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                            March 11, 2022

       John Trainer
       Chief Financial Officer
       NexImmune, Inc.
       9119 Gaither Road
       Gaithersburg, MD 20877

                                                        Re: NexImmune, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed March 9, 2022
                                                            File No. 333-263399

       Dear Mr. Trainer:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jessica
Ansart at (202) 551-4511 with any questions.




                            Sincerely,


                            Division of Corporation Finance

                            Office of Life Sciences
       cc:                                              John Rudy