Form S-1

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

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Copies of all communications, including communications sent to agent for service, should be sent to:

Approximate date of commencement of proposed sale to the public: As soon as practicable after this Registration Statement becomes effective.

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. ¨

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ¨

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ¨

If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until the Registration Statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.

The information in this preliminary prospectus is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This preliminary prospectus is not an offer to sell these securities and we are not soliciting offers to buy these securities in any state where the offer or sale is not permitted.

This is the initial public offering of our common stock. We are selling shares of our common stock. We currently expect the initial public offering price to be between $ and $ per share of common stock.

We have granted the underwriters an option to purchase up to additional shares of common stock to cover over-allotments.

We intend to apply to have our common stock listed on The NASDAQ Global Market under the symbol “ .”

Investing in our common stock involves risks. See “Risk Factors” beginning on page 12.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The underwriters expect to deliver the shares to purchasers on or about , 2012 through the book-entry facilities of The Depository Trust Company.

We are responsible for the information contained in this prospectus and in any free-writing prospectus we prepare or authorize. We have not authorized anyone to provide you with different information, and we take no responsibility for any other information others may give you. We are not, and the underwriters are not, making an offer to sell these securities in any jurisdiction where the offer or sale is not permitted. You should not assume that the information contained in this prospectus is accurate as of any date other than its date.

The following terms used in this prospectus have the meanings assigned to them below:

SUMMARY

This summary highlights information contained elsewhere in this prospectus. You should read the following summary together with the more detailed information appearing in this prospectus, including “Risk Factors,” “Selected Historical Financial Data,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” “Business” and our financial statements and related notes before deciding whether to purchase shares of our common stock. Some of the statements in this summary constitute forward-looking statements, with respect to which you should review the section of this prospectus entitled “Special Note Regarding Forward-Looking Statements.” Unless the context otherwise requires, the terms “Coskata,” “our company,” “we,” “us,” “our” and “our business” in this prospectus refer to Coskata, Inc. together with its subsidiaries, if any.

Coskata, Inc.

Company Overview

We are a technology leader in renewable fuels and bio-based chemicals. Our low-cost, proprietary process converts a wide variety of abundant feedstocks, such as woody biomass, agricultural residues, municipal wastes, natural gas and other carbon-containing materials, into fuels and chemicals. We have combined best-in-class synthesis gas production and cleaning technologies with our molecular biology and process engineering capabilities to create a novel synthesis gas fermentation technology platform. While our technology platform is capable of producing multiple renewable fuels and chemicals, we are initially focused on producing cellulosic ethanol for the large, established ethanol market. We operated a production facility at demonstration-scale for more than two years where we achieved what we believe to be the highest yield of cellulosic ethanol per bone dry ton of feedstock demonstrated at this scale. In 2012 we expect to begin constructing our first commercial-scale cellulosic ethanol production facility. We believe our high yield and low production cost provide us with a competitive advantage compared to other producers.

Historically, there were two widely-recognized conversion methods for the production of cellulosic ethanol: biochemical and thermochemical. Our proprietary technology platform utilizes a third, hybrid biothermal process which combines key elements of the biochemical and thermochemical methods and allows us to leverage the benefits of each method without subjecting us to many of their limitations. This biothermal process was noted by Sandia as being the highest-yielding approach for the production of cellulosic ethanol. According to Sandia, yields at early commercial facilities using biochemical and thermochemical conversion are projected to be 55 and 74 gallons of ethanol per bone dry ton of feedstock, respectively. Based on production runs at our demonstration facility in Madison, Pennsylvania, we expect to achieve yields of 100 gallons per bone dry ton of softwood at our first commercial production facility, which is consistent with Sandia’s estimate for initial biothermal yields.

Our high yields and low cost are driven primarily by four factors in our production process:

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the conversion of feedstock into synthesis gas, or syngas, which makes more of the carbon in the feedstocks available for conversion into renewable fuels and chemicals;

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the use of proprietary micro-organisms that ferment syngas to produce renewable fuels and chemicals with a high degree of target end-product selectivity, minimizing production of less-valuable by-products;

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the elimination of expensive chemical catalysts and enzymes; and

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the use of an integrated platform design that allows for a continuous production process.

At our demonstration-scale facility in Madison, Pennsylvania, which we refer to as Lighthouse, we operated our technology platform to produce ethanol for over 15,000 hours. At this facility we converted a wide variety of feedstocks, including wood chips, wood waste, sorted municipal solid waste, and natural gas, into ethanol. Our first commercial facility will be built in Boligee, Alabama. The initial production capacity of this facility, which we refer to as Flagship, will be 16 million gallons of ethanol per year, representing a single integrated production line of our technology platform. We expect to build out Flagship to achieve total production capacity of 78 million gallons of ethanol per year. The feedstock for this facility, wood chips and wood waste, is in plentiful supply in the region and allows us to capitalize on existing wood gathering and processing infrastructure. When fully built out, we expect Flagship to produce fuel-grade cellulosic ethanol at an unsubsidized cash operating cost of less than $1.50 per gallon, net of co-product sales, assuming a feedstock cost of $64 per bone dry ton of softwood. We expect to realize even lower per-unit production costs at future facilities by capitalizing on process efficiencies, economies of scale, ongoing improvements in our micro-organisms and sales of co-products or power.

Our proprietary technology platform can produce valuable bio-based chemicals in addition to renewable fuels like cellulosic ethanol. We are currently collaborating with Total Petrochemicals to develop a unique micro-organism-based technology that produces propanol, a three-carbon precursor to propylene, from the same range of feedstocks that we have already utilized to produce cellulosic ethanol. We believe the coupling of our propanol technology with proprietary technology to dehydrate alcohol into alkenes, including propanol into propylene, will result in a cost-effective new process for the production of propylene from non-petroleum materials. Over time, we expect to further expand our platform to produce valuable four, five and six carbon chain chemicals. We have already demonstrated in a laboratory setting the production of propanol, butanol, butanediol, hexanol, organic acids and certain fatty acids.

Our Market Opportunity

As a result of our low-cost syngas fermentation process, we are able to immediately address the 23 billion gallon global fuel-grade ethanol market. Our cellulosic ethanol will also address the 1.7 billion gallon global industrial ethanol market and can be converted into ethylene, a $140 billion market. In the future, our propanol production technology, combined with alcohol dehydration technology to produce propylene from propanol, under development by Total Petrochemicals together with IFP Energies Nouvelles & Axens, is expected to target the $100 billion global propylene market.

Our first commercial facility, Flagship, will target the U.S. fuel-grade ethanol market. In addition to having drop-in capability with existing infrastructure, ethanol is the most common biofuel, with the United States consuming 13 billion gallons in 2010. At a December 9, 2011 market price of $2.71 per gallon, this represents a $35 billion market. RFS2, a U.S. government incentive program, currently mandates that 21 billion gallons of advanced biofuels be produced by 2022, with at least 16 billion gallons derived from cellulosic biofuels. We believe we will be one of the first companies in the world to produce cellulosic ethanol at commercial-scale using a syngas fermentation process, qualifying us for both advanced biofuel and cellulosic biofuel credits under RFS2. We will selectively target international markets based on feedstock availability, strong market demand and local government support.

Our cellulosic ethanol can be converted with dehydration technology to ethylene, a key petrochemical building block. Ethylene, a two carbon hydrocarbon, is used for automotive fluids, insulation pipes and polyethylene plastics, such as trash bags and milk cartons. Worldwide demand for ethylene was approximately 121 million metric tons in 2010. Our platform technology can also produce propanol, a precursor to propylene. Propylene is a key input to the plastics and petrochemical industry that is used for everyday products such as packaging, textiles and automotive components. Worldwide demand for propylene was approximately 80 million metric tons in 2010.

Our Production Technology Platform

Our fully-integrated biorefinery platform allows for the high-yield, low-cost production of renewable fuels and chemicals from numerous carbon-containing feedstocks by combining three major process steps: syngas production, fermentation and separation. Importantly, our process is not dependent on sugar-based feedstocks or the use of enzymes and catalysts. Our integrated technology platform encompasses all aspects of the production process, from feedstock handling to product separation. By working with a select group of partners on syngas production and ethanol separation, we believe we have been able to minimize scale-up risk associated with our process while maintaining feedstock and end-product flexibility. With our process, the three core steps of syngas production, fermentation and separation remain in place regardless of the feedstock being utilized or the end-product being produced.

Our Commercialization Plan

We intend to take a flexible approach to commercialization that will include wholly-owned facilities, joint ventures and licensing to maximize our technology’s flexibility and potential value. Flagship will be our first commercial-scale project employing our technology platform. In addition to building and operating facilities, we plan to enter into joint ventures for the co-ownership of facilities and to license our technology platform to third parties. We believe this strategy will drive market penetration while minimizing our capital requirements.

Flagship

When fully built out, we expect that Flagship will be capable of producing 78 million gallons of ethanol per year using wood chips and wood waste as a feedstock. The project will be completed in two phases, with Phase I representing a single integrated train of our design with a capacity to produce 16 million gallons per year. Phase II will involve the modular expansion of the facility to add 62 million gallons of annual capacity. We expect Phase I and Phase II to be completed in 2013 and 2015, respectively. In order to minimize risk in our first commercial-scale facility, we have chosen commercially-ready technologies from well-established suppliers for the gasification and distillation components of our technology platform. We are also negotiating multi-year, 100% feedstock procurement and offtake agreements for Flagship. Our Phase I project execution strategy includes a firm-price, date-certain mechanical completion schedule. Phase I of Flagship will be financed by a portion of the proceeds of this offering, cash on hand and $87.9 million of debt financing supported by a 90% loan guarantee through the USDA’s 9003 Biorefinery Assistance Program.

Future Projects

We are in discussions with potential strategic partners about commercializing our technology through joint development or licensing arrangements, and have signed several memoranda of understanding, or MOUs, and engineering service agreements. The location of future facilities, whether they are wholly-owned, developed with strategic partners, or licensed, will depend upon available feedstocks, geography, and co-location synergies.

Our Competitive Strengths

We believe that our business benefits from a number of competitive strengths, including the following:

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Proprietary technology platform. We have developed a proprietary technology platform for the continuous production of renewable fuels and chemicals using a variety of feedstocks. As of November 30, 2011, we had six patents issued and 28 patent applications pending on key elements of our technology platform, including syngas cleanup, micro-organisms and continuous anaerobic fermentation. We have validated our syngas cleaning and fermentation technology at Lighthouse, our demonstration-scale facility, with over 15,000 hours of run time and confirmed that the cellulosic ethanol produced meets ASTM International standards. We believe Lighthouse is one of the largest syngas fermentation facilities in the world.

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Low cost production with high yields. Based on demonstration runs at Lighthouse, we expect to achieve yields of 100 gallons of ethanol per bone dry ton of softwood at Flagship. This yield is 35% to 82% greater than early commercial yields projected by Sandia for biochemical and thermochemical processes. The higher yields of our technology platform translate into lower capital and operating costs per gallon. When fully built out, we expect Flagship to produce cellulosic ethanol with unsubsidized cash operating costs of less than $1.50 per gallon, net of co-product sales, assuming a feedstock cost of $64 per bone dry ton of softwood.

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Significant feedstock flexibility. Our process can utilize a wide variety of carbon-containing feedstocks, including wood chips, wood waste, municipal solid waste, agricultural residue such as corn stover and bagasse, energy crops and fossil fuel sources such as natural gas, coal and petroleum coke. We achieve this flexibility by combining gasification of feedstock with our proprietary syngas cleaning technology to produce a uniform syngas which is then utilized in our fermentation process. Our feedstock flexibility will allow us to use the most cost-effective feedstock or combination of feedstocks at a given location anywhere in the world.

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Multiple end products targeting large existing markets. Our first commercial product will be fuel-grade cellulosic ethanol. Fuel-grade ethanol is an established fuel blendstock, representing a 23 billion gallon global market in 2010, and has drop-in compatibility with existing infrastructure. Our cellulosic ethanol will also satisfy RFS2, which we estimate will represent a separate 21 billion gallon market opportunity in the United States in 2022 based on current government mandated advanced biofuel consumption levels. Our technology platform can also produce cost competitive chemical intermediates that can be converted into propylene and ethylene, which represented $100 billion and $140 billion global markets, respectively, in 2010. In addition, we have demonstrated in a laboratory setting the production of butanol, butanediol, hexanol, organic acids and certain fatty acids.

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Fully-integrated process solution that enables rapid commercialization. Our technology platform is a complete, fully-integrated process solution that can be delivered to our future wholly-owned facilities, as well as to our joint venture projects and licensees. We have developed our platform to be all-inclusive, which allows for straightforward implementation and cost-efficient production of renewable fuels and chemicals. The experience we gained from designing and operating our Lighthouse demonstration facility, designing our Flagship commercial production facility and other research and development endeavors allows us to offer our strategic partners and licensees the extensive knowledge and support in microbiology, engineering, design, construction and operational know-how that drives the value of our platform.

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Experienced management team. We have assembled strong management, scientific and engineering teams with deep knowledge in research and development, new product development, capital project execution, feedstock procurement, plant operations and business plan execution. Our leadership team has an average of more than 25 years of work experience which we believe provides us with valuable experience and enhances our ability to commercialize our technology platform and grow our business.

Our Strategy

Our mission is to commercialize our technology for the production of renewable fuels and chemicals. Key elements of our strategy include the following:

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Build our first commercial-scale facility. We are designing our first commercial facility, Flagship, based on the successful operation of Lighthouse and plan to begin construction in 2012. Flagship is being designed to be capable of producing up to 78 million gallons of ethanol per year when fully built out. The initial production capacity of Flagship will be 16 million gallons, representing a single integrated production line, and will be built out in a subsequent phase to reach its total production capacity. We have secured a site in Boligee, Alabama, received all pre-construction permits, engaged Fagen, Inc. to provide a fixed-price, date certain engineering, procurement and construction contract, and are negotiating multi-year, 100% feedstock procurement and offtake contracts.

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Expand through a flexible, capital-efficient business model. In addition to building and operating production facilities such as Flagship, we plan to enter into joint ventures for the co-ownership of facilities and to license our technology platform to third parties. We believe this strategy will drive market penetration while minimizing our project capital requirements. We expect that our long-term strategy will be as a licensor. In the near term, we will focus on a co-ownership strategy by selectively seeking strategic partners that can provide project capital, feedstock supply, co-location opportunities or product offtake.

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Be a full service solution provider. In addition to delivering our fully-integrated technology platform to our joint venture projects and licensees, we will provide a complete set of services and support, including facility design, start-up assistance and technology upgrades, engineering systems and constant technology support, as well as our proprietary micro-organisms and proprietary nutrient formulas that are core components of our syngas fermentation process. We believe that by delivering services and working closely with our joint venture partners and licensees we can maximize our earnings opportunities and anticipate future needs and develop new solutions and end products.

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Commercialize production of bio-based chemicals. Our technology platform can produce low-cost bio-based chemical intermediates. Through our collaboration with Total Petrochemicals, we are working to develop bio-based propylene. We believe the coupling of our propanol technology with proprietary technology to dehydrate alcohol into alkenes, including propanol into propylene, under development by Total Petrochemicals together with IFP Energies Nouvelles & Axens, will result in a cost-effective new process for the production of propylene from non-petroleum materials. We intend to continue working with technology leaders in the fuels and chemicals industries.

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Identify attractive global market opportunities. Selection of the optimal markets for our production facilities is driven by available feedstock supply, market demand and co-location synergies. Achieving the lowest production cost requires identifying the key low-cost feedstocks in each region or market. The most readily-available feedstocks for cellulosic ethanol are woody biomass, municipal solid waste, agricultural residues, and energy crops. Abundant feedstock supply combined with RFS2 has made the United States an attractive initial market opportunity for our

cellulosic ethanol. Concurrently, we are working with potential local partners to develop municipal solid waste to ethanol facilities in Australia and Asia. We also expect to locate certain of our plants near existing industrial facilities to capture the synergies offered by existing infrastructure and close feedstock proximity.

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Maintain technology leadership through ongoing investment in research and development. We have a development strategy focused on continued innovation. We have developed trade secrets and intellectual property in bacteria strains, anaerobic strain development and advancement, nutrient formulas, syngas cleaning technology and bioreactor designs. We also operate what we believe is one of the only anaerobic high throughput screening laboratories in the world, with a capacity to screen as many as 150,000 new strains per year, which we believe allows us to advance strains at a faster pace than our competitors.

Risks Affecting Us

Our business is subject to a number of risks and uncertainties that you should understand before making an investment decision. These risks are discussed more fully in the section entitled “Risk Factors” following this prospectus summary. These risks include, but are not limited to, the following:

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we are a development stage company and have generated limited revenue, and our business will not succeed if we are unable to successfully commercialize our renewable fuels and chemicals;

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we have a limited operating history and a history of net losses, and we expect significant increases in our costs and expenses to result in continuing losses as we seek to commercialize our renewable fuels and chemicals;

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we have no experience producing renewable fuels or chemicals at a commercial-scale or in building the facilities necessary for such production, and we will not succeed if we cannot effectively scale our proprietary technology platform;

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the results we achieved at our Lighthouse demonstration facility may not be indicative of the results we will achieve at our planned Flagship facility because we expect to use certain technologies at Flagship that differ from or are in addition to the technologies that we tested at Lighthouse;

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the actual cost of constructing, operating and maintaining our commercial production facilities may be significantly higher than we plan or anticipate;

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we will need substantial additional capital in the future in order to expand our business, and our failure to obtain such capital could interfere with our business plans and growth strategies;

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we are involved in negotiations with a lender to provide debt financing that will fund a portion of the cost of constructing Phase I of our planned Flagship facility and with the USDA for a 90% guarantee of such debt financing, and the process for finalizing the definitive documentation may take longer than expected or may not happen at all;

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competitors and potential competitors who have greater resources and experience than we do may develop products and technologies that compete with ours or may use their greater resources to gain market share at our expense; and

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there are many companies developing technology in this area of business, and other parties may have or obtain intellectual property rights which could limit our ability to operate freely.

The Offering

Shares of common stock offered by us

shares.

Shares of our common stock to be outstanding immediately after this offering

shares.

Option to purchase additional shares of common stock

We have granted the underwriters a 30-day option to purchase up to additional shares of our common stock at the initial public offering price to cover over-allotments, if any.

Use of proceeds

We estimate that the net proceeds we will receive from this offering, after deducting estimated underwriting discounts and other estimated offering expenses payable by us, will be approximately $ million, or approximately $ million if the underwriters’ option to purchase additional shares is exercised in full. We intend to use the net proceeds we will receive from this offering, together with cash on hand and $87.9 million of debt financing that will be supported by a 90% guarantee from the USDA, to fund the construction of Phase I of Flagship, our planned commercial production facility in Boligee, Alabama, additional research and development efforts, our working capital needs, future development projects and general corporate purposes, including the costs associated with being a public company. See “Use of Proceeds.”

Risk factors

You should carefully read and consider the information set forth under the heading “Risk Factors” and all other information set forth in this prospectus before investing in our common stock.

The NASDAQ Global Market symbol

“ ”

Except as otherwise indicated, all information in this prospectus relating to the number of shares of common stock to be outstanding immediately after this offering:

•

gives effect to the automatic conversion effective upon the completion of this offering of all outstanding shares of our Series A convertible preferred stock, Series B convertible preferred stock, Series C convertible preferred stock and Series D convertible preferred stock, or, collectively, our convertible preferred stock, into an aggregate of 28,255,438 shares of our common stock on a 1-to-1 basis, or the Preferred Stock Conversion;

•

gives effect to the -for- reverse stock split effective upon the completion of this offering, or, together with the Preferred Stock Conversion, the IPO Share Adjustments;

•

assumes the effectiveness of our amended and restated certificate of incorporation and amended and restated bylaws;

Summary Historical Financial Data

The following table presents a summary of our historical financial data as of the dates and for the periods indicated. The summary statement of operations data for the years ended December 31, 2008, 2009 and 2010 has been derived from our audited financial statements that are included elsewhere in this prospectus. The summary statement of operations data for the nine months ended September 30, 2010 and 2011 and the summary condensed balance sheet data as of September 30, 2011 have been derived from our unaudited interim financial statements that are included elsewhere in this prospectus.

The summary historical financial data presented below should be read in conjunction with the sections entitled “Risk Factors,” “Selected Historical Financial Data,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and the financial statements and the related notes thereto and other financial data included elsewhere in this prospectus. Our unaudited interim financial statements have been prepared on the same basis as our audited financial statements, and in our opinion, include all adjustments, consisting of normal and recurring adjustments that we consider necessary for a fair presentation of our financial position and results of operations for such periods. Operating results for the nine months ended September 30, 2010 and 2011 are not necessarily indicative of results for a full year or for any other period.


	Year Ended December 31,									(unaudited) Nine Months Ended September 30,
	2008			2009			2010			2010			2011
	(in thousands, except per share amounts)
Statement of Operations Data:
Revenues from services	$	—		$	—		$	250		$	—		$	—
Cost of services (exclusive of depreciation in operating expenses)		—			—			116			—			—

Revenues less related costs		—			—			134			—			—
Operating expenses:
Research and development		6,505			7,399			10,128			6,979			9,821
Engineering		504			1,398			1,698			1,334			1,481
Selling, general and administrative		4,054			3,937			5,774			4,105			6,247
Depreciation		888			3,579			10,583			9,012			5,451
Accretion		—			134			437			332			348

Total operating expenses		11,951			16,447			28,620			21,762			23,348

Loss from operations		(11,951	)		(16,447	)		(28,486	)		(21,762	)		(23,348	)

Other income (expense):
Interest income		324			108			11			9			1
Interest expense		(183	)		(119	)		(251	)		(228	)		—
Other, net		1			—			2			(3	)		36

Total other income (expense), net		142			(11	)		(238	)		(222	)		37

Loss before income taxes		(11,809	)		(16,458	)		(28,724	)		(21,984	)		(23,311	)
Income tax benefit		—			—			—			—			—

Net loss	$	(11,809	)	$	(16,458	)	$	(28,724	)	$	(21,984	)	$	(23,311	)

Net loss per share of common stock, basic and diluted	$	(2.03	)	$	(2.81	)	$	(4.84	)	$	(3.72	)	$	(3.87	)

Weighted-average common shares outstanding, basic and diluted		5,806			5,847			5,936			5,911			6,030

Pro forma net loss per share of common stock, basic and diluted (unaudited)⁽¹⁾							$	(0.97	)				$	(0.73	)

Pro forma weighted-average common shares outstanding, basic and diluted (unaudited)⁽¹⁾								29,567						32,013


	(unaudited) As of September 30, 2011
	Actual		Pro Forma⁽¹⁾		Pro Forma As Adjusted⁽²⁾
	(in thousands)
Summary Balance Sheet Data:
Cash and cash equivalents	$	18,860	$	18,860	$
Working capital⁽³⁾		13,400		13,400
Property, plant and equipment, net		19,773		19,773
Total assets		39,612		39,612
Long-term debt, including current portion		—		—
Convertible preferred stock (liquidation value)		132,868		—		—
Total stockholders’ equity		33,076		33,076

(1)	Gives effect to the IPO Share Adjustments but not to this offering.

(2)

Gives effect to (i) the IPO Share Adjustments, (ii) our incurrence of $87.9 million of indebtedness following this offering in connection with financing the construction of Phase I of our Flagship facility, and (iii) our issuance and sale of shares of common stock in this offering at an assumed initial public offering price of $ per share, which is the midpoint of the price range listed on the cover page of this prospectus, after deducting underwriting discounts and commissions and estimated offering expenses payable by us. For more information on the indebtedness we will incur following this offering, see “Description of Certain Indebtedness.”

(3)	Working capital is the amount by which current assets exceed current liabilities.

Investing in our common stock involves a high degree of risk. You should carefully consider the following risks and all other information contained in this prospectus, including our financial statements and the related notes, before investing in our common stock. If any of the following risks materialize, our business, prospects, financial condition and operating results could be materially harmed. In such case, the price of our common stock could decline, and you may lose some or all of your investment.

We are a development stage company and have generated limited revenue, and our business will not succeed if we are unable to successfully commercialize our renewable fuels and chemicals.

We are a development stage company with a limited operating history. We have not yet commercialized our renewable fuels or chemicals and we have generated limited revenue. We are subject to the substantial risk of failure facing businesses seeking to develop new products. Certain factors that could, alone or in combination, prevent us from successfully commercializing our products include:

We have a limited operating history and a history of net losses, and we expect significant increases in our costs and expenses to result in continuing losses as we seek to commercialize our renewable fuels and chemicals.

We have incurred substantial net losses since our inception, including net losses of $28.7 million for the year ended December 31, 2010 and $23.3 million for the nine months ended September 30, 2011. We expect these losses to continue for the foreseeable future. As of September 30, 2011, we had an accumulated deficit of $88.2 million. We expect to incur additional costs and expenses related to the continued development and expansion of our business, including our research and development expenses, engineering and design work and

construction of our Flagship commercial production facility. We have not yet constructed or operated a commercial-scale production facility and we have generated limited revenue. We cannot assure you that we will ever achieve or sustain profitability on a quarterly or annual basis.

We have no experience producing renewable fuels or chemicals at a commercial-scale or in building the facilities necessary for such production, and we will not succeed if we cannot effectively scale or integrate our proprietary technology platform.

We must integrate and apply our proprietary technology platform at commercial-scale to produce renewable fuels, including our first commercial product, ethanol, and chemicals on an economically viable basis. Such production will require that our proprietary technology platform design be scalable from our Lighthouse demonstration facility to commercial production facilities, including our planned Flagship commercial production facility. We have not yet begun construction of or operated a commercial-scale production facility, and our technology may not perform as expected when applied at the scale that we plan or we may encounter operational challenges for which we are unable to devise a workable solution. In particular, we cannot assure you that our Flagship commercial production facility will be completed on the schedule or within the budget that we intend, or at all. If the construction of Phase I of our Flagship facility takes longer than expected or if we encounter unforeseen issues during the construction of Phase I, we may not begin construction of Phase II according to our schedule, or at all. If and when completed, our Flagship facility may not process biomass at designed levels or produce our renewable fuels at acceptable volumes. As a result of these risks, we may be unable to achieve commercial-scale production in a timely manner, or at all. If these risks materialize, our business and ability to commercialize our technology would be adversely affected.

The results we achieved at our Lighthouse demonstration facility may not be indicative of the results we will achieve at our planned Flagship facility because we expect to use certain technologies at Flagship that differ from or are in addition to the technologies that we tested at Lighthouse.

While we validated our syngas cleaning and fermentation technology at Lighthouse, we expect to use certain technologies at our planned Flagship facility that differ from or are in addition to the technologies that we tested at our Lighthouse demonstration facility. In particular, in place of the plasma gasifier that we used at our Lighthouse facility, we expect to integrate an indirect biomass gasifier with our syngas cleaning technology, which have never been tested together for fuels production. In addition, while biomass gasifiers are a proven technology, they have only been used commercially on a limited basis and have experienced operational reliability issues. Generally, these issues are handled through redundancy and a backup syngas production system. We intend to install a natural gas reformer at Flagship to provide a backup feedstock for uninterrupted operation of the fermenter. However, sustained use of a natural gas reformer in lieu of the biomass gasifier may negatively affect our financial performance. Furthermore, biomass gasification at Lighthouse was done on a batch basis and stored, as opposed to on a continuous integrated basis. Each of these changes presents additional technology risks. If the indirect biomass gasifier and syngas cleanup technology that we intend to use at Flagship on a continuous integrated basis does not perform as we expect, we may incur additional costs or experience reduced production that would interfere with our business plans. Because certain of the technologies that we expect to use at our planned Flagship facility have never been integrated, we cannot assure you that Flagship will perform as expected or that we will not encounter operational challenges for which we are unable to devise a workable solution. Failure to successfully integrate these technologies at our Flagship facility would have a material adverse effect on our business, financial condition and results of operations.

The actual cost of constructing, operating and maintaining our commercial production facilities may be significantly higher than we anticipate.

The construction of our Flagship facility, as well as any future facilities, will require the expenditure of significant amounts of capital, which may exceed our estimates. In addition, because our estimated capital expenditures for construction of our Flagship facility are based in part on publicly available estimates, they are subject to greater uncertainty than estimated capital expenditures based on actual bids or contracts would be. We

may be unable to complete commercial-scale facilities, including our Flagship facility, at the planned costs, on schedule or at all. The construction of these facilities may be subject to construction cost overruns due to labor costs, labor shortages or delays, costs of equipment and materials, weather delays, inflation or other factors, which could be material. In addition, the construction and operation of these facilities may be subject to the receipt of approvals and permits from various regulatory agencies. Those agencies may not approve the projects in a timely manner or may impose restrictions or conditions on a production facility that could potentially prevent construction from proceeding, lengthen its expected completion schedule and/or increase its anticipated cost.

If and when our Flagship facility or any other future facility is constructed, our operating and maintenance costs may be significantly higher than we anticipate. In addition, it may not operate as efficiently as we expect and may experience unplanned downtime, which may be significant. As a result, our Flagship facility or any of our other future commercial production facilities may be unable to achieve our expected investment return, which could adversely affect our business and results of operations.

We will need substantial additional capital in the future in order to expand our business, and our failure to obtain such capital could interfere with our business plans and growth strategies.

Our Flagship facility will be built in two phases. Phase I, with an expected completion date of late 2013, will be financed by a portion of the proceeds of this offering, cash on hand and $87.9 million of debt financing that will be supported by a 90% guarantee from the USDA based on its 9003 Biorefinery Assistance Program. See “Use of Proceeds” and “Description of Certain Indebtedness.” We expect to begin construction of Phase II upon completion of Phase I, with an expected completion date in 2015, but we have not yet secured the capital that would be required for Phase II. Potential investors or lenders for Phase II may require us to delay commencement of Phase II until after Phase I has been operating successfully for a period of time. Following the completion of Flagship, we expect to expand our business by constructing additional commercial production facilities, including facilities located in foreign countries, either alone or in collaboration with joint venture or strategic partners.

We will require substantial additional capital to successfully pursue our business strategy. We cannot predict with certainty how much additional capital we will require or specifically when our capital needs will arise in the future, although we estimate that we will have to secure between $ million and $ million for constructing Phase II of our Flagship facility. The extent and timing of our need for additional capital will depend on many factors, including our ability to construct our commercial production facilities within budget, our ability to control operating and administrative costs, our ability to find and engage joint venture or strategic partners for particular projects or technologies, whether we initially succeed in producing cellulosic ethanol at commercial-scale, the progress and scope of our research and development projects, our ability to license our technology platform and the filing, prosecution and enforcement of patent claims.

Our ability to obtain future financing will also depend on many factors, including conditions in the financial markets, our operating performance and investor interest. These factors may make the timing, amount, terms and conditions of any financing unattractive. In addition, debt financing sources may be unavailable to us and any debt financing may subject us to restrictive covenants that limit our ability to conduct our business or contain other unfavorable terms. If we raise additional funds through strategic partnerships and licensing agreements with third parties, we may have to relinquish valuable rights to our technologies or grant licenses on terms that are not favorable to us. We may be unable to raise sufficient additional capital on acceptable terms, or at all. If adequate funds are not available when needed or are not available on terms acceptable to us, our ability to fund our operations (including the construction of additional commercial production facilities), take advantage of strategic opportunities, develop technologies or otherwise respond to competitive pressures could be significantly limited. If this happens, we may be forced to delay or terminate the construction of commercial production facilities, delay, scale back or terminate research and development programs or the commercialization of products resulting from our technologies, curtail or cease operations or obtain funds through collaborative and licensing arrangements that may require us to relinquish commercial rights or grant licenses on terms that are unfavorable to us. If adequate funds are unavailable, we will be unable to execute successfully our business plan or to continue our business.

We are involved in negotiations with a lender to provide debt financing that will fund a portion of the cost of constructing Phase I of our planned Flagship facility and with the USDA for a 90% guarantee of such debt financing. The process for finalizing the definitive documentation with the lender and the USDA may take longer than expected or may not happen at all.

We have entered into an MOU with a lender for $87.9 million of debt financing to fund a portion of the cost of constructing Phase I of our planned Flagship facility. We have also received a conditional commitment from the USDA relating to a 90% guarantee of such debt financing, which commitment is conditioned upon us complying with a number of terms and provisions set forth therein. We may be unable to complete such debt financing on the schedule or terms we currently expect, meet all the conditions for the USDA guarantee or complete such financing or secure such guarantee at all. Failure to complete the debt financing and related USDA guarantee would have a material adverse impact on our ability to fund and complete Phase I of Flagship.

Competitors and potential competitors who have greater resources and experience than we do may develop products and technologies that compete with ours or may use their greater resources to gain market share at our expense.

Our ability to compete successfully will depend on our ability to develop proprietary technologies that produce renewable fuels and chemicals at commercial-scale and at costs below the prevailing market prices. Some of our competitors have substantially greater production, financial, research and development, personnel and marketing resources than we do, and may also have larger and more developed patent portfolios. In addition, certain of our competitors may also benefit from local government programs and incentives that are not available to us. As a result, our competitors may be able to develop competing and/or superior technologies and processes, and compete more aggressively and sustain that competition over a longer period of time than we could. Our technologies and products may be rendered uneconomical or otherwise obsolete by technological advances or entirely different approaches developed by one or more of our competitors. As more companies develop new intellectual property in our markets, the possibility of a competitor acquiring patent or other rights that may limit our products or potential products increases, which could lead to litigation.

In addition, various governments have recently announced a number of spending programs focused on the development of clean technology, including alternatives to petroleum-based fuels and the reduction of carbon emissions. Such spending programs could lead to increased funding for our competitors or the rapid increase in the number of competitors within those markets.

Our limited resources relative to some of our competitors may cause us to fail to anticipate or respond adequately to new developments and other competitive pressures. This failure could reduce our competitiveness and market share, adversely affect our results of operations and financial position, and prevent us from achieving or maintaining profitability.

We expect that the offtake agreement for the sale of ethanol to be produced at our Flagship facility will be an exclusive arrangement and will require the satisfaction of certain quality specifications. If the counterparty fails to purchase the total output of our ethanol, or if we fail to meet the quality specifications set forth in the agreement, our commercialization plan could be materially delayed or harmed.

We are currently negotiating an offtake agreement that will provide for the sale of ethanol to be produced at our Flagship facility on an exclusive basis to a single purchaser. The agreement will obligate the counterparty to purchase the total ethanol output from Flagship. To the extent the counterparty fails to purchase Flagship’s total output, we may sell our ethanol to third parties, but the counterparty is obligated to reimburse us for any costs and expenses incurred in such sales and any difference between the price the counterparty would have offered and the price we are able to obtain from such third parties. Nevertheless, negotiating purchase and sale arrangements with a third party could cause material delays or disruptions in our business and could affect our results of operations.

The offtake agreement will also require that our ethanol meet certain quality specifications. To the extent our ethanol fails to meet such specifications, we will be liable for any damages resulting from such failure and for the cost of storing, transporting, returning and disposing of such ethanol. Any failure to meet the quality specifications could materially harm our sales and reputation, and our commercialization plan could be delayed or harmed if we need to find other offtake counterparties.

We may have difficulty structuring offtake agreements for the purchase of our renewable fuels and chemicals, including price mechanisms that allow us to realize the benefit of any government incentives our renewable fuels may generate, particularly in light of the larger size and negotiating leverage of expected counterparties.

Our business model relies to a significant extent upon our ability to successfully negotiate and structure offtake agreements for the renewable fuels and chemicals we produce, whereby a buyer agrees to purchase all or a significant portion of a facility’s output for a given time period. We may fail to successfully negotiate these agreements in a timely manner or on favorable terms which, in turn, may force us to slow our production, delay the construction of new facilities or dedicate additional resources to sales in spot markets. Furthermore, should we become more dependent on spot market sales, our profitability will become increasingly vulnerable to short-term fluctuations in the price and demand for petroleum-based fuels and competing substitutes.

In particular, our pricing formula with the purchasers of our cellulosic ethanol must be designed to allow us to realize the benefits of cellulosic biofuel Renewable Identification Number, or RIN, credits and other government incentives we generate for ourselves or our customers. RIN credits were created by the Environmental Protection Agency, or EPA, and may be sold by blenders of renewable fuels who exceed mandated blending thresholds. However, markets that value cellulosic biofuel RIN credits and other government incentives may take a long period of time to develop or may not materialize at all. We may not be able to accurately value the RIN credits generated by our cellulosic ethanol if an active market is not sustained or if buyers of RIN credits have greater market visibility than us. As a result, our ability to capitalize on opportunities presented by RIN credits and other government incentives associated with our technology may be limited or delayed, which could materially adversely affect our growth strategy, business, financial condition and results of operations.

In addition, the companies with which we expect to have offtake arrangements, including the counterparty to the offtake agreement we expect to enter into relating to the cellulosic ethanol to be produced at our Flagship facility, generally are much larger and have substantially greater bargaining power than us. As a result, we may be ineffective in negotiating the most favorable pricing terms, which could have a material adverse effect on our business, financial condition and results of operations.

Our commercialization strategy relies in part on our ability to negotiate and execute definitive agreements with third parties.

In order to commercialize our technology, we will need to negotiate and enter into definitive agreements with our collaborators for the financing, construction and operation of our future facilities, as well as feedstock supply agreements. We have limited experience negotiating these types of agreements. Each of these agreements is important to our commercialization strategy and we cannot be certain of entering into definitive agreements with any of these parties. If we lose our business relationships with any of our potential collaborators for any reason, our business and prospects could be adversely affected.

The demand for and price of the renewable fuels we will produce in the future will be influenced by numerous factors, many of which are outside of our control.

There has been a substantial increase in ethanol production in recent years, but increases in the demand for ethanol may be limited because of market resistance to ethanol. Ethanol is approved for blending in gasoline in the United States at a 10% blend level in all vehicles, a 15% blend level in vehicles of 2001 or newer model year, and

up to an 85% blend level in flex fuel vehicles. At current consumption levels, the industry is approaching saturation of the 10% blend level market. While new export markets for U.S. produced ethanol are developing and should help alleviate such pressures, the current blend level requirements may limit the size of the U.S. ethanol market. If increases in ethanol supply exceed increases in ethanol demand, it could lead to a decrease in the price of ethanol.

In addition, the renewable fuels we expect to produce will be subject to commodity price risk as is typical for all transportation fuels in the United States. The premium value we expect to achieve for our renewable fuels will be determined by the market for regulatory compliance credits, including the RIN credits under RFS2. RFS2 allows additional RIN credits to be granted to obligated parties who blend into their fuel more than the required percentage of renewable fuels in a given year. These credits may be traded to other parties or may be used in subsequent years to satisfy RFS2 requirements. The trading prices of renewable fuel and advanced biofuel RIN credits are influenced by, among other factors, the transportation costs associated with renewable fuels, the mandated level of renewable fuel use for a specific year, the price of renewable fuels compared to that of petroleum products, the possibility of waivers of renewable fuel mandates and the expected supply of renewable fuel products. If RIN credits from other sources become available at a lower price, it could reduce the demand for our renewable fuels.

Our future success will depend, in part, on our ability to produce our renewable fuels on a cost-competitive basis with petroleum-based fuels. If the current or anticipated government incentives are reduced significantly or eliminated and petroleum-based fuel prices are lower relative to the cost of our renewable fuels, demand for our products may decline, which could have a material adverse effect on our business, financial condition and results of operations.

Changes in government regulations, including mandates, tax credits, subsidies and other incentives, could have a material adverse effect upon our business, financial condition and results of operations.

The market for renewable fuels, including cellulosic biofuels, is heavily influenced by federal, state, local and foreign government regulations and policies. Changes to existing, or adoption of new, federal, state, local and foreign legislative and regulatory initiatives that impact the production, distribution or sale of renewable fuels may harm our business. For example, RFS2 currently requires that approximately 14 billion gallons of liquid transportation fuels sold in 2011 be renewable fuels, a mandate that is scheduled to increase to 36 billion gallons by 2022. Of this amount, 16 billion gallons of renewable fuels used annually in 2022 are required by the EISA to be cellulosic biofuel. On November 9, 2011, the EPA sent a final rule to the White House Office of Management and Budget for approval proposing the total renewable fuel standard and the cellulosic biofuel standard for 2012. While the 2012 renewable fuel target, set at 15.2 billion gallons, and the advanced biofuel target, set at 2.0 billion gallons, match the targets set under the EISA in 2007, the cellulosic biofuel standard is set at 3.45 million to 12.9 million gallons of cellulosic ethanol, a much lower target than the 500 million gallons mandated under the EISA. In the United States and in a number of other countries, regulations and policies like RFS2 have been modified in the past to partially waive renewable fuels requirements, effectively decreasing the mandated volumes for some or all renewable fuels, and may be similarly modified again in the future. In the United States, the Administrator of the EPA, in consultation with the Secretary of Energy and the Secretary of Agriculture, may waive certain renewable fuels standards, on his or her own motion or in response to a petition requesting such waiver, to avert economic harm or in response to inadequate supply. The Administrator of the EPA is also required to reduce the mandate for cellulosic biofuel use if projected supply for a given year falls below a minimum threshold for that year. The size of the potential renewable fuel market for cellulosic biofuel in 2022 cannot be accurately predicted. It is possible that the producers of cellulosic ethanol and other renewable fuels will fail to produce sufficient volumes to sustain a market. The EISA projects that in 2022 the total production of all renewable fuels, including those not considered to be cellulosic biofuels, will be 25.7 billion gallons, versus 36 billion gallons required under the current RFS2 mandate in 2022. It is expected that a significant portion of the shortfall will be due to a shortfall in cellulosic biofuels. An October 2011 National Research Council report also projects that the United States will not meet its 16 billion gallon cellulosic biofuels target in 2022 due to such lack of supply. Any reduction in, or waiver of,

mandated requirements for fuel alternatives and additives to gasoline may cause demand for renewable fuels, including cellulosic ethanol, to decline and deter investment in the research and development of renewable fuels. The EPA Administrator could also revise qualification standards for renewable fuels or interpret existing requirements in ways that increase our expenses by requiring different feedstocks, imposing extensive tracking and sourcing requirements, or prevent our products or a portion of our products from qualifying as a renewable fuel under RFS2.

In addition, the U.S. Congress has passed legislation that extends tax credits for, among other things, the production of certain renewable fuel products. However, we cannot assure you that this or any other favorable legislation will remain in place. Any reduction in or phasing out or elimination of existing tax credits, subsidies and other incentives in the United States and foreign markets for renewable fuels, or any inability of us or our prospective customers to access such credits, subsidies and other incentives, may adversely affect demand for, and increase the overall cost of our renewable fuels, which would adversely affect our business. In addition, market uncertainty regarding future policies may also affect our ability to develop and sell renewable fuels. Any inability to address these requirements and any regulatory or policy changes could have a material adverse effect on our business, financial condition and results of operations.

Our business depends on our ability to develop and maintain our proprietary microbes.

We develop and intend to license to third parties proprietary micro-organisms, and we intend to develop further micro-organisms in the future. If we lose or fail to maintain a strain or fail to develop improved strains in the future, we may lose our ability to operate our commercial production facilities economically or to execute our strategy to develop a licensing business, either of which would have a material adverse effect on our business and results of operations.

Our operations are subject to federal and state laws and regulations governing the quality specifications of the products that we will produce, store and sell.

Various federal and state agencies have the authority to prescribe specific quality specifications to the sale of commodities, including ethanol. Changes in quality specifications could reduce our ability to produce our product and could reduce our sales volume. It could also require us to make capital expenditures to modify our facilities. Failure to comply with these regulations could result in substantial penalties. If we are unable to recover these additional costs through increased sales, our business, financial condition and results of operations could be adversely affected.

The production of our renewable fuels and chemicals will require significant amounts of feedstock, and we may be unable to acquire sufficient amounts of feedstock to produce the amount of our products that we commit to sell to potential customers, or we may experience difficulties or incur higher than anticipated costs obtaining such feedstock.

The successful commercialization of our renewable fuels and chemicals will require us to acquire and process large amounts of feedstock. We may experience difficulties in obtaining access to feedstock and transporting feedstock to our commercial production facilities. Our access to feedstock may be adversely affected by weather or actions by landowners, sellers or competing buyers of feedstock. In addition, fires or other natural disasters in the vicinity of our commercial production facilities could affect the availability of feedstock. We may be unable to secure access to feedstock or to secure the transportation of feedstock to our planned commercial production facilities on terms acceptable to us or at all. If we are unable to secure cost-effective access to feedstock, our ability to produce our renewable fuels and chemicals would be adversely affected.

The price of whole tree chips and wood waste, the feedstock for our Flagship facility, and other renewable feedstock could increase or become volatile, or their availability could be reduced, which would increase the production costs of our renewable fuels and chemicals.

The price of whole tree chips and wood waste, the feedstock for our Flagship facility, and other renewable feedstock may increase or become volatile due to changes in demand. Such changes could result in higher feedstock prices and/or a significant decrease in the volume of woody biomass and other renewable feedstock available for the production of the renewable fuels and chemicals we plan to sell, which could adversely affect our business and results of operations.

We may be unable to locate facilities near low-cost, abundant and sustainable sources of feedstock and adequate infrastructure, which may affect our ability to produce renewable fuels on a cost-effective basis.

Our business strategy anticipates the construction of a significant number of renewable fuel and chemical commercial production facilities. Our ability to place facilities in locations where we can economically produce our renewable fuels and chemicals from nearby feedstock and transport these products to potential customers will be subject to the availability and cost of land, the availability of adequate infrastructure and skilled labor resources in such areas, and to legal and regulatory risks related to land use, permitting and environmental regulations. If we are unable to locate sites that allow economical production and transport of our products, our ability to produce renewable fuels and chemicals cost-effectively could be adversely affected.

A disruption in our supply chain for components of our proprietary nutrient package could materially disrupt or impair our ability to produce renewable fuels and chemicals.

We will rely on third parties to supply the components of our proprietary nutrient package, which helps stimulate the proprietary micro-organisms utilized in our fermentation process. Our operations could be materially disrupted if we lose any of these suppliers or if any supplier experiences a significant interruption in its manufacturing and is unable to provide an adequate supply of these components to meet our demand. Any such disruptions or delays could have a material adverse effect on our business and results of operations.

We may face delay and cost in complying with government and industry regulations and standards for the use, manufacture or distribution of our chemicals, which could substantially hinder our ability to commercialize our bio-based chemicals.

Any bio-based chemicals developed using our technologies will need to meet a significant number of regulations and standards. In the United States, these will include regulations imposed by the U.S. Department of Transportation, the EPA, the Occupational Safety and Health Administration and various other federal and state agencies. Any failure to comply, or delay in compliance, with the various existing and evolving industry regulations and standards could prevent or delay the commercialization of any chemicals developed using our technology platform and subject us to fines and other penalties. We will also incur time and cost to comply with regulations in other countries in which we operate.

Any failure to obtain or delay in obtaining regulatory approvals for our bio-based chemicals or noncompliance with associated requirements could have a material adverse effect on our business, financial condition and results of operations.

Our business will be subject to fluctuations in the prices of commodities, including petroleum and natural gas.

We believe that some of the present and projected demand for renewable fuels, including cellulosic ethanol, results from relatively recent increases in the cost of petroleum. If the prices of petroleum-based products decline, the cellulosic ethanol we intend to produce may not be a cost-effective alternative to its petroleum-based counterparts or may be unable to be cost-effective without government incentives. Declining oil prices, or the perception of a future decline in oil prices, would adversely affect the prices we can obtain from our potential customers or prevent us from entering into agreements with potential customers for our products. As a result, any economic conditions and other factors that impact the price of oil indirectly impact our business.

Lower petroleum prices over extended periods of time may change the perceptions in government and the private sector that cheaper, more readily available energy alternatives should be developed and produced. If petroleum prices were to decline from present levels and remain at lower levels for extended periods of time, the demand for renewable fuels could be reduced, and our results of operations and financial condition may be adversely affected. In the future, we will also encounter similar risks in our planned bio-based chemicals business, where declines in the price of oil may make petroleum-based hydrocarbons less expensive, which could reduce the competitiveness of the chemicals we produce.

In addition, our commercial production facilities may use significant amounts of natural gas to operate. Accordingly, our business depends on natural gas supplied by third parties. An increase in the price of natural gas could adversely affect our results of operations and financial condition.

The chemicals we produce using our technology platform may not be accepted by the market.

Obtaining market acceptance in the chemical industry is complicated by the fact that many potential chemical industry customers have invested substantial amounts of time and money in developing established production channels. These potential customers generally have well-developed manufacturing processes and arrangements with suppliers of chemical components and may display substantial resistance to changing these processes. Pre-existing contractual commitments, unwillingness to invest in new infrastructure or technology, distrust of new production methods and long-standing relationships with current suppliers may slow market acceptance of our bio-based chemicals. To be successful, we must also demonstrate our ability to produce chemicals reliably on a commercial-scale and be able to sell them at a competitive price, or we may experience a material adverse effect on our business, financial condition and results of operations.

The growth of our company may place significant demands on our management team and our administrative and financial infrastructure.

We have experienced, and may continue to experience, expansion of our management team and administrative and financial infrastructure as we continue to make efforts to develop and commercialize our technology platform. Our growth has placed, and will continue to place, significant demands on our management and our administrative and financial infrastructure. In particular, continued growth could strain our ability to:

Managing our growth will require significant expenditures and allocation of valuable management resources. If we fail to achieve the necessary level of efficiency in our organization as it grows, our business, results of operations and financial condition would be harmed.

Loss of key personnel, including key management personnel, engineers and other technical personnel, or failure to attract and retain additional personnel could harm our product development programs, delay the commercialization of our technology platform and harm our research and development efforts and our ability to meet our business objectives.

Our business spans a variety of disciplines and requires a management team and employee workforce that is knowledgeable in the many areas necessary for our operations. The loss of any key member of our management, or key scientific, engineering, technical or operational employees, or the failure to attract or retain such employees, could prevent us from developing and commercializing our technology platform and executing our business strategy. We may be unable to attract or retain qualified employees in the future due to the intense competition for qualified personnel among refining, alternative and renewable fuel and chemical businesses, or due to the unavailability of personnel with the qualifications or experience necessary for our business. In particular, our process development endeavors depend on our ability to attract and retain highly skilled technical and operational personnel with particular experience and backgrounds. Competition for such personnel from numerous industries, companies and academic and other research institutions may limit our ability to hire individuals with the necessary experience and skills on acceptable terms. In addition, we expect that the successful execution of our strategy of constructing multiple commercial production facilities, including through joint ventures, to bring our products to market will require the expertise of individuals experienced and skilled in managing complex, first-of-kind capital development projects.

Each of our employees is an at-will employee, which means that either the employee or we may terminate their employment at any time. If we are unable to attract and retain the necessary personnel to accomplish our business objectives, we may experience staffing constraints that will adversely affect our ability to commercialize our technology platform, meet the demands of our potential customers in a timely fashion or support our internal research and development programs, which could impair our ability to meet our business objectives and adversely affect our results of operations and financial condition.

Our management team has a limited history of working together and may not be able to execute our business plan.

Our management team has worked together for only a limited period of time and has a limited track record of executing our business plan as a team. We have recently filled a number of positions in our senior management and finance and accounting staff. Additionally, certain key personnel have only recently assumed the duties and responsibilities they are now performing. Accordingly, it is difficult to predict whether our management team, individually and collectively, will be effective in operating our business.

We expect to rely to a significant extent on third parties to design, engineer and construct our commercial production facilities and to provide certain technologies, and actions by these third parties may adversely affect the commercialization and market acceptance of our technology platform.

We expect to rely to a significant extent on third parties to design, engineer and construct our commercial production facilities and for the provision of certain technology utilized in our platform. With respect to our Flagship facility, we are in the process of designing Phase I. We have engaged Fagen, Inc. to lead the engineering, procurement and construction activities and third-party technology providers will provide gasification, distillation and waste water treatment technologies. Our use of third parties reduces our control over our facilities and exposes us to certain risks. For example, our operations could be materially disrupted if we lose one of these third parties or if one of our third-party service or technology providers experiences a significant interruption in its business and is unable to perform. If it is necessary to replace any third-party service or technology provider, we may need to incur additional costs. If any of these third-party service or technology providers do not fulfill their contractual duties, meet expected deadlines or provide quality technologies, we may not be able to meet our obligations to our future customers, joint venture partners or licensees, which could result in damage to our reputation and adversely affect our business and results of operations. We may also rely on other third parties to assist in the sale of our renewable fuels and chemicals. These third parties may not be effective at selling our products. If the third parties we rely on to sell our renewable fuels and chemicals do not fulfill their contractual duties or perform effectively, our business, results of operations and financial condition could be materially and adversely affected. Further, if we rely on a single or small number of third-party service or technology providers, we will be exposed to the credit risk of those third parties.

Severe weather, natural or man-made disasters and accidents could disrupt normal business operations at our Flagship facility or other future commercial production facilities, which could have a material adverse effect on our business, financial condition and results of operations.

Our planned Flagship facility will be located in Boligee, Alabama, which is an area exposed to and affected by hurricanes. Our other future commercial production facilities may also be located in areas susceptible to natural disasters, such as hurricanes, wildfires, earthquakes and floods. Natural or man-made disasters could damage our production facilities, require us to temporarily shut down our facilities or otherwise significantly disrupt our operations, including the supply of feedstock to our facilities and the transportation of our renewable fuels or chemicals from our facilities. In addition, environmental pollution could result from any such natural disasters. We may not carry sufficient business insurance to compensate us for losses that may occur as a result of natural disasters. Any resulting losses, damages or claims could have a material adverse effect on our business, financial condition and results of operations.

Our operations are subject to risks inherent in the production of renewable fuels and chemicals such as ethylene and propylene, and we could be subject to liabilities for which we are not fully insured or that are not otherwise mitigated.

We maintain property, general liability, casualty and other types of insurance that we believe are in accordance with customary industry practices. However, we are not fully insured against all potential hazards incident to our business, including losses resulting from natural disasters, war risks or terrorist acts, and we are not insured against environmental pollution. Changes in insurance market conditions have caused, and may in the future cause, premiums and deductibles for certain insurance policies to increase substantially and, in some instances, for certain insurance to become unavailable or available only for reduced amounts of coverage. If we were to incur a significant liability for which we were not fully insured, we might not be able to finance the amount of the uninsured liability on terms acceptable to us or at all, and might be obligated to divert a significant portion of our cash flow from normal business operations.

Further, our business strategy involves the licensing of our technology platform. Hazardous incidents involving our licensees, if they result or are perceived to result from use of our technologies, may harm our reputation, threaten our relationships with other licensees and/or lead to customer attrition and financial losses. While we expect to limit these risks through contractual limitations of liability and indemnities and through insurance coverage, we may not always be successful in doing so. If a hazardous incident involving one of our licensees occurs, our financial condition and results of operation would be adversely affected, and other companies with competing technologies may have the opportunity to secure a competitive advantage.

We may incur significant costs complying with environmental laws and regulations, and failure to comply with these laws and regulations could expose us to significant liabilities.

Our operations, including the production of renewable fuels and chemicals, are subject to various federal, state, regional, local and foreign environmental, health and safety laws, regulations and permitting requirements, including the Clean Air Act, or CAA, and the Clean Water Act, or CWA. These laws, regulations and permitting requirements may restrict our emissions, affect our ability to make changes to our operations, and otherwise impose limitations on or require controls on our operations. In addition to costs that we expect to incur to achieve and maintain compliance with these laws, new or more stringent CAA or CWA standards or other environmental requirements in the future also may limit our operating flexibility or require the installation of new controls at our facilities.

We use, produce and transport hazardous substances, chemicals and materials in our business and are subject to a variety of federal, state and local laws and regulations governing the use, generation, manufacture, transportation, storage, handling and disposal of these substances, chemicals and materials. Our safety procedures for handling, transporting and disposing of these substances, chemicals, materials and waste products may be incapable of eliminating the risk of accidental injury or contamination from these activities. In the event

of contamination or injury, we could be held liable for any resulting damages, including toxic tort claims. Liability under certain environmental laws for contamination at our current, former or future sites or third-party sites where we have disposed or may dispose of hazardous substances, chemicals or materials can be joint and several and without regard to comparative fault. There can be no assurance that violations of environmental, health and safety laws will not occur in the future as a result of human error, accident, equipment failure or other causes. Compliance with applicable environmental laws and regulations may be expensive, and the failure to comply with past, present or future laws and regulations could result in the imposition of fines, revocation of permits, third-party property damage, product liability and personal injury claims, investigation and remediation costs, the suspension of production or a cessation of operations, and our liability may exceed our total assets. Environmental laws could become more stringent over time, imposing greater compliance costs and increasing risks and penalties associated with violations, which could impair our research, development or production efforts and harm our business. Federal, state, local and foreign environmental requirements may substantially increase our costs or delay or prevent the construction and operation of our facilities, which could have a material adverse effect on our business, financial condition and results of operations. Consequently, considerable resources may be required to comply with environmental regulations.

Climate change legislation, regulatory initiatives and litigation could result in increased operating costs.

In recent years, the U.S. Congress has been considering legislation to restrict or regulate emissions of GHGs, such as carbon dioxide and methane. In addition, almost half of U.S. states, either individually or through multi-state regional initiatives, have begun to address GHG emissions. Independent of Congress, the EPA has adopted regulations controlling GHG emissions under its existing CAA authority. For example, on December 15, 2009, the EPA officially published its findings that emissions of carbon dioxide, methane and other GHGs present an endangerment to human health and the environment because emissions of such gases are, according to the EPA, contributing to warming of the earth’s atmosphere and other climatic changes. On October 30, 2009, the EPA issued a final rule requiring the mandatory reporting of GHG emissions from specified large greenhouse gas emission sources in the United States beginning in 2011 for emissions occurring in 2010. In June 2010, the EPA also issued a final rule, known as the “Tailoring Rule,” that makes certain large stationary sources and modification projects subject to Prevention of Significant Deterioration and Title V permitting requirements for greenhouse gas emissions under the CAA.

At this time, the actual and projected GHG emissions from our facilities, including our Flagship commercial production facility to be built near Boligee, Alabama, could meet the applicable thresholds under the Tailoring Rule and reporting requirements, but currently qualify for exemptions or exclusions from both. Although it is not possible at this time to accurately estimate how potential future laws or regulations addressing GHG emissions would impact our business, any future laws or implementing regulations that may be adopted to address GHG emissions, or any current exemptions or exclusions that we are entitled to that may be eliminated, could require us to incur increased operating costs. The potential increase in the costs of our operations resulting from any legislation or regulation to restrict emissions of GHGs could include new or increased costs to operate and maintain our facilities, install new emission controls on our facilities, acquire allowances to authorize our GHG emissions, pay any taxes related to our GHG emissions and administer and manage a GHG emissions program, which, in turn, could have a material adverse effect on our business, financial condition and results of operations.

In addition, our efforts to sell renewable fuels in California may be impacted by changes to California’s Low Carbon Fuel Standard program, a regulatory measure intended to reduce GHG emissions by 16 million metric tons in 2020. This program requires us to achieve an acceptable carbon intensity rating. The imposition of new or more stringent requirements to qualify with the program could increase our expenses or prevent our product from qualifying with the program, which could have a material adverse effect on our business, financial condition and results of operations.

Joint ventures, joint development arrangements and other strategic collaborations could result in operating difficulties, dilution to stockholders, liabilities and other adverse consequences.

Our business strategy contemplates employing joint ventures to drive market penetration of our technologies and strategic partnerships to accelerate the development of our technology. In that context, we expect to evaluate and consider a wide array of potential strategic transactions. At any given time, we may be engaged in discussions or negotiations with respect to one or more of these types of transactions. Any of these transactions could be material to our financial condition and results of operations. We may face difficulties with respect to these transactions, including:

Moreover, we may not realize the anticipated benefits of any or all of our strategic transactions, or we may not realize them in the time frame expected. Future strategic transactions may require us to issue additional equity securities, spend a substantial portion of our available cash, or incur debt or liabilities, amortize expenses related to intangible assets or incur write-offs of goodwill, which could adversely affect our results of operations and dilute the economic and voting rights of our stockholders.

Our commercialization strategy relies in part on third parties, and therefore the successful commercialization of our technology platform will be dependent on such third parties performing satisfactorily.

We expect to collaborate with third parties to fund, build, develop and operate future commercial-scale facilities that use our proprietary technology platform. Our reliance on third parties would reduce our control over the funding and construction of these facilities and the production and sale of the renewable fuels produced using our technology, including the operating costs of the facilities, which will expose us to certain risks. These facilities will be first-of-kind projects, and we cannot assure you that our collaborators will be able to complete construction on schedule, effectively operate our proprietary technology platform or produce renewable fuels and chemicals of sufficient quality at high enough yields and low enough costs to be profitable. If and when these facilities are completed, we may have limited or no control over the amount or timing of resources that our collaborators commit to our collaboration. Our collaborators may experience a change of policy or priorities or may fail to perform their obligations as expected. These collaborators may breach or terminate their agreements with us or otherwise fail to conduct their collaborative activities successfully and in a timely manner. Further, our collaborators may not devote sufficient resources to the manufacturing, marketing or sale of renewable fuels and chemicals produced using our proprietary technology platform. Moreover, disagreements with a collaborator regarding strategic direction, economics of our relationship, intellectual property or other matters could develop, and any such conflict could reduce our ability to enter into future collaboration agreements and negatively impact our relationships with one or more existing strategic collaborators. In addition, our collaborators may also pursue competing technologies that may ultimately prove more compelling than ours. If any of these events occur, we may not be able to successfully commercialize our technology platform. Additionally, our business could be negatively impacted if any of our collaborators undergoes a change of control. If any of our collaborators fails to perform up to the obligations set forth in our agreements with them, our business and prospects could be materially and adversely affected.

Our technology platform may not perform as expected or be accepted by first generation biofuel producers.

Our business strategy includes the co-ownership of production facilities through joint ventures and the licensing of our technology platform to third parties, including first generation biofuel producers. However, first generation biofuel producers have been using existing technologies to produce ethanol from sources such as sugar and corn for many years. Existing ethanol producers may not be willing to try, or may be skeptical of trying, new technologies to produce ethanol. Such licensees, particularly early adopters, may initially use our technology platform for a limited percentage of their operations in order to confirm for themselves the technology’s efficacy and performance. These trials may result in slower commercialization through licensing than we currently expect.

Although we have operated Lighthouse for over 15,000 hours of run time, and confirmed that the cellulosic ethanol produced meets ASTM International standards, our technology has not been tested by a broad range of potential licensees or joint venture partners or at commercial-scale. There can be no assurance that the results achieved by potential licensees or joint venture partners will be consistent with results achieved by us in a pilot or laboratory setting. There can be no assurance that our technology platform or any future version of our technology platform will perform as expected or that the cost savings to first generation biofuel producers will meet our or their expectations. Failure by us to successfully commercialize our technology platform to one or more of the first generation biofuel industry’s leading participants would limit our market penetration and could influence the reputation in the biofuel industry of our technology platform. If first generation biofuel producers do not adopt our technology platform, our business and results of operations could be materially and adversely affected.

During the ordinary course of business, we may become subject to lawsuits or indemnity claims, which could materially and adversely affect our reputation, business, financial condition and results of operations.

From time to time, we may in the ordinary course of business be named as a defendant in lawsuits, claims and other legal proceedings. These actions may seek, among other things, compensation for alleged personal injury, workers compensation, employment discrimination, environmental violations or liabilities, breach of contract, property damages or civil penalties and other losses or injunctive or declaratory relief. In the event that such actions or indemnities are ultimately resolved unfavorably at amounts exceeding our accrued liability, or at material amounts, the outcome could materially and adversely affect our reputation, business, financial condition and results of operations. In addition, payments of significant amounts, even if reserved, could adversely affect our liquidity position.

Our quarterly operating results may fluctuate in the future. As a result, we may fail to meet or exceed the expectations of research analysts or investors, which could cause our stock price to decline.

Our financial condition and operating results may vary significantly from quarter to quarter and year to year due to a variety of factors, many of which are beyond our control. Factors relating to our business that may contribute to these fluctuations include the following factors, as well as other factors described elsewhere in this prospectus:

Due to the various factors mentioned above, and other factors described in this prospectus, the results of any prior quarterly or annual periods should not be relied upon as indications of our future operating performance.

We may not be able to utilize a significant portion of our net operating loss carry-forwards, other deferred tax assets, and certain tax credits, which could adversely affect our results of operations.

Due to losses recognized for federal and state income tax purposes in prior periods, we have generated significant federal and state net operating loss carry-forwards that may expire before we are able to utilize them. In addition, under U.S. federal and state income tax laws, if over a rolling three-year period, the cumulative change in our ownership exceeds 50%, our ability to utilize our net operating loss carry-forwards to offset future taxable income may be limited. Changes in ownership can occur due to transactions in our stock or the issuance of additional shares of our common stock or, in certain circumstances, securities convertible into our common stock. We have not performed a detailed analysis to determine whether an ownership change has occurred after each of our previous issuances of common stock and convertible preferred stock. The effect of such transactions on our cumulative change in ownership may further limit our ability to utilize our net operating loss carry-forwards to offset future taxable income. Furthermore, it is possible that transactions in our stock that may not be within our control may cause us to exceed the 50% cumulative change threshold and may impose a limitation on the utilization of our net operating loss carry-forwards in the future. We have also generated other deferred tax assets and certain tax credits that are subject to limitations and may not be utilized. In the event the usage of our net operating loss carry-forwards, deferred tax assets or tax credits is subject to limitation and we are profitable, our results of operations could be materially adversely affected.

If we fail to maintain an effective system of internal controls, we might be unable to report our financial results accurately or prevent fraud; in that case, our stockholders could lose confidence in our financial reporting, which would harm our business and could negatively impact the price of our stock.

Effective internal controls are necessary for us to provide reliable financial reports and prevent fraud. In addition, Section 404 of the Sarbanes-Oxley Act of 2002, or the Sarbanes-Oxley Act, will require us and our independent registered public accounting firm to evaluate and report on our internal control over financial reporting beginning with our Annual Report on Form 10-K for the year ending December 31, 2013. The process of implementing our internal controls and complying with Section 404 will be expensive and time consuming, and will require significant attention of management. We cannot be certain that these measures will ensure that we implement and maintain adequate controls over our financial processes and reporting in the future. Even if we conclude, and our independent registered public accounting firm concurs, that our internal control over financial reporting provides reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles, because of its inherent limitations, internal control over financial reporting may not prevent or detect fraud or misstatements. Failure to implement required new or improved controls, or difficulties encountered in their implementation, could harm our results of operations or cause us to fail to meet our reporting obligations. If we or our independent registered public accounting firm discover a material weakness, the disclosure of that fact, even if quickly remedied, could reduce the market’s confidence in our financial statements and harm our stock price. In addition, a delay in compliance with Section 404 of the Sarbanes-Oxley Act could subject us to a variety of administrative sanctions, including Securities and Exchange Commission, or SEC, action, ineligibility for short form resale registration, the suspension or delisting of our common stock from The NASDAQ Global Market and the inability of registered broker-dealers to make a market in our common stock, which would further reduce our stock price and could harm our business.

International expansion is one of our growth strategies, and international operations will expose us to additional risks that we do not face in the United States, which could have an adverse effect on our operating results.

We expect to focus the initial commercialization of our technology platform in the United States; however, international expansion, including to China and other areas of Asia, is part of our growth strategy. As we expand internationally, our operations will be subject to a variety of risks that we do not face in the United States, including:

Our overall success in international markets will depend, in part, on our ability to succeed in differing legal, regulatory, economic, social and political conditions. We may not be successful in developing and implementing policies and strategies, including joint venture and licensing arrangements, that will be effective in managing these risks in each country where we do business. Our failure to manage these risks successfully could harm our international operations, reduce our international sales and increase our costs, thus adversely affecting our business, financial condition and operating results.

We may be subject to interruptions or failures in our information technology systems.

We currently rely on information technology systems to run our business, and as we complete production of our manufacturing facilities, we will transition to and rely on sophisticated information technology systems and infrastructure to support our commercial production operations, including process control technology at our biorefineries. Any of these systems may be susceptible to outages due to fire, floods, power loss, telecommunications failures and similar events. The failure of any of our information technology systems may cause disruptions in our operations, adversely affecting our revenue and profitability.

There are other companies developing technology in this area of business, and other parties may have or obtain intellectual property rights which could limit our ability to operate freely.

Our commercial success depends on our ability to operate without infringing the patents and proprietary rights of other parties and without breaching any agreements to which we become a party. We are aware of other parties applying various technologies, including Ineos Bio and LanzaTech NZ Ltd., to make cellulosic ethanol and other end-products from biomass. We cannot determine with certainty whether patents of other parties may materially affect our ability to conduct our business. Because patent applications can take several years to issue, there may currently be pending applications, unknown to us, that may result in issued patents that cover our technologies or product candidates. We are aware of a number of patent applications filed by, and patents issued to, third parties relating to aspects of our technologies and products. The existence of third-party patent applications and patents could significantly reduce the scope of coverage of any patents granted to us and limit our ability to obtain meaningful patent protection.

We cannot be certain that the conduct of our business does not and will not infringe intellectual property or other proprietary rights of others in the United States and in foreign jurisdictions. Third parties may allege that our proposed technologies, processes and products or our methods infringe their patent or other proprietary rights. Many companies have employed intellectual property litigation as a way to gain a competitive advantage, and it is possible that such allegations may increase as the number of products and competitors in our market increases. In addition, to the extent that we gain greater visibility and market exposure as a public company, we face a greater risk of being the subject of such allegations. If the making, using, selling, offering for sale or importing of our proposed products or the practice of our proprietary technologies or processes are alleged to infringe or otherwise violate third party patents or other proprietary rights, we may need to obtain a license, which may not be available on commercially reasonable terms or at all, or redesign our technology, if possible. Otherwise, we could face issues that seriously harm our competitive position and operations, including:

Even if we are able to redesign our technology platform (including micro-organisms and other proprietary technologies) to avoid an infringement claim, our efforts to design around the patent could require significant time, effort and expense and ultimately lead to an inferior or more costly technology platform.

Many of our past and present employees were previously employed at specialty chemical, oil and pharmaceutical companies, some of which include our competitors or potential competitors. We may be subject to claims that these employees or we have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of their former employers. Litigation may be necessary to defend against these claims. For example, we are currently defending such a complaint filed by Ineos Bio. See “Business—Legal Proceedings.” If we fail in defending this claim, in addition to paying monetary damages, we may lose valuable intellectual property rights and be enjoined from certain activities. If we fail in defending against other claims, in addition to paying monetary damages, we may lose valuable intellectual property rights or personnel and be enjoined from certain activities. A loss of key research personnel or their work product could hamper or prevent our ability to commercialize our products, which could severely harm our business. Even if we are successful in defending against these claims, litigation could result in substantial costs and demands on management resources, which could have a material adverse effect on our business, financial condition and results of operations and adversely impact our stock price.

Patents and other intellectual property may not adequately protect our products and technologies, which may allow competitors to more easily exploit technology similar to ours.

Our intellectual property portfolio is a valuable asset of our business. Part of our expected market advantage depends on our ability to maintain adequate protection of our intellectual property for our technologies and products and potential products in the United States and other countries. To protect our proprietary rights, we rely on a combination of patent and trade secret laws, confidentiality procedures and contractual provisions, and physical security measures in the United States. As of November 30, 2011, we have six issued U.S. patents, including four related to membrane arrangements, one related to treatment of syngas streams, and one related to genetically modified organisms for the production of alcohols. We also have an additional allowed application related to membrane arrangements and 28 pending patent applications in the U.S., of which approximately 10 also have international or foreign patent applications pending. Our pending patent applications are related to a variety of technologies, including microorganisms and our second generation bioreactor designs that use membranes to dramatically reduce the size of the bioreactors and volume of water needed for fermentation.

Such patents and various other measures we take to protect our intellectual property from use by others may not be effective for various reasons, including, but not limited to, the following:

In addition, the research undertaken by the colleges and universities from which we have licensed technology, was funded by the U.S. federal government. When new technologies are developed with U.S. government funding, the government obtains certain rights in any resulting patents, including a non-exclusive license authorizing the government to use the invention for non-commercial purposes. These rights may permit the government to disclose our confidential information to third parties and to exercise “march-in” rights to use or allow third parties to use our patented technology. The government can exercise its march-in rights if it determines that action is necessary because we fail to achieve practical application of the U.S. government-funded technology, because action is necessary to alleviate health or safety needs, to meet requirements of federal regulations or to give preference to U.S. industry. In addition, U.S. government-funded inventions must be reported to the government and U.S. government funding must be disclosed in any resulting patent applications. In addition, our rights in such inventions are subject to certain requirements to manufacture products in the United States. If the measures that we take to protect our intellectual property are ineffective, this could have a material adverse effect on our business, financial condition and results of operations.

We may not retain exclusive rights to intellectual property created as a result of our collaborations.

Under certain of our license agreements, our license rights are limited to a certain field of use and/or our licensors have retained certain rights in and outside of our field of use. In addition, under certain of our license agreements and agreements with our research, development or collaboration partners, we are obligated to grant such licensors and partners certain rights in and outside of our field of use under any new technology or intellectual property created as a result of our research, development or collaborations. Such provisions may limit our ability to gain commercial benefit from some of the intellectual property we develop and may lead to costly or time-consuming disputes with parties with whom we have commercial relationships over rights to certain innovations.

Our ability to compete may decline if we are required to enforce or defend our intellectual property rights through costly litigation or administrative proceedings.

Unauthorized parties may attempt to copy or otherwise obtain and use our technology platform. Identifying unauthorized use of our intellectual property is difficult, because we may be unable to monitor the processes and materials employed by other parties, and the end products of our proprietary technology may be commodities from which it would be difficult to ascertain the methods or materials used in their manufacture. We cannot be certain that the steps we have taken will prevent unauthorized use of our technology, particularly in foreign countries where enforcement of intellectual property rights is more difficult than in the United States. Proceedings to enforce or defend our intellectual property rights could result in substantial costs, even if the eventual outcome were favorable to us, and would divert both funds and other resources from our business objectives. If the outcome of any such proceedings is unfavorable and competitors are able to use our technology without payment to us, our ability to compete effectively could be harmed. Furthermore, the nature of any protection against foreign competition that may be afforded by any patents we may have is often difficult to predict and varies significantly from country to country. Moreover, others may independently develop and obtain patents for technologies that are similar or superior to our technologies. If that happens, we may need to license these technologies, and we may not be able to obtain licenses on reasonable terms, if at all, which could cause harm to our business.

Confidentiality agreements with employees and others may not adequately prevent disclosures of trade secrets and other proprietary information.

In addition to patented technology, we rely on our unpatented proprietary technology, trade secrets, processes and know-how. However, this information is difficult to protect. We generally seek to protect this information by confidentiality, non-disclosure and assignment of invention agreements with our employees, consultants, scientific advisors, licensees and other third parties. These agreements generally require that all confidential information developed by the party or made known to the party by us during the course of the party’s relationship with us be kept confidential and not disclosed to third parties. However, such agreements may be breached, may not provide adequate remedies, or may be the subject of disputes that may not be resolved in our favor. In addition, third parties could reverse engineer, steal or misappropriate our proprietary micro-organisms and/or processes, and others may independently develop substantially equivalent proprietary information and techniques or otherwise gain access to our trade secrets and other confidential information. Costly and time-consuming litigation could be necessary to enforce and determine the scope of our proprietary rights, and failure to obtain or maintain protection of our trade secrets and other confidential information could adversely affect our competitive business position.

We may not be able to obtain and enforce our intellectual property rights throughout the world.

We expect in the future to build, or to collaborate with others in building, production facilities using our technology platform in countries other than the United States. However, our intellectual property rights outside the United States may be less extensive than our intellectual property rights in the United States. In addition, the laws of some foreign countries do not protect intellectual property rights to the same extent as federal and state laws in the United States. Consequently, we may not be able to prevent third parties from practicing our inventions outside the United States, or from selling or importing products made using our inventions in and into

the United States or other territories. Many companies have encountered significant problems in protecting and enforcing intellectual property rights in certain foreign jurisdictions. The legal systems of certain countries, particularly certain developing countries, do not favor the enforcement of patents and other intellectual property protection, particularly those relating to renewable fuel technologies. This could make it difficult for us or our licensors to stop any infringement of our or our licensors’ patents or misappropriation of the subject matter of our other proprietary or intellectual property rights. Proceedings or litigation that we or our licensors initiate to enforce our and our licensors’ patents and other proprietary rights in the United States or foreign jurisdictions could result in substantial costs and divert our efforts and attention from other aspects of our business, and put our patents at risk of being invalidated or interpreted narrowly and our patent applications at risk of not issuing. Additionally, we may provoke third parties to assert claims against us. We may not prevail in any lawsuits that we initiate and the damages or other remedies awarded, if any, may not be commercially valuable. Accordingly, our efforts to enforce our intellectual property rights around the world may be inadequate to obtain a significant commercial advantage from the intellectual property that we develop or license.

Our rights to certain intellectual property utilized in our research and development efforts and technology platform are licensed to us by third parties, and our failure to maintain or renew such arrangements, or enter into new licensing arrangements as technology advances, could adversely affect our business.

We have entered into, and may enter into additional, license agreements pursuant to which we have, or will obtain, the right to develop, use and commercialize certain intellectual property. There can be no assurance that we will be successful in maintaining our relationships with our licensors or be successful in negotiating additional in-licensing agreements on terms acceptable to us or at all. We may also be subject to claims from our licensors that we have breached the terms of our agreements, or have infringed or misappropriated their intellectual property. If a license agreement is terminated or not renewed, we may be unable to develop, market or continue to use products, technologies or processes covered by the applicable licensed intellectual property. In addition, there can be no assurance that other third parties will not enter into arrangements with our licensors or collaboration partners for the development or commercialization of the same or similar products or technologies or that the parties with whom we have made such arrangements will not pursue alternative technologies or develop products on their own or in collaboration with others, including our competitors. The occurrence of any of the foregoing events may adversely affect our business, financial condition and results of operations.

No public market for our common stock currently exists and an active trading market may not develop or be sustained following this offering.

Prior to this offering, there has been no public market for our common stock. An active trading market may not develop following the completion of this offering or, if developed, may not be sustained. The lack of an active market may impair your ability to sell your shares at the time you wish to sell them or at a price that you consider reasonable. The lack of an active market may also reduce the fair market value of your shares. An inactive market may also impair our ability to raise capital to continue to fund operations by selling shares.

You may be unable to sell your shares at or above the offering price, and our share price may be volatile, which could subject us to securities class action litigation.

The initial public offering price for our shares will be determined by negotiations between us and representatives of the underwriters and may not be indicative of prices that will prevail in the trading market. The market price of shares of our common stock could be subject to wide fluctuations in response to many risk factors listed in this section, and others beyond our control, including:

Furthermore, the stock markets recently have experienced extreme price and volume fluctuations that have affected and continue to affect the market prices of equity securities of many companies. These fluctuations often have been unrelated or disproportionate to the operating performance of those companies. These broad market and industry fluctuations, as well as general economic, political and market conditions such as recessions, interest rate changes or international currency fluctuations, may negatively impact the market price of shares of our common stock. If the market price of our common stock after this offering does not exceed the initial public offering price, you may not realize any return on your investment in us and may lose some or all of your investment.

In addition, other companies that have experienced volatility in the market price of their stock have been subject to securities class action litigation. We may be the target of this type of litigation in the future. Securities litigation against us could result in substantial costs and divert our management’s attention from other business concerns, which could harm our business.

Future sales of shares by existing stockholders could cause our stock price to decline.

If our existing stockholders sell, or indicate an intent to sell, substantial amounts of our common stock in the public market after the 180-day contractual lock-up and other legal restrictions on resale discussed in this prospectus lapse, the trading price of our common stock could decline significantly and could decline below the initial public offering price. We cannot predict the effect, if any, that future public sales of these shares or the availability of these shares for sale will have on the market price of our common stock. Based on 34,316,223 shares of common stock outstanding as of September 30, 2011, after giving effect to the IPO Share Adjustments, upon the completion of this offering, we will have outstanding shares of common stock. Of these shares, shares of common stock, plus any shares sold pursuant to the underwriters’ option to purchase additional shares, will be immediately freely tradable, without restriction, in the public market. Our officers, directors and substantially all of our other stockholders have executed lock-up agreements preventing them from selling any stock they hold for a period of 180 days from the date of this prospectus, subject to certain limited exceptions and extensions described under the section entitled “Underwriting.” Citigroup Global Markets Inc. may, in its sole discretion, permit our officers, directors and current stockholders to sell shares prior to the expiration of these lock-up agreements.

After the lock-up agreements pertaining to this offering expire, an additional shares will be eligible for sale in the public market in accordance with and subject to the limitation on sales by affiliates as provided in Rule 144 under the Securities Act of 1933, as amended, or the Securities Act. In addition, as of September 30, 2011, 1,355,206 shares reserved for future issuance under our 2006 Option Plan, that are not issued or subject to outstanding grants, will become eligible for sale in the public market in the future, subject to certain legal and contractual limitations. Moreover, 180 days after the completion of this offering, certain holders of shares of our common stock will have the right to require us to register these shares under the Securities Act pursuant to an amended and restated investors’ rights agreement. If our existing stockholders sell substantial amounts of our common stock in the public market, or if the public perceives that such sales could occur, this could have an adverse impact on the market price of our common stock, even if there is no relationship between such sales and the performance of our business.

Purchasers in this offering will experience immediate and substantial dilution in the book value of their investment.

The initial public offering price will be substantially higher than the tangible book value per share of shares of our common stock based on the total value of our tangible assets less our total liabilities immediately following this offering. Therefore, if you purchase shares of our common stock in this offering, you will experience immediate and substantial dilution of approximately $ per share in the price you pay for shares of our common stock as compared to its tangible book value, assuming an initial public offering price of $ per share, which is the midpoint of the price range set forth on the cover page of this prospectus. To the extent outstanding options and warrants to purchase shares of common stock are exercised, there will be further dilution. In addition, future financings that involve the issuance of equity securities could cause our existing stockholders to suffer further dilution. For further information, please see “Dilution” elsewhere in this prospectus.

If securities or industry analysts do not publish research or reports about our business, or publish negative reports about our business, our stock price and trading volume could decline.

The trading market for our common stock will be influenced by the research and reports that industry or securities analysts may publish about us, our business, our market or our competitors. If any of the analysts who may cover us change their recommendation regarding our stock adversely, or provide more favorable recommendations about our competitors, our stock price would likely decline. If any analyst who may cover us were to cease coverage of our company or fail to regularly publish reports on us, we could lose visibility in the financial markets, which in turn could cause our stock price or trading volume to decline.

We have broad discretion in the use of net proceeds from this offering and may not use them effectively.

Although we currently intend to use the net proceeds from this offering in the manner described in “Use of Proceeds,” we will have broad discretion in the application of the net proceeds. Our failure to apply these net proceeds effectively could affect our ability to continue to develop and grow our business, which could cause the value of your investment to decline.

We will incur significant increased costs as a result of operating as a public company, and our management will be required to devote substantial time to new compliance initiatives.

As a public company, we will incur significant legal, accounting and other expenses that we did not incur as a private company. For example, we will be required to comply with the requirements of the Sarbanes-Oxley Act, as well as rules and regulations subsequently implemented by the SEC and The NASDAQ Global Market, including the establishment and maintenance of effective disclosure and financial controls and changes in corporate governance practices. We expect that compliance with these requirements will increase our legal and financial compliance costs and will make some activities more time-consuming and costly. In addition, we expect that our management and other personnel will need to divert attention from operational and other business matters to devote substantial time to these public company requirements. In particular, we expect to incur significant expenses and devote substantial management effort toward ensuring compliance with the requirements of Section 404 of the Sarbanes-Oxley Act. In that regard, we currently do not have an internal audit function, and we will need to hire additional accounting and financial staff with appropriate public company experience and technical accounting knowledge. We also expect that operating as a public company will make it more difficult and more expensive for us to obtain director and officer liability insurance, and we may be required to accept reduced policy limits and coverage or incur substantially higher costs to obtain the same or similar coverage. As a result, it may be more difficult for us to attract and retain qualified people to serve on our board of directors, our board committees or as executive officers.

We do not anticipate paying any cash dividends in the foreseeable future, and accordingly, stockholders must rely on stock appreciation for any return on their investment.

After the completion of this offering, we do not anticipate declaring any cash dividends to holders of our common stock for the foreseeable future. Consequently, investors must rely on sales of their common stock after price appreciation, which may never occur, as the only way to realize any future gains on their investment. Investors seeking cash dividends in the foreseeable future should not invest in our common stock.

Anti-takeover provisions contained in our certificate of incorporation and bylaws, as well as provisions of Delaware law, could impair a takeover attempt.

Our amended and restated certificate of incorporation and our amended and restated bylaws to be effective upon the completion of this offering will contain provisions that could delay or prevent a change in control of our company. These provisions could also make it more difficult for stockholders to elect directors and take other corporate actions. These provisions include:

In addition, we will be governed by the provisions of Section 203 of the Delaware General Corporation Law, or the DGCL, which limits the ability of stockholders owning in excess of 15% of our outstanding voting stock to merge or combine with us. Although we believe these provisions collectively provide for an opportunity to obtain greater value for stockholders by requiring potential acquirers to negotiate with our board of directors, they would apply even if an offer rejected by our board were considered beneficial by some stockholders. In addition, these provisions may frustrate or prevent any attempts by our stockholders to replace or remove our current management by making it more difficult for stockholders to replace members of our board of directors, which is responsible for appointing the members of our management.

These anti-takeover provisions and other provisions under Delaware law could discourage, delay or prevent a transaction involving a change in control of our company, even if doing so would benefit our stockholders. These provisions could also discourage proxy contests and make it more difficult for you and other stockholders to elect directors of your choosing and to cause us to take other corporate actions you desire.

This prospectus, including the sections entitled “Summary,” “Risk Factors,” “Use of Proceeds,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” and “Business,” contains forward-looking statements. All statements other than statements of historical fact included in this prospectus, including statements regarding financial projections and other statements regarding other future performance or events, are forward-looking statements. Forward-looking statements generally can be identified by the use of forward-looking terminology such as “may,” “will,” “expect,” “intend,” “estimate,” “anticipate,” “believe” or “continue” or the negatives thereof or variations thereon or similar terminology. Such statements were prepared by us in good faith, based on conditions existing at the time of preparation of this prospectus and represent our best estimate of future events. All such forward-looking statements are based on various underlying assumptions and expectations and are subject to risks and uncertainties which could cause actual events to differ materially from those expressed in the forward-looking statements, including:

We derive many of our forward-looking statements from our operating budgets and forecasts, which are based upon many detailed assumptions. While we believe that our assumptions are reasonable, we caution that it is very difficult to predict the impact of known factors, and it is impossible for us to anticipate all factors that could affect our actual results. Important factors that could cause actual results to differ materially from our expectations, or cautionary statements, are disclosed under the sections entitled “Risk Factors” and “Management’s Discussion

and Analysis of Financial Condition and Results of Operations” in this prospectus. All written and oral forward-looking statements attributable to us, or persons acting on our behalf, are expressly qualified in their entirety by the cautionary statements as well as other cautionary statements that are made from time to time in our other SEC filings and public communications. You should evaluate all forward-looking statements made in this prospectus in the context of these risks and uncertainties.

We caution you that the important factors referenced above may not be all of the factors that are important to you. We operate in a competitive and rapidly changing environment in which new risks emerge from time to time, and it is not possible for our management to predict all risks. In addition, we cannot assure you that we will realize the results or developments we expect or anticipate or, even if substantially realized, that they will result in the consequences or affect us or our operations in the way we expect. The forward-looking statements included in this prospectus are made only as of the date hereof. We undertake no obligation to publicly update or revise any forward-looking statement as a result of new information, future events or otherwise, except as otherwise required by law.

Unless otherwise indicated, information contained in this prospectus concerning our industry and the markets in which we operate, including our general expectations and market opportunity and market size, is based on the most recently available information of which we are aware from various publicly available sources that are not affiliated with us, including: the EIA; ICIS; the National Renewable Energy Laboratory; RISI; Sandia; and Timber Mart-South, a publisher of timber market prices. We have also relied on assumptions that we have made that are based on those data and other similar sources and on our knowledge of the markets for renewable fuels and bio-based chemicals. We believe that the market opportunity and market size information included in this prospectus is generally reliable; however, these data involve a number of assumptions and limitations. In addition, projections, assumptions and estimates of our future performance and the future performance of the industry in which we operate are necessarily subject to a high degree of uncertainty and risk due to a variety of factors, including those described in “Risk Factors” and elsewhere in this prospectus. These and other factors could cause results to differ materially from those expressed in the estimates made by the independent parties and by us.

We estimate that our net proceeds from the sale of shares of common stock in this offering will be approximately $ million, or approximately $ million if the underwriters’ option to purchase additional shares is exercised in full, based on an assumed initial public offering price of $ per share (the midpoint of the price range set forth on the cover page of this prospectus), and after deducting estimated underwriting discounts and commissions and estimated offering expenses that we must pay in connection with this offering. Each $1.00 increase or decrease in the assumed initial public offering price would increase or decrease, as applicable, our cash and cash equivalents, working capital, total assets and total stockholders’ equity by approximately $ million, assuming that the number of shares offered by us, as set forth on the cover page of this prospectus, remains the same and after deducting the estimated underwriting discounts and commissions and estimated offering expenses payable by us.

We intend to use the net proceeds of this offering to partially fund the construction of Phase I of Flagship, our planned commercial production facility in Boligee, Alabama, additional research and development efforts, our working capital needs, future development projects and general corporate purposes, including the costs associated with being a public company. In addition to the net proceeds of this offering, we intend to finance the construction of Phase I with our cash on hand and $87.9 million of debt financing that will be supported by a 90% guarantee from the USDA. Until we use the net proceeds of this offering, we intend to invest the net proceeds in short-term, interest-bearing, investment-grade securities.

We have not declared or paid any cash dividends on our capital stock, and we do not anticipate paying any cash dividends on our capital stock in the foreseeable future. We currently expect to retain all future earnings, if any, in the operation and expansion of our business. Any future determination relating to our dividend policy will be at the discretion of our board of directors, subject to compliance with covenants in agreements governing our indebtedness, and will depend on our results of operations, financial condition, capital requirements and other factors deemed relevant by our board of directors.

The following table sets forth our cash and cash equivalents and our capitalization as of September 30, 2011 on:

You should read this table together with “Use of Proceeds,” “Selected Historical Financial Data,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and our financial statements and related notes included elsewhere in this prospectus.

The number of shares of common stock to be outstanding after this offering is based on 34,316,223 shares of our common stock outstanding as of September 30, 2011, as adjusted to give effect to the IPO Share Adjustments and excludes:

If you invest in our common stock, your interest will be diluted to the extent of the difference between the public offering price per share of our common stock and the pro forma as adjusted net tangible book value per share of our common stock after this offering.

Our pro forma net tangible book value as of September 30, 2011 was $ million, or $ per share of common stock. Pro forma net tangible book value per share represents total tangible assets less total liabilities, divided by the number of outstanding shares of common stock on September 30, 2011, after giving effect to the IPO Share Adjustments.

Our pro forma as adjusted net tangible book value as of September 30, 2011, after giving effect to the sale by us of shares of common stock in this offering at an assumed initial public offering price of $ per share (the midpoint of the price range set forth on the cover page of this prospectus) and after deducting the estimated underwriting discounts and commissions and estimated offering expenses payable by us, would have been approximately $ million, or $ per share of common stock. This represents an immediate increase in pro forma as adjusted net tangible book value of $ per share to existing stockholders and an immediate dilution of $ per share to new investors, or approximately % of the assumed initial public offering price of $ per share. The following table illustrates this per share dilution:

A $1.00 increase (decrease) in the assumed initial public offering price of $ per share (the midpoint of the price range set forth on the cover page of this prospectus) would increase (decrease) our pro forma as adjusted net tangible book value by $ million, the pro forma as adjusted net tangible book value per share by $ per share and the dilution in the pro forma net tangible book value to new investors in this offering to $ per share, assuming the number of shares offered by us, as set forth on the cover page of this prospectus, remains the same and after deducting the estimated underwriting discounts and commissions and estimated offering expenses payable by us.

If the underwriters exercise their over-allotment option in full, the pro forma as adjusted net tangible book value will increase to $ per share, representing an immediate increase to existing stockholders of $ per share and an immediate dilution of $ per share to new investors.

The following table summarizes, on a pro forma basis as of September 30, 2011 (giving effect to the IPO Share Adjustments), the number of shares of common stock purchased from us, the total consideration paid to us, and the average price paid per share by both existing stockholders and by new investors purchasing common stock in this offering at an assumed initial public offering price of $ per share (the midpoint of the price range set forth on the cover page of this prospectus), before deducting the estimated underwriting discounts and commissions and estimated offering expenses payable by us.

A $1.00 increase (decrease) in the assumed initial public offering price of $ per share (the midpoint of the price range set forth on the cover page of this prospectus) would increase (decrease) total consideration paid by new investors by $ million, assuming the number of shares offered by us, as set forth on the cover page of this prospectus, remains the same.

If the underwriters exercise their option to purchase additional shares in full, our existing stockholders would own approximately % and our new public investors would own approximately % of the total number of shares of our common stock outstanding upon the completion of this offering.

The discussion and tables in this section regarding dilution are based on 34,316,223 shares of common stock issued and outstanding as of September 30, 2011, after giving effect to the IPO Share Adjustments. The number of shares of our common stock to be outstanding after this offering excludes:

To the extent that outstanding options or warrants are exercised, you will experience further dilution. If all of our outstanding options and warrants were exercised, our pro forma net tangible book value as of September 30, 2011 would have been $ million, or $ per share, and the pro forma, as adjusted net tangible book value after this offering would have been $ million, or $ per share, causing dilution to new investors of $ per share.

In addition, we plan to raise additional capital to fund our commercialization plan. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the issuance of these securities could result in further dilution to our stockholders.

The following table presents our selected historical financial data as of the dates and for the periods indicated. The summary statement of operations data for the years ended December 31, 2008, 2009 and 2010 and the summary balance sheet data as of December 31, 2009 and 2010 have been derived from our audited financial statements that are included elsewhere in this prospectus. The summary statement of operations data for the nine months ended September 30, 2010 and 2011 and the summary condensed balance sheet data as of September 30, 2011 have been derived from our unaudited interim condensed financial statements that are included elsewhere in this prospectus. The summary statement of operations data for the period from May 3, 2006 (date of inception) through December 31, 2006 and for the year ended December 31, 2007, and the summary balance sheet data as of December 31, 2006, 2007 and 2008 are derived from our audited financial statements not included in this prospectus.

The selected historical financial data presented below should be read in conjunction with the sections entitled “Risk Factors,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and the financial statements and the related notes thereto and other financial data included elsewhere in this prospectus. Our unaudited interim financial statements have been prepared on the same basis as our audited financial statements, and in our opinion, include all adjustments, consisting of normal and recurring adjustments that we consider necessary for a fair presentation of our financial position and results of operations for such periods. Operating results for the nine months ended September 30, 2010 and 2011 are not necessarily indicative of results for a full year or for any other period.

The following discussion and analysis of our financial condition and results of operations should be read together with our financial statements and the other financial information appearing elsewhere in this prospectus. This discussion contains forward-looking statements that involve risks and uncertainties. Our actual results could differ materially from those anticipated in the forward-looking statements as a result of various factors, including those discussed below and those discussed in the section entitled “Risk Factors” included elsewhere in this prospectus. Due to the fact that we have not generated any on-going revenue, we believe that the financial information contained in this prospectus is not indicative of, or comparable to, the financial profile that we expect to have if and when we begin to generate revenue. Except to the extent required by law, we undertake no obligation to update publicly any forward-looking statements for any reason, even if new information becomes available or other events occur in the future.

We are a technology leader in renewable fuels and bio-based chemicals. Our low-cost, proprietary process converts a wide variety of abundant feedstock, such as woody biomass, agricultural residues, municipal wastes, natural gas and other carbon-containing materials, into fuels and chemicals. We have combined best-in-class synthesis gas production and cleaning technologies with our molecular biology and process engineering capabilities to create a novel synthesis gas fermentation technology platform. While our technology platform is capable of producing multiple renewable fuels and chemicals, we are initially focused on producing cellulosic ethanol for the large, established ethanol market. We operated a production facility at demonstration scale for more than two years where we achieved what we believe to be the highest yield of cellulosic ethanol per bone dry ton of feedstock demonstrated at this scale. In 2012 we expect to begin constructing our first commercial-scale cellulosic ethanol production facility. We believe our high yield and low production cost provide us with a competitive advantage compared to other producers.

We were incorporated and commenced operations in May 2006 and are a development stage company. At our demonstration-scale facility in Madison, Pennsylvania, which we refer to as Lighthouse, we operated our technology platform to produce ethanol for over 15,000 hours. At this facility we converted a wide variety of feedstocks, including wood chips, wood waste, sorted municipal solid waste, and natural gas, into ethanol, and, at our first commercial production facility, we expect to achieve yields of 100 gallons per bone dry ton of softwood. Our first commercial facility will be built in Boligee, Alabama. The initial production capacity of this facility, which we refer to as Flagship, will be 16 million gallons of ethanol per year, representing a single integrated production line of our technology platform. We expect to build out Flagship to achieve total production capacity of 78 million gallons of ethanol per year. The feedstock for this facility, wood chips and wood waste, is in plentiful supply in the region and allows us to capitalize on existing wood gathering and processing infrastructure. When fully built out, we expect Flagship to produce fuel-grade cellulosic ethanol at an unsubsidized cash operating cost of less than $1.50 per gallon, net of co-product sales, assuming a feedstock cost of $64 per bone dry ton of softwood.

Although our proprietary process is initially focused on producing ethanol, we intend to leverage our technology so that we can address other renewable fuel and chemical opportunities.

Since our inception, we have advanced our syngas fermentation technology from the test tube to our Lighthouse facility, which we believe is one of the largest syngas fermentation facilities in the world. The key milestones we have achieved in the development of our technology are:

Until recently, we have focused our efforts on research and development, and we have not yet generated any significant revenue. As a result, we have generated $88.2 million of operating losses and an accumulated deficit of $88.2 million from our inception through September 30, 2011. We expect to continue to incur operating losses through at least 2013 as we continue into the commercialization stage of our business.

Flagship will be our first commercial-scale project employing our technology platform. In addition to developing wholly-owned facilities, we plan to enter into joint ventures for the co-ownership of facilities and to license our technology platform to third parties. We believe this strategy will drive market penetration while minimizing our capital requirements. We intend to generate revenue through selling renewable fuels produced at wholly-owned or co-owned production facilities, licensing of our technology platform, selling engineered equipment systems and providing ongoing service and supplies to licensees and joint ventures.

Our Flagship facility will be built in two phases. We expect construction of the 16 million gallon first phase to begin in 2012 and commercial operations to begin in 2014. Once Phase I has been completed and Flagship begins operations, we expect to begin constructing the second phase of Flagship in 2014, which we expect to begin commercial operations in 2015, to achieve total production capacity of 78 million gallons of ethanol per year.

We plan to finance Phase I of Flagship with a combination of $87.9 million of debt financing, cash on hand and a portion of the net proceeds from this offering. The debt financing will be 90% guaranteed by the USDA under their Section 9003 Biorefinery Assistance Program. For more information, see “— Liquidity and Capital Resources.”

In addition to Flagship, we are in discussions with potential strategic partners about commercializing our technology through joint development or licensing arrangements, and have signed several MOUs and engineering service agreements. The location of future facilities, whether they are wholly-owned, developed with strategic partners, or licensed, will depend upon available feedstocks, geography, and co-location synergies.

We expect that the principal drivers of our gross and operating margins will be the following:

Revenue. To date, we have only generated a limited amount of engineering project service revenue from an affiliate of one of our stockholders. We do not expect to generate on-going product revenue until our Flagship facility begins operations. Our revenue will be generated primarily from the sale of ethanol produced at

our wholly-owned or co-owned production facilities, which includes the value of the associated RINs. We will also generate revenue through licensing of our technology platform, selling engineered equipment systems and providing ongoing service and supplies to licensees and joint ventures.

Cost of goods sold. To date, we have only generated a small amount of cost of goods sold related to the engineering project services revenue described above. When our facilities begin production, our gross margin will be derived from the sale of ethanol, including the value of the associated RINs, less the costs incurred to generate the renewable fuel. Cost of goods sold will then consist primarily of raw materials (initially wood feedstock), facility-related fixed costs, other plant-related variable costs and depreciation. Our cost of goods sold will be primarily driven by varying raw material and labor costs in the regions where our facilities are located and by the impact of inflation on the materials, spare parts, utilities and other facility-related costs necessary for operating our facilities. Additionally, once we begin to deliver engineering services to our customers, the direct costs of those services provided will be recorded within cost of goods sold.

Research and Development Expenses. Research and development expenses consist primarily of expenses for personnel focused on finding and developing improved strains of micro-organisms. These expenses also consist of facilities costs, lab materials and related overhead. Our research and development expenses have included the costs associated with our Lighthouse facility. We expense all of our research and development costs as they are incurred. We expect to continue to invest in the development of our proprietary biomass-to-renewable fuels and chemicals technology platforms. Accordingly, we expect to incur ongoing research and development expenses.

Engineering Expenses. Engineering expenses consist primarily of the personnel and related expenses for staff dedicated to the designing, planning and monitoring the construction of our Flagship facility. In the future, as we begin to generate revenue through providing engineering services, certain direct engineering costs will be reflected within cost of services and goods sold.

Selling, General and Administrative Expenses. Selling, general and administrative expenses consist primarily of personnel expenses for our executive, legal, finance, human resource and information technology functions, as well as fees for professional services and facility overhead expenses. These expenses also include costs related to our business development function, including marketing programs. Professional services consist principally of external legal, accounting, tax, audit and other consulting services. We expect selling, general and administrative expenses to increase as we incur additional costs related to operating as a public company, including increased legal and accounting fees, costs of compliance with securities, corporate governance and other regulations, investor relations expenses and higher insurance premiums, particularly those related to director and officer insurance. In addition, we expect to incur additional costs as we hire personnel and enhance our infrastructure to support the anticipated growth of our business.

Depreciation Expense. Depreciation expense consists of depreciation of our property, plant and equipment over their estimated useful lives, including our Lighthouse facility. For future plants, depreciation will commence when they begin operations.

Accretion Expense. Accretion expense relates to the asset retirement obligation for our Lighthouse facility. The accretion expense increases the asset retirement obligation accrual from its present value to its future liability value. For future plants, we will determine if asset retirement obligations exist and will record the required liability and accretion expense as needed.

Interest Income. Interest income is comprised of interest earned on invested funds and cash on hand. We expect interest income will fluctuate in the future with changes to the balance of funds invested, cash on hand and market interest rates.

Interest Expense. We incurred interest expense in connection with our capitalized equipment lease obligations. The capital lease obligations were fully paid off in 2010. We currently are not incurring any interest expense on debt obligations.

Income Tax Benefit. Since inception, we have incurred net losses and have not recorded any U.S. federal or state income tax expense. We have a full valuation allowance for our net deferred tax assets because we have incurred losses since inception.

Research and Development. Our research and development expenses increased by $2.8 million, or 41%, for the nine months ended September 30, 2011 as compared to the same period in 2010. The increase is due primarily to costs related to the operation of our Lighthouse facility. This facility’s operating costs, which include host site fees, personnel, repairs, utilities and supplies, increased approximately $2.8 million in the nine months ended September 30, 2011 compared to the same period in 2010. This facility suspended continuous operations effective in October 2011 after two years of operation during which it produced cellulosic ethanol from multiple feedstocks and provided key insights into the design and operation of our planned Flagship facility. Most of Lighthouse’s personnel were relocated to the research facility at our headquarters in Warrenville, Illinois. Our Lighthouse facility is available to be restarted as new micro-organisms are ready for evaluation at this scale and the site lease is extended.

Engineering. Our engineering expenses increased by $0.1 million, or 11%, for the nine months ended September 30, 2011 as compared to the same period in 2010. The increase is due to $0.1 million of higher payroll and related expenses due to hiring additional engineers.

Selling, General and Administrative. Our selling, general and administrative expenses increased by $2.1 million, or 52%, for the nine months ended September 30, 2011 as compared to the same period in 2010, primarily due to a $1.6 million increase in legal fees related to the Ineos litigation. For more information on the Ineos litigation, see “Business—Legal Proceedings” and Note 6 to our financial statements included elsewhere in this prospectus. The remainder of the increase was attributable to a $0.3 million increase in payroll and related expenses due to hiring additional general and administrative support staff, $0.1 million in facility costs due to the

renting of additional office space, $0.1 million for additional outside services and consultants, and $0.1 million for other outside legal fees, partially offset by a $0.2 million reduction in outside services and fees incurred in 2010 that related to procuring financing for our Flagship facility.

Depreciation. Our depreciation expense decreased by $3.6 million, or 40%, for the nine months ended September 30, 2011 as compared to the same period in 2010 due to a change in the estimated useful life of site-specific assets at our Lighthouse facility. The original estimated life for site-specific assets at this facility was set to end in December 2010, consistent with the expiration of the contract with a host provider for the use of the land and related facilities. A significant amount of the original cost of our Lighthouse facility’s fixed assets was depreciated over this original contract life. Assets that are not site-specific and which can be relocated to another site are being depreciated over their useful lives. In August 2010, the contract with the host provider was extended until March 2012. Effective with that revised contract, the remaining net book value of the site-specific assets was depreciated over the extended revised period through October 2011 in which they were utilized, thus reducing the go-forward monthly depreciation amount into 2011.

Interest Expense. Interest expense, which relates to capitalized lease obligations, decreased by approximately $0.2 million, or 100%, for the nine months ended September 30, 2011 as compared to the same period in 2010. The capitalized lease obligations were fully paid off in October 2010. There are no capitalized lease obligations in 2011.

In 2010 we generated a limited amount of engineering project services revenue and a small amount of related direct cost of services from an affiliate of one of our shareholders.

Research and Development. Our research and development expenses increased by $2.7 million, or 37%, for the year ended December 31, 2010 as compared to the same period in 2009. In October 2009, we began operating our Lighthouse facility and commenced testing of feedstocks, microorganisms and other process variables under a simulated commercial production environment. The operating costs associated with running this facility for a full year, including personnel, repairs and maintenance, supplies and outside services, accounted for a $3.2 million increase in research and development expenses. Partially offsetting the cost increases were a $0.2 million decrease in lab supplies and a $0.2 million decrease in research and development outside services at our headquarters in Warrenville, Illinois.

Engineering. Our engineering expenses increased by $0.3 million, or 21%, for the year ended December 31, 2010 as compared to the same period in 2009. The increase resulted from $0.3 million of higher payroll and related expenses due to hiring additional engineers.

Selling, General and Administrative. Our selling, general and administrative expenses increased by $1.8 million, or 47%, for the year ended December 31, 2010 as compared to the same period in 2009. This increase was primarily the result of $0.6 million of higher payroll and related expenses due to hiring additional personnel for business development and support staff, a $0.6 million increase in legal fees related to the Ineos litigation, a $0.4 million increase in expenses for consultants, and a $0.2 million increase in travel expenses. For more information on the Ineos litigation, see “Business—Legal Proceedings” and Note 6 to our financial statements included elsewhere in this prospectus.

Depreciation. Our depreciation expense increased by $7.0 million in the year ended December 31, 2010 due to the addition of a full year of depreciation expense associated with our Lighthouse facility.

Accretion. Accretion expense increased by approximately $0.3 million in the year ended December 31, 2010 as compared to the same period in 2009. Our Lighthouse facility operated for a full year in 2010 compared to only a quarter of a year in 2009.

Interest Income. Interest income decreased by $0.1 million due to lower average cash balances and lower interest rates.

Interest Expense. Interest expense increased by approximately $0.1 million for the year ended December 31, 2010 as compared to the same period in 2009. Interest expense relates to capitalized lease obligations.

Research and Development. Our research and development expenses increased by $0.9 million, or 14%, for the year ended December 31, 2009 as compared to the same period in 2008. The increase is primarily due to increases in personnel costs, travel, property insurance, equipment rental, lab supplies and non-capitalized equipment costs primarily related to the start-up of our Lighthouse facility which began operating in October 2009.

Engineering. Our engineering expenses increased by $0.9 million, or 177%, for the year ended December 31, 2009 as compared to the same period in 2008. The increase is due to $0.8 million of higher payroll and related expenses due to hiring additional engineers to support the growth of our business.

Selling, General and Administrative. Our selling, general and administrative expenses decreased by approximately $0.1 million, or 3%, for the year ended December 31, 2009 as compared to the same period in 2008. The decrease is due to a $0.8 million decrease in stock compensation expense offset by $0.6 million in higher payroll and related costs. The higher payroll and related costs primarily relate to hiring additional personnel for business development and general and administrative staff to support the development of our business.

Depreciation. Our depreciation expense increased by approximately $2.7 million in 2009 as compared to the same period in 2008. This increase is primarily the result of the additional depreciation related to the start-up of our Lighthouse facility in October 2009.

Accretion. Accretion expense increased by approximately $0.1 million in 2009 as compared to the same period in 2008 due to the start-up of our Lighthouse facility in October 2009.

Interest Income. Interest income decreased by $0.2 million in 2009 as compared to 2008 due primarily to significantly lower interest rates.

Interest Expenses. Interest expense decreased by $0.1 million in 2009 as compared to 2008 due to lower capitalized lease obligation balances.

We maintain our cash balances at two financial institutions in the United States. The Federal Deposit Insurance Corporation insures the U.S. account balances in an amount up to $250,000. We do not believe that we are exposed to any significant credit risk on any uninsured amounts.

Since inception, we have generated significant losses. As of September 30, 2011, we had an accumulated deficit of approximately $88.2 million. We have never generated any recurring revenues. We expect to continue to incur operating losses through at least 2013 as we continue into the commercialization stage of our business. Commercialization of our technology will require significant additional capital expenditures.

We anticipate that our material liquidity needs in the near and intermediate term will consist of the following:

As of September 30, 2011, we had paid a total of $5.7 million of the above estimated Phase I and Phase II amounts primarily for up-front engineering costs.

We believe that our current cash and cash equivalents, $87.9 million of debt financing supported by a 90% loan guarantee from the USDA and the net proceeds from this offering will be sufficient to fund completion of Phase I of our Flagship facility and to fund our operations through the commencement of operations of Phase I.

We do not anticipate paying any cash dividends on our capital stock in the foreseeable future as we currently expect to retain all future earnings, if any, in the operation and expansion of our business.

To help finance the construction of Phase I of Flagship, we anticipate entering into an $87.9 million debt financing. We are in discussions with our potential lender with respect to the terms of the debt financing and the specific form of the debt financing transaction. In general, we expect that the debt financing will contain representations and warranties, financial and restrictive covenants, events of defaults and collateral arrangements

that are customary for this type of financing. In this regard, we expect that the debt financing will condition our ability to make cash distributions from the Flagship project entity to Coskata on our continued compliance with one or more financial ratios. The actual terms of the debt financing will depend on the results of negotiations with our lender and the requirements of the related USDA guarantee.

In June 2011, the USDA issued a 9003 Biorefinery Assistance Program conditional commitment for a 90% guarantee supporting $87.9 million of debt financing, which will be used to fund a portion of the construction cost of Phase I of our Flagship facility. The remaining 10% of the debt financing will not be guaranteed by the USDA. The USDA will receive the following fees in connection with the guarantee: a one-time fee equal to 3.0% on the guaranteed portion of the principal amount of the debt financing, payable at the closing, and an annual renewal fee equal to 0.5% of the year-end principal balance of the debt financing, payable by January 31 of the following year. We expect that the debt financing will require interest-only payments for three years. Thereafter, quarterly principal and interest payments will be due with full debt amortization of not more than 20 years from the debt financing closing date.

The USDA guarantee is subject to a number of significant conditions, including that (i) Phase I of Flagship must be funded by equity contributions from us equal to at least 50% of the total project costs, (ii) feedstock and offtake agreements must be in place, (iii) we must meet or exceed a specified collateral coverage ratio and (iv) we must satisfy a number of additional conditions and comply with additional criteria related to the underlying debt financing. The USDA may terminate the conditional guarantee if the debt financing is not in place, and other terms and conditions are not satisfied, by June 2, 2012.

We will need substantial additional capital resources to fund the construction and startup of the anticipated Phase II build out of our Flagship facility, the construction of which we expect to begin in 2014. We estimate that the construction costs for Phase II will be between approximately $ million and $ million. By staging the construction of our Flagship facility in discrete Phase I and Phase II projects that are independently viable, we believe that we will have flexibility to plan our growth in response to capital availability and market conditions. We plan to fund the construction costs for Phase II of our Flagship facility with debt and equity from one or more public or private sources, none of which are committed at this time.

The related party capital lease obligations for laboratory equipment were fully paid off in 2010. At the end of the lease term, we exercised our contractual right to purchase the laboratory equipment at 10% of the original cost of the equipment. There are no current leased assets under capital lease obligations, and we do not expect to enter into any major capitalized lease commitments in the next 12 months.

Operating activities. Net cash used in operating activities for the year ended 2010 was $14.9 million compared with $11.8 million for the year ended 2009 and $10.5 million for the year ended 2008. The increase in cash used in 2010 is attributed primarily to increased research and development and selling, general and administrative expenses when compared to 2009, partially offset by increases in current unpaid accrued liabilities. The increase in cash used in 2009 is attributed primarily to increased research and development and engineering expenses when compared to 2008. Net cash used in operating activities for the nine months ended September 30, 2011 was $15.6 million compared with $10.7 million in the same period in 2010. This increase in cash used was attributable to running our Lighthouse facility, increased employee costs, a $1.0 million increase in legal fees related to the Ineos litigation, and an increase in unpaid current liabilities in 2010 that were paid in 2011.

Investing Activities. Net cash used in investing activities for the year ended 2010 was $7.9 million compared with net cash used in investing activities of $6.0 million for the year ended 2009 and $20.9 million for the year ended 2008. The high amount of investing activity in 2008 was related to taking $10.0 million of the excess cash provided by 2008 financing activities and investing it into a 120 day certificate of deposit at year-end. The maturity of the certificate of deposit in 2009 was reflected as a positive cash offset to investing activities in 2009. Excluding this temporary certificate of deposit, investing activities were $10.9 million and $16.0 million in 2008 and 2009, respectively. The increase in net cash used in investing activities during 2009 is attributed to costs incurred in connection with the construction of our Lighthouse facility. This facility was constructed from late 2008 to late 2009. The cash used in investing activities for the year ended 2010 is attributed to engineering fees for our planned Flagship facility, final payment of capital expenditures related to our Lighthouse facility and additional laboratory equipment. Net cash used in investing activities for the nine months ended September 30, 2011 was $0.9 million compared to $6.0 million in the same period in 2010. The net cash used for investing activities primarily relate to on-going engineering fees for our planned Flagship facility.

Financing Activities. For the nine months ended September 2011, cash provided by financing activities was $20.2 million, which was attributable to $20.2 million in net proceeds from the issuance of Series D convertible preferred stock. For the nine months ended September 30, 2010 and the year ended December 31, 2010, cash provided by financing activities was $29.1 million and $28.9 million, respectively, which was attributable to $29.3 million in net proceeds from the issuance of Series C convertible preferred stock, partially offset by capital lease obligation payments of $0.2 million and $0.4 million, respectively. For the year ended 2009, cash used by financing activities was $0.5 million, which was attributable to payments on capital lease obligations. No additional financing was obtained in 2009 as financing obtained in late 2008 was used for operating and investing activities in 2009. For the year ended December 31, 2008, cash provided by financing activities was $57.8 million, which was attributable to $19.9 million net proceeds from the issuance of Series B convertible preferred stock and $38.3 million net proceeds from the issuance of Series C convertible preferred stock in the fourth quarter of 2008, partially offset by $0.4 million of capital lease obligation payments.

The following is a summary of our contractual obligations as of December 31, 2010:

The summary above does not include the $87.9 million of indebtedness we expect to incur to finance a portion of the construction cost of Phase I of our Flagship facility.

During the periods presented, we did not, nor do we currently have, any off-balance sheet arrangements, as defined under SEC rules, such as relationships with unconsolidated entities or financial partnerships, which are often referred to as structured finance or special purpose entities, established for the purpose of facilitating financing transactions that are not required to be reflected on our consolidated balance sheets.

We do not expect that commercial production of our renewable fuels or chemicals will be subject to seasonality.

Our discussion and analysis of our financial condition and results of operations is based upon our financial statements, which have been prepared in accordance with accounting principles generally accepted in the United States. The notes to our financial statements include disclosure of our significant accounting policies. The preparation of these financial statements requires us to make estimates and assumptions that affect the reported amounts of assets, liabilities, expenses and related disclosures. We base our estimates and assumptions on historical experience and on various other factors that we believe to be reasonable under the circumstances. We evaluate our estimates and assumptions on an ongoing basis. The results of our analysis form the basis for making assumptions about the carrying values of assets and liabilities that are not readily apparent from other sources. Our actual results may differ from these estimates under different assumptions or conditions.

We believe the following critical accounting policies involve significant areas of management’s judgment and estimates in the preparation of our financial statements.

We recognize revenue in accordance with the Financial Accounting Standards Board, or FASB, Accounting Standards Codification, or ASC, Topic 605 “Revenue Recognition.” Under FASB ASC Topic 605, revenue is recognized when persuasive evidence of an arrangement exists, the related services or products are

provided, the price is fixed and determinable and collectability is reasonably assured. We recognize revenue as earned when services are performed and milestones accomplished under FASB ASC Topic 605-28-50-1, or ratably in instances where there is no evidence that a proportional performance model is appropriate. Once Phase I of our Flagship facility is operational, revenue will be recognized when the product is shipped, assuming all other criteria are met.

Revenues related to service-based fixed-fee engagements are recognized based on estimates of work completed versus the total services to be provided under the engagement, if the total amount of services to be provided can be reasonably and reliably estimated. Otherwise, the revenue is deferred and recognized when all the services are provided. Revenues related to performance-based engagements are recognized when all performance-based criteria are met. We may have contracts with customers to deliver multiple services. Revenues under these types of arrangements are allocated to each element (separate unit of accounting) based on the element’s fair value in accordance with ASC Topic 605 and recognized pursuant to the criteria described above. Differences between the timing of billings and the recognition of revenue are recognized as either unbilled services or deferred revenue.

We assess impairment of long-lived assets on at least an annual basis and test long-lived assets for recoverability when events or changes in circumstances indicate that their carrying amount may not be recoverable. Circumstances which could trigger a review include, but are not limited to, significant decreases in the market price of the asset; significant adverse changes in the business climate or legal factors; accumulation of costs significantly in excess of the amount originally expected for the acquisition or construction of the asset; a forecast of continuing losses associated with the use of the asset; or expectations that the asset will more likely than not be sold or disposed of significantly before the end of its estimated useful life.

Recoverability is assessed by using undiscounted future net cash flows of assets grouped at the lowest level for which there are identifiable cash flows independent of the cash flows of other groups of assets. If the undiscounted future net cash flows are less than the carrying amount of the asset, the asset is deemed impaired. The amount of the impairment is measured as the difference between carrying value and the fair value of the asset.

The majority of our long-lived assets consist of our Lighthouse facility and engineering costs related to our planned Flagship facility. Given our history of operating losses, we evaluated the recoverability of the book value of our property, plant and equipment assets by performing an undiscounted forecasted cash flow analysis. Based on our analysis, the sum of the undiscounted cash flows is in excess of the book value of the property, plant and equipment and intangible assets. No impairment charges have been recorded during the period from May 3, 2006 (date of inception) through September 30, 2011.

Our undiscounted cash flow analysis and grouping of assets involves significant estimates and judgments. Although our cash flow forecasts are based on assumptions that are consistent with our plans, there is significant exercise of judgment involved in determining the cash flow attributable to a long-lived asset over its estimated remaining useful life. Our estimates of anticipated cash flows could be reduced significantly in the future. As a result, the carrying amounts of our long-lived assets could be reduced through impairment charges in the future. Changes in estimated future cash flows could also result in shortening the estimated useful life of long-lived assets for depreciation and amortization purposes.

From time to time, we issue stock option awards to our employees, consultants and directors. The determination of the fair value of our stock option awards is estimated using the Black-Scholes option-pricing model and requires the use of highly subjective assumptions relating to potential minimum and maximum range

of values at which holders of common stock, convertible preferred stock and debt may receive value. The option-pricing model also requires inputs such as the expected term of the grant, expected volatility, dividend yield and risk-free interest rate. Further, an estimated forfeiture rate also affects the amount of aggregate compensation that we are required to record as an expense.

The fair value of stock options was estimated using the following weighted-average assumptions:

Our risk-free interest rate is based on U.S. Treasury instruments with terms consistent with those of our stock options.

Our expected volatility is derived from the historical volatilities of several unrelated public companies within our industry over a period equal to the expected term of our options because we do not have any trading history to use for calculating the volatility of our own common stock. We based our analysis of expected volatility on reported data for comparable companies that issued options with substantially similar terms using an average of the historical volatility measures of this group of comparable companies. Even though there have been more current volatility changes over the last two years in the stock market, the weighted impact of the recent stock market changes on our derived long-term 6.5 year period volatility has been minimal. Almost all of the stock options granted over the last two years have the longer expected term period of 6.5 years.

Our expected lives are determined using the simplified method. This method calculates the life by taking the average of the vesting term and contractual life of the option grant.

We estimate our forfeiture rate based on an analysis of our actual forfeitures and will continue to evaluate the appropriateness of the forfeiture rate based on actual forfeiture experience and an analysis of employee turnover. Changes in the estimated forfeiture rate can have a significant effect on reported stock-based compensation expense, as the cumulative effect of adjusting the rate for all expense amortization is recognized in the period the forfeiture estimate is changed.

Our expected dividend yield was assumed to be zero as we have not paid, and do not anticipate paying, cash dividends on our shares of common stock in the foreseeable future.

We will continue to use judgment in evaluating the expected volatility, lives, and dividend yield related to our stock-based compensation on a prospective basis and incorporating these factors into our option-pricing model.

Each of these inputs is subjective and generally requires significant management judgment to determine. If, in the future, we determine that another method for calculating the fair value of our stock options is more reasonable, or if another method for calculating these input assumptions is prescribed by authoritative guidance, and, therefore, should be used to estimate expected volatility or expected term, the fair value calculated for our stock options could change significantly. Higher volatility and longer expected terms generally result in an increase to stock-based compensation expense determined at the date of grant.

The following table summarizes the options granted from January 1, 2010 through the date of this prospectus and the weighted-average exercise prices of such grants:

On December 13, 2011, an aggregate of 427,000 options were granted to employees at an exercise price of $5.56 per share. Of these options, 100,000 vested immediately, 100,000 will vest upon the attainment of a specified company milestone and the remainder will vest over five years. In addition, we granted eight members of our management team an aggregate of 101,900 options or shares of restricted stock as their 2011 bonus. The management team members must elect to receive either options or restricted stock, and in either case the awards will vest immediately. The option exercise price would be $5.56 per share.

In the absence of a public market for our common stock, the fair value of the common stock underlying our stock options has historically been determined by our board of directors with input from management and an independent third-party valuation specialist. Option grants were intended to be exercisable at the fair value of our common stock underlying those options on the date of grant based on information known at that time. We determined the fair value of our common stock utilizing methodologies, approaches, and assumptions consistent with the American Institute of Certified Public Accountants Practice Aid, Valuation of Privately-Held-Company Equity Securities Issued as Compensation, or the AICPA Practice Aid. Our board of directors with input from management, exercised significant judgment and considered numerous objective and subjective factors including milestones to determine the fair value of our common stock as of the date of each option grant.

We based each of our valuations on an implied business enterprise value estimated using one or more of the three generally accepted approaches to value: the market approach, the income approach and the asset-based approach. The market approach measures the value of a company through an analysis of recent sales or offerings of comparable investments. The income approach measures the value of the company based on the present value of expected future benefits. The asset-based approach measures the value of a company based on tangible assets and calculates the fair market value of assets less the fair market value of liabilities.

For each valuation, we prepared financial forecasts that considered our past experience and future expectations. There is inherent uncertainty in these estimates because the assumptions used are highly subjective and subject to changes as a result of new operating data and economic and other conditions that impact our business. We balanced the uncertainty associated with achieving the forecasts through the selection of a discount rate.

For the December 31, 2010 valuation, given various factors (e.g., contemporaneous macroeconomic factors, risks associated with meeting long-term milestones, recent third-party preferred stock issuances, etc.), we determined that it was appropriate to estimate the value of the common stock utilizing the Option Pricing Method, or OPM, accepted by the American Institute of Certified Public Accountants. The OPM treats the rights

of the holders of preferred and common shares as equivalent to that of call options on any value of the enterprise above certain break points of value based upon the liquidation preferences of the holders of preferred shares, as well as their rights to participation and conversion. Thus, the value of the common stock can be determined by estimating the value of its portion of each of these call option rights, using the Black-Scholes model to price the call option. We determined the weighted equity value of the company distributable to equity holders as a whole. We multiplied each gross preference value by the percentage attributable to each security to determine the amount of value attributable to and allocated to each security. The aggregate value of the common stock was then divided by the number of shares of common stock outstanding to arrive at the per share value. The value per share was then adjusted for the discount attributable to a lack of marketability.

For the August 31, 2011 valuation, once the enterprise value was computed under the various approaches, we calculated a weighted-average of the methods. We then allocated the total equity value between all classes of equity using a probability-weighted expected return method, or PWERM, accepted by the American Institute of Certified Public Accountants. We considered four exit events: (1) an initial public offering, (2) a sale or merger of the company, (3) continuing as a private company and (4) dissolution of the company. We calculated the residual common stock value under each scenario and based on our estimate of the probability of the various expected outcomes of each of the four events. The aggregate value of our common stock was then divided by the number of shares of common stock outstanding to arrive at the per share value. The value per share was then adjusted for the discount attributable to a lack of marketability.

Subjective considerations and objective milestones taken into account in determining stock value at any point in time include the following:

Our board of directors used third-party valuation specialists to assist in calculating the value of our common stock. If our board of directors determines that any material intervening developments have occurred since the most recent external third-party valuation that are deemed likely to appreciably impact the prior third-party valuation, then our board reassesses the valuation of our common stock. Otherwise, the most recent third-party valuation report is used when granting stock options. Pursuant to this methodology, our board used an independent third-party valuation specialist to estimate the fair market value of our common stock on three valuation dates as follows:

As of each stock option valuation date listed in the table above, our board of directors believes it made a thorough evaluation of the relevant factors to determine the fair value of our common stock and accordingly set the exercise price of the options granted equal to the fair value of our common stock based on the respective valuations.

December 31, 2010. The increase in fair value determination from $1.93 per share as of December 31, 2009 to $2.10 per share, was primarily attributable to our continued progress in the development of our renewable fuels and chemicals proprietary technology, future project development activities, commercialization efforts, and favorable results in 2010 of running our Lighthouse facility. We also raised $29.3 million in net proceeds from the issuance of convertible preferred stock during 2010.

August 31, 2011. The increase in fair value determination from $2.10 per share as of December 31, 2010 to $5.56 per share as of August 31, 2011 was primarily attributable to the factors set forth below, which contributed in a short period of time to further reducing the technical and operational risks attendant to our long-term growth plan, as well as increasing the prospects for significant future capital raising activities to fund construction of our Flagship facility, which we believe supported a significant increase in the enterprise value of our company:

Total stock-based compensation expense is recorded within research and development, engineering and selling, general and administrative for the years ended December 31, 2008, 2009, and 2010, and for the period from May 3, 2006 (date of inception) to September 30, 2011, as follows:

At December 31, 2010, there was approximately $1.8 million of unrecognized compensation expense under our 2006 Option Plan. This expense is expected to be recognized over a weighted-average vesting period of 2.2 years.

Total stock-based compensation expense is recorded within research and development, engineering and selling, general and administrative for the nine months ended September 30, 2010 and 2011 as follows:

We are subject to income taxes in the United States. We use the liability method of accounting for income taxes, whereby deferred tax asset or liability account balances are calculated at the balance sheet date using current tax laws and rates in effect for the year in which the differences are expected to affect taxable income.

We must make certain estimates and judgments in determining income tax expense for financial statement purposes. These estimates and judgments occur in the calculation of tax credits, benefits and deductions and in the calculation of certain tax assets and liabilities, which arise from differences in the timing of recognition of expenses for tax and financial statement purposes. Significant changes to these estimates may result in an increase or decrease to our tax provision and breakdown of deferred tax assets in a subsequent period.

Recognition of deferred tax assets is appropriate when realization of such assets is more likely than not. We recognize a valuation allowance against our net deferred tax assets if it is more likely than not that some portion of the deferred tax assets will not be fully realizable. This assessment requires judgment as to the likelihood and amounts of future taxable income by tax jurisdiction. Due to our historical losses, at December 31, 2008, 2009 and 2010 and at September 30, 2011, we had a full valuation allowance against all of our deferred tax assets, including our net operating loss, start-up expense and research and development tax credit carryforwards.

In February 2010, the FASB issued Accounting Standards Update 2010-09, “Subsequent Events (Topic 855): Amendments to Certain Recognition and Disclosure Requirements,” effective immediately, which removes the requirement to disclose the date through which subsequent events were evaluated in both originally issued and reissued financial statements for SEC filers. An SEC filer is required to evaluate subsequent events through the date the financial statements were issued. The adoption of this guidance did not have a material impact on our financial statements.

In April 2010, the FASB issued new guidance Accounting Standards Update 2010-17 regarding the milestone method of revenue recognition (under ASC Topic 605). This new update provides guidance on defining a milestone and determining when it may be appropriate to apply the milestone method of revenue recognition for research and development transactions. Research or development arrangements frequently include payment provisions whereby a portion or all of the consideration is contingent upon milestone events, such as achieving a specific result from the research and development efforts. This new guidance is effective prospectively for milestones achieved in fiscal years beginning on or after June 15, 2010. We adopted this pronouncement effective January 1, 2011. The adoption of this pronouncement did not have a significant impact on our financial statements.

In May 2011, the FASB issued updated guidance Accounting Standards Update 2011-04 to improve the comparability of fair value measurements between GAAP and International Financial Reporting Standards. This update amends the accounting rules for fair value measurements and disclosure. The amendments are of two types: (i) those that clarify FASB’s intent about the application of existing fair value measurement and disclosure requirements and (ii) those that change a particular principle or requirement for measuring fair value or for disclosing information about fair value measurements. The update is effective for us beginning in the first quarter of 2012. We do not believe the adoption of this update will have a material impact on our consolidated financial statements.

In June 2011, the FASB issued Accounting Standards Update 2011-05, “Comprehensive Income (Topic 220): Presentation of Comprehensive Income,” which amends current comprehensive income guidance. This accounting update eliminates the option to present the components of other comprehensive income as part of the statement of shareholders’ equity. Instead, we must report comprehensive income in either a single continuous statement of comprehensive income which contains two sections, net income and other comprehensive income, or in two separate but consecutive statements. This guidance will be effective for us beginning in the first quarter of 2012. We do not expect the guidance to impact our consolidated financial statements, as it only requires a change in the format of presentation.

There have been no other recent accounting pronouncements or changes in accounting pronouncements which we expect to have a material impact on our financial statements, nor do we believe that any other recently issued, but not yet effective, accounting standards if currently adopted would have a material effect on our financial statements.

Our exposure to market risk for changes in interest rates relates primarily to our investment portfolio. We generally invest our cash in investments with short maturities or with frequent interest reset terms. Accordingly, our interest income fluctuates with short-term market conditions. As of December 31, 2010 and September 30, 2011, our investment portfolio equaled $15.1 million and $18.9 million, respectively, and in each case consisted primarily of money market funds. If market interest rates for comparable investments were to change by 100 basis points from levels at December 31, 2010 and September 30, 2011, this impact would not be material.

We are a technology leader in renewable fuels and bio-based chemicals. Our low-cost, proprietary process converts a wide variety of abundant feedstock, such as woody biomass, agricultural residues, municipal wastes, natural gas and other carbon-containing materials, into fuels and chemicals. We have combined best-in-class synthesis gas production and cleaning technologies with our molecular biology and process engineering capabilities to create a novel synthesis gas fermentation technology platform. While our technology platform is capable of producing multiple renewable fuels and chemicals, we are initially focused on producing cellulosic ethanol for the large, established ethanol market. We operated a production facility at demonstration-scale for more than two years where we have achieved what we believe to be the highest yield of cellulosic ethanol per bone dry ton of feedstock demonstrated at this scale. In 2012 we expect to begin constructing our first commercial-scale cellulosic ethanol production facility. We believe our high yield and low production cost provide us with a competitive advantage compared to other producers.

Renewable fuels are fuels produced from renewable resources such as plant biomass, in contrast to fuels produced from non-renewable sources such as crude oil and natural gas. Ethanol is the primary renewable fuel consumed globally and is blended with gasoline as an oxygenate, to increase gasoline octane ratings and decrease tailpipe emissions, and as an alternative transportation fuel. According to the EIA, approximately 138 billion gallons of gasoline were sold in the United States in 2010. In addition, according to the Renewable Fuels Association, or RFA, approximately 13 billion gallons of ethanol were sold in the United States in 2010.

Extend fuel supplies. Ethanol is a valuable blend component that is used by refiners in the United States to extend gasoline supplies. According to the EIA, from 2000 to 2010, ethanol as a component of the U.S. gasoline supply grew from 1.3% to 9.6%. In certain markets, ethanol represents a significantly larger percentage of transportation fuel. For example, in Brazil, ethanol represented an average of 57% of transportation fuel consumed (by volume) between 2008 and 2010.

Economic benefits. The ethanol industry is important economically, helping to reduce expensive oil imports, and supporting domestic manufacturing and job growth. According to the RFA, the ethanol industry contributed nearly $53.6 billion to U.S. gross domestic product, or GDP, in 2010 and was responsible for 400,000 direct and indirect jobs and upwards of $36 billion in personal income.

Reduce trade deficit and promote energy independence. The United States is a net importer of transportation fuels, including both crude oil and refined products. These imports not only create a dependence upon international sources of production, but also contribute to a significant portion of our country’s current trade deficit. In 2010, 42% of the United States’ approximately $635 billion trade deficit in goods was associated with the cost of net trade in petroleum.

Environmental benefits. Ethanol, when blended with gasoline, reduces vehicle GHG emissions as compared to non-blended gasoline or other fossil fuels. Oxygenated gasoline continues to be used to help meet separate federal and state air emission standards, and ethanol is the primary clean air oxygenate currently used.

In 2010, there were approximately 200 ethanol plants in the United States producing over 13 billion gallons of ethanol and ethanol exports hit a record 397 million gallons. Virtually all the ethanol produced globally today is from edible sugar and starch sources, including corn in the United States and sugarcane in Brazil. Corn and sugarcane-derived ethanol is commonly referred to as first generation biofuel. According to the RFA, United States’ corn ethanol production increased from 3.9 billion gallons in 2005 to over 13 billion gallons in 2010, which represented a compound annual growth rate of over 25%. Outside the United States, fuel-grade ethanol consumption was 10 billion gallons in 2010.

Ethanol is also used in several industrial applications across various end-markets including personal care, pharmaceuticals, coatings and food products. According to SRI Consulting, the global demand for industrial ethanol was approximately 1.7 billion gallons in 2010. China accounts for more than half of the demand for industrial ethanol. Other major markets are the United States, Europe, and Brazil. We believe industrial ethanol demand growth in China will grow between 8% and 10% per year over the next ten years.

As the demand for biofuels continues to grow, we believe production will shift increasingly from food-based to non-food based sources. Fuels produced from municipal solid waste and non-food plant materials such as woody biomass, bagasse, corn stover and dedicated energy crops like switchgrass and miscanthus, are commonly referred to as second generation biofuels. While corn is expected to remain the primary feedstock for ethanol production in the United States in the near-term, there is an increasing global push to produce second generation biofuels. This push is largely driven by concerns about strains placed on global food supplies and the environment by food-based feedstock sources. For example, China now restricts the construction of new ethanol plants that use food crops as a feedstock. Aside from being sourced from non-food sources, second generation biofuels provide the additional advantage of offering significantly lower lifecycle GHG emissions relative to gasoline and corn-based ethanol.

The renewable fuels industry benefits from government programs, incentives and regulations that seek to promote the development and commercialization of renewable fuel technologies, including renewable fuel standards, state and local programs and tax credits and incentives.

RFS was created under the Energy Policy Act of 2005 and established the first renewable fuel volume mandate in the United States. In 2007, the U.S. Congress passed the EISA to amend RFS, creating RFS2. According to RFS2, any refiner or importer of gasoline or diesel fuel in the United States is an “obligated party” and must comply on an annual basis with volume requirements for both renewable fuels as a whole as well as those for each of three additional renewable fuel categories. The regulation caps the amount of cornstarch-derived ethanol that may be used to meet the total renewable fuel mandate at 12 billion gallons in 2010, increasing annually by 0.6 billion gallons to 15 billion gallons in 2015, after which point the cap remains constant until 2022. The general renewable fuel requirement is currently set at 36 billion gallons by 2022, with the following additional specifications:

Despite the renewable fuel standards set forth in RFS2, the EPA is required to set the cellulosic biofuel standard each year based on the volume projected to be available, using Energy Information Administration, or EIA, projections and assessments of production capability from industry, and may waive, in whole or in part, the renewable fuels standards for total renewable fuels, advanced biofuels and/or cellulosic biofuels. On November 9, 2011, the EPA sent a final rule to the White House Office of Management and Budget for approval proposing the total renewable fuel standard and the cellulosic biofuel standard for 2012. While the 2012 renewable fuel target, set at 15.2 billion gallons, and the advanced biofuel target, set at 2.0 billion gallons, match the targets set under the EISA in 2007, the cellulosic biofuel standard is set at 3.45 million to 12.9 million gallons of cellulosic ethanol, a much lower target than the 500 million gallons mandated under the EISA.

The following chart depicts the renewable fuel production currently mandated under RFS2:

The EPA assigns Renewable Identification Numbers, or RINs, to each batch of renewable fuel produced or imported. RINs demonstrate compliance with, and are the credit currency of, RFS2. Each fuel category has a unique set of RINs. Each obligated party must obtain its mandated number of RINs for each fuel category based on its volume obligations; the obligated party can obtain such RINs by blending gasoline or diesel, as applicable, with renewable fuels that have been assigned a RIN. When the fuels are blended, the RIN detaches from the renewable fuel and may be used by the obligated party for compliance with volume mandates or for trading. If an obligated party meets or exceeds its volume obligations, that obligated party may either trade its excess RINs to other obligated parties or use its excess RINs to satisfy its volume obligations in the subsequent year.

Under RFS2, in any compliance year for which the projected volume of cellulosic biofuel production is less than the mandate required, the EPA is required to make waiver credits available for sale for that compliance

year to ensure that obligated parties have the ability to meet their cellulosic biofuel RIN volume obligations. The EPA is required to sell the waiver credits for an inflation-adjusted price that is the higher of $0.25 per gallon or the amount by which $3.00 per gallon exceeds the average wholesale price of a gallon of gasoline in the United States for the preceding twelve months. For 2011, waiver credits are priced at $1.13 per gallon.

The RFS2 volume obligations combined with the waiver credits can operate as a floor price for cellulosic ethanol, since all refiners or importers of gasoline or diesel fuel in the United States must meet the RFS2 volume standard either by purchasing cellulosic ethanol RINs or by purchasing the waiver credit in a given compliance year where the projected production volume falls below the mandated volume. As a result, qualified cellulosic ethanol producers can expect to receive a price equal to the price of advanced biofuels plus the price of a waiver credit for every gallon of qualified cellulosic ethanol produced in a compliance year.

Ethanol is approved for blending in gasoline in the United States at a 10% blend level (E10) in all vehicles, a 15% blend level (E15) in vehicles of 2001 or newer model year, and up to an 85% blend level (E85) in flex fuel vehicles. At current consumption levels, the industry is approaching saturation of the E10 market, or the E10 blend wall. However, the USDA and several states provide incentives for investment in infrastructure necessary for broad adoption of E15 and E85 markets. New export markets for U.S. produced conventional ethanol are also developing and should help alleviate blend wall pressures. U.S. ethanol exports hit a record 397 million gallons in 2010, and according to the Renewable Fuels Association, U.S. ethanol exports through September 30, 2011 stand at 746 million gallons and are expected to reach 900 million to 1.0 billion gallons for full year 2011. More broadly, we do not believe that the blend wall represents a hurdle to the adoption of cellulosic ethanol. We believe that market access for cellulosic ethanol is assured because of the higher compliance value of cellulosic ethanol compared to first generation ethanol.

According to the Pew Research Center, or the Pew Center, more than half of U.S. states provide incentives for alternative fuels, ethanol blends, alternative-fuel vehicles and low-emission vehicles. Biofuels incentives include tax credits and excise tax exemptions. According to the Pew Center, 13 states, including California, Florida, Massachusetts, Pennsylvania and Washington, have adopted renewable fuels standards which require that gasoline sold in the state contain a specified percentage of renewable fuel such as ethanol.

Several states are in the process of implementing low-carbon fuels standards, or LCFS, to lower the carbon content of fuels used in transportation. California adopted the first LCFS in January 2010. California’s LCFS requires all refiners, blenders, producers or importers of transportation fuels, which we refer to as providers, to ensure that the mix of transportation fuel they sell, supply or offer for sale in the California market meets the established declining annual limits for GHG emissions measured in carbon intensity. The California directive calls for a reduction of at least 10% in the carbon intensity of California’s transportation fuels between 2011 and 2020.

The LCFS may be met through any combination of approved fuels with carbon intensity above or below the set limit as well as through the purchase or banking of credits. Providers earn credits when their aggregate fuel carbon intensities during an annual compliance period fall below the annual regulatory limit for that period. Credits earned can be sold to other providers, or banked for future sale or use. For refiners with significant capacity in California, the LCFS represents a major challenge. However, the regulations allow refiners to import and use lower emission fuels produced outside of California as a component of the fuel portfolio used to achieve the annual carbon intensity standards. As a result, biofuel producers located outside California could also benefit from the market created by the LCFS.

The Biorefinery Assistance Program was established in Section 9003 of the Food, Conservation and Energy Act of 2008 to provide guarantees for loans up to $250 million for the development, construction and retrofitting of commercial-scale biorefineries. Loans are held and administered by private lenders, who are required to retain a portion of the loan. The program also provides grants to help pay for the development of demonstration-scale biorefineries. The aims of the program are to increase energy independence, promote resource conservation, diversify markets for agricultural and forestry products, and create jobs to enhance the economic development of rural communities.

Many countries other than the United States have renewable fuels standards and policies that require mandatory ethanol blending with gasoline. The largest foreign ethanol market is Brazil, with a growing fleet of flex-fuel vehicles due to a history of utilizing ethanol as a transportation fuel. Brazil has one of the largest minimum blend requirements in the world at 25%, which is temporarily reduced to 18 to 20% due to local availability of sugar. The European Union implemented the Renewable Energy Directive requiring that the share of renewable energy sources increase to 10% of total transport fuel use by 2020. Both China and India have set targets for minimum ethanol blending of 15% and 20%, respectively. According to the Food and Agriculture Organization, the foreign markets of the European Union, Brazil, China and India combined will account for 43% of global ethanol consumption by 2020.

The following table sets forth ethanol blend target levels in certain key countries around the world:

Cellulosic biomass feedstocks are an abundant resource that can be used to produce substantial amounts of ethanol and other fuels to meet U.S. fuel demand. They are waste products or, in the case of trees and grasses, plant matter grown specifically for ethanol production on marginal lands not suitable for other crops. The use of cellulosic feedstock to produce ethanol also alleviates food supply concerns attendant to starch- and sugar-based feedstocks. Cellulosic biomass feedstocks suited to ethanol production include the following:

The total forestland in the United States is approximately 750 million acres, about one-third of the nation’s total land area, according to a 2011 report by the Department of Energy. Current removals from U.S. forestlands are about 250 million dry tons annually, which is estimated to be well below net annual forest growth. In 2006, forest growth net of harvesting, land clearing and mortality is estimated to have exceeded removals by 72%. To qualify as cellulosic biofuel under RFS2, products derived from trees generally must be sourced from tree plantations or logging slash and thinnings from private land. The amount of forest biomass available is estimated to vary with price, and is expected to grow over time.

Wood Chips and Wood Waste. We have selected wood chips and wood waste as the primary feedstock for our first commercial-scale facility, in part due to a recent growing surplus of plantation pine trees and excess logging and wood chipping capacity. Surplus is defined as the proportion by which growth exceeds harvest. For softwood in the southern United States, surplus was 21% in 2007, which represents excess supply of nearly 58,000 dry tons per day. If growth is equal to harvest, the supply of timber is stabilized. Thus, growth in excess of harvest indicates that timber inventory is increasing. Given that our first commercial facility will be located in Alabama, we expect that southern softwood will represent a majority of the feedstock consumed.

The surplus of southern softwood has been driven by both supply and demand factors. Government incentives, such as the USDA’s Conservation Reserve Program, led to aggressive planting of fast growing pine plantations by forest products companies and private timberland owners in the late 1980s and 1990s. Genetically enhanced seeds and enriched genotypes allowed foresters to increase the productivity of their land. In addition, demand for pine diminished as many paper mills and oriented strand board plants closed due to weak paper and housing markets.

The following chart sets forth the historical and projected inventory of Southern softwood:

Favorable Feedstock Economics. Logging and chipping costs are generally stable, and hauling costs vary with diesel prices. The stumpage price, or the price of standing timber, is the only component of cost that varies with the timber market. Since 1976, the 2010 inflation-adjusted stumpage price of Southern pulpwood has hovered around $17 per bone dry ton and has ranged between $7 and $29 per bone dry ton. Historical data shows that spikes are more likely to occur when harvests exceed growth but tend to normalize within a few years. The price of delivered woodchips has been much less volatile than other food-based biofuel feedstock or product markets. For example, from 2000 to 2010 the maximum 12-month price increase was 18% for pine woodchips versus 50% for corn, 46% for sugar and 51% for West Texas Intermediate crude according to average quarterly data from Timber Mart-South, the USDA and the EIA.

The following chart shows the relative prices of wood, sugar, soy oil, corn and crude oil since the beginning of 2000:

According to the EPA, annual municipal solid waste generation in the United States has trended upwards over the past several decades, increasing from 88 million tons in 1960 to 243 million tons in 2009. On average, each person in the United States generates approximately 0.8 tons of municipal solid waste per year, according to the EPA. The Resource Conservation and Recovery Act, or RCRA, was passed by Congress in 1976 and sets forth a framework for the management of non-hazardous solid wastes. Standards imposed under the RCRA include location restrictions and more comprehensive monitoring requirements that increased costs for landfill operators and accelerated the closure of many of the nation’s landfills. As a result, since the 1980s, landfills have moved farther away from densely populated regions, which increased the costs of transporting municipal solid waste to landfills.

Waste collectors are charged fees for landfill waste disposal, which are referred to as tipping fees. According to the Columbia University’s Earth Engineering Center, average U.S. landfill tipping fees were $44 per ton in 2010, with considerably higher tipping fees in more densely populated regions. Tipping fees outside of the United States can be considerably higher. According to Bloomberg New Energy Finance, average tipping fees in Europe can exceed $100 per ton. We estimate that tipping fees can exceed $250 per ton in Japan. These tipping fees can result in low-cost, free, or occasionally negative-cost feedstock for facilities that utilize municipal solid waste.

Crop residues are desirable feedstocks for bioenergy applications because of their low cost, immediate availability, and relatively concentrated location in the major grain growing regions. The most plentiful residues include stalks and leaves from corn (stover) and straw and stubble from other small grains, such as wheat, barley, oats, and sorghum. According to the “U.S. Billion-Ton Update - Biomass Supply for a Bioenergy and Bioproducts Industry,” published in August 2011 by the U.S. Department of Energy, about 27 million dry tons of crop residues can be sustainably supplied in 2012 at a cost of $40 per ton, increasing to 80 million tons at that same cost point by 2030. At higher supply costs of $60 per ton, the study estimates that 111 million tons would be available in 2012, growing to 180 million tons by 2030.

The global chemicals industry is an approximately $4.1 trillion market, based on total global chemical shipments in 2010, according to the American Chemistry Council. The majority of the market is comprised of organic (carbon-containing) chemicals that are primarily produced using fossil-fuel feedstocks. Organic chemicals can also be produced from renewable carbon sources in feedstocks such as plant-derived matter and municipal solid waste, which are key inputs in sustainable bio-based chemical manufacturing processes. Bio-based chemicals promise reduced production cost, raw material price volatility, and capital expenditures to deliver drop-in ready substances, and the potential to increase and diversify the sources of supply.

Coskata’s platform technology can produce propanol, a precursor to propylene. Propylene is a three-carbon chemical that is traditionally a byproduct of oil refining and natural gas processing. In 2010, global production of propylene was 80 million metric tons, representing sales of approximately $100 billion based on average 2010 market prices. According to SRI Consulting, a business research service for the global chemistry industry, global consumption of propylene is expected to grow at an average of 5% per year over the next five years.

Propylene is a key feedstock to the plastics and petrochemical industry. According to ICIS, the dominant outlet for propylene is polypropylene, accounting for nearly two-thirds of global propylene consumption. Injection molding is the largest polypropylene market but it can also be made into fibers, film and sheet and extruded into pipe and conduit. The world’s largest producers of propylene are predominantly integrated oil companies including Sinopec, ExxonMobil, Shell, Petrochina and Total. Other top producers include chemical companies such as LyondellBasell, Dow Chemical, Formosa and BASF.

Propylene is primarily produced as a byproduct of oil refining and natural gas processing, and propylene demand has exceeded the growth of these traditional manufacturing routes. As a result, routes to on-purpose propylene production have started to materialize, including dehydration of propanol to produce propylene. These on-purpose sources are expected to grow significantly. However, these routes are generally considered less cost competitive than “traditional” means, requiring high capital investments and opportunistic feedstock economics. Certain on-purpose routes produce a significant amount of co-products which will require a disposition strategy and potentially unfavorably impact project economics.

Ethylene is the simplest hydrocarbon and is also one of the most widely-produced petrochemicals in the world. Ethylene can be converted from ethanol through a dehydration process. According to SRI Consulting, global production and consumption of ethylene in 2010 were both approximately 121 million metric tons, representing sales of approximately $140 billion based on average 2010 market prices. According to SRI Consulting, global demand for ethylene is forecast to grow at 3.4% over the next five years.

Ethylene is the raw material used in the manufacturing of polymers such as polyethylene, polyethylene terephthalate, polyvinyl chloride, and polystyrene. These polymers are used in a wide variety of industrial and consumer markets such as the packaging, transportation, electrical/electronic, textile, and construction industries.

Today, ethylene is primarily produced from steam-cracking fossil-fuel feedstocks including ethane, propane and naphtha. Our platform technology, however, could enable cost-effective production of ethanol for dehydration to ethylene. Historically, the process has been constrained by availability of fermentable material. The feedstock flexibility of our process could overcome this constraint. Bio-ethylene currently sells at a premium to traditional fossil-fuel based ethylene. The market for bio-renewable chemicals, including bio-ethylene, is expected to more than double between 2010 and 2015.

Our high yields and low cost are driven primarily by four factors in our production process:

Our process can utilize a variety of carbon-containing feedstocks to produce renewable fuels and chemicals, resulting in significant flexibility. We expect to use a wide variety of other feedstocks, in addition to woody biomass, for subsequent facilities, including municipal solid waste, agricultural residues, energy crops and fossil fuel sources. For example, we are currently working with companies in Australia and Japan to evaluate production facilities that would convert municipal solid waste into ethanol. Municipal solid waste is a particularly advantageous feedstock, since it can generally be procured for low or negative cost. As a result, we expect that utilizing municipal solid waste in our production process will result in the production of cellulosic ethanol at significantly lower operating costs per gallon than our facilities that utilize woody biomass as a feedstock. We also believe that corn ethanol producers can expand their capacity by co-locating our technology at their existing ethanol production facilities, since it would allow them to convert agricultural residue into cellulosic ethanol. We are in discussions with several corn ethanol producers about expanding their ethanol production by utilizing our technology. We intend to take a flexible approach to commercialization that will include wholly-owned facilities, joint ventures, and licensing.

Our proprietary technology platform can produce valuable bio-based chemicals in addition to renewable fuels like cellulosic ethanol. We are currently collaborating with Total Petrochemicals to develop a unique micro-organism-based technology that produces propanol, a three-carbon precursor to propylene, from the same range of feedstocks that we have already utilized to produce cellulosic ethanol. We believe the coupling of our propanol technology with proprietary technology to dehydrate alcohol into alkenes, including propanol into propylene, under development by Total Petrochemicals together with IFP Energies Nouvelles & Axens, will result in a cost-effective new process for the production of propylene from non-petroleum materials. Over time, we expect to further expand our platform to produce valuable four, five and six carbon chain chemicals.

We believe that our business benefits from a number of competitive strengths, including the following:

Our mission is to commercialize our technology for the production of renewable fuels and chemicals. Key elements of our strategy include the following:

Our first commercial facility, Flagship, will target the U.S. fuel-grade ethanol market. In addition to having drop-in capability with existing infrastructure, ethanol is the most common biofuel with the United States consuming 13 billion gallons in 2010. At a December 9, 2011 market price of $2.71 per gallon, this represents a $35 billion market. RFS2 currently mandates that 21 billion gallons of advanced biofuels be produced by 2022, with at least 16 billion gallons derived from cellulosic biofuels. We believe we will be one of the first companies in the world to produce cellulosic ethanol at commercial-scale using a syngas fermentation process.

Future joint venture facilities and licensing agreements will target the incremental 10 billion gallon international fuel ethanol market. We will selectively target international markets based on feedstock availability, strong market demand, and local government support.

Ethanol also has many industrial applications. The global industrial ethanol market was an estimated 1.7 billion gallon market in 2010. Industrial ethanol can command higher prices for certain applications in attractive end-markets such as personal care, pharmaceuticals, food-products, and paints. More than half of demand for industrial ethanol comes from China, which presents a significant growth opportunity.

Our cellulosic ethanol can be used in conjunction with dehydration technology to convert it to ethylene, a key petrochemical building block. Ethylene, a two carbon hydrocarbon, is used for automotive fluids, insulation pipes and polyethylene plastics, such as trash bags and milk cartons. Worldwide demand for ethylene was approximately 121 million metric tons in 2010, or $140 billion based on average 2010 market prices. There is a strong incentive for petrochemical companies in Western Europe and Northeast Asia that rely on high-cost fossil fuels to find lower-cost methods for producing ethylene. We believe that dehydrating our ethanol to produce ethylene would be cost competitive and would also result in bio-based plastics.

Propanol is a three carbon alcohol that is a pre-cursor to propylene, which is used for everyday products such as packaging, textiles and automotive components. Propanol can be dehydrated to produce propylene.

Worldwide demand for propylene was approximately 80 million metric tons in 2010, or $100 billion based on average 2010 market prices. Propylene is primarily produced as a by-product of oil refining and natural gas processing, and propylene demand has exceeded the growth of these traditional manufacturing routes, resulting in increased prices. As a result, routes to on-purpose propylene production have started to materialize, including dehydration of propanol to produce propylene.

We believe our technology platform can be applied to the biological production of other chemicals that contain up to six carbon atoms. We believe our syngas fermentation platform is a unique route for metabolizing carbon atoms into commercially significant chemicals, since our process uses a cheaper raw material than sugar-based fermentation and has greater selectivity and lower cost than chemical catalysts. Our research and development teams are focused on developing syngas fermentation pathways for commercially-significant chemicals where our technology has the potential to significantly lower production costs versus other methods. We have already demonstrated in a laboratory setting the production of propanol, butanol, butanediol, hexanol, organic acids, and certain fatty acids.

Since our inception in 2006, we have combined best-in-class syngas production and cleaning technologies with our molecular biology and process engineering capabilities to create a technology platform that produces renewable fuels and chemicals at low costs. Our technology platform is capable of utilizing a variety of feedstock sources, such as woody biomass, agricultural and municipal wastes, natural gas and other carbon-containing materials. Though our proprietary process is initially focused on producing cellulosic ethanol, we intend to leverage our technology so that we can address other renewable fuel and chemical opportunities.

Historically, there were two widely-recognized conversion methods for the production of cellulosic ethanol: biochemical and thermochemical. Though these methods are well known, they each suffer from unique efficiency and economic limitations. Our integrated technology combines the key elements of the biochemical and thermochemical approaches to create a third, hybrid biothermal process that delivers higher ethanol conversion yields, lower per gallon production costs, and lower capital costs than are otherwise achievable through the two traditional methods.

According to reports issued in 2011 by the National Renewable Energy Laboratory, a U.S. federal laboratory dedicated to the research, development, commercialization and deployment of renewable energy and energy efficiency technology, long-term yields using biochemical and thermochemical processes are expected to equal 79 and 84 gallons of ethanol per bone dry ton of feedstock, respectively. In 2009, Sandia projected yields at early commercial facilities equal to 55 and 74 gallons per bone dry ton of feedstock from biochemical and thermochemical processes. Based on demonstration runs at Lighthouse, we expect to achieve yields of 100 gallons per bone dry ton of softwood at Flagship, which is consistent with Sandia’s estimate for initial biothermal yields. We believe that high yields will be a critical success factor in achieving low-cost, high-volume production of cellulosic ethanol.

Our fully-integrated biorefinery platform combines three major process steps: syngas production, fermentation and separation. Our approach allows for the high-yield, low-cost production of renewable fuels and chemicals from numerous carbon-containing feedstocks. Importantly, our process is not dependent on sugar-based feedstocks or the use of enzymes and catalysts. Our integrated technology platform encompasses all aspects of the production process, from feedstock handling to product separation. In addition, by working with a select group of partners on syngas production and ethanol separation, we believe we have been able to minimize scale-up risk associated with our process while maintaining feedstock and end-product flexibility. With our

process, the three core steps of syngas production, fermentation, and separation remain in place regardless of the feedstock or end-product being produced.

The graphic below depicts our integrated production process for cellulosic ethanol, and a summary of each of the core steps follows.

Syngas Production. In the first process step, we convert carbon-containing feedstock into syngas, which is a mixture of carbon monoxide, hydrogen, and carbon dioxide. Our method of producing syngas varies based on the type of feedstock being utilized. For solid feedstocks such as woody biomass, municipal solid waste, or agricultural residues, we produce syngas through gasification. Rather than burning the feedstock directly, gasification uses high temperatures and controlled amounts of oxygen to break down feedstock into its basic chemical constituents. We have the ability to select from an array of plasma, direct, and indirect gasification technologies and their respective providers to match each feedstock with the appropriate conditions for producing syngas. For gaseous feedstocks such as natural gas, we use commercial methane thermal reformers to convert the feedstock into syngas. Natural gas reforming is a common process used in the production of fertilizers and chemicals. Our ability to employ proven gasification and reforming technologies adds to the flexibility of our platform. As we look for process efficiency, we will match feedstocks with their optimal syngas production technology.

Regardless of the syngas production method, the resulting syngas mixture passes through a cleaning and cooling phase to remove particulates and impurities. Our process is highly integrated in order to maximize energy efficiency. For example, during the syngas cooling and cleaning step, excess heat is recovered and utilized to dry biomass and to separate ethanol, which results in production cost savings.

Fermentation. In the second process step, clean and cooled syngas enters a bioreactor where our proprietary micro-organisms convert the syngas to ethanol through their specialized metabolic pathway. We intend to continually improve our proprietary micro-organisms in order to further reduce production costs. In

addition, we are developing a range of micro-organisms that are genetically selected to produce various higher-value end-products from syngas. These micro-organisms can produce renewable fuels and chemicals that contain up to six carbon atoms, which allows us to access higher-value end markets.

At Lighthouse we used existing fermentation equipment to reduce the scale-up risk associated with the equipment required for this process step. Our bioreactors also operate at lower pressure and lower temperatures than our competitors who use thermochemical processes, which results in cost and energy advantages for us. In addition, our syngas mixture flows from the bottom to the top of the bioreactor, without requiring supplemental mixing. In contrast, biochemical processes typically require a large impellor to stir the tank, resulting in higher energy consumption and operating costs.

Separation. In the third process step, we utilize existing, commercially-available distillation technologies to efficiently separate the ethanol from the ethanol-water mixture exiting the bioreactor. The resulting water by-product is recycled back into the bioreactor, which contributes to the integrated nature of our process and the resulting utility consumption and conservation advantages. The final result is fuel-grade cellulosic ethanol and bio-based chemicals ready for existing distribution channels. Product separation via distillation is a well-known and heavily utilized practice in numerous industries, including the corn ethanol and petrochemicals industries. While there are a large number of equipment providers for this step, we are working with ICM, Inc., an industry leader in the design and construction of ethanol distillation equipment. We expect to utilize existing, commercially-available designs regardless of the selected feedstock, micro-organism or end product.

Based on our findings from operating our Lighthouse facility for more than 15,000 hours, we believe that when fully built out our first commercial production facility, Flagship, will produce cellulosic ethanol at an unsubsidized cash operating cost of less than $1.50 per gallon, net of co-product sales, assuming a feedstock cost of $64 per bone dry ton of softwood. This wood price is consistent with current prices in the region around Flagship. For low-cost and negative-cost feedstocks such as municipal solid waste, we believe our process can produce cellulosic ethanol at significantly lower operating costs per gallon. At current and expected commodity agricultural prices, we believe these production costs are competitive with existing, first-generation ethanol production methods. We expect that constructing and operating our Flagship facility will provide key learnings that will lead to operational and capital efficiencies for our subsequent projects. For our future facilities, we expect to realize even lower per unit production costs. We expect to achieve the cost improvement through increased process efficiencies, economies of scale, ongoing improvements in our micro-organisms and sales of co-products or power.

Since our inception in 2006, we have advanced our syngas fermentation technology from the test tube to our Lighthouse facility, which we believe is one of the largest syngas fermentation facilities in the world. The other significant milestones we have achieved to date are discussed below. We believe these achievements demonstrate the commercial readiness of our technology platform.

We believe one of our core competencies is identifying and optimizing high-yield, naturally-occurring micro-organisms for the efficient fermentation of syngas. At our headquarters in Warrenville, Illinois, we have developed a complete anaerobic bacteria strain management facility that is capable of advancing native strains through guided mutation and selection. We believe that this is one of the only anaerobic high throughput facilities in the world. Current capacity at this facility allows us to screen over 150,000 new strains per year. During our first year of operations, our scientists were able to improve the overall productivity of our micro-organisms a thousand-fold and minimize the requirements for additional nutrients, such that our current

commercial strains require only syngas as an energy source and a very small amount of key micronutrients and minerals. We will continue to optimize our micro-organisms to increase overall yield, lower production costs and allow for the production of additional bio-based chemicals and other end-products.

Since 2008, we have operated our Horizon pilot facility at our headquarters. The Horizon facility is an integrated processing system consisting of a methane thermal reformer, multiple bioreactor designs and a distillation system. At this facility, our longest production run was over 3,500 hours. These operations have enabled us to establish scale-up metrics utilized in the design of our Flagship facility. We continue to utilize our Horizon facility to test and optimize new anaerobic bacteria strains and process conditions to enhance our technology platform.

The design and construction of Lighthouse, our demonstration-scale production facility in Madison, Pennsylvania, was a critical step in the development and demonstration of our technology. We specifically designed, engineered, and constructed our Lighthouse facility such that it models a linear scale-up of our fermentation process to commercial production. We believe that Lighthouse is one of the largest syngas fermentation facilities in the world. Since its completion in August 2009, we recorded over 15,000 hours of operation. The facility includes a biomass gasifier and a natural gas reformer which allowed us to demonstrate the production of ethanol from multiple feedstocks. We have successfully demonstrated the conversion of wood chips, wood waste, sorted municipal solid waste and natural gas to ethanol, and based on demonstration runs at Lighthouse, we expect to achieve yields of 100 gallons per bone dry ton of softwood at Flagship.

Since completing the first conceptual design for a commercial-scale cellulosic ethanol plant in February 2007, we have successfully executed on key engineering scale-up milestones and continue to progress towards commercial scale. Our Lighthouse facility has provided us with operating data critical for finalizing our plans for commercial deployment of our technology platform, and we believe it has reduced the scale-up risk associated with moving from a demonstration facility to a commercial facility. In January 2010, we engaged R.W. Beck to conduct a review of our technology embodied in the current state of design and testing. R.W. Beck’s analysis included an in-depth review of our process and technology, operating data from Lighthouse, design parameters for Lighthouse and Flagship and Flagship scale-up factors.

In December 2010, we entered into a joint development agreement with Total Petrochemicals pursuant to which we are collaborating to develop micro-organisms and a syngas fermentation platform to produce propanol from biomass, waste, and/or fossil fuels such as coal and natural gas. Total Petrochemicals, together with IFP Energies Nouvelles & Axens, is developing a new process to dehydrate alcohol into alkenes, including propanol into propylene, which can be linked to our syngas fermentation platform producing propanol. We believe this will result in the commercial-scale deployment of an end-to-end process to competitively produce propylene, allowing us and our future licensees and joint venture partners to access a large and fast growing market for a key petrochemical intermediate.

When fully built out, we expect that Flagship will be capable of producing 78 million gallons of ethanol per year using wood chips and wood waste as a feedstock. The project will be completed in two phases, with Phase I representing a single integrated train of our design with a capacity to produce 16 million gallons per year. Phase II will involve the modular expansion of the facility to add 62 million gallons of annual capacity. We expect Phase I and Phase II to be completed in 2013 and 2015, respectively. When fully built out, we expect Flagship will produce fuel grade cellulosic ethanol at an unsubsidized cash operating cost of less than $1.50 per gallon, net of co-product sales, assuming a feedstock cost of $64 per bone dry ton of softwood. This wood price is consistent with current prices in the region around Flagship. We believe Flagship will provide a showcase for commercial deployment, and support the company’s ongoing technology development program.

Financing. Phase I of Flagship will be financed by a portion of the proceeds of this offering, cash on hand and $87.9 million of debt financing supported by a 90% loan guarantee through the USDA’s 9003 Biorefinery Assistance Program. We expect that Phase II will be financed by new capital from public or private sources, none of which is committed at this time.

Site and Permits. Flagship will be located at the Crossroads of America industrial park in Boligee, Alabama. This site was chosen based on favorable attributes such as plentiful wood biomass supply, close proximity to large ethanol markets, and strong state and county support. All key operating permits for the facility have been obtained, including air operating and water discharge permits.

Feedstock Availability. Flagship will consume approximately 2,100 dry tons of wood per day when fully built out. This level of wood use is comparable to an average-sized pulp and paper mill. Several independent, third-party studies assessing feedstock availability and pricing dynamics for Flagship have concluded that Flagship will exert only limited pricing pressure on the local wood market. The area surrounding the Flagship site is a major softwood supply basin with annual wood growth significantly above demand. We are negotiating an exclusive, seven-year feedstock supply agreement for 100% of Flagship’s wood consumption. The agreement provides for purchase prices equal to prevailing market prices, with a gain-sharing mechanism for achieving better than posted market prices, which we believe will allow us to procure wood at an attractive price.

Ethanol Marketing. Flagship will be strategically located in the under-supplied Southeast ethanol market. Flagship’s target market includes many large metropolitan areas within a 250-mile trucking radius of the plant, including: Atlanta, Georgia; Birmingham, Alabama; Memphis, Tennessee; Mobile, Alabama; and New Orleans, Louisiana. This size of this market is estimated to be nearly one billion gallons of ethanol per year based on projected 2012 demand at a 10% ethanol blend level. Most ethanol in the region is delivered over long-distances, primarily from the corn-growing regions of the Midwest. We believe that our shorter shipping distance will add to our cost advantage. We are negotiating an exclusive ten year (subject to extension) agreement, for the purchase and marketing of 100% of Flagship’s ethanol production. Our offtake provider will be responsible for all scheduling and logistics, including tracking and reporting of compliance certificates. We expect that our agreement will include an index-based minimum formula price, gainsharing mechanisms and a most favored nation provision with respect to the marketing fee, which we believe will allow us to receive an attractive price for our ethanol.

Project Execution. In order to minimize risk in our first commercial-scale facility, we have chosen commercially-ready technologies from well-established suppliers for the gasification and distillation components of our technology platform. We also plan to install a natural gas reformer to ensure a continuous supply of syngas. Our Phase I project execution strategy includes a firm-price, date-certain mechanical completion schedule. We have engaged Fagen, Inc. to lead engineering, procurement and construction activities, and it will be supported by the Harris Group, which has worked closely with our engineers over the last 18 months to develop the conceptual engineering design for Flagship. Under the terms of our contract with Fagen, it will provide a mechanical completion “wrap” around the project with complete site responsibility for project cost, scope, schedule, and safety. Process warranties will be provided by each of the third-party technology providers.

We are in discussions with potential strategic partners about commercializing our technology through joint development or licensing arrangements, and have signed several MOUs and engineering service agreements. The location of future facilities, whether they are wholly-owned, developed with strategic partners, or licensed, will depend upon available feedstocks, geography, and co-location synergies.

The most readily available renewable cellulosic feedstocks are woody biomass, municipal solid waste, and agricultural residues. In certain geographies, there is also significant potential from using non-renewable feedstocks such as natural gas and coal. Abundant feedstock supply combined with the RFS2 mandate has made the United States an attractive initial market opportunity for our cellulosic ethanol. Concurrently, we are working with potential partners to deploy our technology platform in Asia using municipal solid waste as a feedstock. In Asia, in particular, traditional feedstock supplies are not sufficient to satisfy strong end-market demand. Further, we believe we will experience synergies from co-locating our cellulosic ethanol plants near existing industrial facilities, which will result in capital and operating cost savings. The table below summarizes the initial market segments we have identified as high priority, and a description of each segment follows.

Woody Biomass. Woody biomass represents a large market opportunity for our technology platform. Based on the Department of Energy’s Billion-Ton Study, we believe there is sufficient woody biomass in the United States to produce up to 10 billion gallons of cellulosic ethanol per year. Woody biomass is a readily-available feedstock with established supply chains and feedstock handling and processing equipment. The high land density of woody biomass availability allows for shorter hauling distances and larger facilities, leading to significant economies of scale. We believe that our future woody-biomass facilities will have annual production capacities of up to 160 million gallons of cellulosic ethanol per plant. The wood use associated with a production facility of that size using our technology platform is comparable to a large pulp and paper mill. We believe that many of our competitors, whose lower yields require the consumption of more wood for every gallon of end-product produced, will not be able to build facilities of this size without impacting feedstock availability and pricing.

In addition, we believe the large woody biomass resource located in the Southeast allows us to address large fuel markets where local ethanol production has been limited due to the lack of traditional ethanol feedstocks such as corn. We believe that our shorter shipping distance to these markets, compared to corn ethanol shipped from the Midwest, will add to our cost advantage.

Corn Ethanol Co-Location. There were approximately 200 corn ethanol plants in the United States in 2010, and we believe that these plants are well positioned to access agricultural residues such as corn stover and corn ethanol by-products such as corn fiber. We also believe there are significant capital and operating synergies

that can be achieved from co-locating one of our cellulosic ethanol plants with an existing corn ethanol plant, including: (i) lower capital costs due to existing infrastructure and utilities; (ii) lower production costs due to low-cost feedstock; (iii) energy cost savings due to the ability of our technology platform to supply steam as an energy input; and (iv) synergies in labor and maintenance across the traditional ethanol plant and our technology platform. Greater energy efficiency also results in an improvement in the environmental footprint of a corn ethanol plant, which in turn bolsters market access for their ethanol in low-carbon fuel standard markets.

Municipal Solid Waste. We believe municipal solid waste is an attractive feedstock opportunity because of its large supply and low cost. In certain markets municipal solid waste can be procured for no cost, and sometimes at negative cost due to tipping fees. Because municipal solid waste represents household and business waste, its availability generally coincides with dense populations and large transportation fuel markets. Turning municipal solid waste into ethanol reduces reliance on landfills and adds new products to our strategic partners’ potential revenue streams.

We are currently working with Flex Ethanol Australia, a partnership among CalTex, GM Holden, and Phoenix Energy Corp., to develop a commercial-scale waste-to-ethanol facility in Melbourne, Australia. High-level planning for this project has been underway for over a year, and the project enjoys significant support from local, state, and federal governments. Two potential sites have been identified in the Melbourne metropolitan area and discussions to secure long-term feedstock supply are underway. In August 2011, we successfully converted sorted municipal solid waste provided by Flex Ethanol Australia into ethanol at our Lighthouse facility. The partnership is now completing conceptual engineering work on the project and we are negotiating the terms and conditions for the licensing of our technology platform. We are also in active discussions with industrial companies in Japan related to municipal solid waste-to-ethanol opportunities. The cost advantages of municipal solid waste-to-ethanol facilities in Japan are enhanced by extremely high tipping fees, which can exceed $250 per ton.

China. We also anticipate expanding into the fuel-grade ethanol market in China, based on strong demand and government support. We expect that the economics of locating one or more facilities in China will be advantageous based on lower capital and feedstock cost expectations versus the United States. Equally as important, the Chinese government has shown strong and consistent pricing support for alternative energy technologies that increase energy security and improve the nation’s environmental footprint. We have already begun the exploration of the Chinese market. We are in discussions with several multinational entities with significant operating experience in the Chinese market, as well as local companies that could serve as the main deployment partner for our technology platform in the Chinese market.

We believe that technical advantage is the key to sustainable competitive advantage, and therefore our research and development efforts are focused on the continued enhancement of our technology platform. Through the collective knowledge and experience of our research and development team, we have developed unique competencies in the area of anaerobic bacteria advancement, in particular, the use of such living organisms to conduct single-carbon molecule metabolism using syngas as the raw material. These competencies have enabled us to: locate mixed strains of potentially useful anaerobes in the environment; enrich environmental cultures and then separate the anaerobes into individual colonies; assess the capacity of bacterial isolates to produce desired products from syngas; optimize the nutritional requirements of selected microbial strains; characterize the DNA of isolated strains and link genetic traits to performance; advance strains of anaerobic bacteria through mutagenesis and selection processes developed by us; and evaluate production capabilities of developed strains in bio-reactors built and operated by our scientists and engineers.

We were formed in 2006 after our founders were successful in obtaining exclusive rights to several proprietary strains of anaerobic bacteria developed by researchers at Oklahoma University and Oklahoma State University. These strains provided the initial impetus to create the requisite processes and procedures to develop even more active microbes. In the first year of research and development, our scientists were able to improve the

overall productivity of the micro-organisms a thousand-fold. Thereafter, we advanced the strains to minimize the requirements for additional nutrients, such that our current commercial strains require only syngas as an energy source and a very small amount of key micronutrients and minerals.

A critical aspect of our start-up strategy was to combine the microbiology described above with innovative engineering concepts to create a biological syngas conversion process that is capable of being operated at commercial-scale and at low cost. As a result, we had to develop in-house expertise in biomass gasification, bio-reactor designs that maximize mass transfer of syngas to reaction broth, alcohol separation and cleanup techniques. Through our development of superior microbial strains and properly engineered production equipment, we have created an integrated technology platform which we believe provides significant competitive advantages.

Our Lighthouse facility was designed, engineered, and built by us. The key learnings derived from designing, constructing and operating that facility also added significantly to our technology base. In particular, operating the facility for two years led to important technical improvements in our technology platform and the development of new intellectual property in several areas that we believe will provide competitive advantages.

As of November 30, 2011, our technical team was made up of 43 professionals, including scientists and engineers. In our Research and Development department, we employ microbiologists, geneticists, and chemists, with a degree distribution of 14 PhD’s, four masters of science, and nine bachelors of science. In our Engineering department, we employ 16 degreed engineers with specific backgrounds in chemical engineering, gasification, liquid processing, and project management. Our research and development expenditures were approximately $6.5 million, $7.4 million and $10.1 million for the fiscal years ended December 31, 2008, 2009 and 2010, respectively, and $7.0 million and $9.8 million for the nine months ended September 30, 2010 and 2011, respectively.

Our success depends, at least in part, on our ability to protect our proprietary technology and intellectual property, and to operate without infringing the proprietary rights of others. We rely on a combination of patents, patent applications, trade secrets and know-how, trademarks, intellectual property licenses and other contractual rights (including confidentiality and invention assignment agreements) to establish and protect our proprietary rights in our technology.

As of November 30, 2011, we have six issued U.S. patents, including four related to membrane arrangements, one related to treatment of syngas streams, and one related to genetically modified organisms for the production of alcohols. We also have an additional allowed application related to membrane arrangements and 28 pending patent applications in the United States, of which approximately 10 also have international or foreign patent applications pending. Our pending patent applications are related to a variety of technologies, including microorganisms and our second generation bioreactor designs that use membranes to dramatically reduce the size of the bioreactors and volume of water needed for fermentation. We intend to continue to file patent applications with respect to our technology with a particular emphasis on protecting our core technologies, however, there can be no assurance that any patent applications will result in the issuance of patents, or, if our patent applications are granted, that they will provide us with meaningful protection.

In December 2006, we entered into a license agreement with Oklahoma State University and the University of Oklahoma, or collectively, Oklahoma, that grants us an exclusive, worldwide license to certain of Oklahoma’s patents, patent applications and know-how (including certain pre-existing patent applications and future domestic and foreign patents issued thereon) in the field of conversion of syngas (including biomass-based syngas and coal-based syngas) to ethanol using micro-organisms. We agreed to sponsor research with Oklahoma in the amount of $1.1 million and to grant Oklahoma the option to purchase 35,000 shares of our common stock at a price of $0.10 per share, which option can be exercised at any time during the term of the agreement. In addition, with respect to syngas-to-ethanol owned or operated facilities that utilize the licensed technology, we

are required to pay Oklahoma a one-time fee equal to a specified amount per gallon of such facility’s annual ethanol production capacity, as well as a specified share of non-royalty fees received from sublicensees. Unless earlier terminated, the term of this agreement lasts for the life of the last to issue of the licensed patents.

In the ordinary course of business we have entered into, and may enter into additional, license agreements pursuant to which we have, or will obtain, the right to develop, use and commercialize certain intellectual property that are utilized in our research and development efforts or our technology platform. Under certain of these license agreements, our license rights are limited to a certain field of use and/or our licensors have retained certain rights in and outside of our field of use. Under certain of our license agreements and agreements with our research, development or collaboration partners, we are obligated to grant such licensors and partners certain rights in and outside of our field of use under any new technology or intellectual property created as a result of our research, development or collaborations. Such provisions may limit our ability to gain commercial benefit from some of the intellectual property we develop and may lead to disputes with parties with whom we have commercial relationships over rights to certain innovations.

We rely on, among other things, confidentiality and invention assignment agreements to protect our proprietary know-how and other intellectual property that may not be patentable, or that we believe is best protected by means that do not require public disclosure. However, we may be unable to obtain, maintain and protect the intellectual property rights necessary to conduct our business, and may be subject to claims that we infringe or otherwise violate the intellectual property rights of others, which could materially harm our business. For more information, see “Risk Factors—Risks Related to our Intellectual Property.”

In December 2010, we entered into a joint development agreement with Total Petrochemicals pursuant to which we are collaborating to develop micro-organisms and a syngas fermentation platform to produce propanol from biomass, waste, and/or fossil fuels such as coal and natural gas. Total Petrochemicals, together with IFP Energies Nouvelles & Axens, is developing a new process to dehydrate alcohol into alkenes, including propanol into propylene, which can be linked to our syngas fermentation platform producing propanol. We believe this will result in the commercial-scale deployment of an end-to-end process to competitively produce propylene, allowing us, our joint ventures and licensees to access a large and fast growing market for a key petrochemical intermediate.

Pursuant to the agreement, we and Total Petrochemicals created a “steering committee” consisting of two members from each party which is responsible for the overall project, including evaluating progress under the agreement, resolving any intellectual property matters that arise, managing the preparation of the commercialization of the technology and other major decisions relating to implementing the agreement. The steering committee is allowed to take actions only if all members of the committee agree. The agreement envisions three phases to the development program. In the first phase, which began in early 2011, we are working with Total Petrochemicals to develop a unique micro-organism-based technology that produces propanol, a three-carbon precursor to propylene, from the same range of feedstocks that we have already utilized to produce cellulosic ethanol. Key metrics and timelines have been derived to assess success in this phase. Subject to success in the first phase, the second phase of the program will involve the scale-up of the preferred strains at a demonstration-scale plant, using both biomass-derived syngas and syngas from reformed natural gas. In the final phase, we will work with Total Petrochemicals to develop an engineering package and cost estimate for the process. The engineering package will embed key learnings and operational data from the demonstration-scale facility and provide the foundation for the engineering, construction and operation of a commercial-scale propanol production facility.

The successful conclusion of the collaboration project would result in: (i) joint ownership of the propanol production technology between us and Total Petrochemicals, (ii) us possessing exclusive licensing rights globally for the propanol production technology that is developed, (iii) end-to-end link of this propanol

production technology to the proprietary propanol-to-propylene technology under development by Total Petrochemicals and IFP Energies Nouvelles & Axens for commercial deployment purposes, and (iv) preferential access by Total Petrochemicals to the propanol production technology for its own production.

The term of this agreement is 20 years, although it may be terminated early (i) upon our and Total’s mutual agreement, (ii) by either party after the second anniversary of the agreement if the steering committee determines that the technology has not achieved certain criteria and will not achieve such criteria even if the agreement is continued, (iii) by either party if the steering committee decides that a given milestone cannot be achieved within the required time period and will not be achieved even if the agreement is continued, (iv) by either party if no license agreement is signed with a third-party licensee within three years of the technology’s readiness or six years after the date of the agreement, or (v) upon certain other events, including the bankruptcy of one party or the assignment of the agreement by one party without the other party’s prior consent.

We are party to a collaboration agreement with Sumitomo Corporation, or Sumitomo, pursuant to which we have agreed to collaborate to develop commercial-scale projects deploying our technology in Australia, Indonesia, Japan, Thailand and other Asian countries. Sumitomo agreed to screen reliable local partners, conduct feasibility studies and establish joint venture entities to develop, own and operate plants. We are in discussions to license our technology platform to one project identified through our collaboration with Sumitomo. This agreement will expire in October 2013, but will automatically extend for additional one-year terms unless one of the parties provides notice of its intention to terminate the relationship.

We have also entered into a number of arrangements with respect to our Flagship facility, as more fully described above under “—Our Commercialization Plan—Flagship.”

We believe that the primary competitive factors in the renewable fuels market are: cost of production; the scope of qualification of fuels under existing or future regulations, including RFS2; compatibility with existing infrastructure; product performance and other measures of quality; ability to produce meaningful volumes; price; and reliability of supply.

In the near-term, we expect that our ethanol will compete with other cellulosic biofuels, advanced biofuels and renewable fuels developed by established enterprises and new companies that seek to produce these renewable fuels to satisfy RFS2 mandates. In the longer term, we believe that our technology platform will compete with technologies currently being developed, or that will be developed in the future, that ferment syngas to ethanol and chemical products, and more broadly with large chemical companies and new companies developing processes for producing renewable fuels and chemicals.

Given the size of the traditional transportation fuels markets and the developing stage of renewable fuels markets, we do not believe that the success of other renewable fuel producers will prevent our cellulosic ethanol from achieving commercial success. However, with the wide range of renewable fuels products under development, we must be successful in the low cost production of our cellulosic ethanol and in reaching potential customers. Our potential competitors include integrated oil companies, independent refiners, large chemical companies and well-established agricultural products companies that are much larger than we are, in many cases have well-developed distribution systems and networks for their products, have historical relationships with the potential customers we are seeking to serve and have sales and marketing programs in place to promote their products.

We have demonstrated the production of ethanol and propanol using our proprietary technology platform. We believe that ethylene and propylene produced by dehydrating this ethanol and propanol will serve as direct substitutes for ethylene and propylene that is currently sold in the market. We believe our technology will be cost competitive in the production of these products. Existing producers of commodity and petrochemicals include large integrated oil companies and large chemical companies. While we expect to compete with these large and established producers, we may also partner or collaborate with one or more of these or other companies.

Our operations are subject to a variety of federal, state, local and foreign environmental regulations that govern the discharge of materials into the environment or otherwise relate to environmental protection. Examples of these laws include the federal Clean Air Act, or CAA, and the federal Clean Water Act, or CWA, and analogous state laws that regulate discharges from our facilities into state and federal waters.

The laws, regulations and permitting requirements under the CAA may restrict emissions from facilities similar to ours or require controls or limitations on operations. In the United States, legislative and regulatory initiatives have been implemented or are underway to limit GHG emissions by certain facilities that are large emitters of GHGs. At this time, the actual and projected GHG emissions from our facilities, including our Flagship facility, could meet the applicable thresholds for GHG Prevention of Significant Deterioration and Title V permitting or EPA reporting requirements, but currently qualify for exemptions or exclusions from both. In the case of Prevention of Significant Deterioration and Title V permitting requirements related to GHG emissions, our facilities qualify for a 3-year exemption for emissions from biogenic carbon sources. We are also currently not required to report our emissions under the EPA reporting rule, as emissions from ethanol fermentation are excluded from reporting requirements. While our Flagship facility qualifies for an exemption from GHG Prevention of Significant Deterioration and Title V permitting and reporting requirements, the EPA could decline to renew or extend such exemptions or exclusions such that our facilities might accordingly be required to meet Prevention of Significant Deterioration and Title V permitting, reporting and other requirements after operations begin. Because regulation of GHG emissions is relatively new, further regulatory, legislative and judicial developments are likely to occur.

CWA and analogous state laws impose restrictions regarding the discharge of pollutants into state and federal waters. Further, general permits issued under the federal National Pollutant Discharge Elimination System, or NPDES, program prohibit discharges into surface waters, ground waters, wells and publicly-owned treatment works, or POTWs, except in strict conformance with the permits.

Compliance with existing and new laws and regulations may result in increased capital expenditures, increased operating costs and additional operating restrictions for our business. In addition to the costs expected to be incurred to maintain compliance with these requirements, new or more stringent standards may limit our operating flexibility or require the installation of additional controls at the planned and future facilities.

To date, we have obtained an initial air operating permit, a Synthetic Minor permit under the CAA, for our Flagship facility that will regulate our air emissions from plant operations, including dust and fugitive emission from wood handling and ethanol storage and process emissions from dryer vents. The air operating permit application will be resubmitted prior to the start of construction to allow for minor changes in the final design. We expect the permit will be approved after the resubmission. In addition, we have obtained permits for process water and storm water discharge. Both air and water permits will require us to conduct periodic testing and report ongoing emissions. In addition, Fagen, Inc., our engineering, procurement and construction contractor, will be obligated to obtain all required permits during the course of the engineering, procurement and construction of Flagship.

In order to be able to realize the material regulatory benefits of our cellulosic ethanol, our Flagship facility must be registered with the EPA, we must be registered as a producer of cellulosic biofuel with the Internal Revenue Service in order to qualify for the Cellulosic Biofuel Tax Credit, and we must also register with the California Air Resources Board to supply fuel under that state’s LCFS.

RFS2 Cellulosic Biofuel. In connection with our registration with the EPA, we will need to demonstrate that we will be using an approved feedstock and generating an approved end product. The woody biomass to ethanol pathway is already defined and approved by the EPA as qualifying for the production of cellulosic ethanol. To date, the EPA has approved several energy crop species, crop residue, slash, pre-commercial thinnings, tree residue, annual cover crops and cellulosic components of separated yard waste, separated food waste, and separated municipal solid waste as qualifying feedstocks.

Cellulosic Biofuel Tax Credit. Upon the successful registration of our cellulosic ethanol with the EPA and our successful registration with the Internal Revenue Service as a producer of cellulosic biofuel, under current law we would be entitled to the Cellulosic Biofuel Tax Credit of $1.01 per gallon of our cellulosic ethanol that we produce in 2012, unless this deadline is extended.

California LCFS. In order to supply our cellulosic ethanol to California markets, and earn credits from the LCFS regime instituted there, we must register our Flagship facility with the California Air Resources Board. This registration will require obtaining a “carbon intensity” score for the expected production of Flagship and require a lifecycle analysis of the GHGs associated with our production. We are in the process of conducting an updated lifecycle analysis that will be specific to Flagship. Following the completion of the updated lifecycle analysis, we expect to submit an application to the California Air Resources Board and obtain approval for supplying the LCFS.

As of November 30, 2011, we had 61 full-time employees, including 43 scientists, engineers and technical support personnel. We will be required to hire a significant number of new employees as we build Flagship and future commercial production facilities and expand upon our joint venture and licensing strategies. None of our employees is represented by a labor union or covered by a collective bargaining agreement. We have never experienced any employment-related work stoppages, and we consider our employee relationships to be good.

We lease approximately 33,500 square feet of space in Warrenville, Illinois. We use approximately 15,000 square feet for general office purposes and 18,500 for our lab and Horizon pilot plant. The lease expires in November 2015 and we have an option to extend the lease for five years. We lease our Lighthouse facility in Madison, Pennsylvania. That lease ends in March 2012 and we expect to extend it on a month to month basis as needed. We also have a purchase agreement in place for the site of our Flagship facility which covers 150 acres in Boligee, Alabama. We believe that our current facilities are suitable and adequate to meet our needs and that suitable additional space will be available to accommodate the foreseeable expansion of our operations.

On March 24, 2010, Ineos Bio USA, LLC and Ineos Bio Ltd., or, collectively, Ineos Bio, filed a complaint in the 18th Judicial Circuit Court of Illinois against us and one of our former employees, alleging conflicting proprietary rights relating to our intellectual property, including misappropriation of trade secrets. Ineos Bio is seeking injunctive and monetary relief in an unspecified amount. On March 8, 2011, we filed a state anti-trust claim and an abuse of process claim against Ineos Bio as part of this litigation. Our claim seeks to

enjoin Ineos Bio from violating Illinois antitrust regulations, as well as punitive damages, attorney’s fees, and treble damages. Although the outcome of this litigation matter is subject to numerous uncertainties, we believe the litigation does not implicate technology essential to our business plans. We intend to contest and defend this matter vigorously.

Our directors, executive officers and other key persons and their ages and their positions as of November 15, 2011 are as follows:

William J. Roe has served as our President and Chief Executive Officer since September 2007 and as a director since November 2007. Prior to joining Coskata, Mr. Roe spent 29 years with Nalco Holding Company, the world’s largest provider of industrial water-treatment chemicals and process additives, where he served as the Chief Operating Officer from June 2001 to June 2007. Previously, Mr. Roe served as President of Nalco’s Asia Pacific Division from December 1998 to June 2001, where he was responsible for Nalco’s operations in China, Japan, Korea, Taiwan, Southeast Asia, India, Australia and New Zealand. Mr. Roe earned an M.S. in Organic Chemistry from the University of Notre Dame and a B.S. in Chemistry from Creighton University.

As the former Chief Operating Officer of Nalco Holding Company, Mr. Roe brings to our board of directors significant expertise in leading a complex organization and forming and executing strategy for a public company. Mr. Roe has also been a key contributor in establishing the overall vision for our technology platform and has direct responsibility for our strategy and operations.

David J. Blair has served as our Chief Financial Officer since April 2008 and Treasurer since December 2008. Prior to joining Coskata, Mr. Blair served as the Chief Financial Officer of Westmoreland Coal Company (NASDAQ: WLB), a leading coal mining and energy company, from April 2005 to March 2008. From 1987 to January 2004, Mr. Blair worked in various capacities for Nalco Holding Company, including as Vice President of Corporate Finance, Treasurer and Acting Chief Financial Officer. Mr. Blair earned a Bachelor of Commerce degree from the University of Toronto and is a Chartered Accountant with the Ontario Institute of Chartered Accountants.

Richard Troyer joined Coskata in July 2011 as our Chief Business Officer. Prior to joining Coskata, Mr. Troyer was at the Blackstone Group from June 2008 to June 2011, most recently as a Managing Director. At Blackstone, he focused on the biofuels and biochemical sectors and helped launch the firm’s clean technology practice, Blackstone Clean Technology Partners. While there, he was involved in the firm’s investments in Coskata, Rive Technology and other clean technology companies. Before joining Blackstone, Mr. Troyer was a vice president at AllianceBernstein from August 2005 to May 2008, where he was responsible for investments in

public and private companies in the clean technology and biotechnology sectors. He was previously a r


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Title of Each Class of Securities to be Registered	Proposed Maximum Aggregate Offering Price(1)(2)	Amount of Registration Fee(3)
Common, par value $0.001 per share	$100,000,000	$11,460


	Per Share	Total
Public Offering Price	$	$
Underwriting Discount	$	$
Proceeds to Coskata, Inc. (before expenses)	$	$


SUMMARY			1
RISK FACTORS			12
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS			37
MARKET, INDUSTRY AND OTHER DATA			38
USE OF PROCEEDS			39
DIVIDEND POLICY			39
CAPITALIZATION			40
DILUTION			42
SELECTED HISTORICAL FINANCIAL DATA			44
MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS			46
INDUSTRY			67
BUSINESS			76
MANAGEMENT			94
EXECUTIVE COMPENSATION			101
CERTAIN RELATIONSHIPS AND RELATED PERSON TRANSACTIONS			117
PRINCIPAL STOCKHOLDERS			123
DESCRIPTION OF CERTAIN INDEBTEDNESS			126
DESCRIPTION OF CAPITAL STOCK			127
SHARES ELIGIBLE FOR FUTURE SALE			132
MATERIAL U.S. FEDERAL INCOME TAX CONSIDERATIONS TO NON-US HOLDERS			134
UNDERWRITING			138
LEGAL MATTERS			143
EXPERTS			143
WHERE YOU CAN FIND MORE INFORMATION			143
INDEX TO FINANCIAL STATEMENTS			F-1


“ASTM International”		ASTM International (formerly known as the American Society for Testing and Materials), a developer and provider of international voluntary consensus standards.
“EIA”		U.S. Energy Information Administration, a U.S. government agency which collects, analyzes and disseminates energy information, including information with respect to energy production, demand, imports, exports and pricing.
“EISA”		Energy Independence and Security Act of 2007.
“GHG”		Greenhouse gas.
“ICIS”		ICIS, a provider of price information, news and analysis for the global chemical, energy and fertilizer industries.
“RISI”		RISI, Inc., a research organization focusing on the global forest products industry.
“RFS”		The Renewable Fuel Standard Program created under the Energy Policy Act of 2005.
“RFS2”		The Renewable Fuel Standard Program, as amended by the Energy Independence and Security Act of 2007.
“Sandia”		Sandia National Laboratories, a government-owned facility developing technologies to support U.S. national security.
“ton”		A short ton, or 2,000 pounds.
“Total Petrochemicals”		Total Petrochemicals Research Feluy S.A.
“USDA”		United States Department of Agriculture.


	September 30, 2011
	Actual			Pro Forma			Pro Forma As Adjusted
	(in thousands, except share and per share data)

Cash and cash equivalents⁽¹⁾	$	18,860		$	18,860		$

Long-term debt, including current portion	$	—		$	—		$
Stockholders’ equity:

Common stock, $0.001 par value, 48,400,000 shares authorized, 6,060,785 shares issued and outstanding, actual; 34,316,223 shares issued and outstanding, pro forma; shares issued and outstanding, pro forma as adjusted		6			34
Series A convertible preferred stock, $0.01 par value, 10,052,500 shares authorized, 10,000,000 shares issued and outstanding, actual; no shares authorized, issued or outstanding, pro forma and pro forma as adjusted		100			—			—
Series B convertible preferred stock, $0.01 par value, 4,000,000 shares authorized, 3,798,888 shares issued and outstanding, actual; no shares authorized, issued or outstanding, pro forma and pro forma as adjusted		38			—			—
Series C convertible preferred stock, $0.01 par value, 11,571,500 shares authorized, 11,570,835 shares issued and outstanding, actual; no shares authorized, issued or outstanding, pro forma and pro forma as adjusted		116			—			—
Series D convertible preferred stock, $0.01 par value, 6,000,000 shares authorized, 2,885,715 shares issued and outstanding, actual; no shares authorized, issued or outstanding, pro forma and pro forma as adjusted		29			—			—
Additional paid-in capital⁽¹⁾		120,946			121,201
Deficit accumulated during the development stage		(88,159	)		(88,159	)

Total stockholders’ equity⁽¹⁾		33,076			33,076

Total capitalization⁽¹⁾	$	33,076		$	33,076		$


Assumed initial public offering price per share		$
Pro forma net tangible book value per share of common stock as of September 30, 2011, before giving effect to this offering	$
Increase in pro forma net tangible book value per share attributed to new investors purchasing shares in this offering	$

Pro forma as adjusted net tangible book value per share after this offering		$

Dilution per share to investors in this offering		$


	Shares Purchased				Total Consideration				Average Price Per Share
	Number	Percent			Amount	Percent			Average Price Per Share
	(in thousands other than percentages and per share data)
Existing stockholders				%	$			%	$
Investors participating in this offering


Total			100	%	$		100	%


	May 3, 2006 (Date of Inception) through December 31, 2006			Year Ended December 31,												(unaudited) Nine Months Ended September 30,
				2007			2008			2009			2010			2010			2011
	(in thousands, except per share amounts)
Statement of Operations Data:
Revenues from services	$	—		$	—		$	—		$	—		$	250		$	—		$	—
Cost of services (exclusive of depreciation in operating expenses)		—			—			—			—			116			—			—

Revenues less related costs		—			—			—			—			134			—			—
Operating expenses:
Research and development		319			5,104			6,505			7,399			10,128			6,979			9,821
Engineering		—			—			504			1,398			1,698			1,334			1,481
Selling, general and administrative		549			1,691			4,054			3,937			5,774			4,105			6,247
Depreciation		14			331			888			3,579			10,583			9,012			5,451
Accretion		—			—			—			134			437			332			348

Total operating expenses		882			7,126			11,951			16,447			28,620			21,762			23,348

Loss from operations		(882	)		(7,126	)		(11,951	)		(16,447	)		(28,486	)		(21,762	)		(23,348	)

Other income (expense):
Interest income		53			121			324			108			11			9			1
Interest expense		—			(8	)		(183	)		(119	)		(251	)		(228	)		—
Other, net		—			(15	)		1			—			2			(3	)		36

Total other income (expense), net		53			98			142			(11	)		(238	)		(222	)		37

Loss before income taxes		(829	)		(7,028	)		(11,809	)		(16,458	)		(28,724	)		(21,984	)		(23,311	)
Income tax benefit		—			—			—			—			—			—			—

Net loss	$	(829	)	$	(7,028	)	$	(11,809	)	$	(16,458	)	$	(28,724	)	$	(21,984	)	$	(23,311	)

Net loss per share of common stock, basic and diluted	$	(0.26	)	$	(1.26	)	$	(2.03	)	$	(2.81	)	$	(4.84	)	$	(3.72	)	$	(3.87	)

Weighted-average shares of common stock outstanding, basic and diluted		3,177			5,570			5,806			5,847			5,936			5,911			6,030

Pro forma net loss per share of common stock, basic and diluted (unaudited)⁽¹⁾													$	(0.97	)				$	(0.73	)

Pro forma weighted-average common shares outstanding, basic and diluted (unaudited)⁽¹⁾														29,567						32,013


	As of December 31,										(unaudited) As of September 30,
	2006		2007		2008		2009		2010		2011
	(in thousands)
Summary Balance Sheet Data:
Cash and cash equivalents	$	1,925	$	964	$	37,321	$	9,009	$	15,108	$	18,860
Working capital⁽²⁾		1,671		143		37,265		6,840		13,174		13,400
Property, plant and equipment, net		465		3,112		13,094		29,749		24,782		19,773
Total assets		2,594		4,783		51,673		40,294		41,031		39,612
Long-term debt, including current portion		63		1,458		972		464		—		—
Preferred stock – liquidation value		3,000		10,000		70,552		73,797		108,244		132,868
Total stockholders’ equity		2,096		2,090		49,794		34,505		35,756		33,076


	Year Ended December 31,									(unaudited) Nine Months Ended September 30,
	2008			2009			2010			2010			2011
	(in thousands)
Statement of Operations:
Revenues from services	$	—		$	—		$	250		$	—		$	—
Cost of services (exclusive of depreciation in operating expenses)		—			—			116			—			—

Revenues less related costs		—			—			134			—			—

Operating expenses:
Research and development		6,505			7,399			10,128			6,979			9,821
Engineering		504			1,398			1,698			1,334			1,481
Selling, general and administrative		4,054			3,937			5,774			4,105			6,247
Depreciation		888			3,579			10,583			9,012			5,451
Accretion		—			134			437			332			348

Total operating expenses		11,951			16,447			28,620			21,762			23,348

Loss from operations		(11,951	)		(16,447	)		(28,486	)		(21,762	)		(23,348	)


Other income (expense):
Interest income		324			108			11			9			1
Interest expense		(183	)		(119	)		(251	)		(228	)		—
Other, net		1			—			2			(3	)		36

Total other income (expense), net		142			(11	)		(238	)		(222	)		37

Loss before income taxes		(11,809	)		(16,458	)		(28,724	)		(21,984	)		(23,311	)
Income tax benefit		—			—			—			—			—

Net loss	$	(11,809	)	$	(16,458	)	$	(28,724	)	$	(21,984	)	$	(23,311	)


	(unaudited) Nine Months Ended September 30,						Increase (Decrease)
	2010			2011			Dollar			%
	(in thousands, except percentages)
Statement of Operations Data:
Revenues from services	$	—		$	—		$	—			—	%
Cost of services (exclusive of depreciation in operating expenses)		—			—			—			—

Revenues less related costs		—			—			—

Operating expenses:
Research and development		6,979			9,821			2,842			41
Engineering		1,334			1,481			147			11
Selling, general and administrative		4,105			6,247			2,142			52
Depreciation		9,012			5,451			(3,561	)		(40	)
Accretion		332			348			16			5

Total operating expenses		21,762			23,348			1,586			7

Loss from operations		(21,762	)		(23,348	)		1,586			7


Other income (expense):
Interest income		9			1			(8	)		(89	)
Interest expense		(228	)		—			(228	)		(100	)
Other, net		(3	)		36			39			N/A

Total other income (expense), net		(222	)		37			(259	)		N/A

Loss before income taxes		(21,984	)		(23,311	)		1,327			6
Income tax benefit		—			—			—			—

Net loss	$	(21,984	)	$	(23,311	)	$	1,327			6	%


	Year Ended December 31						Increase (Decrease)
	2009			2010			Dollar			%
	(in thousands, except percentages)
Statement of Operations Data:
Revenues from services	$	—		$	250		$	250			100	%
Cost of services (exclusive of depreciation in operating expenses)		—			116			116			100

Revenues less related costs		—			134			134			100

Operating expenses:
Research and development		7,399			10,128			2,729			37
Engineering		1,398			1,698			300			21
Selling, general and administrative		3,937			5,774			1,837			47
Depreciation		3,579			10,583			7,004			196
Accretion		134			437			303			226

Total operating expenses		16,447			28,620			12,173			74

Loss from operations		(16,447	)		(28,486	)		12,039			73


Other income (expenses):
Interest income		108			11			(97	)		(90	)
Interest expense		(119	)		(251	)		132			111
Other, net		—			2			2			100

Total other income (expense), net		(11	)		(238	)		227			2,064

Loss before income taxes		(16,458	)		(28,724	)		12,266			75
Income tax benefit		—			—			—

Net loss	$	(16,458	)	$	(28,724	)	$	12,266			75	%


	December 31,					September 30,
	2009			2010		2011
	(in thousands)
Long-Term Debt:
Related party capital lease obligations for laboratory equipment	$	464		$	—	$	—
Less: current portion		(464	)		—		—

Long-term debt, less current portion		$—		$	—	$	—


	Total		Less Than 1 Year		1 - 3 Years		4 - 5 Years		After 5 Years
	(in thousands)
Noncancelable operating leases	$	2,110		$405		$846	$	859	$	—
Asset retirement obligation⁽¹⁾		2,098		—		2,098		—		—
Purchase and termination commitments⁽²⁾		3,060		3,060		—		—		—

Total contractual obligations	$	7,268		$ 3,465	$	2,944	$	859	$	—


Citigroup		Barclays Capital		Piper Jaffray


	Year Ended December 31,			Nine Months Ended September 30, 2011
	2008	2009	2010	Nine Months Ended September 30, 2011
Risk-free interest rate	1.55%-3.37%	1.87%-3.28%	1.38%-3.20%	2.40%-2.69%
Expected volatility	100%	100%	100%	100%
Expected option term (in years)	5.0 - 6.5	5.0 - 6.5	5.0 - 6.5	6.5
Expected dividend yield	0.00%	0.00%	0.00%	0.00%


Three Months Ended:	Shares Underlying Options⁽¹⁾		Weighted-Average Exercise Price
March 31, 2010		602,000	$	1.93
June 30, 2010		-		-
September 30, 2010⁽²⁾		19,900	$	1.57
December 31, 2010		31,000	$	1.93
March 31, 2011		18,000	$	2.10
June 30, 2011		10,000	$	2.10
September 30, 2011		-		-


Valuation Date		Value per Share
December 31, 2009		$ 1.93
December 31, 2010		2.10
August 31, 2011		5.56


	Year Ended December 31,						(unaudited) May 3, 2006 (Date of Inception) To September 30,
	2008		2009		2010		2011
	(in thousands)
Research and development	$	71	$	414	$	155	$	768
Engineering		30		196		103		414
Selling, general and administrative		1,134		558		393		2,382

Total stock-based compensation	$	1,235	$	1,168	$	651	$	3,564


	(unaudited) Nine Months Ended September 30,
	2010		2011
	(in thousands)
Research and development	$	114	$	100
Engineering		76		85
Selling, general and administrative		287		277

Total stock-based compensation	$	477	$	462


Country		Ethanol Blend Targets
Australia		5% in Queensland; 4% in New South Wales
Brazil		25% (temporarily reduced to 18-20% due to local availability of sugar)
Canada		RFS of 5%
China		9 provinces require 10% to date; 15% overall biofuels target by 2020
Colombia		8%, plans to increase to 10%
European Union		10% by 2020
India		Current 5% and moving to 10%; overall biofuels target of 20% by 2017
Nigeria		10%
Philippines		10%
Thailand		10%
United States		36 billion gallons of biofuels by 2022


Feedstock	Initial Target Geographies	Rationale
Woody biomass	United States	• Readily-available feedstock with existing supply chain • Highly scalable • Advantaged in serving large ethanol markets in Southeast
Agricultural residue or corn co-location	United States	• Feedstock availability through existing sourcing relationships and ability to use by-products of ethanol production • Cost savings from utility, infrastructure, logistics and operations synergies
Municipal solid waste	Asia United States	• Readily-available feedstock with existing supply chain • Available close to transportation centers • Attractive tipping fees for early plants
Various	China	• Readily-available feedstock with existing supply chain • Strong government support • Strong demand drivers


Name	Age		Position
*Executive Officers*:
William J. Roe		58	President, Chief Executive Officer and Director
David J. Blair		57	Chief Financial Officer and Treasurer
Richard Troyer		41	Chief Business Officer
Jeffrey E. Burgard		58	Vice President of Engineering and Operations
Dr. Rathin Datta		63	Chief Scientific Officer
James S. Fawley		42	Vice President of Strategic Business Development
Richard E. Tobey		55	Vice President of Research and Development
*Non-Employee Directors*:
Bradley J. Bell		59	Director
Benoit Charpentier		50	Director
T. Kevin DeNicola		57	Director
Samir Kaul		37	Director
James Kiggen		54	Director
Andrew Perlman		36	Director
William Wiberg		51	Director