The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABORATORIES COM 002824900 2,347 555 SH Call DFND 1 0 555 0
ABBOTT LABORATORIES COM 002824100 4,774 112,888 SH   DFND 1 0 112,888 0
ABBOTT LABORATORIES COM 002824950 21,145 5,000 SH Put DFND 1 0 5,000 0
ABBVIE INC COM 00287Y959 7,430 1,178 SH Put DFND 1 0 1,178 0
ABBVIE INC COM 00287Y909 26,086 4,136 SH Call DFND 1 0 4,136 0
ACADIA PHARMACEUTICALS INC COM 00404A959 1,743 548 SH Put DFND 1 0 548 0
ACADIA PHARMACEUTICALS INC COM 00404A909 24,761 7,784 SH Call DFND 1 0 7,784 0
ACHILLION PHARMACEUTICALS INC COM 00448Q951 1,362 1,681 SH Put DFND 1 0 1,681 0
ACHILLION PHARMACEUTICALS INC COM 00448Q901 7,322 9,039 SH Call DFND 1 0 9,039 0
ACORDA THERAPEUTICS INC COM 00484M906 374 179 SH Call DFND 1 0 179 0
ACORDA THERAPEUTICS INC COM 00484M956 1,176 563 SH Put DFND 1 0 563 0
ACORDA THERAPEUTICS INC 15 JUN 21 1.75% NOTE 00484MAA4 4,160 5,100,000 PRN   DFND 1 0 5,100,000 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 1,867 1,382,629 SH   DFND 1 0 1,382,629 0
ACURA PHARMACEUTICALS INC COM 00509L802 565 352,835 SH   DFND 1 0 352,835 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 463 28,200 SH   DFND 1 0 28,200 0
ADAMIS PHARMACEUTICALS CORP COM 00547W958 51 148 SH Put DFND 1 0 148 0
ADVERUM BIOTECHNOLOGIES COM 00773U108 1,655 402,603 SH   DFND 1 0 402,603 0
AERIE PHARMACEUTICALS INC COM 00771V908 4,453 1,180 SH Call DFND 1 0 1,180 0
AETERNA ZENTARIS INC COM 007975402 230 66,982 SH   DFND 1 0 66,982 0
AETERNA ZENTARIS INC COM 007975952 254 740 SH Put DFND 1 0 740 0
AGENUS INC COM 00847G955 1,795 2,500 SH Put DFND 1 0 2,500 0
AGIOS PHARMACEUTICALS INC COM 00847X904 21,698 4,108 SH Call DFND 1 0 4,108 0
AKARI THERAPEUTICS PLC ADR 00972G108 148 17,428 SH   DFND 1 0 17,428 0
ALCOBRA LTD SHS M2239P109 42 17,058 SH   DFND 1 0 17,058 0
ALCOBRA LTD SHS M2239P959 138 559 SH Put DFND 1 0 559 0
ALCOBRA LTD SHS M2239P909 1,192 4,826 SH Call DFND 1 0 4,826 0
ALKERMES PLC SHS G01767905 28,201 3,249 SH Call DFND 1 0 3,249 0
ALLIQUA BIOMEDICAL INC COM 019621200 1,031 1,321,726 SH   DFND 1 0 1,321,726 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q957 5,890 869 SH Put DFND 1 0 869 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q907 9,815 1,448 SH Call DFND 1 0 1,448 0
AMARIN CORPORATION PLC ADR 023111956 358 1,121 SH Put DFND 1 0 1,121 0
AMARIN CORPORATION PLC ADR 023111906 4,354 13,648 SH Call DFND 1 0 13,648 0
AMGEN INC COM 031162100 22,215 133,176 SH   DFND 1 0 133,176 0
AMGEN INC COM 031162900 42,853 2,569 SH Put DFND 1 0 2,569 0
AMICUS THERAPEUTICS INC COM 03152W959 1,689 2,282 SH Put DFND 1 0 2,282 0
AMICUS THERAPEUTICS INC COM 03152W909 7,128 9,632 SH Call DFND 1 0 9,632 0
AMPLIPHI BIOSCIENCES CORP COM 03211P202 782 521,378 SH   DFND 1 0 521,378 0
ANAVEX LIFE SCIENCES CORP COM 032797950 311 858 SH Put DFND 1 0 858 0
ANTHERA PHARMACEUTICALS INC COM 03674U201 297 94,201 SH   DFND 1 0 94,201 0
ANTHERA PHARMACEUTICALS INC COM 03674U901 668 2,121 SH Call DFND 1 0 2,121 0
ARBUTUS BIOPHARMA CORP COM 03879J900 670 1,949 SH Call DFND 1 0 1,949 0
ARBUTUS BIOPHARMA CORP COM 03879J100 3,022 878,531 SH   DFND 1 0 878,531 0
ASSEMBLY BIOSCIENCES INC COM 045396108 542 75,200 SH   DFND 1 0 75,200 0
ASTERIAS BIOTHERAPEUTICS INC COM 04624N907 85 200 SH Call DFND 1 0 200 0
ASTRAZENECA PLC COM 046353908 11,567 3,520 SH Call DFND 1 0 3,520 0
ATHERSYS INC COM 04744L106 190 89,139 SH   DFND 1 0 89,139 0
ATHERSYS INC COM 04744L956 101 476 SH Put DFND 1 0 476 0
AVEXIS ORD SHS COM 05366U100 412 10,000 SH   DFND 1 0 10,000 0
AXOVANT SCIENCES LTD COM G0750W104 1,304 93,109 SH   DFND 1 0 93,109 0
AXOVANT SCIENCES LTD COM G0750W904 6,552 4,680 SH Call DFND 1 0 4,680 0
BARCLAYS BANK PLC IPATH 06740Q260 2,215 65,000 SH   DFND 1 0 65,000 0
BENITEC BIOPHARMA LTD ADR 82053307 385 274,573 SH   DFND 1 0 274,573 0
BENITEC BIOPHARMA LTD *W 082053117 17 98,146 SH   DFND 1 0 98,146 0
BIO PATH HOLDINGS INC COM 09057N102 1,841 1,314,692 SH   DFND 1 0 1,314,692 0
BIOBLAST PHARMA LTD SHS M20156101 1,356 784,057 SH   DFND 1 0 784,057 0
BIOCRYST PHARMACEUTICALS INC COM 09058V903 1,140 2,584 SH Call DFND 1 0 2,584 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J906 478 1,770 SH Call DFND 1 0 1,770 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 1,863 689,900 SH   DFND 1 0 689,900 0
BIOGEN INC COM 09062X953 3,130 100 SH Put DFND 1 0 100 0
BIOGEN INC COM 09062X903 20,879 667 SH Call DFND 1 0 667 0
BIOPHARMX CORP COM 09072X101 363 654,462 SH   DFND 1 0 654,462 0
BLUEBIRD BIO INC COM 09609G900 9,354 1,380 SH Call DFND 1 0 1,380 0
BLUEPRINT MEDICINES CORP COM 09627Y959 564 190 SH Put DFND 1 0 190 0
BRAINSTORM CELL THERAPEUTICS COM 10501E201 1,062 444,500 SH   DFND 1 0 444,500 0
BRISTOL MYERS SQUIBB CO. COM 110122108 8,459 156,887 SH   DFND 1 0 156,887 0
BRISTOL MYERS SQUIBB CO. COM 110122958 18,705 3,469 SH Put DFND 1 0 3,469 0
BRISTOL MYERS SQUIBB CO. COM 110122908 29,165 5,409 SH Call DFND 1 0 5,409 0
CALITHERA BIOSCIENCES INC. COM 13089P101 1,055 324,500 SH   DFND 1 0 324,500 0
CANCER GENETICS INC COM 13739U104 191 109,048 SH   DFND 1 0 109,048 0
CAPNIA INC. COM 14066L105 236 245,737 SH   DFND 1 0 245,737 0
CAPRICOR THERAPEUTICS INC. COM 14070B101 1,183 357,436 SH   DFND 1 0 357,436 0
CARDIOME PHARMA CORP COM 14159U301 1,521 484,505 SH   DFND 1 0 484,505 0
CASCADIAN THERAPEUTICS INC. COM 14740B101 392 238,899 SH   DFND 1 0 238,899 0
CEL SCI CORP COM 150837508 1,029 3,372,642 SH   DFND 1 0 3,372,642 0
CELGENE CORP COM 151020104 3,944 37,728 SH   DFND 1 0 37,728 0
CELGENE CORP COM 151020954 25,244 2,415 SH Put DFND 1 0 2,415 0
CELGENE CORP COM 151020904 36,073 3,451 SH Call DFND 1 0 3,451 0
CELLECT BIOTECHNOLOGY LTD ADS 15116C102 264 57,348 SH   DFND 1 0 57,348 0
CELLECTAR BIOSCIENCES INC *W 15117F120 188 228,788 SH   DFND 1 0 228,788 0
CELSION CORP. COM 15117N404 1,091 894,406 SH   DFND 1 0 894,406 0
CEMPRA INC COM 15130J909 7,306 3,019 SH Call DFND 1 0 3,019 0
CEMPRA INC COM 15130J959 15,302 6,323 SH Put DFND 1 0 6,323 0
CHAMPIONS ONCOLOGY INC COM 15870P307 905 538,593 SH   DFND 1 0 538,593 0
CHECK CAP LTD SHS M2361E112 1,159 585,569 SH   DFND 1 0 585,569 0
CHIMERIX INC. COM 16934W106 443 79,900 SH   DFND 1 0 79,900 0
CIDARA THERAPEUTICS INC. COM 171757107 2,180 190,358 SH   DFND 1 0 190,358 0
CLOVIS ONCOLOGY INC COM 189464950 7,538 2,091 SH Put DFND 1 0 2,091 0
CLOVIS ONCOLOGY INC COM 189464900 21,089 5,850 SH Call DFND 1 0 5,850 0
COMBIMATRIX CORP. *W 20009T147 429 857,746 SH   DFND 1 0 857,746 0
COMMUNITY HEALTH SYSTEMS INC COM 203668108 359 31,122 SH   DFND 1 0 31,122 0
COMMUNITY HEALTH SYSTEMS INC COM 203668958 477 413 SH Put DFND 1 0 413 0
CYTORI THERAPEUTICS INC. *W 23283K121 1,547 895,017 SH   DFND 1 0 895,017 0
CYTORI THERAPEUTICS INC. COM 23283K204 3,579 1,762,846 SH   DFND 1 0 1,762,846 0
CYTRX CORP. COM 232828509 4,368 7,424,786 SH   DFND 1 0 7,424,786 0
DEPOMED INC COM 249908904 10,798 4,321 SH Call DFND 1 0 4,321 0
DERMIRA INC COM 24983L954 2,293 678 SH Put DFND 1 0 678 0
DERMIRA INC COM 24983L904 2,442 722 SH Call DFND 1 0 722 0
DEXCOM INC COM 252131907 7,065 806 SH Call DFND 1 0 806 0
DEXTERA SURGICAL INC COM 252366109 851 450,507 SH   DFND 1 0 450,507 0
DICERNA PHARMACEUTICALS INC COM 253031108 294 50,000 SH   DFND 1 0 50,000 0
DRAGONWAVE INC. COM 26144M400 1,018 378,338 SH   DFND 1 0 378,338 0
DURECT CORP COM 266605904 245 1,759 SH Call DFND 1 0 1,759 0
DURECT CORP COM 266605104 2,502 1,800,000 SH   DFND 1 0 1,800,000 0
DYNAVAX TECHNOLOGIES CORP COM 268158201 5,474 521,875 SH   DFND 1 0 521,875 0
DYNAVAX TECHNOLOGIES CORP COM 268158951 8,002 7,628 SH Put DFND 1 0 7,628 0
DYNAVAX TECHNOLOGIES CORP COM 268158901 10,473 9,984 SH Call DFND 1 0 9,984 0
EDAP TMS S A ADR 268311957 53 182 SH Put DFND 1 0 182 0
EDAP TMS S A ADR 268311107 1,583 545,918 SH   DFND 1 0 545,918 0
EDITAS MEDICINE INC. COM 28106W103 1,820 135,000 SH   DFND 1 0 135,000 0
EIGER BIOPHARMACEUTICALS INC. COM 28249U105 3,090 230,803 SH   DFND 1 0 230,803 0
ELI LILLY & CO COM 532457958 39,311 4,898 SH Put DFND 1 0 4,898 0
ELI LILLY & CO COM 532457908 235,539 29,347 SH Call DFND 1 0 29,347 0
ENDO INTERNATIONAL PLC SHS G30401106 1,194 59,237 SH   DFND 1 0 59,237 0
ENDO INTERNATIONAL PLC SHS G30401956 2,208 1,096 SH Put DFND 1 0 1,096 0
EVOKE PHARMA INC. COM 30049G104 144 63,768 SH   DFND 1 0 63,768 0
EXACT SCIENCES CORP COM 30063P955 2,137 1,153 SH Put DFND 1 0 1,153 0
EXELIXIS INC COM 30161Q904 2,468 1,930 SH Call DFND 1 0 1,930 0
EXELIXIS INC COM 30161Q954 6,896 5,392 SH Put DFND 1 0 5,392 0
EXPRESS SCRIPTS HOLDING CO COM 30219G958 11,927 1,691 SH Put DFND 1 0 1,691 0
EXPRESS SCRIPTS HOLDING CO COM 30219G908 20,433 2,897 SH Call DFND 1 0 2,897 0
EYEGATE PHARMACEUTICALS INC *W 30233M115 16 46,968 SH   DFND 1 0 46,968 0
EYEGATE PHARMACEUTICALS INC COM 30233M107 834 508,598 SH   DFND 1 0 508,598 0
FIBROGEN INC COM 31572Q908 339 164 SH Call DFND 1 0 164 0
FIBROGEN INC COM 31572Q808 1,504 72,669 SH   DFND 1 0 72,669 0
FLEXION THERAPEUTICS INC COM 33938J106 238 12,176 SH   DFND 1 0 12,176 0
FLEXION THERAPEUTICS INC COM 33938J956 395 202 SH Put DFND 1 0 202 0
FOAMIX PHARMACEUTICALS LTD SHS M46135905 670 724 SH Call DFND 1 0 724 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 1,866 201,564 SH   DFND 1 0 201,564 0
FORWARD PHARMA A/S ADR 34986J105 2,080 99,053 SH   DFND 1 0 99,053 0
GALECTIN THERAPEUTICS INC COM 363225952 93 825 SH Put DFND 1 0 825 0
GALECTIN THERAPEUTICS INC COM 363225202 99 87,999 SH   DFND 1 0 87,999 0
GALENA BIOPHARMA INC COM 363256108 49 141,000 SH   DFND 1 0 141,000 0
GALENA BIOPHARMA INC COM 363256958 57 1,624 SH Put DFND 1 0 1,624 0
GENVEC INC COM 37246C307 696 1,510,377 SH   DFND 1 0 1,510,377 0
GILEAD SCIENCES INC COM 375558953 6,100 771 SH Put DFND 1 0 771 0
GILEAD SCIENCES INC COM 375558903 92,499 11,691 SH Call DFND 1 0 11,691 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U908 1,662 721 SH Call DFND 1 0 721 0
GREAT PANTHER SILVER LTD COM 39115V101 55 40,450 SH   DFND 1 0 40,450 0
GW PHARMACEUTICALS PLC ADS 36197T953 2,548 192 SH Put DFND 1 0 192 0
GW PHARMACEUTICALS PLC ADS 36197T903 3,624 273 SH Call DFND 1 0 273 0
HALOZYME THERAPEUTICS INC COM 40637H909 5,920 4,901 SH Call DFND 1 0 4,901 0
HCA HOLDINGS INC COM 40412C951 2,390 316 SH Put DFND 1 0 316 0
HCA HOLDINGS INC COM 40412C901 58,084 7,680 SH Call DFND 1 0 7,680 0
HEMISPHERX BIOPHARMA INC. COM 42366C301 1,690 1,351,850 SH   DFND 1 0 1,351,850 0
HESS CORP COM 42809H907 11,040 2,059 SH Call DFND 1 0 2,059 0
HISTOGENICS CORP. COM 43358V109 151 47,823 SH   DFND 1 0 47,823 0
HORIZON PHARMA PLC COM G4617B955 839 463 SH Put DFND 1 0 463 0
HORIZON PHARMA PLC COM G4617B905 7,412 4,088 SH Call DFND 1 0 4,088 0
HUMANA INC COM 444859902 4,918 278 SH Call DFND 1 0 278 0
HUMANA INC COM 444859952 12,382 700 SH Put DFND 1 0 700 0
IGNYTA INC COM 451731103 1,421 225,900 SH   DFND 1 0 225,900 0
IMMUNOCELLULAR THERAPEUTICS COM 452536105 756 6,405,230 SH   DFND 1 0 6,405,230 0
IMMUNOCELLULAR THERAPEUTICS *W 452536113 1,077 15,161,641 SH   DFND 1 0 15,161,641 0
IMMUNOMEDICS INC. COM 452907108 966 297,310 SH   DFND 1 0 297,310 0
INCYTE CORP COM 45337C902 339 36 SH Call DFND 1 0 36 0
INFINITY PHARMACEUTICALS INC COM 45665G903 26 167 SH Call DFND 1 0 167 0
INOTEK PHARMACEUTICALS CORP COM 45780V902 100 106 SH Call DFND 1 0 106 0
INOTEK PHARMACEUTICALS CORP COM 45780V952 474 500 SH Put DFND 1 0 500 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 1,365 144,002 SH   DFND 1 0 144,002 0
INSMED INC COM 457669957 1,811 1,247 SH Put DFND 1 0 1,247 0
INSMED INC COM 457669907 2,118 1,459 SH Call DFND 1 0 1,459 0
INSPIREMD INC COM 45779A507 54 679,224 SH   DFND 1 0 679,224 0
INSPIREMD INC *W 45779A119 888 29,594,500 SH   DFND 1 0 29,594,500 0
INTEC PHARMA LTD. COM M53644106 2,898 498,006 SH   DFND 1 0 498,006 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,784 104,841 SH   DFND 1 0 104,841 0
INTRA CELLULAR THERAPIES INC COM 46116X951 226 148 SH Put DFND 1 0 148 0
INTRA CELLULAR THERAPIES INC COM 46116X101 226 14,800 SH   DFND 1 0 14,800 0
INTRA CELLULAR THERAPIES INC COM 46116X901 812 533 SH Call DFND 1 0 533 0
INVIVO THERAPEUTICS HOLDINGS CORP COM 46186M909 135 199 SH Call DFND 1 0 199 0
IONIS PHARMACEUTICALS INC COM 462222950 2,700 737 SH Put DFND 1 0 737 0
IONIS PHARMACEUTICALS INC COM 462222900 7,955 2,171 SH Call DFND 1 0 2,171 0
ISHARES RUSSELL 2000 ETF 464287905 67,583 5,441 SH Call DFND 1 0 5,441 0
ISHARES RUSSELL 2000 ETF 464287955 184,973 14,892 SH Put DFND 1 0 14,892 0
JUNO THERAPEUTICS INC COM 48205A909 309 103 SH Call DFND 1 0 103 0
KITE PHARMA INC COM 49803L909 6,044 1,082 SH Call DFND 1 0 1,082 0
KITE PHARMA INC COM 49803L959 6,575 1,177 SH Put DFND 1 0 1,177 0
LA JOLLA PHARMACEUTICAL CO COM 503459604 2,878 120,964 SH   DFND 1 0 120,964 0
LA JOLLA PHARMACEUTICAL CO COM 503459904 4,910 2,064 SH Call DFND 1 0 2,064 0
LEXICON PHARMACEUTICALS INC COM 528872952 1,084 600 SH Put DFND 1 0 600 0
LEXICON PHARMACEUTICALS INC COM 528872902 11,317 6,263 SH Call DFND 1 0 6,263 0
LION BIOTECHNOLOGIES INC COM 53619R902 408 496 SH Call DFND 1 0 496 0
LION BIOTECHNOLOGIES INC COM 53619R102 2,027 246,342 SH   DFND 1 0 246,342 0
LION BIOTECHNOLOGIES INC COM 53619R952 6,503 7,901 SH Put DFND 1 0 7,901 0
MANNKIND CORP COM 56400P201 1,107 1,785,368 SH   DFND 1 0 1,785,368 0
MANNKIND CORP COM 56400P951 3,863 62,303 SH Put DFND 1 0 62,303 0
MEDGENICS INC COM 58436Q903 297 533 SH Call DFND 1 0 533 0
MEDGENICS INC COM 58436Q203 791 141,977 SH   DFND 1 0 141,977 0
MEDICINES CO COM 584688955 377 100 SH Put DFND 1 0 100 0
MEDICINES CO COM 584688105 510 13,508 SH   DFND 1 0 13,508 0
MEDICINES CO COM 584688905 4,340 1,150 SH Call DFND 1 0 1,150 0
MEDIGUS LTD COM 58471G102 1,373 1,042,813 SH   DFND 1 0 1,042,813 0
MERCK & CO INC COM 58933Y905 28,003 4,487 SH Call DFND 1 0 4,487 0
MIRATI THERAPEUTICS INC. COM 60468T105 659 99,735 SH   DFND 1 0 99,735 0
MOMENTA PHARMACEUTICALS INC COM 60877T900 321 275 SH Call DFND 1 0 275 0
MONSANTO CO COM 61166W901 57,304 5,607 SH Call DFND 1 0 5,607 0
MYLAN N.V. SHS N59465909 10,689 2,804 SH Call DFND 1 0 2,804 0
NATERA INC COM 632307904 161 145 SH Call DFND 1 0 145 0
NEURALSTEM INC. COM 64127R302 892 2,787,745 SH   DFND 1 0 2,787,745 0
NEUROCRINE BIOSCIENCES INC COM 64125C909 6,148 1,214 SH Call DFND 1 0 1,214 0
NEUROMETRIX INC COM 641255500 338 219,336 SH   DFND 1 0 219,336 0
NEUROMETRIX INC *W 641255153 400 3,060,947 SH   DFND 1 0 3,060,947 0
NEVRO CORP COM 64157F903 1,681 161 SH Call DFND 1 0 161 0
NEWLINK GENETICS CORP COM 651511957 150 100 SH Put DFND 1 0 100 0
NEWLINK GENETICS CORP COM 651511107 519 34,561 SH   DFND 1 0 34,561 0
NEWLINK GENETICS CORP COM 651511907 4,336 2,887 SH Call DFND 1 0 2,887 0
NIVALIS THERAPEUTICS INC COM 65481J109 2,176 267,650 SH   DFND 1 0 267,650 0
NOVAVAX INC COM 670002954 176 844 SH Put DFND 1 0 844 0
NOVAVAX INC COM 670002904 457 2,195 SH Call DFND 1 0 2,195 0
NOVO NORDISK A/S ADR 670100955 3,573 859 SH Put DFND 1 0 859 0
OCERA THERAPEUTICS INC COM 67552A108 1,060 400,035 SH   DFND 1 0 400,035 0
OCULAR THERAPEUTIX INC COM 67576A100 262 38,100 SH   DFND 1 0 38,100 0
ONCOBIOLOGICS INC *W 68235M113 905 902,050 SH   DFND 1 0 902,050 0
ONCOBIOLOGICS INC *W 68235M121 1,332 926,651 SH   DFND 1 0 926,651 0
ONCOBIOLOGICS INC COM 68235M105 9,643 2,268,585 SH   DFND 1 0 2,268,858 0
ONCONOVA THERAPEUTICS INC COM 68232V306 1,039 392,023 SH   DFND 1 0 392,023 0
ONCONOVA THERAPEUTICS INC *W 68232V116 1,124 725,434 SH   DFND 1 0 725,434 0
ONCOSEC MEDICAL INC COM 68234L207 1,426 834,004 SH   DFND 1 0 834,004 0
OPGEN INC. COM 68373L109 3,545 2,161,467 SH   DFND 1 0 2,161,467 0
OPHTHOTECH CORP COM 683745903 6,998 1,517 SH Call DFND 1 0 1,517 0
OPKO HEALTH INC COM 68375N953 2,147 2,027 SH Put DFND 1 0 2,027 0
OPKO HEALTH INC COM 68375N903 2,638 2,491 SH Call DFND 1 0 2,491 0
OVASCIENCE INC COM 69014Q101 358 50,000 SH   DFND 1 0 50,000 0
PACIRA PHARMACEUTICALS INC COM 695127950 544 159 SH Put DFND 1 0 159 0
PACIRA PHARMACEUTICALS INC COM 695127900 1,057 309 SH Call DFND 1 0 309 0
PARATEK PHARMACEUTICALS INC COM 699374302 2,277 175,000 SH   DFND 1 0 175,000 0
PARNELL PHARMACEUTICALS HOLDINGS LTD SHS Q73622104 532 369,700 SH   DFND 1 0 369,700 0
PIERIS PHARMACEUTICALS INC COM 720795103 2,824 1,543,307 SH   DFND 1 0 1,543,307 0
PORTOLA PHARMACEUTICALS INC COM 737010908 681 300 SH Call DFND 1 0 300 0
PRONAI THERAPEUTICS INC. COM 74346L101 1,252 687,734 SH   DFND 1 0 687,734 0
PROQR THERAPEUTICS N V COM N71542109 393 58,910 SH   DFND 1 0 58,910 0
PROTHENA CORPORATION PLC SHS G72800990 1,949 325 SH Call DFND 1 0 325 0
PROVECTUS BIOPHARMACEUTICALS INC COM 74373P108 107 1,077,555 SH   DFND 1 0 1,077,555 0
PSIVIDA CORP COM 74440J101 587 195,100 SH   DFND 1 0 195,100 0
PTC THERAPEUTICS INC COM 69366J900 5,589 3,989 SH Call DFND 1 0 3,989 0
PUMA BIOTECHNOLOGY INC COM 74587V957 4,311 643 SH Put DFND 1 0 643 0
PUMA BIOTECHNOLOGY INC COM 74587V907 13,551 2,021 SH Call DFND 1 0 2,021 0
QUEST RESOURCE HOLDING CORP COM 74836W203 281 138,980 SH   DFND 1 0 138,980 0
RADIUS HEALTH INC COM 750469957 763 141 SH Put DFND 1 0 141 0
RADIUS HEALTH INC COM 750469907 1,055 195 SH Call DFND 1 0 195 0
REDHILL BIOPHARMA LTD ADS 757468103 888 63,800 SH   DFND 1 0 63,800 0
REGENERON PHARMACEUTICALS INC COM 75886F907 2,533 63 SH Call DFND 1 0 63 0
REGENERON PHARMACEUTICALS INC COM 75886F107 30,521 75,919 SH   DFND 1 0 75,919 0
REGENERON PHARMACEUTICALS INC COM 75886F957 72,042 1,792 SH Put DFND 1 0 1,792 0
REGENXBIO ORD SHS COM 75901B107 3,687 263,177 SH   DFND 1 0 263,177 0
REGULUS THERAPEUTIC INC COM 75915K901 3,630 11,000 SH Call DFND 1 0 11,000 0
RENNOVA HEALTH INC *W 759757123 258 3,682,014 SH   DFND 1 0 3,682,014 0
RENNOVA HEALTH INC COM 759757107 516 2,724,721 SH   DFND 1 0 2,724,721 0
RETROPHIN INC COM 761299956 897 401 SH Put DFND 1 0 401 0
RETROPHIN INC COM 761299906 14,084 6,293 SH Call DFND 1 0 6,293 0
REXAHN PHARMACEUTICALS INC COM 761640101 1,988 9,464,849 SH   DFND 1 0 9,464,849 0
RICEBRAN TECHNOLOGIES COM 762831204 1,073 794,436 SH   DFND 1 0 794,436 0
RIGEL PHARMACEUTICALS INC COM 766559903 116 316 SH Call DFND 1 0 316 0
RIGEL PHARMACEUTICALS INC COM 766559603 319 86,900 SH   DFND 1 0 86,900 0
SAGE THERAPEUTICS INC COM 78667J958 1,220 265 SH Put DFND 1 0 265 0
SAGE THERAPEUTICS INC COM 78667J908 5,365 1,165 SH Call DFND 1 0 1,165 0
SANGAMO BIOSCIENCES INC COM 800677106 152 32,804 SH   DFND 1 0 32,804 0
SANGAMO BIOSCIENCES INC COM 800677906 2,598 5,611 SH Call DFND 1 0 5,611 0
SAREPTA THERAPEUTICS INC COM 803607900 21,653 3,526 SH Call DFND 1 0 3,526 0
SAREPTA THERAPEUTICS INC COM 803607100 32,933 536,282 SH   DFND 1 0 536,282 0
SAREPTA THERAPEUTICS INC COM 803607950 164,259 26,748 SH Put DFND 1 0 26,748 0
SHIRE PLC COM 82481R106 6,043 31,172 SH   DFND 1 0 31,172 0
SHIRE PLC COM 82481R906 13,531 698 SH Call DFND 1 0 698 0
SHIRE PLC COM 82481R956 13,531 698 SH Put DFND 1 0 698 0
SOPHIRIS BIO INC. COM 83578Q209 2,354 757,033 SH   DFND 1 0 757,033 0
SORRENTO THERAPEUTICS INC COM 83587F902 127 164 SH Call DFND 1 0 164 0
SORRENTO THERAPEUTICS INC COM 83587F202 162 20,986 SH   DFND 1 0 20,986 0
SPDR S&P 500 ETF TRUST UNIT 78462F903 216,300 10,000 SH Call DFND 1 0 10,000 0
SPDR S&P 500 ETF TRUST UNIT 78462F953 302,820 14,000 SH Put DFND 1 0 14,000 0
SPDR SERIES TRUST UNIT 78464A950 12,980 1,958 SH Put DFND 1 0 1,958 0
STEMLINE THERAPEUTICS INC COM 85858C907 240 222 SH Call DFND 1 0 222 0
STEMLINE THERAPEUTICS INC COM 85858C107 1,062 98,050 SH   DFND 1 0 98,050 0
STRATA SKIN SCIENCES INC COM 86272A107 510 1,000,790 SH   DFND 1 0 1,000,790 0
SUNSHINE HEART INC. COM 86782U106 518 908,021 SH   DFND 1 0 908,021 0
SUPERCONDUCTOR TECHNOLOGIES INC. COM 867931503 669 250,474 SH   DFND 1 0 250,474 0
SYNERGY PHARMACEUTICALS INC. *W 871639118 268 348,743 SH   DFND 1 0 348,743 0
SYNERGY PHARMACEUTICALS INC. COM 871639958 2,117 3,842 SH Put DFND 1 0 3,842 0
SYNERGY PHARMACEUTICALS INC. COM 871639908 4,360 7,912 SH Call DFND 1 0 7,912 0
TENAX THERAPEUTICS INC COM 88032L950 39 169 SH Put DFND 1 0 169 0
TENAX THERAPEUTICS INC COM 88032L900 583 2,534 SH Call DFND 1 0 2,534 0
TENAX THERAPEUTICS INC COM 88032L100 5,550 2,412,857 SH   DFND 1 0 2,412,857 0
TENET HEALTHCARE CORP COM 88033G407 2,557 112,831 SH   DFND 1 0 112,831 0
TENET HEALTHCARE CORP COM 88033G957 3,952 1,744 SH Put DFND 1 0 1,744 0
TENET HEALTHCARE CORP COM 88033G907 7,204 3,179 SH Call DFND 1 0 3,179 0
TESARO INC COM 881569957 501 50 SH Put DFND 1 0 50 0
TESARO INC COM 881569107 2,757 27,500 SH   DFND 1 0 27,500 0
TESARO INC COM 881569907 3,338 333 SH Call DFND 1 0 333 0
THERAPEUTICSMD INC COM 88338N107 232 34,030 SH   DFND 1 0 34,030 0
THERAPEUTICSMD INC COM 88338N957 399 586 SH Put DFND 1 0 586 0
THERAPEUTICSMD INC COM 88338N907 1,301 1,910 SH Call DFND 1 0 1,910 0
TOKAI PHARMACEUTICALS INC. COM 88907J107 492 321,600 SH   DFND 1 0 321,600 0
TONIX PHARMACEUTICALS HOLDING CORP. COM 890260201 142 203,097 SH   DFND 1 0 203,097 0
UNITED THERAPEUTICS CORP COM 91307C102 3,319 28,112 SH   DFND 1 0 28,112 0
UNITED THERAPEUTICS CORP COM 91307C952 12,965 1,098 SH Put DFND 1 0 1,098 0
VANDA PHARMACEUTICALS INC COM 921659908 2,075 1,247 SH Call DFND 1 0 1,247 0
VERSARTIS INC. COM 92529L102 2,143 174,968 SH   DFND 1 0 174,968 0
VERTEX PHARMACEUTICALS INC COM 92532F950 2,267 260 SH Put DFND 1 0 260 0
VERTEX PHARMACEUTICALS INC COM 92532F900 17,050 1,955 SH Call DFND 1 0 1,955 0
VIKING THERAPEUTICS INC *W 92686J114 53 117,008 SH   DFND 1 0 117,008 0
VISTAGEN THERAPEUTICS INC COM 92840H202 1,452 349,096 SH   DFND 1 0 349,096 0
VTV THERAPEUTICS INC CL A 918385105 969 134,747 SH   DFND 1 0 134,747 0
WAFERGEN BIO SYSTEMS INC. COM 93041P308 1,520 1,578,616 SH   DFND 1 0 1,578,616 0
WINDTREE THERAPEUTICS INC. COM 97382D105 797 310,000 SH   DFND 1 0 310,000 0
XTL BIOPHARMACEUTICALS LTD ADR 98386D208 714 751,289 SH   DFND 1 0 751,289 0
ZAFGEN INC COM 98885E903 15 2,149 SH Call DFND 1 0 2,149 0
ZOGENIX INC COM 98978L204 1,715 150,000 SH   DFND 1 0 150,000 0
ZOGENIX INC COM 98978L904 3,265 1,228 SH Call DFND 1 0 1,228 0
ZOSANO PHARMA CORP. COM 98979H103 82 103,600 SH   DFND 1 0 103,600 0