X0306 4 2019-05-31 0 0001539029 Clearside Biomedical, Inc. CLSD 0001732744 Raymond Brion S. C/O CLEARSIDE BIOMEDICAL, INC. 900 NORTH POINT PARKWAY, SUITE 200 ALPHARETTA GA 30005 0 1 0 0 Chief Commercial Officer Common Stock 2019-05-31 4 A 0 50000 0.00 A 50000 D These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares underlying this restricted stock unit award will vest in full on May 31, 2020, subject to the Reporting Person's continuous service with the Issuer as of such vesting date, and subject to accelerated vesting in specified circumstances. /s/ Brian F. Leaf, Attorney-in-Fact 2019-06-04