X0306 4/A 2022-01-18 2022-01-20 0 0001539029 Clearside Biomedical, Inc. CLSD 0001664690 Deignan Charles A. C/O CLEARSIDE BIOMEDICAL, INC. 900 NORTH POINT PARKWAY, SUITE 200 ALPHARETTA GA 30005 0 1 0 0 Chief Financial Officer Common Stock 2022-01-18 4 A 0 46250 0.00 A 362699 D Stock Option (Right to Buy) 2.19 2022-01-18 4 A 0 138750 0.00 A 2032-01-18 Common Stock 138750 138750 D These shares are represented by restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of common stock of the Issuer. The shares underlying the RSU vest in 4 equal annual installments on each of January 18, 2023, January 18, 2024, January 18, 2025 and January 18, 2026, subject to the Reporting Person's continuous service as of each such vesting date. One-fourth of the shares underlying this option vest on January 18, 2023 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the Reporting Person's continuous service as of each such vesting date. This amendment to the Reporting Person's Form 4 filed with the Securities and Exchange Commission on January 20, 2022 is being filed to correct the total number of stock options and restricted stock units awarded to the Reporting Person on January 18, 2022. Based on the foregoing, the total number of shares beneficially owned following the reported transactions should have been 353,866 instead of 351,366. /s/ Mark Ballantyne, Attorney-in-Fact 2022-01-28