The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABILITY INC COM G8789K124 680 357,974 SH   DFND 1 0 357,974 0
ACASTI PHARMA INC CL A 00430K402 229 275,000 SH   DFND 1 0 275,000 0
ALTIMMUNE INC COM 02155H950 139 673 SH Put DFND 1 0 673 0
ALTIMMUNE INC COM 02155H200 490 237,921 SH   DFND 1 0 237,921 0
AMARIN CORPORATION PLC ADR 023111206 1,157 85,038 SH   DFND 1 0 85,038 0
AMARIN CORPORATION PLC ADR 023111956 3,736 2,745 SH Put DFND 1 0 2,745 0
AMARIN CORPORATION PLC ADR 023111906 6,074 4,463 SH Call DFND 1 0 4,463 0
AMPLIPHI BIOSCIENCES CORP COM 03211P301 168 816,095 SH   DFND 1 0 816,095 0
APPLIED DNA SCIENCES INC *W 03815U110 2 602,062 SH   DFND 1 0 602,062 0
APPLIED DNA SCIENCES INC COM 03815U201 24 60,835 SH   DFND 1 0 60,835 0
AQUABOUNTY TECHNOLOGIES INC COM 03842K200 649 316,654 SH   DFND 1 0 316,654 0
ARCADIA BIOSCIENCES INC COM 039014204 303 95,682 SH   DFND 1 0 95,682 0
ASTRAZENECA PLC ADR 046353908 5,640 1,485 SH Call DFND 1 0 1,485 0
ASTRAZENECA PLC ADR 046353958 12,579 3,312 SH Put DFND 1 0 3,312 0
ATOSSA GENETICS INC COM 04962H506 513 502,448 SH   DFND 1 0 502,448 0
AVEO PHARMACEUTICALS INC COM 053588909 1,717 10,731 SH Call DFND 1 0 10,731 0
AVINGER INC COM 053734208 34 112,270 SH   DFND 1 0 112,270 0
AYTU BIOSCIENCE INC COM 054754700 408 515,002 SH   DFND 1 0 515,002 0
BENITEC BIOPHARMA LTD *W 082053117 7 58,050 SH   DFND 1 0 58,050 0
BIOCEPT INC COM 09072V402 49 57,505 SH   DFND 1 0 57,505 0
BIOGEN INC COM 09062X903 903 30 SH Call DFND 1 0 30 0
BIOGEN INC COM 09062X103 37,908 125,975 SH   DFND 1 0 125,975 0
BIOGEN INC COM 09062X953 38,006 1,263 SH Put DFND 1 0 1,263 0
BRAINSTORM CELL THERAPEUTICS INC COM 10501E201 3,588 1,010,682 SH   DFND 1 0 1,010,682 0
BRIDGELINE DIGITAL INC COM 10807Q403 180 778,983 SH   DFND 1 0 778,983 0
CELLECT BIOTECHNOLOGY LTD ADS 15116C102 84 40,032 SH   DFND 1 0 40,032 0
CEL-SCI CORP COM 150837957 32 110 SH Put DFND 1 0 110 0
CEL-SCI CORP COM 150837607 93 32,256 SH   DFND 1 0 32,256 0
CELSION CORPORATION COM 15117N503 15 10,843 SH   DFND 1 0 10,843 0
CHECK CAP LTD *W M2361E161 101 252,155 SH   DFND 1 0 252,155 0
CHECK CAP LTD SHS M2361E203 37 16,979 SH   DFND 1 0 16,979 0
CHF SOLUTIONS INC COM 12542Q508 108 221,033 SH   DFND 1 0 221,033 0
CITIUS PHARMACEUTICALS INC COM 17322U207 29 28,045 SH   DFND 1 0 28,045 0
CONATUS PHARMACEUTICALS INC COM 20600T908 0 187 SH Call DFND 1 0 187 0
CORMEDIX INC COM 21900C100 40 30,661 SH   DFND 1 0 30,661 0
CORMEDIX INC COM 21900C950 41 305 SH Put DFND 1 0 305 0
CYTRX CORP COM 232828608 833 1,855,879 SH   DFND 1 0 1,855,879 0
DBV TECHNOLOGIES SA ADR 23306J901 0 116 SH Call DFND 1 0 116 0
DELMAR PHARMACEUTICALS INC COM 247078207 488 1,410,178 SH   DFND 1 0 1,410,178 0
DURECT CORP COM 266605904 27 549 SH Call DFND 1 0 549 0
DURECT CORP COM 266605104 64 131,900 SH   DFND 1 0 131,900 0
ELECTRAMECCANICA VEHICLES CORP *W 284849114 14 30,905 SH   DFND 1 0 30,905 0
ELECTRAMECCANICA VEHICLES CORP COM 284849205 213 200,000 SH   DFND 1 0 200,000 0
ESPERION THERAPEUTICS INC COM 29664W105 6,392 138,958 SH   DFND 1 0 138,958 0
ESPERION THERAPEUTICS INC COM 29664W955 38,948 8,467 SH Put DFND 1 0 8,467 0
EYENOVIA INC COM 30234E104 505 177,110 SH   DFND 1 0 177,110 0
FIBROCELL SCIENCE INC COM 315721407 64 42,400 SH   DFND 1 0 42,400 0
FIBROGEN INC COM 31572Q808 2,102 45,417 SH   DFND 1 0 45,417 0
FIBROGEN INC COM 31572Q958 4,235 915 SH Put DFND 1 0 915 0
FUELCELL ENERGY INC COM 35952H502 20 37,110 SH   DFND 1 0 37,110 0
FUELCELL ENERGY INC COM 35952H952 31 565 SH Put DFND 1 0 565 0
GENPREX INC COM 372446104 915 832,244 SH   DFND 1 0 832,244 0
HEAT BIOLOGICS INC COM 42237K300 384 391,985 SH   DFND 1 0 391,985 0
INSPIREMD INC *W 45779A135 2 1,432,133 SH   DFND 1 0 1,432,133 0
INSPIREMD INC COM 45779A861 89 560,562 SH   DFND 1 0 560,562 0
INTELLIPHARMACEUTICS INTL INC COM 458173309 469 1,944,978 SH   DFND 1 0 1,944,978 0
ISHARES RUSSELL 2000 ETF 464287950 57,577 4,300 SH Put DFND 1 0 4,300 0
ISORAY INC COM 46489V104 676 2,254,829 SH   DFND 1 0 2,254,829 0
JAGUAR HEALTH INC COM 47010C300 300 1,311,580 SH   DFND 1 0 1,311,580 0
KITOV PHARMA LTD. COM 49803V107 13 19,980 SH   DFND 1 0 19,980 0
LM FDG AMER INC COM 502074305 117 98,927 SH   DFND 1 0 98,927 0
MADRIGAL PHARMACEUTICALS INC COM 558868905 1,736 154 SH Call DFND 1 0 154 0
MAGENTA THERAPEUTICS INC COM 55910K108 611 107,156 SH   DFND 1 0 107,156 0
MANNKIND CORP COM 56400P706 14 12,797 SH   DFND 1 0 12,797 0
MANNKIND CORP COM 56400P906 48 449 SH Call DFND 1 0 449 0
MANNKIND CORP COM 56400P956 253 2,388 SH Put DFND 1 0 2,388 0
MARINUS PHARMACEUTICALS INC COM 56854Q901 82 287 SH Call DFND 1 0 287 0
MEDIGUS LTD *W 58471G128 522 1,043,764 SH   DFND 1 0 1,043,764 0
MICROBOT MED INC COM 59503A204 150 87,243 SH   DFND 1 0 87,243 0
MONAKER GROUP INC COM 609011200 613 510,426 SH   DFND 1 0 510,426 0
MOSYS INC COM 619718208 66 398,408 SH   DFND 1 0 398,408 0
NEKTAR THERAPEUTICS COM 640268908 2,137 650 SH Call DFND 1 0 650 0
NEKTAR THERAPEUTICS COM 640268108 2,594 78,915 SH   DFND 1 0 78,915 0
NEKTAR THERAPEUTICS COM 640268958 2,685 817 SH Put DFND 1 0 817 0
NEURALSTEM INC COM 64127R401 490 1,558,145 SH   DFND 1 0 1,558,145 0
NEUROMETRIX INC COM 641255708 505 664,177 SH   DFND 1 0 664,177 0
NOVAN INC COM 66988N106 177 213,064 SH   DFND 1 0 213,064 0
ODONATE THERAPEUTICS INC COM 676079106 14,355 518,125 SH   DFND 1 0 518,125 0
ONCONOVA THERAPEUTICS INC COM 68232V405 101 47,794 SH   DFND 1 0 47,794 0
ONCONOVA THERAPEUTICS INC *W 68232V116 26 660,970 SH   DFND 1 0 660,970 0
OPGEN INC COM NEW COM 68373L208 326 251,095 SH   DFND 1 0 251,095 0
OPHTHOTECH CORP COM 683745953 16 133 SH Put DFND 1 0 133 0
OPHTHOTECH CORP COM 683745903 173 1,438 SH Call DFND 1 0 1,438 0
OPHTHOTECH CORP COM 683745103 2,445 2,037,460 SH   DFND 1 0 2,037,460 0
ORAMED PHARMACEUTICALS INC COM 68403P203 2,799 933,050 SH   DFND 1 0 933,050 0
OUTLOOK THERAPEUTICS INC COM 69012T107 1,393 2,786,448 SH   DFND 1 0 2,786,448 0
OUTLOOK THERAPEUTICS INC *W 69012T115 27 177,439 SH   DFND 1 0 177,439 0
PAVMED INC *W 70387R122 1,255 3,923,204 SH   DFND 1 0 3,923,204 0
PHIO PHARMACEUTICALS COM 71880W204 520 1,575,157 SH   DFND 1 0 1,575,157 0
PHIO PHARMACEUTICALS *W 71880W105 5 194,959 SH   DFND 1 0 194,959 0
PLURISTEM THERAPEUTICS INC COM 72940R952 24 309 SH Put DFND 1 0 309 0
RESHAPE LIFESCIENCES INC COM 761123405 187 732,648 SH   DFND 1 0 732,648 0
REWALK ROBOTICS LTD COM M8216Q101 569 3,267,652 SH   DFND 1 0 3,267,652 0
RITTER PHARMACEUTICALS INC COM 767836307 206 343,642 SH   DFND 1 0 343,642 0
SANGAMO THERAPEUTICS INC COM 800677956 932 81,161 SH   DFND 1 0 81,161 0
SANGAMO THERAPEUTICS INC COM 800677106 946 824 SH Put DFND 1 0 824 0
SAREPTA THERAPEUTICS INC COM 803607950 9,429 864 SH Put DFND 1 0 864 0
SAREPTA THERAPEUTICS INC COM 803607900 19,054 1,746 SH Call DFND 1 0 1,746 0
SCYNEXIS INC COM 811292101 8 15,764 SH   DFND 1 0 15,764 0
SENESTECH INC COM 81720R109 86 146,530 SH   DFND 1 0 146,530 0
SESEN BIO INC COM 817763955 260 1,830 SH Put DFND 1 0 1,830 0
SIGMA LABS INC *W 826598112 74 188,813 SH   DFND 1 0 188,813 0
SOLENO THERAPEUTICS INC COM 834203200 906 529,921 SH   DFND 1 0 529,921 0
SONOMA PHARMACEUTICALS INC COM 83558L105 331 465,000 SH   DFND 1 0 465,000 0
SOPHIRIS BIO INC COM 83578Q209 10 12,046 SH   DFND 1 0 12,046 0
SORRENTO TECH INC COM 83587F202 0 84,536 SH   DFND 1 0 84,536 0
SPDR S&P 500 ETF ETF 78462F953 108,215 4,330 SH Put DFND 1 0 4,330 0
SPDR S&P BIOTECH ETF 78464A870 4,468 62,266 SH   DFND 1 0 62,266 0
SPDR S&P BIOTECH ETF 78464A900 4,979 694 SH Call DFND 1 0 694 0
SPDR S&P BIOTECH ETF 78464A950 23,096 3,219 SH Put DFND 1 0 3,219 0
SUNESIS PHARMACEUTICALS INC COM 867328900 47 1,141 SH Call DFND 1 0 1,141 0
SUNESIS PHARMACEUTICALS INC COM 867328700 166 400,140 SH   DFND 1 0 400,140 0
SUPERCONDUCTOR TECHNOLOGIES COM 867931602 421 326,288 SH   DFND 1 0 326,288 0
SYNERGY PHARMACEUTICALS INC COM 871639908 59 5,382 SH Call DFND 1 0 5,382 0
SYNTHETIC BIOLOGICS INC COM 87164U201 626 1,117,459 SH   DFND 1 0 1,117,459 0
TENAX THERAPEUTICS INC COM 88032L209 131 108,427 SH   DFND 1 0 108,427 0
TONIX PHARMACEUTICALS HLDG COM 890260508 653 296,727 SH   DFND 1 0 296,727 0
UNUM THERAPEUTICS INC COM 903214104 1,966 446,814 SH   DFND 1 0 446,814 0
VASCULAR BIOGENICS LTD COM M96883109 2,302 2,373,203 SH   DFND 1 0 2,373,203 0
VIKING THERAPEUTICS INC COM 92686J906 77 100 SH Call DFND 1 0 100 0
VIKING THERAPEUTICS INC COM 92686J906 555 72,500 SH   DFND 1 0 72,500 0
XERIS PHARMACEUTICALS INC COM 98422L107 3,450 202,916 SH   DFND 1 0 202,916 0
ZOGENIX INC COM 98978L904 3,613 991 SH Call DFND 1 0 991 0
ZOSANO PHARMA CORP COM 98979H202 355 167,403 SH   DFND 1 0 167,403 0