The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADVERUM BIOTECHNOLOGIES INC COM 00773U908 1,349 2,230 SH Call DFND 1 0 2,230 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U958 102 168 SH Put DFND 1 0 168 0
ALDEYRA THERAPEUTICS INC COM 01438T906 589 427 SH Call DFND 1 0 427 0
ALKERMES PLC SHS G01767905 2,423 571 SH Call DFND 1 0 571 0
AMARIN CORPORATION PLC ADR 023111956 828 509 SH Put DFND 1 0 509 0
AMARIN CORPORATION PLC ADR 023111906 16,000 9,834 SH Call DFND 1 0 9,834 0
AMICUS THERAPEUTICS INC COM 03152W109 1,874 155,044 SH   DFND 1 0 155,044 0
AMICUS THERAPEUTICS INC COM 03152W959 2,002 1,656 SH Put DFND 1 0 1,656 0
AMICUS THERAPEUTICS INC COM 03152W909 2,841 2,350 SH Call DFND 1 0 2,350 0
APPLIED DNA SCIENCES *W 03815U110 136 616,043 SH   DFND 1 0 616,043 0
APTINYX INC COM 03836N103 1,188 41,037 SH   DFND 1 0 41,037 0
ARCADIA BIOSCIENCES INC COM 039014204 1,355 277,181 SH   DFND 1 0 277,181 0
ASTRAZENECA PLC ADR 046353958 14,265 3,605 SH Put DFND 1 0 3,605 0
ASTRAZENECA PLC ADR 046353908 15,155 3,830 SH Call DFND 1 0 3,830 0
ATOSSA GENETICS INC COM 04962H506 814 465,039 SH   DFND 1 0 465,039 0
AVEO PHARMACEUTICALS INC COM 053588909 4,032 12,182 SH Call DFND 1 0 12,182 0
AXOVANT SCIENCES LTD COM G0750W104 327 135,272 SH   DFND 1 0 135,272 0
AYTU BIOSCIENCE INC COM 054754700 98 35,466 SH   DFND 1 0 35,466 0
BENITEC BIOPHARMA LTD *W 082053117 7 58,050 SH   DFND 1 0 58,050 0
BIO PATH HOLDINGS INC COM 09057N201 437 970,877 SH   DFND 1 0 970,877 0
BIOCEPT INC COM 09072V402 392 142,417 SH   DFND 1 0 142,417 0
BIOGEN INC COM 09062X103 12,555 35,534 SH   DFND 1 0 35,534 0
BIOGEN INC COM 09062X953 61,723 1,747 SH Put DFND 1 0 1,747 0
BRAINSTORM CELL THERAPEUTICS INC COM 10501E201 3,465 906,956 SH   DFND 1 0 906,956 0
CELLECT BIOTECHNOLOGY LTD COM 15116C102 412 86,517 SH   DFND 1 0 86,517 0
CEL-SCI CORP COM 150837607 101 24,816 SH   DFND 1 0 24,816 0
CESCA THERAPEUTICS INC COM 157131202 6 19,988 SH   DFND 1 0 19,988 0
CHECK CAP LTD *W M2361E161 230 306,878 SH   DFND 1 0 306,878 0
CHECK CAP LTD SHS M2361E203 363 90,771 SH   DFND 1 0 90,771 0
CHF SOLUTIONS INC COM 12542Q508 499 423,218 SH   DFND 1 0 423,218 0
CITIUS PHARMACEUTICALS INC COM 17322U207 20 11,564 SH   DFND 1 0 11,564 0
CONATUS PHARMACEUTICALS INC COM 20600T908 253 437 SH Call DFND 1 0 437 0
CORMEDIX INC COM 21900C950 28 287 SH Put DFND 1 0 287 0
CYTORI THERAPEUTICS *W 23283K121 0 37,793 SH   DFND 1 0 37,793 0
CYTRX CORP COM 232828608 1,333 1,269,731 SH   DFND 1 0 1,269,731 0
DBV TECHNOLOGIES SA ADR 23306J901 261 116 SH Call DFND 1 0 116 0
DURECT CORP COM 266605904 69 627 SH Call DFND 1 0 627 0
DURECT CORP COM 266605104 145 131,900 SH   DFND 1 0 131,900 0
EIDOS THERAPEUTICS INC COM 28249H104 766 76,740 SH   DFND 1 0 76,740 0
ELECTRAMECCANICA VEHICLES CORP *W 284849114 38 101,000 SH   DFND 1 0 101,000 0
ESPERION THERAPEUTICS INC COM 29664W105 4,453 100,369 SH   DFND 1 0 100,369 0
ESPERION THERAPEUTICS INC COM 29664W955 29,692 6,692 SH Put DFND 1 0 6,692 0
EYENOVIA INC COM 30234E104 657 163,357 SH   DFND 1 0 163,357 0
FIBROGEN INC COM 31572Q808 730 12,019 SH   DFND 1 0 12,019 0
FIBROGEN INC COM 31572Q908 5,565 916 SH Call DFND 1 0 916 0
FIBROGEN INC COM 31572Q958 8,772 1,444 SH Put DFND 1 0 1,444 0
FUELCELL ENERGY INC COM 35952H952 372 3,480 SH Put DFND 1 0 3,480 0
GALMED PHARMACEUTICALS LTD SHS M47238106 599 44,136 SH   DFND 1 0 44,136 0
GENPREX INC COM 372446104 1,664 733,200 SH   DFND 1 0 733,200 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U908 4,986 1,312 SH Call DFND 1 0 1,312 0
HELIOS AND MATHESON ANALYTICS INC COM 42327L909 0 125 SH Call DFND 1 0 125 0
HEMISPHERX BIOPHARMA INC COM 42366C301 263 1,143,632 SH   DFND 1 0 1,143,632 0
INSMED INC COM 457669307 303 15,000 SH   DFND 1 0 15,000 0
INSMED INC COM 457669957 833 412 SH Put DFND 1 0 412 0
INSPIREMD INC *W 45779A127 1 498,797 SH   DFND 1 0 498,797 0
INSPIREMD INC *W 45779A135 7 1,847,636 SH   DFND 1 0 1,847,636 0
INSPIREMD INC COM 45779A861 236 1,071,004 SH   DFND 1 0 1,071,004 0
ISHARES RUSSELL 2000 ETF 464287905 35,648 2,115 SH Call DFND 1 0 2,115 0
ISHARES RUSSELL 2000 ETF 464287955 67,420 4,000 SH Put DFND 1 0 4,000 0
ISORAY INC COM 46489V104 999 1,925,487 SH   DFND 1 0 1,925,487 0
KITOV PHARMA LTD ADR 49803V107 47 27,043 SH   DFND 1 0 27,043 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 321 1,500 SH   DFND 1 0 1,500 0
MADRIGAL PHARMACEUTICALS INC COM 558868905 3,298 154 SH Call DFND 1 0 154 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,132 94,224 SH   DFND 1 0 94,224 0
MANNKIND CORP COM 56400P956 1,309 7,154 SH Put DFND 1 0 7,154 0
MARINUS PHARMACEUTICALS INC COM 56854Q901 1,595 1,595 SH Call DFND 1 0 1,595 0
MEDIGUS LTD *W 58471G128 926 1,268,146 SH   DFND 1 0 1,268,146 0
MEDIGUS LTD ADS 58471G300 1,006 296,712 SH   DFND 1 0 296,712 0
MICROBOT MED INC COM 59503A204 405 54,518 SH   DFND 1 0 54,518 0
MONAKER GROUP INC COM 609011200 956 444,572 SH   DFND 1 0 444,572 0
NEKTAR THERAPEUTICS COM 640268908 3,609 592 SH Call DFND 1 0 592 0
NEKTAR THERAPEUTICS COM 640268108 18,008 295,405 SH   DFND 1 0 295,405 0
NEKTAR THERAPEUTICS COM 640268958 28,560 4,685 SH Put DFND 1 0 4,685 0
NEUROMETRIX INC COM 641255708 496 372,913 SH   DFND 1 0 372,913 0
NOVAN INC COM 66988N106 700 250,958 SH   DFND 1 0 250,958 0
ODONATE THERAPEUTICS INC COM 676079106 10,164 523,653 SH   DFND 1 0 523,653 0
ONCOBIOLOGICS INC COM 68235M105 3,318 3,354,909 SH   DFND 1 0 3,354,909 0
ONCONOVA THERAPEUTICS INC *W 68232V116 67 665,470 SH   DFND 1 0 665,470 0
OPGEN INC COM NEW COM 68373L208 34 16,958 SH   DFND 1 0 16,958 0
OPHTHOTECH CORP COM 683745953 31 133 SH Put DFND 1 0 133 0
OPHTHOTECH CORP COM 683745903 287 1,217 SH Call DFND 1 0 1,217 0
OPHTHOTECH CORP COM 683745103 3,820 1,618,820 SH   DFND 1 0 1,618,820 0
OPIANT PHARMACEUTICALS INC COM 683750103 781 43,736 SH   DFND 1 0 43,736 0
ORAMED PHARMACEUTICALS INC COM 68403P203 3,876 801,242 SH   DFND 1 0 801,242 0
OVASCIENCE INC COM 69014Q101 187 255,803 SH   DFND 1 0 255,803 0
PAVMED INC *W 70387R122 915 1,946,838 SH   DFND 1 0 1,946,838 0
PLURISTEM THERAPEUTICS INC COM 72940R952 41 312 SH Put DFND 1 0 312 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 482 199,900 SH   DFND 1 0 199,900 0
RESHAPE LIFESCIENCES INC COM 761123405 20 461,704 SH   DFND 1 0 461,704 0
RICEBRAN TECHNOLOGIES COM 762831204 807 281,061 SH   DFND 1 0 281,061 0
RITTER PHARMACEUTICALS INC COM 767836307 186 100,000 SH   DFND 1 0 100,000 0
RXI PHARMACEUTICALS *W 74979C121 68 195,259 SH   DFND 1 0 195,259 0
SANGAMO THERAPEUTICS INC COM 800677106 2,660 156,913 SH   DFND 1 0 156,913 0
SANGAMO THERAPEUTICS INC COM 800677956 5,251 3,098 SH Put DFND 1 0 3,098 0
SAREPTA THERAPEUTICS INC COM 803607950 14,665 908 SH Put DFND 1 0 908 0
SAREPTA THERAPEUTICS INC COM 803607900 28,200 1,746 SH Call DFND 1 0 1,746 0
SCYNEXIS INC COM 811292101 50 41,579 SH   DFND 1 0 41,579 0
SELLAS LIFE SCIENCES GROUP INC COM 81642T100 96 78,294 SH   DFND 1 0 78,294 0
SENESTECH INC COM 81720R109 675 978,702 SH   DFND 1 0 978,702 0
SESEN BIO INC COM 817763955 392 1,823 SH Put DFND 1 0 1,823 0
SIGMA LABS INC *W 826598112 87 280,529 SH   DFND 1 0 280,529 0
SOLENO THERAPEUTICS INC COM 834203200 1,631 755,312 SH   DFND 1 0 755,312 0
SOPHIRIS BIO INC COM 83578Q959 440 1,578 SH Put DFND 1 0 1,578 0
SPDR S&P 500 TR 78462F903 116,317 4,001 SH Call DFND 1 0 4,001 0
SPDR S&P 500 TR 78462F953 117,044 4,026 SH Put DFND 1 0 4,026 0
SPDR S&P BIOTECH TR 78464A950 5,177 540 SH Put DFND 1 0 540 0
SPDR S&P BIOTECH TR 78464A900 18,014 1,879 SH Call DFND 1 0 1,879 0
STELLAR BIOTECHNOLOGIES INC COM 85855A302 65 46,859 SH   DFND 1 0 46,859 0
SUNESIS PHARMACEUTICALS INC COM 867328900 191 955 SH Call DFND 1 0 955 0
SUNESIS PHARMACEUTICALS INC COM 867328700 556 278,184 SH   DFND 1 0 278,184 0
SUPERCONDUCTOR TECHNOLOGIES INC COM 867931602 533 287,948 SH   DFND 1 0 287,948 0
SYNERGY PHARMACEUTICALS INC COM 871639908 915 5,382 SH Call DFND 1 0 5,382 0
TILRAY INC COM 88688T950 15,252 1,062 SH Put DFND 1 0 1,062 0
TITAN PHARMACEUTICALS INC COM 888314309 314 1,518,294 SH   DFND 1 0 1,518,294 0
TROVAGENE INC COM 897238408 125 153,638 SH   DFND 1 0 153,638 0
UNUM THERAPEUTICS INC COM 903214104 5,577 541,420 SH   DFND 1 0 541,420 0
VASCULAR BIOGENICS LTD COM M96883109 3,454 2,125,738 SH   DFND 1 0 2,125,738 0
VIKING THERAPEUTICS INC COM 92686J906 941 540 SH Call DFND 1 0 540 0
VIKING THERAPEUTICS INC COM 92686J106 2,848 163,463 SH   DFND 1 0 163,463 0
VIKING THERAPEUTICS INC COM 92686J956 6,747 3,873 SH Put DFND 1 0 3,873 0
XERIS PARMACEUTICALS INC COM 98422L107 8,560 486,938 SH   DFND 1 0 486,938 0
YIELD10 BIOSCIENCE INC COM 98585K201 68 47,740 SH   DFND 1 0 47,740 0
ZOGENIX INC COM 98978L904 13,084 2,638 SH Call DFND 1 0 2,638 0
ZOSANO PHARMA CORP COM 98979H202 12,439 250,783 SH   DFND 1 0 250,783 0