144 0001539937 XXXXXXXX LIVE 0001356576 SUPERNUS PHARMACEUTICALS, INC. 001-35518 9715 Key West Avenue Rockville MD 20850 3018382500 JACK A KHATTAR Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

16587 763665.48 56073088 09/22/2025 NASDAQ Common 09/22/2025 Exercise of Stock Options Issuer N 16587 09/22/2025 Cash N 10b5-1 Sales for JACK A KHATTAR

9715 Key West Avenue Rockville MD 20850

Common 09/08/2025 6322 292654.86 10b5-1 Sales for JACK A KHATTAR

9715 Key West Avenue Rockville MD 20850

Common 09/05/2025 55578 2556888.12 10b5-1 Sales for JACK A KHATTAR

9715 Key West Avenue Rockville MD 20850

Common 08/28/2025 24150 1089575.55 10b5-1 Sales for JACK A KHATTAR

9715 Key West Avenue Rockville MD 20850

Common 08/27/2025 10650 479826.17 10b5-1 Sales for JACK A KHATTAR

9715 Key West Avenue Rockville MD 20850

Common 08/25/2025 1000 45001.00 10b5-1 Sales for JACK A KHATTAR

9715 Key West Avenue Rockville MD 20850

Common 08/22/2025 1500 67504.05 10b5-1 Sales for JACK A KHATTAR

9715 Key West Avenue Rockville MD 20850

Common 08/06/2025 38500 1549055.20 10b5-1 Sales for JACK A KHATTAR

9715 Key West Avenue Rockville MD 20850

Common 08/06/2025 38000 1596000.00 10b5-1 Sales for JACK A KHATTAR

9715 Key West Avenue Rockville MD 20850

Common 08/06/2025 63500 2738177.15 09/22/2025 11/14/2024 /s/ Jack A. Khattar