 29
VANGUARD WORLD FD INDUSTRIAL ETF 92204A603 BBG001SHVTX5 17,172 68 SH   SOLE   0 0 68
VANGUARD WORLD FD INDUSTRIAL ETF 92204A603 BBG001SHVTX5 7,494,833 29,462 SH   SOLE 1 0 0 29,462
VANGUARD WORLD FD INF TECH ETF 92204A702 BBG001SHTTR5 7,763,899 12,486 SH   SOLE 1 0 0 12,486
VANGUARD WORLD FD INF TECH ETF 92204A702 BBG001SHTTR5 18,965 30 SH   SOLE   0 0 30
VANGUARD WORLD FD MATERIALS ETF 92204A801 BBG001SHTTP7 3,464,170 18,441 SH   SOLE 1 0 0 18,441
VANGUARD WORLD FD MATERIALS ETF 92204A801 BBG001SHTTP7 13,994 74 SH   SOLE   0 0 74
VANGUARD WORLD FD UTILITIES ETF 92204A876 BBG001SHVTP4 7,926 49 SH   SOLE   0 0 49
VANGUARD WORLD FD UTILITIES ETF 92204A876 BBG001SHVTP4 7,531,310 46,085 SH   SOLE 1 0 0 46,085