X0202 SCHEDULE 13G/A 0000902664-26-001400 0001603466 XXXXXXXX LIVE 1 Common Shares, without par value 03/31/2026 0001540159 Edesa Biotech, Inc. 27966L306 100 Spy Court Markham A6 L3R 5H6 Rule 13d-1(c) Point72 Asset Management, L.P. b DE 0.00 2.00 0.00 2.00 2.00 N 0 PN Point72 Capital Advisors, Inc. b DE 0.00 2.00 0.00 2.00 2.00 N 0 CO Steven A. Cohen b X1 0.00 2.00 0.00 2.00 2.00 N 0 IN Edesa Biotech, Inc. 100 Spy Court, Markham, ON, Canada L3R 5H6 This statement is filed by: (i) Point72 Asset Management, L.P. ("Point72 Asset Management") with respect to the common shares, without par value ("Common Shares"), of Edesa Biotech, Inc. held by an investment fund it manages; (ii) Point72 Capital Advisors, Inc. ("Point72 Capital Advisors Inc.") with respect to the Common Shares held by an investment fund managed by Point72 Asset Management; and (iii) Steven A. Cohen ("Mr. Cohen") with respect to the Common Shares beneficially owned by Point72 Asset Management and Point72 Capital Advisors Inc. Cubist Systematic Strategies, LLC is a relying adviser on the Form ADV of Point72 Asset Management and acts as a sub-advisor with respect to a portion of the Common Shares reported herein. The address of the principal business office of Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902. Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a Delaware corporation. Mr. Cohen is a United States citizen. Y The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on March 31, 2026. Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen own directly no Common Shares. Pursuant to an investment management agreement, Point72 Asset Management maintains investment and voting power with respect to the securities held by an investment fund it manages. Point72 Capital Advisors Inc. is the general partner of Point72 Asset Management. Mr. Cohen controls each of Point72 Asset Management and Point72 Capital Advisors Inc. The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, the beneficial owner of the Common Shares reported herein. 0% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on March 31, 2026. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on March 31, 2026. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on March 31, 2026. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on March 31, 2026. N Y N See Item 2(a). Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Point72 Asset Management, L.P. /s/ Jason M. Colombo 05/15/2026 Point72 Capital Advisors, Inc. /s/ Jason M. Colombo 05/15/2026 Steven A. Cohen /s/ Jason M. Colombo 05/15/2026