0001144204-16-133740.txt : 20161114
0001144204-16-133740.hdr.sgml : 20161111
20161114093706
ACCESSION NUMBER: 0001144204-16-133740
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20160930
FILED AS OF DATE: 20161114
DATE AS OF CHANGE: 20161114
EFFECTIVENESS DATE: 20161114
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SABBY MANAGEMENT, LLC
CENTRAL INDEX KEY: 0001535610
IRS NUMBER: 000000000
STATE OF INCORPORATION: DE
FISCAL YEAR END: 1231
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15245
FILM NUMBER: 161991288
BUSINESS ADDRESS:
STREET 1: 10 MOUNTAINVIEW ROAD
STREET 2: SUITE 205
CITY: UPPER SADDLE RIVER
STATE: NJ
ZIP: 07458
BUSINESS PHONE: 646-307-4527
MAIL ADDRESS:
STREET 1: 10 MOUNTAINVIEW ROAD
STREET 2: SUITE 205
CITY: UPPER SADDLE RIVER
STATE: NJ
ZIP: 07458
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001535610
XXXXXXXX
09-30-2016
09-30-2016
false
SABBY MANAGEMENT, LLC
10 Mountainview Road
Suite 205
Upper Saddle River
NJ
07458
13F HOLDINGS REPORT
028-15245
N
Robert Grundstein
Chief Operating Officer
646-307-4527
/s/ Robert Grundstein
Upper Saddle River
NJ
11-14-2016
1
307
2669231
01
0001433766
028-13502
Mintz Hal
INFORMATION TABLE
2
infotable.xml
ABBOTT LABORATORIES
COM
002824900
2347
555
SH
Call
DFND
1
0
555
0
ABBOTT LABORATORIES
COM
002824100
4774
112888
SH
DFND
1
0
112888
0
ABBOTT LABORATORIES
COM
002824950
21145
5000
SH
Put
DFND
1
0
5000
0
ABBVIE INC
COM
00287Y959
7430
1178
SH
Put
DFND
1
0
1178
0
ABBVIE INC
COM
00287Y909
26086
4136
SH
Call
DFND
1
0
4136
0
ACADIA PHARMACEUTICALS INC
COM
00404A959
1743
548
SH
Put
DFND
1
0
548
0
ACADIA PHARMACEUTICALS INC
COM
00404A909
24761
7784
SH
Call
DFND
1
0
7784
0
ACHILLION PHARMACEUTICALS INC
COM
00448Q951
1362
1681
SH
Put
DFND
1
0
1681
0
ACHILLION PHARMACEUTICALS INC
COM
00448Q901
7322
9039
SH
Call
DFND
1
0
9039
0
ACORDA THERAPEUTICS INC
COM
00484M906
374
179
SH
Call
DFND
1
0
179
0
ACORDA THERAPEUTICS INC
COM
00484M956
1176
563
SH
Put
DFND
1
0
563
0
ACORDA THERAPEUTICS INC 15 JUN 21 1.75%
NOTE
00484MAA4
4160
5100000
PRN
DFND
1
0
5100000
0
ACTINIUM PHARMACEUTICALS INC
COM
00507W107
1867
1382629
SH
DFND
1
0
1382629
0
ACURA PHARMACEUTICALS INC
COM
00509L802
565
352835
SH
DFND
1
0
352835
0
ADAMAS PHARMACEUTICALS INC
COM
00548A106
463
28200
SH
DFND
1
0
28200
0
ADAMIS PHARMACEUTICALS CORP
COM
00547W958
51
148
SH
Put
DFND
1
0
148
0
ADVERUM BIOTECHNOLOGIES
COM
00773U108
1655
402603
SH
DFND
1
0
402603
0
AERIE PHARMACEUTICALS INC
COM
00771V908
4453
1180
SH
Call
DFND
1
0
1180
0
AETERNA ZENTARIS INC
COM
007975402
230
66982
SH
DFND
1
0
66982
0
AETERNA ZENTARIS INC
COM
007975952
254
740
SH
Put
DFND
1
0
740
0
AGENUS INC
COM
00847G955
1795
2500
SH
Put
DFND
1
0
2500
0
AGIOS PHARMACEUTICALS INC
COM
00847X904
21698
4108
SH
Call
DFND
1
0
4108
0
AKARI THERAPEUTICS PLC
ADR
00972G108
148
17428
SH
DFND
1
0
17428
0
ALCOBRA LTD
SHS
M2239P109
42
17058
SH
DFND
1
0
17058
0
ALCOBRA LTD
SHS
M2239P959
138
559
SH
Put
DFND
1
0
559
0
ALCOBRA LTD
SHS
M2239P909
1192
4826
SH
Call
DFND
1
0
4826
0
ALKERMES PLC
SHS
G01767905
28201
3249
SH
Call
DFND
1
0
3249
0
ALLIQUA BIOMEDICAL INC
COM
019621200
1031
1321726
SH
DFND
1
0
1321726
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q957
5890
869
SH
Put
DFND
1
0
869
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q907
9815
1448
SH
Call
DFND
1
0
1448
0
AMARIN CORPORATION PLC
ADR
023111956
358
1121
SH
Put
DFND
1
0
1121
0
AMARIN CORPORATION PLC
ADR
023111906
4354
13648
SH
Call
DFND
1
0
13648
0
AMGEN INC
COM
031162100
22215
133176
SH
DFND
1
0
133176
0
AMGEN INC
COM
031162900
42853
2569
SH
Put
DFND
1
0
2569
0
AMICUS THERAPEUTICS INC
COM
03152W959
1689
2282
SH
Put
DFND
1
0
2282
0
AMICUS THERAPEUTICS INC
COM
03152W909
7128
9632
SH
Call
DFND
1
0
9632
0
AMPLIPHI BIOSCIENCES CORP
COM
03211P202
782
521378
SH
DFND
1
0
521378
0
ANAVEX LIFE SCIENCES CORP
COM
032797950
311
858
SH
Put
DFND
1
0
858
0
ANTHERA PHARMACEUTICALS INC
COM
03674U201
297
94201
SH
DFND
1
0
94201
0
ANTHERA PHARMACEUTICALS INC
COM
03674U901
668
2121
SH
Call
DFND
1
0
2121
0
ARBUTUS BIOPHARMA CORP
COM
03879J900
670
1949
SH
Call
DFND
1
0
1949
0
ARBUTUS BIOPHARMA CORP
COM
03879J100
3022
878531
SH
DFND
1
0
878531
0
ASSEMBLY BIOSCIENCES INC
COM
045396108
542
75200
SH
DFND
1
0
75200
0
ASTERIAS BIOTHERAPEUTICS INC
COM
04624N907
85
200
SH
Call
DFND
1
0
200
0
ASTRAZENECA PLC
COM
046353908
11567
3520
SH
Call
DFND
1
0
3520
0
ATHERSYS INC
COM
04744L106
190
89139
SH
DFND
1
0
89139
0
ATHERSYS INC
COM
04744L956
101
476
SH
Put
DFND
1
0
476
0
AVEXIS ORD SHS
COM
05366U100
412
10000
SH
DFND
1
0
10000
0
AXOVANT SCIENCES LTD
COM
G0750W104
1304
93109
SH
DFND
1
0
93109
0
AXOVANT SCIENCES LTD
COM
G0750W904
6552
4680
SH
Call
DFND
1
0
4680
0
BARCLAYS BANK PLC
IPATH
06740Q260
2215
65000
SH
DFND
1
0
65000
0
BENITEC BIOPHARMA LTD
ADR
82053307
385
274573
SH
DFND
1
0
274573
0
BENITEC BIOPHARMA LTD
*W
082053117
17
98146
SH
DFND
1
0
98146
0
BIO PATH HOLDINGS INC
COM
09057N102
1841
1314692
SH
DFND
1
0
1314692
0
BIOBLAST PHARMA LTD
SHS
M20156101
1356
784057
SH
DFND
1
0
784057
0
BIOCRYST PHARMACEUTICALS INC
COM
09058V903
1140
2584
SH
Call
DFND
1
0
2584
0
BIODELIVERY SCIENCES INTERNATIONAL INC
COM
09060J906
478
1770
SH
Call
DFND
1
0
1770
0
BIODELIVERY SCIENCES INTERNATIONAL INC
COM
09060J106
1863
689900
SH
DFND
1
0
689900
0
BIOGEN INC
COM
09062X953
3130
100
SH
Put
DFND
1
0
100
0
BIOGEN INC
COM
09062X903
20879
667
SH
Call
DFND
1
0
667
0
BIOPHARMX CORP
COM
09072X101
363
654462
SH
DFND
1
0
654462
0
BLUEBIRD BIO INC
COM
09609G900
9354
1380
SH
Call
DFND
1
0
1380
0
BLUEPRINT MEDICINES CORP
COM
09627Y959
564
190
SH
Put
DFND
1
0
190
0
BRAINSTORM CELL THERAPEUTICS
COM
10501E201
1062
444500
SH
DFND
1
0
444500
0
BRISTOL MYERS SQUIBB CO.
COM
110122108
8459
156887
SH
DFND
1
0
156887
0
BRISTOL MYERS SQUIBB CO.
COM
110122958
18705
3469
SH
Put
DFND
1
0
3469
0
BRISTOL MYERS SQUIBB CO.
COM
110122908
29165
5409
SH
Call
DFND
1
0
5409
0
CALITHERA BIOSCIENCES INC.
COM
13089P101
1055
324500
SH
DFND
1
0
324500
0
CANCER GENETICS INC
COM
13739U104
191
109048
SH
DFND
1
0
109048
0
CAPNIA INC.
COM
14066L105
236
245737
SH
DFND
1
0
245737
0
CAPRICOR THERAPEUTICS INC.
COM
14070B101
1183
357436
SH
DFND
1
0
357436
0
CARDIOME PHARMA CORP
COM
14159U301
1521
484505
SH
DFND
1
0
484505
0
CASCADIAN THERAPEUTICS INC.
COM
14740B101
392
238899
SH
DFND
1
0
238899
0
CEL SCI CORP
COM
150837508
1029
3372642
SH
DFND
1
0
3372642
0
CELGENE CORP
COM
151020104
3944
37728
SH
DFND
1
0
37728
0
CELGENE CORP
COM
151020954
25244
2415
SH
Put
DFND
1
0
2415
0
CELGENE CORP
COM
151020904
36073
3451
SH
Call
DFND
1
0
3451
0
CELLECT BIOTECHNOLOGY LTD
ADS
15116C102
264
57348
SH
DFND
1
0
57348
0
CELLECTAR BIOSCIENCES INC
*W
15117F120
188
228788
SH
DFND
1
0
228788
0
CELSION CORP.
COM
15117N404
1091
894406
SH
DFND
1
0
894406
0
CEMPRA INC
COM
15130J909
7306
3019
SH
Call
DFND
1
0
3019
0
CEMPRA INC
COM
15130J959
15302
6323
SH
Put
DFND
1
0
6323
0
CHAMPIONS ONCOLOGY INC
COM
15870P307
905
538593
SH
DFND
1
0
538593
0
CHECK CAP LTD
SHS
M2361E112
1159
585569
SH
DFND
1
0
585569
0
CHIMERIX INC.
COM
16934W106
443
79900
SH
DFND
1
0
79900
0
CIDARA THERAPEUTICS INC.
COM
171757107
2180
190358
SH
DFND
1
0
190358
0
CLOVIS ONCOLOGY INC
COM
189464950
7538
2091
SH
Put
DFND
1
0
2091
0
CLOVIS ONCOLOGY INC
COM
189464900
21089
5850
SH
Call
DFND
1
0
5850
0
COMBIMATRIX CORP.
*W
20009T147
429
857746
SH
DFND
1
0
857746
0
COMMUNITY HEALTH SYSTEMS INC
COM
203668108
359
31122
SH
DFND
1
0
31122
0
COMMUNITY HEALTH SYSTEMS INC
COM
203668958
477
413
SH
Put
DFND
1
0
413
0
CYTORI THERAPEUTICS INC.
*W
23283K121
1547
895017
SH
DFND
1
0
895017
0
CYTORI THERAPEUTICS INC.
COM
23283K204
3579
1762846
SH
DFND
1
0
1762846
0
CYTRX CORP.
COM
232828509
4368
7424786
SH
DFND
1
0
7424786
0
DEPOMED INC
COM
249908904
10798
4321
SH
Call
DFND
1
0
4321
0
DERMIRA INC
COM
24983L954
2293
678
SH
Put
DFND
1
0
678
0
DERMIRA INC
COM
24983L904
2442
722
SH
Call
DFND
1
0
722
0
DEXCOM INC
COM
252131907
7065
806
SH
Call
DFND
1
0
806
0
DEXTERA SURGICAL INC
COM
252366109
851
450507
SH
DFND
1
0
450507
0
DICERNA PHARMACEUTICALS INC
COM
253031108
294
50000
SH
DFND
1
0
50000
0
DRAGONWAVE INC.
COM
26144M400
1018
378338
SH
DFND
1
0
378338
0
DURECT CORP
COM
266605904
245
1759
SH
Call
DFND
1
0
1759
0
DURECT CORP
COM
266605104
2502
1800000
SH
DFND
1
0
1800000
0
DYNAVAX TECHNOLOGIES CORP
COM
268158201
5474
521875
SH
DFND
1
0
521875
0
DYNAVAX TECHNOLOGIES CORP
COM
268158951
8002
7628
SH
Put
DFND
1
0
7628
0
DYNAVAX TECHNOLOGIES CORP
COM
268158901
10473
9984
SH
Call
DFND
1
0
9984
0
EDAP TMS S A
ADR
268311957
53
182
SH
Put
DFND
1
0
182
0
EDAP TMS S A
ADR
268311107
1583
545918
SH
DFND
1
0
545918
0
EDITAS MEDICINE INC.
COM
28106W103
1820
135000
SH
DFND
1
0
135000
0
EIGER BIOPHARMACEUTICALS INC.
COM
28249U105
3090
230803
SH
DFND
1
0
230803
0
ELI LILLY & CO
COM
532457958
39311
4898
SH
Put
DFND
1
0
4898
0
ELI LILLY & CO
COM
532457908
235539
29347
SH
Call
DFND
1
0
29347
0
ENDO INTERNATIONAL PLC
SHS
G30401106
1194
59237
SH
DFND
1
0
59237
0
ENDO INTERNATIONAL PLC
SHS
G30401956
2208
1096
SH
Put
DFND
1
0
1096
0
EVOKE PHARMA INC.
COM
30049G104
144
63768
SH
DFND
1
0
63768
0
EXACT SCIENCES CORP
COM
30063P955
2137
1153
SH
Put
DFND
1
0
1153
0
EXELIXIS INC
COM
30161Q904
2468
1930
SH
Call
DFND
1
0
1930
0
EXELIXIS INC
COM
30161Q954
6896
5392
SH
Put
DFND
1
0
5392
0
EXPRESS SCRIPTS HOLDING CO
COM
30219G958
11927
1691
SH
Put
DFND
1
0
1691
0
EXPRESS SCRIPTS HOLDING CO
COM
30219G908
20433
2897
SH
Call
DFND
1
0
2897
0
EYEGATE PHARMACEUTICALS INC
*W
30233M115
16
46968
SH
DFND
1
0
46968
0
EYEGATE PHARMACEUTICALS INC
COM
30233M107
834
508598
SH
DFND
1
0
508598
0
FIBROGEN INC
COM
31572Q908
339
164
SH
Call
DFND
1
0
164
0
FIBROGEN INC
COM
31572Q808
1504
72669
SH
DFND
1
0
72669
0
FLEXION THERAPEUTICS INC
COM
33938J106
238
12176
SH
DFND
1
0
12176
0
FLEXION THERAPEUTICS INC
COM
33938J956
395
202
SH
Put
DFND
1
0
202
0
FOAMIX PHARMACEUTICALS LTD
SHS
M46135905
670
724
SH
Call
DFND
1
0
724
0
FOAMIX PHARMACEUTICALS LTD
SHS
M46135105
1866
201564
SH
DFND
1
0
201564
0
FORWARD PHARMA A/S
ADR
34986J105
2080
99053
SH
DFND
1
0
99053
0
GALECTIN THERAPEUTICS INC
COM
363225952
93
825
SH
Put
DFND
1
0
825
0
GALECTIN THERAPEUTICS INC
COM
363225202
99
87999
SH
DFND
1
0
87999
0
GALENA BIOPHARMA INC
COM
363256108
49
141000
SH
DFND
1
0
141000
0
GALENA BIOPHARMA INC
COM
363256958
57
1624
SH
Put
DFND
1
0
1624
0
GENVEC INC
COM
37246C307
696
1510377
SH
DFND
1
0
1510377
0
GILEAD SCIENCES INC
COM
375558953
6100
771
SH
Put
DFND
1
0
771
0
GILEAD SCIENCES INC
COM
375558903
92499
11691
SH
Call
DFND
1
0
11691
0
GLOBAL BLOOD THERAPEUTICS INC
COM
37890U908
1662
721
SH
Call
DFND
1
0
721
0
GREAT PANTHER SILVER LTD
COM
39115V101
55
40450
SH
DFND
1
0
40450
0
GW PHARMACEUTICALS PLC
ADS
36197T953
2548
192
SH
Put
DFND
1
0
192
0
GW PHARMACEUTICALS PLC
ADS
36197T903
3624
273
SH
Call
DFND
1
0
273
0
HALOZYME THERAPEUTICS INC
COM
40637H909
5920
4901
SH
Call
DFND
1
0
4901
0
HCA HOLDINGS INC
COM
40412C951
2390
316
SH
Put
DFND
1
0
316
0
HCA HOLDINGS INC
COM
40412C901
58084
7680
SH
Call
DFND
1
0
7680
0
HEMISPHERX BIOPHARMA INC.
COM
42366C301
1690
1351850
SH
DFND
1
0
1351850
0
HESS CORP
COM
42809H907
11040
2059
SH
Call
DFND
1
0
2059
0
HISTOGENICS CORP.
COM
43358V109
151
47823
SH
DFND
1
0
47823
0
HORIZON PHARMA PLC
COM
G4617B955
839
463
SH
Put
DFND
1
0
463
0
HORIZON PHARMA PLC
COM
G4617B905
7412
4088
SH
Call
DFND
1
0
4088
0
HUMANA INC
COM
444859902
4918
278
SH
Call
DFND
1
0
278
0
HUMANA INC
COM
444859952
12382
700
SH
Put
DFND
1
0
700
0
IGNYTA INC
COM
451731103
1421
225900
SH
DFND
1
0
225900
0
IMMUNOCELLULAR THERAPEUTICS
COM
452536105
756
6405230
SH
DFND
1
0
6405230
0
IMMUNOCELLULAR THERAPEUTICS
*W
452536113
1077
15161641
SH
DFND
1
0
15161641
0
IMMUNOMEDICS INC.
COM
452907108
966
297310
SH
DFND
1
0
297310
0
INCYTE CORP
COM
45337C902
339
36
SH
Call
DFND
1
0
36
0
INFINITY PHARMACEUTICALS INC
COM
45665G903
26
167
SH
Call
DFND
1
0
167
0
INOTEK PHARMACEUTICALS CORP
COM
45780V902
100
106
SH
Call
DFND
1
0
106
0
INOTEK PHARMACEUTICALS CORP
COM
45780V952
474
500
SH
Put
DFND
1
0
500
0
INOTEK PHARMACEUTICALS CORP
COM
45780V102
1365
144002
SH
DFND
1
0
144002
0
INSMED INC
COM
457669957
1811
1247
SH
Put
DFND
1
0
1247
0
INSMED INC
COM
457669907
2118
1459
SH
Call
DFND
1
0
1459
0
INSPIREMD INC
COM
45779A507
54
679224
SH
DFND
1
0
679224
0
INSPIREMD INC
*W
45779A119
888
29594500
SH
DFND
1
0
29594500
0
INTEC PHARMA LTD.
COM
M53644106
2898
498006
SH
DFND
1
0
498006
0
INTELLIA THERAPEUTICS INC
COM
45826J105
1784
104841
SH
DFND
1
0
104841
0
INTRA CELLULAR THERAPIES INC
COM
46116X951
226
148
SH
Put
DFND
1
0
148
0
INTRA CELLULAR THERAPIES INC
COM
46116X101
226
14800
SH
DFND
1
0
14800
0
INTRA CELLULAR THERAPIES INC
COM
46116X901
812
533
SH
Call
DFND
1
0
533
0
INVIVO THERAPEUTICS HOLDINGS CORP
COM
46186M909
135
199
SH
Call
DFND
1
0
199
0
IONIS PHARMACEUTICALS INC
COM
462222950
2700
737
SH
Put
DFND
1
0
737
0
IONIS PHARMACEUTICALS INC
COM
462222900
7955
2171
SH
Call
DFND
1
0
2171
0
ISHARES RUSSELL 2000
ETF
464287905
67583
5441
SH
Call
DFND
1
0
5441
0
ISHARES RUSSELL 2000
ETF
464287955
184973
14892
SH
Put
DFND
1
0
14892
0
JUNO THERAPEUTICS INC
COM
48205A909
309
103
SH
Call
DFND
1
0
103
0
KITE PHARMA INC
COM
49803L909
6044
1082
SH
Call
DFND
1
0
1082
0
KITE PHARMA INC
COM
49803L959
6575
1177
SH
Put
DFND
1
0
1177
0
LA JOLLA PHARMACEUTICAL CO
COM
503459604
2878
120964
SH
DFND
1
0
120964
0
LA JOLLA PHARMACEUTICAL CO
COM
503459904
4910
2064
SH
Call
DFND
1
0
2064
0
LEXICON PHARMACEUTICALS INC
COM
528872952
1084
600
SH
Put
DFND
1
0
600
0
LEXICON PHARMACEUTICALS INC
COM
528872902
11317
6263
SH
Call
DFND
1
0
6263
0
LION BIOTECHNOLOGIES INC
COM
53619R902
408
496
SH
Call
DFND
1
0
496
0
LION BIOTECHNOLOGIES INC
COM
53619R102
2027
246342
SH
DFND
1
0
246342
0
LION BIOTECHNOLOGIES INC
COM
53619R952
6503
7901
SH
Put
DFND
1
0
7901
0
MANNKIND CORP
COM
56400P201
1107
1785368
SH
DFND
1
0
1785368
0
MANNKIND CORP
COM
56400P951
3863
62303
SH
Put
DFND
1
0
62303
0
MEDGENICS INC
COM
58436Q903
297
533
SH
Call
DFND
1
0
533
0
MEDGENICS INC
COM
58436Q203
791
141977
SH
DFND
1
0
141977
0
MEDICINES CO
COM
584688955
377
100
SH
Put
DFND
1
0
100
0
MEDICINES CO
COM
584688105
510
13508
SH
DFND
1
0
13508
0
MEDICINES CO
COM
584688905
4340
1150
SH
Call
DFND
1
0
1150
0
MEDIGUS LTD
COM
58471G102
1373
1042813
SH
DFND
1
0
1042813
0
MERCK & CO INC
COM
58933Y905
28003
4487
SH
Call
DFND
1
0
4487
0
MIRATI THERAPEUTICS INC.
COM
60468T105
659
99735
SH
DFND
1
0
99735
0
MOMENTA PHARMACEUTICALS INC
COM
60877T900
321
275
SH
Call
DFND
1
0
275
0
MONSANTO CO
COM
61166W901
57304
5607
SH
Call
DFND
1
0
5607
0
MYLAN N.V.
SHS
N59465909
10689
2804
SH
Call
DFND
1
0
2804
0
NATERA INC
COM
632307904
161
145
SH
Call
DFND
1
0
145
0
NEURALSTEM INC.
COM
64127R302
892
2787745
SH
DFND
1
0
2787745
0
NEUROCRINE BIOSCIENCES INC
COM
64125C909
6148
1214
SH
Call
DFND
1
0
1214
0
NEUROMETRIX INC
COM
641255500
338
219336
SH
DFND
1
0
219336
0
NEUROMETRIX INC
*W
641255153
400
3060947
SH
DFND
1
0
3060947
0
NEVRO CORP
COM
64157F903
1681
161
SH
Call
DFND
1
0
161
0
NEWLINK GENETICS CORP
COM
651511957
150
100
SH
Put
DFND
1
0
100
0
NEWLINK GENETICS CORP
COM
651511107
519
34561
SH
DFND
1
0
34561
0
NEWLINK GENETICS CORP
COM
651511907
4336
2887
SH
Call
DFND
1
0
2887
0
NIVALIS THERAPEUTICS INC
COM
65481J109
2176
267650
SH
DFND
1
0
267650
0
NOVAVAX INC
COM
670002954
176
844
SH
Put
DFND
1
0
844
0
NOVAVAX INC
COM
670002904
457
2195
SH
Call
DFND
1
0
2195
0
NOVO NORDISK A/S
ADR
670100955
3573
859
SH
Put
DFND
1
0
859
0
OCERA THERAPEUTICS INC
COM
67552A108
1060
400035
SH
DFND
1
0
400035
0
OCULAR THERAPEUTIX INC
COM
67576A100
262
38100
SH
DFND
1
0
38100
0
ONCOBIOLOGICS INC
*W
68235M113
905
902050
SH
DFND
1
0
902050
0
ONCOBIOLOGICS INC
*W
68235M121
1332
926651
SH
DFND
1
0
926651
0
ONCOBIOLOGICS INC
COM
68235M105
9643
2268585
SH
DFND
1
0
2268858
0
ONCONOVA THERAPEUTICS INC
COM
68232V306
1039
392023
SH
DFND
1
0
392023
0
ONCONOVA THERAPEUTICS INC
*W
68232V116
1124
725434
SH
DFND
1
0
725434
0
ONCOSEC MEDICAL INC
COM
68234L207
1426
834004
SH
DFND
1
0
834004
0
OPGEN INC.
COM
68373L109
3545
2161467
SH
DFND
1
0
2161467
0
OPHTHOTECH CORP
COM
683745903
6998
1517
SH
Call
DFND
1
0
1517
0
OPKO HEALTH INC
COM
68375N953
2147
2027
SH
Put
DFND
1
0
2027
0
OPKO HEALTH INC
COM
68375N903
2638
2491
SH
Call
DFND
1
0
2491
0
OVASCIENCE INC
COM
69014Q101
358
50000
SH
DFND
1
0
50000
0
PACIRA PHARMACEUTICALS INC
COM
695127950
544
159
SH
Put
DFND
1
0
159
0
PACIRA PHARMACEUTICALS INC
COM
695127900
1057
309
SH
Call
DFND
1
0
309
0
PARATEK PHARMACEUTICALS INC
COM
699374302
2277
175000
SH
DFND
1
0
175000
0
PARNELL PHARMACEUTICALS HOLDINGS LTD
SHS
Q73622104
532
369700
SH
DFND
1
0
369700
0
PIERIS PHARMACEUTICALS INC
COM
720795103
2824
1543307
SH
DFND
1
0
1543307
0
PORTOLA PHARMACEUTICALS INC
COM
737010908
681
300
SH
Call
DFND
1
0
300
0
PRONAI THERAPEUTICS INC.
COM
74346L101
1252
687734
SH
DFND
1
0
687734
0
PROQR THERAPEUTICS N V
COM
N71542109
393
58910
SH
DFND
1
0
58910
0
PROTHENA CORPORATION PLC
SHS
G72800990
1949
325
SH
Call
DFND
1
0
325
0
PROVECTUS BIOPHARMACEUTICALS INC
COM
74373P108
107
1077555
SH
DFND
1
0
1077555
0
PSIVIDA CORP
COM
74440J101
587
195100
SH
DFND
1
0
195100
0
PTC THERAPEUTICS INC
COM
69366J900
5589
3989
SH
Call
DFND
1
0
3989
0
PUMA BIOTECHNOLOGY INC
COM
74587V957
4311
643
SH
Put
DFND
1
0
643
0
PUMA BIOTECHNOLOGY INC
COM
74587V907
13551
2021
SH
Call
DFND
1
0
2021
0
QUEST RESOURCE HOLDING CORP
COM
74836W203
281
138980
SH
DFND
1
0
138980
0
RADIUS HEALTH INC
COM
750469957
763
141
SH
Put
DFND
1
0
141
0
RADIUS HEALTH INC
COM
750469907
1055
195
SH
Call
DFND
1
0
195
0
REDHILL BIOPHARMA LTD
ADS
757468103
888
63800
SH
DFND
1
0
63800
0
REGENERON PHARMACEUTICALS INC
COM
75886F907
2533
63
SH
Call
DFND
1
0
63
0
REGENERON PHARMACEUTICALS INC
COM
75886F107
30521
75919
SH
DFND
1
0
75919
0
REGENERON PHARMACEUTICALS INC
COM
75886F957
72042
1792
SH
Put
DFND
1
0
1792
0
REGENXBIO ORD SHS
COM
75901B107
3687
263177
SH
DFND
1
0
263177
0
REGULUS THERAPEUTIC INC
COM
75915K901
3630
11000
SH
Call
DFND
1
0
11000
0
RENNOVA HEALTH INC
*W
759757123
258
3682014
SH
DFND
1
0
3682014
0
RENNOVA HEALTH INC
COM
759757107
516
2724721
SH
DFND
1
0
2724721
0
RETROPHIN INC
COM
761299956
897
401
SH
Put
DFND
1
0
401
0
RETROPHIN INC
COM
761299906
14084
6293
SH
Call
DFND
1
0
6293
0
REXAHN PHARMACEUTICALS INC
COM
761640101
1988
9464849
SH
DFND
1
0
9464849
0
RICEBRAN TECHNOLOGIES
COM
762831204
1073
794436
SH
DFND
1
0
794436
0
RIGEL PHARMACEUTICALS INC
COM
766559903
116
316
SH
Call
DFND
1
0
316
0
RIGEL PHARMACEUTICALS INC
COM
766559603
319
86900
SH
DFND
1
0
86900
0
SAGE THERAPEUTICS INC
COM
78667J958
1220
265
SH
Put
DFND
1
0
265
0
SAGE THERAPEUTICS INC
COM
78667J908
5365
1165
SH
Call
DFND
1
0
1165
0
SANGAMO BIOSCIENCES INC
COM
800677106
152
32804
SH
DFND
1
0
32804
0
SANGAMO BIOSCIENCES INC
COM
800677906
2598
5611
SH
Call
DFND
1
0
5611
0
SAREPTA THERAPEUTICS INC
COM
803607900
21653
3526
SH
Call
DFND
1
0
3526
0
SAREPTA THERAPEUTICS INC
COM
803607100
32933
536282
SH
DFND
1
0
536282
0
SAREPTA THERAPEUTICS INC
COM
803607950
164259
26748
SH
Put
DFND
1
0
26748
0
SHIRE PLC
COM
82481R106
6043
31172
SH
DFND
1
0
31172
0
SHIRE PLC
COM
82481R906
13531
698
SH
Call
DFND
1
0
698
0
SHIRE PLC
COM
82481R956
13531
698
SH
Put
DFND
1
0
698
0
SOPHIRIS BIO INC.
COM
83578Q209
2354
757033
SH
DFND
1
0
757033
0
SORRENTO THERAPEUTICS INC
COM
83587F902
127
164
SH
Call
DFND
1
0
164
0
SORRENTO THERAPEUTICS INC
COM
83587F202
162
20986
SH
DFND
1
0
20986
0
SPDR S&P 500 ETF TRUST
UNIT
78462F903
216300
10000
SH
Call
DFND
1
0
10000
0
SPDR S&P 500 ETF TRUST
UNIT
78462F953
302820
14000
SH
Put
DFND
1
0
14000
0
SPDR SERIES TRUST
UNIT
78464A950
12980
1958
SH
Put
DFND
1
0
1958
0
STEMLINE THERAPEUTICS INC
COM
85858C907
240
222
SH
Call
DFND
1
0
222
0
STEMLINE THERAPEUTICS INC
COM
85858C107
1062
98050
SH
DFND
1
0
98050
0
STRATA SKIN SCIENCES INC
COM
86272A107
510
1000790
SH
DFND
1
0
1000790
0
SUNSHINE HEART INC.
COM
86782U106
518
908021
SH
DFND
1
0
908021
0
SUPERCONDUCTOR TECHNOLOGIES INC.
COM
867931503
669
250474
SH
DFND
1
0
250474
0
SYNERGY PHARMACEUTICALS INC.
*W
871639118
268
348743
SH
DFND
1
0
348743
0
SYNERGY PHARMACEUTICALS INC.
COM
871639958
2117
3842
SH
Put
DFND
1
0
3842
0
SYNERGY PHARMACEUTICALS INC.
COM
871639908
4360
7912
SH
Call
DFND
1
0
7912
0
TENAX THERAPEUTICS INC
COM
88032L950
39
169
SH
Put
DFND
1
0
169
0
TENAX THERAPEUTICS INC
COM
88032L900
583
2534
SH
Call
DFND
1
0
2534
0
TENAX THERAPEUTICS INC
COM
88032L100
5550
2412857
SH
DFND
1
0
2412857
0
TENET HEALTHCARE CORP
COM
88033G407
2557
112831
SH
DFND
1
0
112831
0
TENET HEALTHCARE CORP
COM
88033G957
3952
1744
SH
Put
DFND
1
0
1744
0
TENET HEALTHCARE CORP
COM
88033G907
7204
3179
SH
Call
DFND
1
0
3179
0
TESARO INC
COM
881569957
501
50
SH
Put
DFND
1
0
50
0
TESARO INC
COM
881569107
2757
27500
SH
DFND
1
0
27500
0
TESARO INC
COM
881569907
3338
333
SH
Call
DFND
1
0
333
0
THERAPEUTICSMD INC
COM
88338N107
232
34030
SH
DFND
1
0
34030
0
THERAPEUTICSMD INC
COM
88338N957
399
586
SH
Put
DFND
1
0
586
0
THERAPEUTICSMD INC
COM
88338N907
1301
1910
SH
Call
DFND
1
0
1910
0
TOKAI PHARMACEUTICALS INC.
COM
88907J107
492
321600
SH
DFND
1
0
321600
0
TONIX PHARMACEUTICALS HOLDING CORP.
COM
890260201
142
203097
SH
DFND
1
0
203097
0
UNITED THERAPEUTICS CORP
COM
91307C102
3319
28112
SH
DFND
1
0
28112
0
UNITED THERAPEUTICS CORP
COM
91307C952
12965
1098
SH
Put
DFND
1
0
1098
0
VANDA PHARMACEUTICALS INC
COM
921659908
2075
1247
SH
Call
DFND
1
0
1247
0
VERSARTIS INC.
COM
92529L102
2143
174968
SH
DFND
1
0
174968
0
VERTEX PHARMACEUTICALS INC
COM
92532F950
2267
260
SH
Put
DFND
1
0
260
0
VERTEX PHARMACEUTICALS INC
COM
92532F900
17050
1955
SH
Call
DFND
1
0
1955
0
VIKING THERAPEUTICS INC
*W
92686J114
53
117008
SH
DFND
1
0
117008
0
VISTAGEN THERAPEUTICS INC
COM
92840H202
1452
349096
SH
DFND
1
0
349096
0
VTV THERAPEUTICS INC
CL A
918385105
969
134747
SH
DFND
1
0
134747
0
WAFERGEN BIO SYSTEMS INC.
COM
93041P308
1520
1578616
SH
DFND
1
0
1578616
0
WINDTREE THERAPEUTICS INC.
COM
97382D105
797
310000
SH
DFND
1
0
310000
0
XTL BIOPHARMACEUTICALS LTD
ADR
98386D208
714
751289
SH
DFND
1
0
751289
0
ZAFGEN INC
COM
98885E903
15
2149
SH
Call
DFND
1
0
2149
0
ZOGENIX INC
COM
98978L204
1715
150000
SH
DFND
1
0
150000
0
ZOGENIX INC
COM
98978L904
3265
1228
SH
Call
DFND
1
0
1228
0
ZOSANO PHARMA CORP.
COM
98979H103
82
103600
SH
DFND
1
0
103600
0