The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 144 27,263 SH   DFND 1 0 27,263 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U908 1,964 3,705 SH Call DFND 1 0 3,705 0
AFFIMED N.V. COM N01045108 143 86,386 SH   DFND 1 0 86,386 0
AFFIMED N.V. COM N01045908 90 543 SH Call DFND 1 0 543 0
AFFIMED N.V. COM N01045958 75 454 SH Put DFND 1 0 454 0
ALPHATEC HOLDINGS INC COM 02081G201 281 94,216 SH   DFND 1 0 94,216 0
AMARIN CORPORATION PLC ADR 023111906 3,308 10,707 SH Call DFND 1 0 10,707 0
AMARIN CORPORATION PLC ADR 023111956 343 1,109 SH Put DFND 1 0 1,109 0
AMICUS THERAPEUTICS INC COM 03152W109 599 38,344 SH   DFND 1 0 38,344 0
AMICUS THERAPEUTICS INC COM 03152W909 697 446 SH Call DFND 1 0 446 0
AMICUS THERAPEUTICS INC COM 03152W959 2,243 1,436 SH Put DFND 1 0 1,436 0
AMYRIS INC COM 03236M950 633 990 SH Put DFND 1 0 990 0
APPLIED DNA SCIENCES INC *W 03815U110 186 663,878 SH   DFND 1 0 663,878 0
APPLIED DNA SCIENCES INC COM 03815U201 349 277,319 SH   DFND 1 0 277,319 0
APTINYX INC COM 03836N103 1,012 41,857 SH   DFND 1 0 41,857 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 146 55,203 SH   DFND 1 0 55,203 0
AQUINOX PHARMACEUTICALS INC COM 03842B951 121 456 SH Put DFND 1 0 456 0
ARCADIA BIOSCIENCES INC COM 039014204 1,004 121,690 SH   DFND 1 0 121,690 0
ASTRAZENECA PLC ADR 046353108 2,404 68,464 SH   DFND 1 0 68,464 0
ASTRAZENECA PLC ADR 046353908 9,589 2,731 SH Call DFND 1 0 2,731 0
ASTRAZENECA PLC ADR 046353958 11,815 3,365 SH Put DFND 1 0 3,365 0
ATOSSA GENETICS INC COM 04962H506 750 340,749 SH   DFND 1 0 340,749 0
AURIS MEDICAL HOLDING AG COM H0381L104 206 263,625 SH   DFND 1 0 263,625 0
AVEO PHARMACEUTICALS INC COM 053588909 2,760 12,214 SH Call DFND 1 0 12,214 0
AXOVANT SCIENCES LTD COM G0750W104 331 146,504 SH   DFND 1 0 146,504 0
AYTU BIOSCIENCE INC COM 054754403 186 709,312 SH   DFND 1 0 709,312 0
BENITEC BIOPHARMA *W 082053117 8 75,904 SH   DFND 1 0 75,904 0
BIOCEPT INC COM 09072V204 36 177,601 SH   DFND 1 0 177,601 0
BIOGEN INC COM 09062X103 44,146 152,102 SH   DFND 1 0 152,102 0
BIOGEN INC COM 09062X903 871 30 SH Call DFND 1 0 30 0
BIOGEN INC COM 09062X953 62,891 2,451 SH Put DFND 1 0 2,451 0
BRAINSTORM CELL THERAPEUTICS INC COM 10501E201 3,626 929,725 SH   DFND 1 0 929,725 0
CAN FITE BIOPHARMA LTD COM 13471N102 130 109,905 SH   DFND 1 0 109,905 0
CEL SCI CORP COM 150837607 15 16,591 SH   DFND 1 0 16,591 0
CELLECT BIOTECHNOLOGY LTD ADR 15116C102 798 111,540 SH   DFND 1 0 111,540 0
CESCA THERAPEUTICS INC COM 157131202 61 146,472 SH   DFND 1 0 146,472 0
CHECK CAP LTD *W M2361E161 428 628,846 SH   DFND 1 0 628,846 0
CHECK CAP LTD COM M2361E203 264 65,139 SH   DFND 1 0 65,139 0
CHF SOLUTIONS INC COM 12542Q508 837 454,811 SH   DFND 1 0 454,811 0
CITIUS PHARMACEUTICALS INC COM 17322U207 937 407,180 SH   DFND 1 0 407,180 0
CYCLACEL PHARMACEUTICALS INC COM 23254L405 36 25,000 SH   DFND 1 0 25,000 0
CYTORI THERAPEUTICS *W 23283K121 3 300,413 SH   DFND 1 0 300,413 0
CYTRX CORP COM 232828608 1,892 1,674,431 SH   DFND 1 0 1,674,431 0
DBV TECHNOLOGIES SA ADR 23306J901 534 277 SH Call DFND 1 0 277 0
DURECT CORP COM 266605104 168 107,675 SH   DFND 1 0 107,675 0
DURECT CORP COM 266605904 95 607 SH Call DFND 1 0 607 0
EGALET CORP COM 28226B104 1 2,134 SH   DFND 1 0 2,134 0
EIDOS THERAPEUTICS INC COM 28249H104 1,014 49,833 SH   DFND 1 0 49,833 0
ESPERION THERAPEUTICS INC COM 29664W105 5,828 148,704 SH   DFND 1 0 148,704 0
ESPERION THERAPEUTICS INC COM 29664W905 1,450 370 SH Call DFND 1 0 370 0
ESPERION THERAPEUTICS INC COM 29664W955 27,386 6,988 SH Put DFND 1 0 6,988 0
EYENOVIA INC COM 30234E104 845 134,164 SH   DFND 1 0 134,164 0
FIBROGEN INC COM 31572Q808 657 10,492 SH   DFND 1 0 10,492 0
FIBROGEN INC COM 31572Q958 2,285 365 SH Put DFND 1 0 365 0
FUELCELL ENERGY INC COM 35952H502 40 30,140 SH   DFND 1 0 30,140 0
FUELCELL ENERGY INC COM 35952H952 695 5,268 SH Put DFND 1 0 5,268 0
GALECTIN THERAPEUTICS INC COM 363225202 89 14,029 SH   DFND 1 0 14,029 0
GALMED PHARMACEUTICALS LTD SHS M47238106 2,763 232,224 SH   DFND 1 0 232,224 0
GENPREX INC. COM 372446104 3,174 414,250 SH   DFND 1 0 414,250 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U908 3,779 836 SH Call DFND 1 0 836 0
HELIOS AND MATHESON ANALYTICS INC COM 42327L200 259 834,318 SH   DFND 1 0 834,318 0
HELIOS AND MATHESON ANALYTICS INC COM 42327L900 30 965 SH Call DFND 1 0 965 0
HELIOS AND MATHESON ANALYTICS INC COM 42327L950 8 246 SH Put DFND 1 0 246 0
HEMISPHERX BIOPHARMA INC COM 42366C301 620 1,938,374 SH   DFND 1 0 1,938,374 0
IMMUNOCELLULAR THERAPEUTICS *W 452536121 1 74,443 SH   DFND 1 0 74,443 0
INCYTE CORP COM 45337C102 2,775 41,419 SH   DFND 1 0 41,419 0
INCYTE CORP COM 45337C952 2,720 406 SH Put DFND 1 0 406 0
INPIXON COM 45790J305 273 1,685,814 SH   DFND 1 0 1,685,814 0
INSMED INC COM 457669307 421 17,800 SH   DFND 1 0 17,800 0
INSMED INC COM 457669957 3,928 1,661 SH Put DFND 1 0 1,661 0
INSPIREMD INC *W 45779A127 8 837,977 SH   DFND 1 0 837,977 0
INSPIREMD INC *W 45779A135 36 1,982,317 SH   DFND 1 0 1,982,317 0
INSPIREMD INC COM 45779A861 155 623,521 SH   DFND 1 0 623,521 0
INTERPACE DIAGNOSTICS GROUP INC COM 46062X204 830 932,954 SH   DFND 1 0 932,954 0
INVIVO THERAPEUTICS HLDGS CORP COM 46186M407 288 169,661 SH   DFND 1 0 169,661 0
ISHARES RUSSELL 2000 ETF 464287905 61,414 3,750 SH Call DFND 1 0 3,750 0
KEZAR LIFE SCIENCES INC COM 49372L100 735 42,507 SH   DFND 1 0 42,507 0
MADRIGAL PHARMACEUTICALS INC COM 558868905 2,238 80 SH Call DFND 1 0 80 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,023 75,800 SH   DFND 1 0 75,800 0
MANNKIND CORP COM 56400P956 1,458 4,550 SH Put DFND 1 0 4,550 0
MARINUS PHARMACEUTICALS INC COM 56854Q901 896 1,268 SH Call DFND 1 0 1,268 0
MICROBOT MED COM 59503A105 366 494,686 SH   DFND 1 0 494,686 0
NEKTAR THERAPEUTICS COM 640268108 11,813 241,922 SH   DFND 1 0 241,922 0
NEKTAR THERAPEUTICS COM 640268908 3,193 654 SH Call DFND 1 0 654 0
NEKTAR THERAPEUTICS COM 640268958 14,537 2,977 SH Put DFND 1 0 2,977 0
NEUROMETRIX INC COM 641255708 451 343,947 SH   DFND 1 0 343,947 0
NOVAN INC COM 66988N106 1,361 462,898 SH   DFND 1 0 462,898 0
NOVO NORDISK A/S ADR 670100205 19,802 429,355 SH   DFND 1 0 429,355 0
NOVO NORDISK A/S ADR 670100905 18,319 3,972 SH Call DFND 1 0 3,972 0
NOVO NORDISK A/S ADR 670100955 28,691 6,221 SH Put DFND 1 0 6,221 0
ODONATE THERAPEUTICS INC COM 676079106 12,775 578,599 SH   DFND 1 0 578,599 0
ONCOBIOLOGICS INC COM 68235M105 3,120 3,692,737 SH   DFND 1 0 3,692,737 0
ONCONOVA THERAPEUTICS COM 68232V306 26 63,218 SH   DFND 1 0 63,218 0
ONCONOVA THERAPEUTICS *W 68232V116 8 654,019 SH   DFND 1 0 654,019 0
OPGEN INC COM NEW COM 68373L208 431 242,257 SH   DFND 1 0 242,257 0
OPHTHOTECH CORP COM 683745103 3,577 1,310,078 SH   DFND 1 0 1,310,078 0
OPHTHOTECH CORP COM 683745903 332 1,217 SH Call DFND 1 0 1,217 0
OPHTHOTECH CORP COM 683745953 36 133 SH Put DFND 1 0 133 0
OVASCIENCE INC COM 69014Q101 866 954,505 SH   DFND 1 0 954,505 0
PAVMED INC *W 70387R122 704 2,128,700 SH   DFND 1 0 2,128,700 0
PAVMED INC COM 70387R106 1,329 1,398,850 SH   DFND 1 0 1,398,850 0
PLURISTEM THERAPEUTICS INC COM 72940R952 35 288 SH Put DFND 1 0 288 0
RESHAPE LIFESCIENCES INC COM 761123405 542 235,498 SH   DFND 1 0 235,498 0
ROSETTA GENOMICS LTD SHS M82183209 19 941,693 SH   DFND 1 0 941,693 0
RXI PHARMACEUTICALS *W 74979C121 49 196,222 SH   DFND 1 0 196,222 0
RXI PHARMACEUTICALS COM 74979C808 325 168,462 SH   DFND 1 0 168,462 0
SANGAMO THERAPEUTICS INC COM 800677106 2,389 168,239 SH   DFND 1 0 168,239 0
SANGAMO THERAPEUTICS INC COM 800677906 1,247 878 SH Call DFND 1 0 878 0
SANGAMO THERAPEUTICS INC COM 800677956 5,027 3,540 SH Put DFND 1 0 3,540 0
SAREPTA THERAPEUTICS INC COM 803607900 27,983 2,117 SH Call DFND 1 0 2,117 0
SAREPTA THERAPEUTICS INC COM 803607950 12,002 908 SH Put DFND 1 0 908 0
SESEN BIO INC COM 817763955 196 1,003 SH Put DFND 1 0 1,003 0
SIGMA LABS *W 826598112 100 284,329 SH   DFND 1 0 284,329 0
SOLENO THERAPEUTICS INC COM 834203200 1,839 785,955 SH   DFND 1 0 785,955 0
SOPHIRIS BIO INC COM 83578Q959 50 1,519 SH Put DFND 1 0 1,519 0
SPARK THERAPEUTICS INC COM 84652J903 4,527 547 SH Call DFND 1 0 547 0
SPARK THERAPEUTICS INC COM 84652J953 1,324 160 SH Put DFND 1 0 160 0
SPDR S&P 500 TR 78462F903 54,229 1,999 SH Call DFND 1 0 1,999 0
SPDR S&P 500 TR 78462F953 65,107 2,400 SH Put DFND 1 0 2,400 0
SPDR S&P BIOTECH TR 78464A900 13,603 1,429 SH Call DFND 1 0 1,429 0
SPDR S&P BIOTECH TR 78464A950 4,760 500 SH Put DFND 1 0 500 0
STRATA SKIN SCIENCES INC COM 86272A206 3,449 1,682,279 SH   DFND 1 0 1,682,279 0
SUNESIS PHARMACEUTICALS INC COM 867328700 1,086 512,036 SH   DFND 1 0 512,036 0
SUNESIS PHARMACEUTICALS INC COM 867328900 488 2,302 SH Call DFND 1 0 2,302 0
SUPERCONDUCTOR TECHNOLOGIES COM 867931503 21 22,748 SH   DFND 1 0 22,748 0
SYNERGY PHARMACEUTICALS INC COM 871639908 914 5,254 SH Call DFND 1 0 5,254 0
TESARO INC COM 881569907 1,472 331 SH Call DFND 1 0 331 0
TRANSLATE BIO INC COM 89374L104 152 12,000 SH   DFND 1 0 12,000 0
TROVAGENE INC COM 897238408 578 750,550 SH   DFND 1 0 750,550 0
UNUM THERAPEUTICS INC COM 903214104 8,342 581,303 SH   DFND 1 0 581,303 0
VASCULAR BIOGENICS LTD COM M96883109 4,084 1,856,169 SH   DFND 1 0 1,856,169 0
VERSARTIS INC COM 92529L102 447 220,600 SH   DFND 1 0 220,600 0
VIKING THERAPEUTICS INC COM 92686J906 1,038 1,094 SH Call DFND 1 0 1,094 0
XERIS PARMACEUTICALS INC COM 98422L107 8,497 447,686 SH   DFND 1 0 447,686 0
YIELD10 BIOSCIENCE INC COM 98585K201 67 47,740 SH   DFND 1 0 47,740 0
ZOGENIX INC COM 98978L904 7,616 1,723 SH Call DFND 1 0 1,723 0
ZOGENIX INC COM 98978L954 561 127 SH Put DFND 1 0 127 0
ZOSANO PHARMA COM 98979H202 2,043 500,700 SH   DFND 1 0 500,700 0