0001144204-15-065626.txt : 20151116
0001144204-15-065626.hdr.sgml : 20151116
20151116100638
ACCESSION NUMBER: 0001144204-15-065626
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20150930
FILED AS OF DATE: 20151116
DATE AS OF CHANGE: 20151116
EFFECTIVENESS DATE: 20151116
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SABBY MANAGEMENT, LLC
CENTRAL INDEX KEY: 0001535610
IRS NUMBER: 000000000
STATE OF INCORPORATION: DE
FISCAL YEAR END: 1231
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15245
FILM NUMBER: 151232189
BUSINESS ADDRESS:
STREET 1: 10 MOUNTAINVIEW ROAD
STREET 2: SUITE 205
CITY: UPPER SADDLE RIVER
STATE: NJ
ZIP: 07458
BUSINESS PHONE: 646-307-4527
MAIL ADDRESS:
STREET 1: 10 MOUNTAINVIEW ROAD
STREET 2: SUITE 205
CITY: UPPER SADDLE RIVER
STATE: NJ
ZIP: 07458
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001535610
XXXXXXXX
09-30-2015
09-30-2015
false
SABBY MANAGEMENT, LLC
10 Mountainview Road
Suite 205
Upper Saddle River
NJ
07458
13F HOLDINGS REPORT
028-15245
N
Robert Grundstein
Chief Operating Officer
646-307-4527
/s/ Robert Grundstein
Upper Saddle River
NJ
11-16-2015
1
379
2427276
01
0001433766
028-13502
Mintz Hal
INFORMATION TABLE
2
infotable.xml
ABBVIE INC
COM
00287Y909
40568
7456
SH
Call
DFND
1
0
7456
0
ABBVIE INC
COM
00287Y109
1280
23516
SH
DFND
1
0
23516
0
ABBVIE INC
COM
00287Y959
12362
2272
SH
Put
DFND
1
0
2272
0
ABEONA THERAPEUTICS INC
COM
00289Y107
1380
340702
SH
DFND
1
0
340702
0
ACADIA PHARMACEUTICALS INC
COM
004225908
4755
1438
SH
Call
DFND
1
0
1438
0
ACADIA PHARMACEUTICALS INC
COM
004225958
7471
2259
SH
Put
DFND
1
0
2259
0
ACELRX PHARMACEUTICALS INC
COM
00444T900
52
172
SH
Call
DFND
1
0
172
0
ACELRX PHARMACEUTICALS INC
COM
00444T950
57
186
SH
Put
DFND
1
0
186
0
ACELRX PHARMACEUTICALS INC
COM
00444T100
301
98602
SH
DFND
1
0
98602
0
ACHILLION PHARMACEUTICALS INC
COM
00448Q901
4779
6916
SH
Call
DFND
1
0
6916
0
ACORDA THERAPEUTICS INC NOTE 1.75%
NOTE
00484MAA4
8664
9600000
SH
DFND
1
0
9600000
0
ACTINIUM PHARMACEUTICALS INC
COM
00507W107
121
68427
SH
DFND
1
0
68427
0
ACURA PHARMACEUTICALS INC
COM
00509L802
1747
743603
SH
DFND
1
0
743603
0
ADAMAS PHARMACEUTICALS INC
COM
00548A106
1284
76717
SH
DFND
1
0
76717
0
ADAPTIMMUNE THERAPEUTICS PLC
ADR
00653A107
120
10004
SH
DFND
1
0
10004
0
ADVAXIS INC
COM
007624958
872
852
SH
Put
DFND
1
0
852
0
ADVAXIS INC
COM
007624208
877
85700
SH
DFND
1
0
85700
0
ADVAXIS INC
COM
007624908
1494
1460
SH
Call
DFND
1
0
1460
0
AERIE PHARMACEUTICALS INC
COM
00771V908
381
215
SH
Call
DFND
1
0
215
0
AFFIMED N V
COM
N01045108
350
56773
SH
DFND
1
0
56773
0
AGIOS PHARMACEUTICALS INC
COM
00847X904
1645
233
SH
Call
DFND
1
0
233
0
AGIOS PHARMACEUTICALS INC
COM
00847X104
7731
109521
SH
DFND
1
0
109521
0
AGIOS PHARMACEUTICALS INC
COM
00847X954
8280
1173
SH
Put
DFND
1
0
1173
0
ALDEYRA THERAPEUTICS INC
COM
01438T106
787
134997
SH
DFND
1
0
134997
0
ALEXION PHARMACEUTICALS INC
COM
015351909
2377
152
SH
Call
DFND
1
0
152
0
ALEXION PHARMACEUTICALS INC
COM
015351109
7725
49397
SH
DFND
1
0
49397
0
ALEXION PHARMACEUTICALS INC
COM
015351959
15248
975
SH
Put
DFND
1
0
975
0
ALKERMES PLC
SHS
G01767105
260
537
SH
Call
DFND
1
0
537
0
ALLIQUA BIOMEDICAL INC
COM
019621200
1047
330128
SH
DFND
1
0
330128
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q107
547
6809
SH
DFND
1
0
6809
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q957
6340
789
SH
Put
DFND
1
0
789
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q907
13468
1676
SH
Call
DFND
1
0
1676
0
AMARIN CORPORATION PLC
ADR
023111906
216
1118
SH
Put
DFND
1
0
1118
0
AMARIN CORPORATION PLC
ADR
023111206
1579
8183
SH
Call
DFND
1
0
8183
0
AMICUS THERAPEUTICS INC
COM
03152W909
1021
730
SH
Call
DFND
1
0
730
0
AMICUS THERAPEUTICS INC
COM
03152W959
3248
2322
SH
Put
DFND
1
0
2322
0
ANACOR PHARMACEUTICALS INC
COM
032420101
942
8000
SH
DFND
1
0
8000
0
ANACOR PHARMACEUTICALS INC
COM
032420901
1177
100
SH
Call
DFND
1
0
100
0
ANACOR PHARMACEUTICALS INC
COM
032420951
1177
100
SH
Put
DFND
1
0
100
0
ANADARKO PETROLEUM CORP
COM
032511957
6178
1023
SH
Put
DFND
1
0
1023
0
ANADARKO PETROLEUM CORP
COM
032511107
6178
102300
SH
DFND
1
0
102300
0
ANTARES PHARMA INC
COM
036642906
466
2742
SH
Call
DFND
1
0
2742
0
ANTARES PHARMA INC
COM
036642106
1228
722567
SH
DFND
1
0
722567
0
ANTHERA PHARMACEUTICALS INC
COM
03674U901
1218
2000
SH
Call
DFND
1
0
2000
0
AOXING PHARMACEUTICAL INC
COM
03740A106
3158
2134054
SH
DFND
1
0
2134054
0
APPLE INC
COM
037833900
12243
1110
SH
Call
DFND
1
0
1110
0
APPLIED DNA SCIENCES EQUITY WARRANTS
*W
03815U110
196
63310
SH
DFND
1
0
63310
0
APPLIED GENETIC TECHNOLOGIES CORP
COM
03820J100
1629
124000
SH
DFND
1
0
124000
0
APRICUS BIOSCIENCES INC SHS
COM
03832V109
18
12176
SH
DFND
1
0
12176
0
APRICUS BIOSCIENCES INC SHS
COM
03832V959
88
605
SH
Put
DFND
1
0
605
0
AQUINOX PHARMACEUTICALS INC
COM
03842B101
844
60000
SH
DFND
1
0
60000
0
ARBUTUS BIOPHARMA CORP
COM
03879J900
479
787
SH
Call
DFND
1
0
787
0
ARBUTUS BIOPHARMA CORP
COM
03879J100
4415
725007
SH
DFND
1
0
725007
0
ARIAD PHARMACEUTICALS INC
COM
04033A950
987
1690
SH
Put
DFND
1
0
1690
0
ARIAD PHARMACEUTICALS INC
COM
04033A100
987
169000
SH
DFND
1
0
169000
0
AVALANCHE BIOTECHNOLOGIES INC
COM
05337G957
247
300
SH
Put
DFND
1
0
300
0
AVALANCHE BIOTECHNOLOGIES INC
COM
05337G907
437
530
SH
Call
DFND
1
0
530
0
AVALANCHE BIOTECHNOLOGIES INC
COM
05337G107
4732
574260
SH
DFND
1
0
574260
0
AXOVANT SCIENCES ORD SHS
COM
G0750W104
272
21053
SH
DFND
1
0
21053
0
BARCLAYS BANK PLC
ETN
06740C909
1736
1334
SH
Call
DFND
1
0
1334
0
BARCLAYS BANK PLC
ETN
06740C519
5861
450500
SH
DFND
1
0
450500
0
BELLICUM PHARMACEUTICALS INC
COM
079481957
472
325
SH
Put
DFND
1
0
325
0
BELLICUM PHARMACEUTICALS INC
COM
079481907
764
526
SH
Call
DFND
1
0
526
0
BELLICUM PHARMACEUTICALS INC
COM
079481107
1745
120094
SH
DFND
1
0
120094
0
BENITEC BIOPHARMA LTD
ADR
082053307
3107
505220
SH
DFND
1
0
505220
0
BENITEC BIOPHARMA LTD
*W
082053117
143
391826
SH
DFND
1
0
391826
0
BIO PATH HOLDINGS INC
COM
09057N102
17
14873
SH
DFND
1
0
14873
0
BIOCRYST PHARMACEUTICALS INC
COM
09058V103
985
86395
SH
DFND
1
0
86395
0
BIOCRYST PHARMACEUTICALS INC
COM
09058V953
2199
1929
SH
Put
DFND
1
0
1929
0
BIODEL INC
COM
09064M204
433
983670
SH
DFND
1
0
983670
0
BIODEL INC
COM
09064M954
8
182
SH
Put
DFND
1
0
182
0
BIODELIVERY SCIENCES INTERNATIONAL INC
COM
09060J906
255
458
SH
Call
DFND
1
0
458
0
BIODELIVERY SCIENCES INTERNATIONAL INC
COM
09060J956
439
789
SH
Put
DFND
1
0
789
0
BIODELIVERY SCIENCES INTERNATIONAL INC
COM
09060J106
2050
368641
SH
DFND
1
0
368641
0
BIOGEN IDEC INC
COM
09062X103
22945
78629
SH
DFND
1
0
78629
0
BIOGEN IDEC INC
COM
09062X953
41408
1419
SH
Put
DFND
1
0
1419
0
BIOGEN IDEC INC
COM
09062X903
90169
3090
SH
Call
DFND
1
0
3090
0
BIOLASE INC
COM
090911108
255
283231
SH
DFND
1
0
283231
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G101
18333
174073
SH
DFND
1
0
174073
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G901
25014
2375
SH
Call
DFND
1
0
2375
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G951
30659
2911
SH
Put
DFND
1
0
2911
0
BIOMARIN PHARMACEUTICAL INC. NOTE .75%
NOTE
09061GAE1
6459
5000000
SH
DFND
1
0
5000000
0
BIOTIE THERAPIES OYJ
ADR
09074D103
524
40000
SH
DFND
1
0
40000
0
BLUEBIRD BIO INC
COM
09609G950
3473
406
SH
Put
DFND
1
0
406
0
BLUEBIRD BIO INC
COM
09609G900
7605
889
SH
Call
DFND
1
0
889
0
BLUEPRINT MEDICINES INC
COM
09627Y109
6583
308504
SH
DFND
1
0
308504
0
BRAINSTORM CELL THERAPEUTICS
COM
10501E201
1952
852348
SH
DFND
1
0
852348
0
BRISTOL MYERS SQUIBB CO
COM
110122908
18192
3073
SH
Call
DFND
1
0
3073
0
CAPRICOR THERAPEUTICS INC
COM
14070B101
1014
250450
SH
DFND
1
0
250450
0
CARDICA INC
COM
14141R101
1521
5281185
SH
DFND
1
0
5281185
0
CASI PHARMACEUTICALS ORD SHS
COM
14757U109
217
202536
SH
DFND
1
0
202536
0
CASTLIGHT HEALTH INC
CL B
14862Q900
447
1065
SH
Call
DFND
1
0
1065
0
CELLDEX THERAPEUTICS INC
COM
15117B953
251
238
SH
Put
DFND
1
0
238
0
CELLDEX THERAPEUTICS INC
COM
15117B903
4688
4448
SH
Call
DFND
1
0
4448
0
CELLECTAR BIOSCIENCES INC
*W
15117F112
1079
653712
SH
DFND
1
0
653712
0
CELLECTAR BIOSCIENCES INC
COM
15117F203
751
381172
SH
DFND
1
0
381172
0
CELSION CORPORATION
COM
15117N954
91
546
SH
Put
DFND
1
0
546
0
CELSION CORPORATION
COM
15117N404
128
76805
SH
DFND
1
0
76805
0
CEMPRA INC
COM
15130J109
2038
73195
SH
DFND
1
0
73195
0
CEMPRA INC
COM
15130J959
3012
1082
SH
Put
DFND
1
0
1082
0
CEMPRA INC
COM
15130J909
10159
3649
SH
Call
DFND
1
0
3649
0
CESCA THERAPEUTICS INC.
COM
157131103
1855
3500037
SH
DFND
1
0
3500037
0
CHAMPIONS ONCOLOGY ORD SHS
COM
15870P307
893
169397
SH
DFND
1
0
169397
0
CHINA BIOLOGIC PRODUCTS INC
COM
16938C106
1796
20000
SH
DFND
1
0
20000
0
CHINA JO-JO DRUGSTORES INC
COM
16949A206
1118
614149
SH
DFND
1
0
614149
0
CHINA MOBILE LIMITED
ADR
16941M909
19
481
SH
Call
DFND
1
0
481
0
CIDARA THERAPEUTICS
COM
171757107
3893
306044
SH
DFND
1
0
306044
0
COLLABRX ORD SHS
COM
19422J108
635
920375
SH
DFND
1
0
920375
0
COMMUNITY HEALTH SYSTEMS INC
COM
203668108
1856
43397
SH
DFND
1
0
43397
0
COMMUNITY HEALTH SYSTEMS INC
COM
203668958
2831
662
SH
Put
DFND
1
0
662
0
CONATUS PHARMACEUTICALS INC
COM
20600T108
278
62500
SH
DFND
1
0
62500
0
CTI BIOPHARMA CORP
COM
12648L906
839
5747
SH
Call
DFND
1
0
5747
0
CYCLACEL PHARMACEUTICALS INC
COM
23254L306
1202
2356091
SH
DFND
1
0
2356091
0
CYMABAY THERAPEUTICS INC
COM
23257D103
569
293294
SH
DFND
1
0
293294
0
CYNAPSUS THERAPEUTICS INC
COM
23257Y859
845
52169
SH
DFND
1
0
52169
0
CYTOKINETICS INC
COM
23282W955
787
1176
SH
Put
DFND
1
0
1176
0
CYTOKINETICS INC
COM
23282W905
2078
3106
SH
Call
DFND
1
0
3106
0
CYTORI THERAPEUTICS INC
COM
23283K105
1000
2941880
SH
DFND
1
0
2941880
0
CYTRX ORD SHS
COM
232828509
378
159584
SH
DFND
1
0
159584
0
DBV TECHNOLOGIES S A
ADR
23306J101
660
18541
SH
DFND
1
0
18541
0
DEPOMED INC
COM
249908104
943
50000
SH
DFND
1
0
50000
0
DEPOMED INC
COM
249908904
5052
2680
SH
Call
DFND
1
0
2680
0
DERMIRA INC
COM
24983L104
4435
190000
SH
DFND
1
0
190000
0
DISCOVERY LABORATORIES INC.
COM
254668403
1411
4703551
SH
DFND
1
0
4703551
0
DYAX CORP
COM
26746E103
1520
79613
SH
DFND
1
0
79613
0
DYAX CORP
COM
26746E953
1941
1017
SH
Put
DFND
1
0
1017
0
DYNAVAX TECHNOLOGIES CORP
COM
268158951
1458
594
SH
Put
DFND
1
0
594
0
DYNAVAX TECHNOLOGIES CORP
COM
268158201
3312
134954
SH
DFND
1
0
134954
0
DYNAVAX TECHNOLOGIES CORP
COM
268158901
5087
2073
SH
Call
DFND
1
0
2073
0
EDAP TMS SA
ADR
268311957
819
1466
SH
Put
DFND
1
0
1466
0
EDWARDS LIFESCIENCES CORP
COM
28176E108
10983
77255
SH
DFND
1
0
77255
0
EDWARDS LIFESCIENCES CORP
COM
28176E958
34896
1682
SH
Put
DFND
1
0
1682
0
ELEVEN BIOTHERAPEUTICS INC
COM
286221106
413
171541
SH
DFND
1
0
171541
0
ELI LILLY & CO
COM
532457958
20404
2438
SH
Put
DFND
1
0
2438
0
ELI LILLY & CO
COM
532457908
182904
21855
SH
Call
DFND
1
0
21855
0
ENDO INTERNATIONAL PLC
SHS
G30401956
1552
224
SH
Put
DFND
1
0
224
0
ENDO INTERNATIONAL PLC
SHS
G30401106
3510
50658
SH
DFND
1
0
50658
0
ENDO INTERNATIONAL PLC
SHS
G30401906
4164
601
SH
Call
DFND
1
0
601
0
ENDOCYTE INC
COM
29269A102
121
26423
SH
DFND
1
0
26423
0
ENDOLOGIX INC
COM
29266S106
1226
100000
SH
DFND
1
0
100000
0
ENTEROMEDICS INC
COM
29365M208
536
2063336
SH
DFND
1
0
2063336
0
ESPERION THERAPEUTICS INC
COM
29664W105
566
23990
SH
DFND
1
0
23990
0
EXACT SCIENCES CORP
COM
30063P105
5201
289112
SH
DFND
1
0
289112
0
EXACT SCIENCES CORP
COM
30063P955
7723
4293
SH
Put
DFND
1
0
4293
0
EXELIXIS INC
COM
30161Q954
157
280
SH
Put
DFND
1
0
280
0
EXELIXIS INC
COM
30161Q904
1000
1783
SH
Call
DFND
1
0
1783
0
EYEGATE PHARMACEUTICALS INC
COM
30233M107
695
243790
SH
DFND
1
0
243790
0
EYEGATE PHARMACEUTICALS WARRANTS
*W
30233M115
204
200000
SH
DFND
1
0
200000
0
FEI CO
COM
30241L909
2483
340
SH
Call
DFND
1
0
340
0
FIBROGEN INC
COM
31572Q808
517
23597
SH
DFND
1
0
23597
0
FLUIDIGM CORP DEL
COM
34385P908
488
3617
SH
Call
DFND
1
0
3617
0
FLUIDIGM CORP DEL
COM
34385P108
5095
628260
SH
DFND
1
0
628260
0
FOAMIX PHARMACEUTICALS LTD
SHS
M46135105
1784
243361
SH
DFND
1
0
243361
0
FORWARD PHARMA A/S
ADR
34986J105
1649
70000
SH
DFND
1
0
70000
0
GALENA BIOPHARMA INC
COM
363256958
1081
6832
SH
Put
DFND
1
0
6832
0
GENOCEA BIOSCIENCES INC
COM
372427104
4995
729141
SH
DFND
1
0
729141
0
GEVO INC
COM
374396208
9819
100000
SH
DFND
1
0
100000
0
GILEAD SCIENCES INC
COM
375558103
4432
45140
SH
DFND
1
0
45140
0
GILEAD SCIENCES INC
COM
375558953
48830
4973
SH
Put
DFND
1
0
4973
0
GILEAD SCIENCES INC
COM
375558903
97169
9896
SH
Call
DFND
1
0
9896
0
GLOBAL BLOOD THERAPEUTICS INC
COM
37890U108
14455
342857
SH
DFND
1
0
342857
0
GLOBUS MEDICAL INC
CL A
379577208
345
16700
SH
DFND
1
0
16700
0
GLOBUS MEDICAL INC
CL A
379577958
1886
913
SH
Put
DFND
1
0
913
0
GW PHARMACEUTICALS PLC
ADS
36197T903
914
100
SH
Call
DFND
1
0
100
0
GW PHARMACEUTICALS PLC
ADS
36197T103
6556
71757
SH
DFND
1
0
71757
0
GW PHARMACEUTICALS PLC
ADS
36197T953
24780
2712
SH
Put
DFND
1
0
2712
0
HALOZYME THERAPEUTICS INC
COM
40637H959
1128
840
SH
Put
DFND
1
0
840
0
HALOZYME THERAPEUTICS INC
COM
40637H909
5391
4014
SH
Call
DFND
1
0
4014
0
HCA HOLDINGS INC
COM
40412C901
4827
624
SH
Call
DFND
1
0
624
0
HEARTWARE INTERNATIONAL INC
COM
422368100
915
17500
SH
DFND
1
0
17500
0
HEARTWARE INTERNATIONAL INC
COM
422368950
1041
199
SH
Put
DFND
1
0
199
0
HEAT BIOLOGICS ORD SHS
COM
42237K102
149
32201
SH
DFND
1
0
32201
0
HERON THERAPEUTICS INC
COM
427746102
3912
160323
SH
DFND
1
0
160323
0
HERON THERAPEUTICS INC
COM
427746902
10304
4223
SH
Call
DFND
1
0
4223
0
HISTOGENICS CORP
COM
43358V109
110
27505
SH
DFND
1
0
27505
0
HORIZON PHARMA PLC
SHS
G4617B105
3264
164658
SH
DFND
1
0
164658
0
HORIZON PHARMA PLC
SHS
G4617B955
3286
1658
SH
Put
DFND
1
0
1658
0
IDERA PHARMACEUTICALS INC
COM
45168K956
372
1111
SH
Put
DFND
1
0
1111
0
IDERA PHARMACEUTICALS INC
COM
45168K306
461
137700
SH
DFND
1
0
137700
0
IDERA PHARMACEUTICALS INC
COM
45168K906
857
2558
SH
Call
DFND
1
0
2558
0
IGNYTA ORD SHS
COM
451731103
2221
252974
SH
DFND
1
0
252974
0
IMMUNE DESIGN CORP
COM
45252L103
244
20000
SH
DFND
1
0
20000
0
IMMUNOCELLULAR THERAPEUTICS
COM
452536105
1751
4169243
SH
DFND
1
0
4169243
0
INFINITY PHARMACEUTICALS INC
COM
45665G953
254
300
SH
Put
DFND
1
0
300
0
INFINITY PHARMACEUTICALS INC
COM
45665G303
254
30000
SH
DFND
1
0
30000
0
INFINITY PHARMACEUTICALS INC
COM
45665G903
1665
1971
SH
Call
DFND
1
0
1971
0
INOTEK PHARMACEUTICALS CORP
COM
45780V102
1034
110000
SH
DFND
1
0
110000
0
INOVIO PHARMACEUTICALS INC
COM
45773H901
2292
3965
SH
Call
DFND
1
0
3965
0
INOVIO PHARMACEUTICALS INC
COM
45773H201
4263
737551
SH
DFND
1
0
737551
0
INSMED INC
COM
457669907
949
511
SH
Call
DFND
1
0
511
0
INSMED INC
COM
457669957
1419
764
SH
Put
DFND
1
0
764
0
INSPIREMD ORD SHS
COM
45779A309
153
927876
SH
DFND
1
0
927876
0
INTEC PHARMA LTD
SHS
M53644106
3438
613910
SH
DFND
1
0
613910
0
INTELLIPHARMACEUTICS INTERNATIONAL INC
COM
458173951
47
187
SH
Put
DFND
1
0
187
0
INTEROIL CORP
COM
460951106
11081
328705
SH
DFND
1
0
328705
0
INTEROIL CORP
COM
460951956
11313
3356
SH
Put
DFND
1
0
3356
0
INTRA-CELLULAR THERAPIES INC
COM
46116X901
5518
1378
SH
Call
DFND
1
0
1378
0
INTREXON CORP
COM
46122T952
426
134
SH
Put
DFND
1
0
134
0
INTREXON CORP
COM
46122T902
1034
325
SH
Call
DFND
1
0
325
0
INVIVO THERAPEUTICS HOLDINGS CORP
COM
46186M909
2248
2608
SH
Call
DFND
1
0
2608
0
ISHARES RUSSELL 2000 ETF
ETF
464287655
35727
327168
SH
DFND
1
0
327168
0
ISHARES RUSSELL 2000 ETF
ETF
464287955
273123
25500
SH
Put
DFND
1
0
25500
0
ISIS PHARMACEUTICALS INC
COM
464330909
4685
1159
SH
Call
DFND
1
0
1159
0
KERYX BIOPHARMACEUTICALS INC
COM
492515951
56
158
SH
Put
DFND
1
0
158
0
KITE PHARMA INC
COM
49803L109
7634
137099
SH
DFND
1
0
137099
0
KITE PHARMA INC
COM
49803L959
10150
1823
SH
Put
DFND
1
0
1823
0
KONINKLIJKE PHILIPS N V
COM
500472903
5569
2374
SH
Call
DFND
1
0
2374
0
LA JOLLA PHARMACEUTICAL CO
COM
503459604
2362
85011
SH
DFND
1
0
85011
0
LEXICON PHARMACEUTICALS INC
COM
528872952
279
260
SH
Put
DFND
1
0
260
0
LEXICON PHARMACEUTICALS INC
COM
528872902
548
510
SH
Call
DFND
1
0
510
0
LEXICON PHARMACEUTICALS INC
COM
528872302
2810
261595
SH
DFND
1
0
261595
0
LION BIOTECHNOLOGIES INC
COM
53619R102
3237
561894
SH
DFND
1
0
561894
0
LIPOCINE INC
COM
53630X104
2383
201409
SH
DFND
1
0
201409
0
LPATH INC.
COM
548910306
213
1086171
SH
DFND
1
0
1086171
0
MACROGENICS INC
COM
556099909
244
114
SH
Call
DFND
1
0
114
0
MANNKIND CORP
COM
56400P201
173
53800
SH
DFND
1
0
53800
0
MANNKIND CORP
COM
56400P951
6701
20875
SH
Put
DFND
1
0
20875
0
MANNKIND CORP
COM
56400P901
9929
30930
SH
Call
DFND
1
0
30930
0
MEDGENICS EQUITY WARRANTS
*W
58436Q112
2544
1453640
SH
DFND
1
0
1453640
0
MEDICINES CO
COM
584688905
44599
11749
SH
Call
DFND
1
0
11749
0
MEDICINES CO 1.375%
DBCV
584688AC9
7278
5000000
SH
DFND
1
0
5000000
0
MEDICINOVA ORD SHS
COM
58468P206
1420
500000
SH
DFND
1
0
500000
0
MEI PHARMA ORD SHS
COM
55279B202
464
295491
SH
DFND
1
0
295491
0
MELA SCIENCES INC.
COM
55277R308
750
657860
SH
DFND
1
0
657860
0
MERRIMACK PHARMACEUTICALS INC
COM
590328900
426
500
SH
Call
DFND
1
0
500
0
MIRATI THERAPEUTICS INC
COM
60468T105
2065
60000
SH
DFND
1
0
60000
0
MOBILEYE N.V.
ORD
N51488907
3120
686
SH
Call
DFND
1
0
686
0
MOBILEYE N.V.
ORD
N51488117
10725
235819
SH
DFND
1
0
235819
0
MOBILEYE N.V.
ORD
N51488957
23459
5158
SH
Put
DFND
1
0
5158
0
MOMENTA PHARMACEUTICALS INC
COM
60877T100
821
50030
SH
DFND
1
0
50030
0
MOMENTA PHARMACEUTICALS INC
COM
60877T900
1641
1000
SH
Call
DFND
1
0
1000
0
MYLAN N.V.
SHS
N59465909
7033
1747
SH
Call
DFND
1
0
1747
0
MYLAN N.V.
SHS
N59465109
15171
376827
SH
DFND
1
0
376827
0
MYLAN N.V.
SHS
N59465959
23174
5756
SH
Put
DFND
1
0
5756
0
NANOSPHERE ORD SHS
COM
63009F204
297
181946
SH
DFND
1
0
181946
0
NATERA ORD SHS
COM
632307104
939
86523
SH
DFND
1
0
86523
0
NEUROCRINE BIOSCIENCES INC
COM
64125C959
4397
1267
SH
Put
DFND
1
0
1267
0
NEUROCRINE BIOSCIENCES INC
COM
64125C909
5583
1403
SH
Call
DFND
1
0
1403
0
NEURODERM LTD
ORD
M74231107
257
12416
SH
DFND
1
0
12416
0
NEUROMETRIX EQUITY WARRANTS
*W
641255138
3052
12212278
SH
DFND
1
0
12212278
0
NEUROMETRIX INC
COM
641255302
771
873454
SH
DFND
1
0
873454
0
NEVRO CORP
COM
64157F103
421
9066
SH
DFND
1
0
9066
0
NEVRO CORP
COM
64157F903
942
203
SH
Call
DFND
1
0
203
0
NEVRO CORP
COM
64157F953
3456
745
SH
Put
DFND
1
0
745
0
NEWLINK GENETICS CORP
COM
651511107
1206
33658
SH
DFND
1
0
33658
0
NEWLINK GENETICS CORP
COM
651511957
1541
430
SH
Put
DFND
1
0
430
0
NEWLINK GENETICS CORP
COM
651511907
13264
3701
SH
Call
DFND
1
0
3701
0
NIVALIS THERAPEUTICS INC
COM
65481J109
4990
384734
SH
DFND
1
0
384734
0
NORTHWEST BIOTHERAPEUTICS INC
COM
66737P600
3578
572518
SH
DFND
1
0
572518
0
NORTHWEST BIOTHERAPEUTICS INC
COM
66737P950
3776
6042
SH
Put
DFND
1
0
6042
0
NOVAVAX INC
COM
670002904
2841
4018
SH
Call
DFND
1
0
4018
0
NOVAVAX INC
COM
670002104
3726
527040
SH
DFND
1
0
527040
0
NOVAVAX INC
COM
670002954
5952
8418
SH
Put
DFND
1
0
8418
0
NOVO NORDISK A/S SHS
ADR
670100955
456
84
SH
Put
DFND
1
0
84
0
NUVASIVE INC
COM
670704905
1543
320
SH
Call
DFND
1
0
320
0
NUVASIVE INC
COM
670704105
1688
35000
SH
DFND
1
0
35000
0
OCERA THERAPEUTICS INC
COM
67552A108
1348
426544
SH
DFND
1
0
426544
0
OCULAR THERAPEUTIX INC
COM
67576A900
162
115
SH
Call
DFND
1
0
115
0
OCULAR THERAPEUTIX INC
COM
67576A100
1479
105190
SH
DFND
1
0
105190
0
OMEROS CORP
COM
682143102
464
42377
SH
DFND
1
0
42377
0
OMEROS CORP
COM
682143902
1632
1489
SH
Call
DFND
1
0
1489
0
ONCOSEC MEDICAL INC
COM
68234L207
1752
340169
SH
DFND
1
0
340169
0
OPEXA THERAPEUTICS EQUITY WARRANTS
*W
68372T129
46
382765
SH
DFND
1
0
382765
0
OPHTHOTECH CORP
COM
683745903
567
140
SH
Call
DFND
1
0
140
0
OPKO HEALTH INC
COM
68375N903
3785
4500
SH
Call
DFND
1
0
4500
0
OPKO HEALTH INC
COM
68375N103
5173
615157
SH
DFND
1
0
615157
0
OPKO HEALTH INC
COM
68375N953
5429
6456
SH
Put
DFND
1
0
6456
0
ORAMED PHARMACEUTICALS INC
COM
68403P203
58
10558
SH
DFND
1
0
10558
0
OVASCIENCE INC
COM
69014Q901
588
692
SH
Call
DFND
1
0
692
0
OVASCIENCE INC
COM
69014Q951
1868
2200
SH
Put
DFND
1
0
2200
0
OVASCIENCE INC
COM
69014Q101
2530
297955
SH
DFND
1
0
297955
0
OXIGENE INC
COM
691828404
305
328431
SH
DFND
1
0
328431
0
PACIRA PHARMACEUTICALS INC
COM
695127100
1278
31100
SH
DFND
1
0
31100
0
PARATEK PHARMACEUTICALS INC
COM
699374302
2224
117046
SH
DFND
1
0
117046
0
PEREGRINE PHARMACEUTICALS INC
COM
713661304
215
10907
SH
DFND
1
0
10907
0
PERRIGO CO. PLC
SHS
G97822903
7722
491
SH
Call
DFND
1
0
491
0
PERSEON EQUITY WARRANTS
*W
715270112
355
1743292
SH
DFND
1
0
1743292
0
PERSEON INC
COM
715270203
177
569985
SH
DFND
1
0
569985
0
PIERIS PHARMACEUTICALS INC
COM
720795103
276
150708
SH
DFND
1
0
150708
0
PIONEER NATURAL RESOURCE INC
COM
723787957
15035
1236
SH
Put
DFND
1
0
1236
0
PIONEER NATURAL RESOURCE INC
COM
723787107
15035
123600
SH
DFND
1
0
123600
0
PLURISTEM THERAPEUTICS INC
COM
72940R952
53
292
SH
Put
DFND
1
0
292
0
PLURISTEM THERAPEUTICS INC
COM
72940R102
2683
1474369
SH
DFND
1
0
1474369
0
PORTOLA PHARMACEUTICALS INC
COM
737010108
477
11201
SH
DFND
1
0
11201
0
PORTOLA PHARMACEUTICALS INC
COM
737010958
878
206
SH
Put
DFND
1
0
206
0
POZEN INC
COM
73941U102
1167
200000
SH
DFND
1
0
200000
0
PROGENICS PHARMACEUTICALS INC
COM
743187906
480
840
SH
Call
DFND
1
0
840
0
PROQR THERAPEUTICS N V
SHS
N71542109
320
21950
SH
DFND
1
0
21950
0
PROVECTUS BIOPHARMACEUTICALS INC
COM
74373P108
1140
1982137
SH
DFND
1
0
1982137
0
PTC THERAPEUTICS INC
COM
69366J950
318
119
SH
Put
DFND
1
0
119
0
PTC THERAPEUTICS INC
COM
69366J200
624
23387
SH
DFND
1
0
23387
0
PTC THERAPEUTICS INC
COM
69366J900
3100
1161
SH
Call
DFND
1
0
1161
0
PUMA BIOTECHNOLOGY INC
COM
74587V907
1470
195
SH
Call
DFND
1
0
195
0
PUMA BIOTECHNOLOGY INC
COM
74587V107
2012
26704
SH
DFND
1
0
26704
0
PUMA BIOTECHNOLOGY INC
COM
74587V957
2170
288
SH
Put
DFND
1
0
288
0
QUEST RESOURCE HOLDING
COM
74836W104
1795
3148401
SH
DFND
1
0
3148401
0
RADIUS HEALTH INC
COM
750469207
804
11600
SH
DFND
1
0
11600
0
RADIUS HEALTH INC
COM
750469907
4006
578
SH
Call
DFND
1
0
578
0
RAPTOR PHARMACEUTICAL CORP
COM
75382F956
264
436
SH
Put
DFND
1
0
436
0
RAPTOR PHARMACEUTICAL CORP
COM
75382F906
4410
7289
SH
Call
DFND
1
0
7289
0
RARE ELEMENT RESOURCES LTD
COM
75381M102
1080
3843873
SH
DFND
1
0
3843873
0
REDHILL BIOPHARMA LTD
ADS
757468103
2241
173550
SH
DFND
1
0
173550
0
REGENERON PHARMACEUTICALS INC
COM
75886F107
535
1150
SH
DFND
1
0
1150
0
REGENERON PHARMACEUTICALS INC
COM
75886F957
2465
53
SH
Put
DFND
1
0
53
0
REGULUS THERAPEUTIC INC
COM
75915K101
2332
356504
SH
DFND
1
0
356504
0
REGULUS THERAPEUTIC INC
COM
75915K901
7931
12127
SH
Call
DFND
1
0
12127
0
RELYPSA INC
COM
759531906
555
300
SH
Call
DFND
1
0
300
0
RELYPSA INC
COM
759531106
1295
69980
SH
DFND
1
0
69980
0
REPROS THERAPEUTICS INC
COM
76028H909
2063
2777
SH
Call
DFND
1
0
2777
0
REPROS THERAPEUTICS INC
COM
76028H959
2075
2793
SH
Put
DFND
1
0
2793
0
REVANCE THERAPEUTICS INC
COM
761330909
2425
815
SH
Call
DFND
1
0
815
0
RICEBRAN TECHNOLOGIES
COM
762831204
1975
901973
SH
DFND
1
0
901973
0
ROCKWELL MEDICAL INC
COM
774374102
358
46469
SH
DFND
1
0
46469
0
ROCKWELL MEDICAL INC
COM
774374952
381
494
SH
Put
DFND
1
0
494
0
SAGE THERAPEUTICS INC
COM
78667J908
1062
251
SH
Call
DFND
1
0
251
0
SAGE THERAPEUTICS INC
COM
78667J108
1694
40019
SH
DFND
1
0
40019
0
SANGAMO BIOSCIENCES INC
COM
800677906
121
215
SH
Call
DFND
1
0
215
0
SANGAMO BIOSCIENCES INC
COM
800677106
2455
435225
SH
DFND
1
0
435225
0
SAREPTA THERAPEUTICS INC
COM
803607950
5895
1836
SH
Put
DFND
1
0
1836
0
SAREPTA THERAPEUTICS INC
COM
803607900
21421
6671
SH
Call
DFND
1
0
6671
0
SERES THERAPEUTICS INC
COM
81750R102
1920
64775
SH
DFND
1
0
64775
0
SKYLINE MEDICAL UNITS
COM
830830105
3454
447944
SH
DFND
1
0
447944
0
SKYSTAR BIO PHARMACEUTICAL
COM
830884300
141
147926
SH
DFND
1
0
147926
0
SORRENTO THERAPEUTICS INC
COM
83587F202
1402
167064
SH
DFND
1
0
167064
0
SORRENTO THERAPEUTICS INC
COM
83587F902
1909
2275
SH
Call
DFND
1
0
2275
0
SPARK THERAPEUTICS INC
COM
84652J953
5755
1379
SH
Put
DFND
1
0
1379
0
SPARK THERAPEUTICS INC
COM
84652J903
5851
1402
SH
Call
DFND
1
0
1402
0
SPDR S&P 500 ETF TRUST
UNIT
78462F953
306773
16250
SH
Put
DFND
1
0
16250
0
SPDR SERIES TRUST
S&P BIOTECH
78464A950
19571
3144
SH
Put
DFND
1
0
3144
0
STEMCELLS INC
COM
85857R204
856
2039122
SH
DFND
1
0
2039122
0
SUNEDISON INC
COM
86732Y909
718
1000
SH
Call
DFND
1
0
1000
0
SUPERCONDUCTOR TECHNOLOGIES INC
COM
867931404
494
796934
SH
DFND
1
0
796934
0
SYNERGY PHARMACEUTICALS EQUITY WARRANTS
*W
871639118
486
291206
SH
DFND
1
0
291206
0
SYNERGY PHARMACEUTICALS INC
COM
871639958
855
1613
SH
Put
DFND
1
0
1613
0
SYNERGY PHARMACEUTICALS INC
COM
871639908
1476
2785
SH
Call
DFND
1
0
2785
0
T2 BIOSYSTEMS INC
COM
89853L104
1354
154521
SH
DFND
1
0
154521
0
TENAX THERAPEUTICS INC
COM
88032L100
7892
2604660
SH
DFND
1
0
2604660
0
TENET HEALTHCARE CORP
COM
88033G407
9080
245938
SH
DFND
1
0
245938
0
TENET HEALTHCARE CORP
COM
88033G957
10733
2907
SH
Put
DFND
1
0
2907
0
TENET HEALTHCARE CORP
COM
88033G907
28595
7745
SH
Call
DFND
1
0
7745
0
TESARO INC
COM
881569957
802
200
SH
Put
DFND
1
0
200
0
TESARO INC
COM
881569107
802
20000
SH
DFND
1
0
20000
0
TETRAPHASE PHARMACEUTICALS INC.
COM
88165N105
606
81185
SH
DFND
1
0
81185
0
THERAPEUTICSMD INC
COM
88338N907
5743
9800
SH
Call
DFND
1
0
9800
0
TOBIRA THERAPEUTICS INC
COM
88883P101
1690
174943
SH
DFND
1
0
174943
0
TOKAI PHARMACEUTICALS ORD SHS
COM
88907J107
6772
654283
SH
DFND
1
0
654283
0
TONIX PHARMACEUTICALS HOLDING CORP
COM
890260201
837
158140
SH
DFND
1
0
158140
0
TONIX PHARMACEUTICALS HOLDING CORP
COM
890260901
863
1631
SH
Call
DFND
1
0
1631
0
TRANSENTERIX INC
COM
89366M901
2266
10026
SH
Call
DFND
1
0
10026
0
TRANSENTERIX INC
COM
89366M201
3596
1591117
SH
DFND
1
0
1591117
0
TRANSITION THERAPEUTICS INC
COM
893716209
685
382600
SH
DFND
1
0
382600
0
TROVAGENE INC
COM
897238309
1138
200000
SH
DFND
1
0
200000
0
TROVAGENE INC
COM
897238909
1479
2600
SH
Call
DFND
1
0
2600
0
UNIQURE B.V.
SHS
N90064951
425
208
SH
Put
DFND
1
0
208
0
UNIQURE B.V.
SHS
N90064901
1726
844
SH
Call
DFND
1
0
844
0
UNITED THERAPEUTICS CORP
COM
91307C902
12048
918
SH
Call
DFND
1
0
918
0
VALEANT PHARMACEUTICALS INTERNATIONAL INC
COM
91911K102
209
1171
SH
DFND
1
0
1171
0
VALEANT PHARMACEUTICALS INTERNATIONAL INC
COM
91911K952
285
16
SH
Put
DFND
1
0
16
0
VAPOR CORP DEL
UNIT
922099502
2015
225387
SH
DFND
1
0
225387
0
VASCULAR SOLUTIONS INC
COM
92231M109
1209
37296
SH
DFND
1
0
37296
0
VASCULAR SOLUTIONS INC
COM
92231M959
1967
607
SH
Put
DFND
1
0
607
0
VERTEX PHARMACEUTICALS INC
COM
92532F100
3124
30000
SH
DFND
1
0
30000
0
VERTEX PHARMACEUTICALS INC
COM
92532F900
3551
341
SH
Call
DFND
1
0
341
0
VIGGLE INC.
COM
92672V204
666
812687
SH
DFND
1
0
812687
0
VITAL THERAPIES INC
COM
92847R904
101
250
SH
Call
DFND
1
0
250
0
VITAL THERAPIES INC
COM
92847R104
156
38700
SH
DFND
1
0
38700
0
VITAL THERAPIES INC
COM
92847R954
404
1000
SH
Put
DFND
1
0
1000
0
VTV THERAPEUTICS INC
CL A
918385105
1047
160556
SH
DFND
1
0
160556
0
XOMA CORP
COM
98419J907
38
500
SH
Call
DFND
1
0
500
0
XTL BIOPHARMACEUTICALS
ADR
98386D208
1794
1149886
SH
DFND
1
0
1149886
0
ZAFGEN INC
COM
98885E953
946
296
SH
Put
DFND
1
0
296
0
ZAFGEN INC
COM
98885E903
3067
960
SH
Call
DFND
1
0
960
0
ZELTIQ AESTHETICS INC
COM
98933Q108
320
10000
SH
DFND
1
0
10000
0
ZELTIQ AESTHETICS INC
COM
98933Q908
3203
1000
SH
Call
DFND
1
0
1000
0
ZOGENIX INC
COM
98978L904
42005
31115
SH
Call
DFND
1
0
31115
0
ZOSANO PHARMA INC
COM
98979H103
647
163365
SH
DFND
1
0
163365
0
ZS PHARMA INC
COM
98979G105
780
11875
SH
DFND
1
0
11875
0
ZS PHARMA INC
COM
98979G905
1950
297
SH
Call
DFND
1
0
297
0
ZS PHARMA INC
COM
98979G955
4202
640
SH
Put
DFND
1
0
640
0