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Pay vs Performance Disclosure - USD ($)

12 Months Ended

Dec. 31, 2024

Dec. 31, 2023

Dec. 31, 2022

PAY VERSUS PERFORMANCE

As required by Section 953(a) of the Dodd-Frank Act and Item 402(v) of Regulation S-K, we are providing the following information about the relationship between executive compensation actually paid and certain financial performance of the Company. For the most recently completed fiscal year, we did not use any “financial performance measures” as defined Item 402(v) of Regulation S-K to link compensation paid to our named executive officers (“NEOs”). Accordingly, we have omitted the tabular list of financial performance measures and the table below does not include a column for a “Company-Selected Measure” as defined in Item 402(v) of Regulation S-K. For further information regarding our compensation philosophy and how we seek to align executive compensation with our performance, refer to “Executive Compensation.”


										Value of Initial
						Average				Fixed $100
		Summary				Summary		Average		Investment Based
		Compensation		Compensation		Compensation		Compensation		On: Total
		Table Total for		Actually Paid to		Table Total for		Actually Paid to		Shareholder		Net Loss
Year		PEO		PEO		Non-PEO NEOs		Non-PEO NEOs		Return		(in thousands)
(a)		(b)		(c)		(d)		(e)		(f)		(h)
	2024	$	1,304,873	$	1,075,605	$	947,161	$	754,392	$	35	$	(34,352	)
	2023	$	1,538,627	$	1,344,839	$	608,953	$	376,792	$	43	$	(32,485	)
	2022	$	1,531,215	$	424,987	$	906,157	$	270,269	$	41	$	(32,917	)

(1) The dollar amounts reported in column (b) are the amounts of total compensation reported for Dr. Lasezkay (our Chief Executive Officer) (“PEO”) for each corresponding year in the “Total” column of the Summary Compensation Table. Refer to “Executive Compensation–Summary Compensation Table.”

(2) The dollar amounts reported in column (c) represent the amount of “compensation actually paid” to Dr. Lasezkay, as computed in accordance with Item 402(v) of Regulation S-K. The dollar amounts do not reflect the actual amount of compensation earned by or paid to Dr. Lasezkay during the applicable year. In accordance with the requirements of Item 402(v) of Regulation S-K, the following adjustments were made to Dr. Lasezkay’s total compensation for each year to determine the compensation actually paid:

          
         Reported

          
         Summary

         Reported

          
         Compensation

         Value of

         Equity

         Compensation

          
         Table Total

         Equity

         Awards

         Actually Paid

         Year

         for PEO

         Awards (a)

         Adjustments (b)

         to PEO

2024

1,304,873

(451,788

)

222,520

1,075,605

(a) The grant date fair value of equity awards represents the total of the amounts reported in the “Stock Awards” and “Option Awards” columns in the Summary Compensation Table for the applicable year.

(b) The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following: (i) the year-end fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the year; (ii) the amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of any awards granted in prior years that are outstanding and unvested as of the end of the applicable year; (iii) for awards that are granted and vest in same applicable year, the fair value as of the vesting date; (iv) for awards granted in prior years that vest in the applicable year, the amount equal to the change as of the vesting date (from the end of the prior fiscal year) in fair value; (v) for awards granted in prior years that are determined to fail to meet the applicable vesting conditions during the applicable year, a deduction for the amount equal to the fair value at the end of the prior fiscal year; and (vi) the dollar value of any dividends or other earnings paid on stock or option awards in the applicable year prior to the vesting date that are not otherwise reflected in the fair value of such award or included in any other component of total compensation for the applicable year. The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. The amounts deducted or added in calculating the equity award adjustments are as follows:

          
         Value of

          
         Dividends of

          
         Fair Value at

         Other

          
         the End of

         Earnings Paid

          
         Year over Year

         the Prior

         on Stock or

          
         Change in Fair

         Year of

         Option

          
         Year over Year

         Fair Value

         Value of

         Equity

         Awards not

          
         Change in Fair

         as of Vesting

         Equity Awards

         Awards that

         Otherwise

          
         Year End

         Value of

         Date of Equity

         Granted in

         Failed to

         Reflected in

          
         Fair Value

         Outstanding

         Awards Granted

         Prior Years

         Meet Vesting

         Fair Value or

         Total

          
         of Equity

         and Unvested

         and Vested

         that Vested

         Conditions

         Total

         Equity Award

         Year

         Awards

         Equity Awards

         in the Year

         in the Year

         in the Year

         Compensation

         Adjustments

2024

279,158

(106,902

)

—

50,264

—

—

222,520

(3) The dollar amounts reported in column (d) represent the average of the amounts reported for the NEOs as a group (excluding our PEO) in the “Total” column of the Summary Compensation Table in each applicable year. The NEOs (excluding our PEO) included for purposes of calculating the average amounts are (i) Mr. Deignan and Dr. Ciulla for the years ended December 31, 2022 and December 31, 2023 and (ii) Mr. Deignan and Dr. Chong for the year ended December 31, 2024.

(4) The dollar amounts reported in column (e) represent the average amount of “compensation actually paid” to the NEOs as a group (excluding our PEO), as computed in accordance with Item 402(v) of Regulation S-K. The dollar amounts do not reflect the actual average amount of compensation earned by or paid to the NEOs as a group (excluding our PEO) during the applicable year. In accordance with the requirements of Item 402(v) of Regulation S-K, the following adjustments were made to average total compensation for the NEOs as a group (excluding our PEO) for each year to determine the compensation actually paid, using the same methodology described above in Note (2):

          
         Average

          
         Reported

          
         Summary

         Average

          
         Compensation

         Reported

         Average

         Average

          
         Table Total

         Value of

         Equity

         Compensation

          
         for Non-PEO

         Equity

         Awards

         Actually Paid

         Year

         NEOs

         Awards

         Adjustments

         to PEO

2024

947,161

(382,415

)

189,646

754,392

(a) The amounts deducted or added in calculating the total average equity award adjustments are as follows:

          
         Average

         Average Value

          
         Fair Value

         of Dividends

          
         at the End

         of Other

          
         of the Prior

         Earnings Paid

          
         Year over Year

         Year of

         on Stock or

          
         Year over Year

         Average

         Equity

         Option

          
         Average

         Average

         Change in Fair

         Awards that

         Awards not

          
         Average

         Change in Fair

         Fair Value as of

         Value of Equity

         Failed to

         Otherwise

          
         Year End

         Value of

         Vesting Date of

         Awards Granted

         Meet

         Reflected in

         Total

          
         Fair Value

         Outstanding

         Equity Awards

         in Prior Years

         Vesting

         Fair Value or

         Average

          
         of Equity

         and Unvested

         Granted and Vested

         that Vested in

         Conditions

         Total

         Equity Award

         Year

         Awards

         Equity Awards

         in the Year

         the Year

         in the Year

         Compensation

         Adjustments

2024

203,906

(24,258

)

—

9,998

—

—

189,646

(5) Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between our stock price at the end and the beginning of the measurement period by our stock price at the beginning of the measurement period.

(6) The dollar amounts reported represent the amount of net income (loss) reflected in our audited financial statements for the applicable year. Due to the fact that we did not have any revenue other than revenue associated with upfront and milestone payments under our license agreements during the periods presented, we do not use net income (loss) as a performance measure in our executive compensation program.

Company Selected Measure Name

TSR

Named Executive Officers, Footnote

The dollar amounts reported in column (d) represent the average of the amounts reported for the NEOs as a group (excluding our PEO) in the “Total” column of the Summary Compensation Table in each applicable year. The NEOs (excluding our PEO) included for purposes of calculating the average amounts are (i) Mr. Deignan and Dr. Ciulla for the years ended December 31, 2022 and December 31, 2023 and (ii) Mr. Deignan and Dr. Chong for the year ended December 31, 2024.

PEO Total Compensation Amount

$ 1,304,873

$ 1,538,627

$ 1,531,215

PEO Actually Paid Compensation Amount

$ 1,075,605

1,344,839

424,987

Adjustment To PEO Compensation, Footnote

          
         Reported

          
         Summary

         Reported

          
         Compensation

         Value of

         Equity

         Compensation

          
         Table Total

         Equity

         Awards

         Actually Paid

         Year

         for PEO

         Awards (a)

         Adjustments (b)

         to PEO

2024

1,304,873

(451,788

)

222,520

1,075,605

The amounts deducted or added in calculating the equity award adjustments are as follows:

          
         Value of

          
         Dividends of

          
         Fair Value at

         Other

          
         the End of

         Earnings Paid

          
         Year over Year

         the Prior

         on Stock or

          
         Change in Fair

         Year of

         Option

          
         Year over Year

         Fair Value

         Value of

         Equity

         Awards not

          
         Change in Fair

         as of Vesting

         Equity Awards

         Awards that

         Otherwise

          
         Year End

         Value of

         Date of Equity

         Granted in

         Failed to

         Reflected in

          
         Fair Value

         Outstanding

         Awards Granted

         Prior Years

         Meet Vesting

         Fair Value or

         Total

          
         of Equity

         and Unvested

         and Vested

         that Vested

         Conditions

         Total

         Equity Award

         Year

         Awards

         Equity Awards

         in the Year

         in the Year

         in the Year

         Compensation

         Adjustments

2024

279,158

(106,902

)

—

50,264

—

—

222,520

          
         Average

          
         Reported

          
         Summary

         Average

          
         Compensation

         Reported

         Average

         Average

          
         Table Total

         Value of

         Equity

         Compensation

          
         for Non-PEO

         Equity

         Awards

         Actually Paid

         Year

         NEOs

         Awards

         Adjustments

         to PEO

2024

947,161

(382,415

)

189,646

754,392

(a) The amounts deducted or added in calculating the total average equity award adjustments are as follows:

          
         Average

         Average Value

          
         Fair Value

         of Dividends

          
         at the End

         of Other

          
         of the Prior

         Earnings Paid

          
         Year over Year

         Year of

         on Stock or

          
         Year over Year

         Average

         Equity

         Option

          
         Average

         Average

         Change in Fair

         Awards that

         Awards not

          
         Average

         Change in Fair

         Fair Value as of

         Value of Equity

         Failed to

         Otherwise

          
         Year End

         Value of

         Vesting Date of

         Awards Granted

         Meet

         Reflected in

         Total

          
         Fair Value

         Outstanding

         Equity Awards

         in Prior Years

         Vesting

         Fair Value or

         Average

          
         of Equity

         and Unvested

         Granted and Vested

         that Vested in

         Conditions

         Total

         Equity Award

         Year

         Awards

         Equity Awards

         in the Year

         the Year

         in the Year

         Compensation

         Adjustments

2024

203,906

(24,258

)

—

9,998

—

—

189,646

Non-PEO NEO Average Total Compensation Amount

$ 947,161

608,953

906,157

Non-PEO NEO Average Compensation Actually Paid Amount

$ 754,392

376,792

270,269

Compensation Actually Paid vs. Total Shareholder Return

Compensation Actually Paid and Cumulative TSR

The chart below shows the relationship between the compensation actually paid to our PEO and the average compensation actually paid to our non-PEO NEOs, on the one hand, to the Company’s cumulative TSR over the three years presented in the table, on the other.

Total Shareholder Return Amount

$ 35

Net Income (Loss)

$ (34,352,000)

$ (32,485,000)

$ (32,917,000)

PEO Name

Dr. Lasezkay

Additional 402(v) Disclosure

The dollar amounts reported in column (e) represent the average amount of “compensation actually paid” to the NEOs as a group (excluding our PEO), as computed in accordance with Item 402(v) of Regulation S-K. The dollar amounts do not reflect the actual average amount of compensation earned by or paid to the NEOs as a group (excluding our PEO) during the applicable year. In accordance with the requirements of Item 402(v) of Regulation S-K, the following adjustments were made to average total compensation for the NEOs as a group (excluding our PEO) for each year to determine the compensation actually paid, using the same methodology described above in Note (2):

Measure:: 1

Pay vs Performance Disclosure

Non-GAAP Measure Description

Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between our stock price at the end and the beginning of the measurement period by our stock price at the beginning of the measurement period.

PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ (451,788)

PEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

222,520

PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

279,158