The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y909 38,730 7,535 SH Call DFND 1 0 7,535 0
ABBVIE INC COM 00287Y959 15,312 2,979 SH Put DFND 1 0 2,979 0
ACADIA PHARMACEUTICALS INC COM 004225108 11,268 463,146 SH   DFND 1 0 463,146 0
ACADIA PHARMACEUTICALS INC COM 004225908 64,929 26,687 SH Call DFND 1 0 26,687 0
ACADIA PHARMACEUTICALS INC COM 004225958 810 333 SH Put DFND 1 0 333 0
ACELRX PHARMACEUTICALS INC COM 00444T100 556 46,316 SH   DFND 1 0 46,316 0
ACELRX PHARMACEUTICALS INC COM 00444T900 563 469 SH Call DFND 1 0 469 0
ACELRX PHARMACEUTICALS INC COM 00444T950 2,789 2,322 SH Put DFND 1 0 2,322 0
ACHILLION PHARMACEUTICALS INC COM 00448Q901 4,834 14,693 SH Call DFND 1 0 14,693 0
ACHILLION PHARMACEUTICALS INC COM 00448Q951 376 1,142 SH Put DFND 1 0 1,142 0
ADAMIS PHARMACEUTICALS CORP COM 00547W208 386 60,767 SH   DFND 1 0 60,767 0
ADVAXIS INC WAR 007624117 181 144,935 SH   DFND 1 0 144,935 0
ADVAXIS INC COM 007624958 314 1,000 SH Put DFND 1 0 1,000 0
AEGERION PHARMACEUTICALS INC COM 00767E102 1,587 34,420 SH   DFND 1 0 34,420 0
AGENUS INC COM 00847G705 589 185,830 SH   DFND 1 0 185,830 0
AGENUS INC COM 00847G905 477 1,506 SH Call DFND 1 0 1,506 0
AGENUS INC COM 00847G955 78 245 SH Put DFND 1 0 245 0
ALEXZA PHARMACEUTICALS INC SHS COM 015384909 904 2,040 SH Call DFND 1 0 2,040 0
ALIMERA SCIENCES INC COM 016259103 3,945 500,000 SH   DFND 1 0 500,000 0
ALIMERA SCIENCES INC COM 016259953 820 1,039 SH Put DFND 1 0 1,039 0
ALKERMES PLC SHS G01767105 226 5,126 SH   DFND 1 0 5,126 0
ALKERMES PLC SHS G01767905 763 173 SH Call DFND 1 0 173 0
ALKERMES PLC SHS G01767955 683 155 SH Put DFND 1 0 155 0
ALLERGAN INC COM 018490902 44,105 3,554 SH Call DFND 1 0 3,554 0
ALLERGAN INC COM 018490952 10,710 863 SH Put DFND 1 0 863 0
AMARIN CORPORATION PLC -ADR ADR 023111206 2,392 1,321,622 SH   DFND 1 0 1,321,622 0
AMARIN CORPORATION PLC -ADR ADR 023111906 36 200 SH Call DFND 1 0 200 0
AMGEN INC COM 031162100 5,219 42,311 SH   DFND 1 0 42,311 0
AMGEN INC COM 031162950 14,036 1,138 SH Put DFND 1 0 1,138 0
AMPIO PHARMACEUTICALS INC COM 03209T109 260 41,000 SH   DFND 1 0 41,000 0
AMPIO PHARMACEUTICALS INC COM 03209T959 1,064 1,676 SH Put DFND 1 0 1,676 0
ANTHERA PHARMACEUTICALS INC COM 03674U201 2,305 688,037 SH   DFND 1 0 688,037 0
ANTHERA PHARMACEUTICALS INC COM 03674U901 108 322 SH Call DFND 1 0 322 0
APPLE INC COM 037833900 31,077 579 SH Call DFND 1 0 579 0
APPLE INC COM 037833950 31,077 579 SH Put DFND 1 0 579 0
APRICUS BIOSCIENCES INC COM 03832V109 27 12,503 SH   DFND 1 0 12,503 0
APRICUS BIOSCIENCES INC COM 03832V959 313 1,457 SH Put DFND 1 0 1,457 0
ARENA PHARMACEUTICALS INC COM 040047102 1,359 215,700 SH   DFND 1 0 215,700 0
ARENA PHARMACEUTICALS INC COM 040047952 1,736 2,756 SH Put DFND 1 0 2,756 0
ARIAD PHARMACEUTICALS INC COM 04033A900 5,819 7,220 SH Call DFND 1 0 7,220 0
ARIAD PHARMACEUTICALS INC COM 04033A950 4,821 5,981 SH Put DFND 1 0 5,981 0
ARROWHEAD RESEARCH CORP COM 042797909 1,686 1,027 SH Call DFND 1 0 1,027 0
ARROWHEAD RESEARCH CORP COM 042797959 4,069 2,478 SH Put DFND 1 0 2,478 0
ATHERSYS INC COM 04744L906 191 588 SH Call DFND 1 0 588 0
ATHERSYS INC COM 04744L956 339 1,045 SH Put DFND 1 0 1,045 0
AUXILIUM PHARMACEUTICALS INC COM 05334D907 10,826 3,983 SH Call DFND 1 0 3,983 0
AVANIR PHARMACEUTICALS INC CL A 05348P901 1,835 5,000 SH Call DFND 1 0 5,000 0
AVANIR PHARMACEUTICALS INC CL A 05348P951 1,376 3,750 SH Put DFND 1 0 3,750 0
AVEO PHARMACEUTICALS INC COM 053588109 857 573,416 SH   DFND 1 0 573,416 0
BIO PATH HOLDINGS INC COM 09057N102 8,781 3,313,600 SH   DFND 1 0 3,313,600 0
BIODEL INC COM 09064M954 50 182 SH Put DFND 1 0 182 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J956 3,335 3,952 SH Put DFND 1 0 3,952 0
BIOGEN IDEC INC COM 09062X903 63,468 2,075 SH Call DFND 1 0 2,075 0
BIOGEN IDEC INC COM 09062X953 1,529 50 SH Put DFND 1 0 50 0
BIOLINERX LTD-SPONS ADR ADR 09071M106 4,243 1,902,800 SH   DFND 1 0 1,902,800 0
BLUEBIRD BIO INC COM 09609G100 2,315 101,786 SH   DFND 1 0 101,786 0
BRISTOL MYERS SQUIBB CO COM 110122908 86,606 16,671 SH Call DFND 1 0 16,671 0
BRISTOL MYERS SQUIBB CO COM 110122958 894 172 SH Put DFND 1 0 172 0
CELATOR PHARMACEUTICALS INC COM 15089R102 2,022 626,077 SH   DFND 1 0 626,077 0
CELGENE CORP COM 151020104 2,722 19,499 SH   DFND 1 0 19,499 0
CELGENE CORP COM 151020954 28,534 2,044 SH Put DFND 1 0 2,044 0
CEL-SCI CORP COM 150837508 20 12,888 SH   DFND 1 0 12,888 0
CEL-SCI CORP-W WAR 150837177 2,684 6,316,000 SH   DFND 1 0 6,316,000 0
CELSION CORP COM 15117N404 766 227,156 SH   DFND 1 0 227,156 0
CELSION CORP COM 15117N954 2,549 7,565 SH Put DFND 1 0 7,565 0
CELSUS THERAPEUTICS-SPON ADR ADR 15119A202 4,342 669,080 SH   DFND 1 0 669,080 0
CEMPRA INC COM 15130J109 4,689 405,946 SH   DFND 1 0 405,946 0
CEMPRA INC COM 15130J909 140 121 SH Call DFND 1 0 121 0
CERES INC COM 156773103 1,488 1,695,700 SH   DFND 1 0 1,695,700 0
CESCA THERAPEUTICS INC COM 157131103 900 529,298 SH   DFND 1 0 529,298 0
CLEVELAND BIOLABS INC COM 185860103 1,244 1,826,158 SH   DFND 1 0 1,826,158 0
CLOVIS ONCOLOGY INC COM 189464900 13,376 1,931 SH Call DFND 1 0 1,931 0
CLOVIS ONCOLOGY INC COM 189464950 6,927 1,000 SH Put DFND 1 0 1,000 0
COMPUGEN LTD ORD M25722905 1,353 1,287 SH Call DFND 1 0 1,287 0
CORCEPT THERAPEUTICS INC COM 218352902 174 400 SH Call DFND 1 0 400 0
CUBIST PHARMACEUTICALS INC COM 229678107 1,214 16,590 SH   DFND 1 0 16,590 0
CUBIST PHARMACEUTICALS INC COM 229678957 4,411 603 SH Put DFND 1 0 603 0
CYTOKINETICS INC COM 23282W905 628 661 SH Call DFND 1 0 661 0
DEPOMED INC COM 249908904 103 551 SH Call DFND 1 0 551 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,455 51,510 SH   DFND 1 0 51,510 0
DISCOVERY LABORATORIES INC COM 254668403 670 311,673 SH   DFND 1 0 311,673 0
DISCOVERY LABORATORIES INC COM 254668903 304 1,414 SH Call DFND 1 0 1,414 0
DYAX CORP COM 26746E103 2,065 230,000 SH   DFND 1 0 230,000 0
DYAX CORP COM 26746E903 146 163 SH Call DFND 1 0 163 0
EDAP TMS SA -ADR ADR 268311107 66 23,200 SH   DFND 1 0 23,200 0
EDAP TMS SA -ADR ADR 268311907 143 500 SH Call DFND 1 0 500 0
ELI LILLY COM 532457908 10,118 1,719 SH Call DFND 1 0 1,719 0
ENANTA PHARMACEUTICALS INC COM 29251M906 408 102 SH Call DFND 1 0 102 0
ENDOCYTE INC COM 29269A902 367 154 SH Call DFND 1 0 154 0
ENDOCYTE INC COM 29269A952 2,786 1,170 SH Put DFND 1 0 1,170 0
ENTREMED INC COM 29382F202 1,949 1,065,217 SH   DFND 1 0 1,065,217 0
EPIZYME INC COM 29428V104 3,443 151,220 SH   DFND 1 0 151,220 0
EXACT SCIENCES CORP COM 30063P105 765 54,000 SH   DFND 1 0 54,000 0
EXACT SCIENCES CORP COM 30063P955 928 655 SH Put DFND 1 0 655 0
EXELIXIS INC COM 30161Q104 1,519 429,000 SH   DFND 1 0 429,000 0
EXELIXIS INC COM 30161Q904 754 2,129 SH Call DFND 1 0 2,129 0
EXELIXIS INC COM 30161Q954 430 1,216 SH Put DFND 1 0 1,216 0
FURIEX PHARMACEUTICALS INC COM 36106P101 625 7,180 SH   DFND 1 0 7,180 0
FURIEX PHARMACEUTICALS INC COM 36106P901 1,322 152 SH Call DFND 1 0 152 0
GALENA BIOPHARMA INC COM 363256108 1,770 708,089 SH   DFND 1 0 708,089 0
GALENA BIOPHARMA INC COM 363256908 350 1,400 SH Call DFND 1 0 1,400 0
GALENA BIOPHARMA INC COM 363256958 2,946 11,782 SH Put DFND 1 0 11,782 0
GALMED PHARMACEUTICALS LTD SHS M47238106 360 31,401 SH   DFND 1 0 31,401 0
GILEAD SCIENCES INC COM 375558103 10,988 155,073 SH   DFND 1 0 155,073 0
GILEAD SCIENCES INC COM 375558903 21,208 2,993 SH Call DFND 1 0 2,993 0
GILEAD SCIENCES INC COM 375558953 79,122 11,166 SH Put DFND 1 0 11,166 0
HORIZON PHARMA INC COM 44047T959 331 219 SH Put DFND 1 0 219 0
IDENIX PHARMACEUTICALS INC COM 45166R904 785 1,302 SH Call DFND 1 0 1,302 0
IDERA PHARMACEUTICALS INC COM 45168K306 61 15,000 SH   DFND 1 0 15,000 0
IDERA PHARMACEUTICALS INC COM 45168K906 162 398 SH Call DFND 1 0 398 0
IGNYTA INC COM 451731103 2,837 341,810 SH   DFND 1 0 341,810 0
IMMUNOCELLULAR THERAPEUTICS LTD COM 452536955 293 2,405 SH Put DFND 1 0 2,405 0
INCYTE CORP COM 45337C902 5,598 1,046 SH Call DFND 1 0 1,046 0
INSMED INC COM 457669907 2,479 1,302 SH Call DFND 1 0 1,302 0
INSMED INC COM 457669957 581 305 SH Put DFND 1 0 305 0
INTERMUNE INC COM 45884X903 22,171 6,624 SH Call DFND 1 0 6,624 0
INTERMUNE INC COM 45884X953 15,667 4,681 SH Put DFND 1 0 4,681 0
INTEROIL CORP COM 460951106 2,743 42,361 SH   DFND 1 0 42,361 0
INTEROIL CORP COM 460951956 5,796 895 SH Put DFND 1 0 895 0
ISHARES ETF 464287655 10,354 890 SH Put DFND 1 0 890 0
ISIS PHARMACEUTICALS INC COM 464330909 6,844 1,584 SH Call DFND 1 0 1,584 0
ISIS PHARMACEUTICALS INC COM 464330959 8,979 2,078 SH Put DFND 1 0 2,078 0
ISORAY INC COM 46489V104 496 225,375 SH   DFND 1 0 225,375 0
KERYX BIOPHARMACEUTICALS COM 492515101 2,863 167,999 SH   DFND 1 0 167,999 0
KERYX BIOPHARMACEUTICALS COM 492515951 8,926 5,238 SH Put DFND 1 0 5,238 0
LIGAND PHARMACEUTICALS INC COM 53220K904 2,825 420 SH Call DFND 1 0 420 0
MACROGENICS INC COM 556099109 4,190 150,553 SH   DFND 1 0 150,553 0
MANNKIND CORP COM 56400P901 1,019 2,536 SH Call DFND 1 0 2,536 0
MANNKIND CORP COM 56400P951 8,486 21,110 SH Put DFND 1 0 21,110 0
MEDGENICS INC WAR 58436Q112 940 817,050 SH   DFND 1 0 817,050 0
MEDICINES CO COM 584688955 523 184 SH Put DFND 1 0 184 0
MEDIVATION INC COM 58501N901 2,768 430 SH Call DFND 1 0 430 0
MELA SCIENCES INC COM 55277R100 2,320 3,724,475 SH   DFND 1 0 3,724,475 0
MERCK & CO INC COM 58933Y905 11,445 2,016 SH Call DFND 1 0 2,016 0
MERCK & CO INC COM 58933Y955 39,705 6,994 SH Put DFND 1 0 6,994 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 213 18,274 SH   DFND 1 0 18,274 0
MOMENTA PHARMACEUTICALS INC COM 60877T900 2,014 1,729 SH Call DFND 1 0 1,729 0
MOMENTA PHARMACEUTICALS INC COM 60877T950 445 382 SH Put DFND 1 0 382 0
NEKTAR THERAPEUTICS COM 640268108 608 50,177 SH   DFND 1 0 50,177 0
NEKTAR THERAPEUTICS COM 640268958 1,771 1,461 SH Put DFND 1 0 1,461 0
NEOSTEM INC COM 640650954 538 763 SH Put DFND 1 0 763 0
NEUROCRINE BIOSCIENCES INC COM 64125C909 2,104 1,307 SH Call DFND 1 0 1,307 0
NEUROCRINE BIOSCIENCES INC COM 64125C959 161 100 SH Put DFND 1 0 100 0
NEWLINK GENETICS CORP COM 651511907 4,760 1,676 SH Call DFND 1 0 1,676 0
NEWLINK GENETICS CORP COM 651511957 472 166 SH Put DFND 1 0 166 0
NORTHWEST BIOTHERAPEUTICS INC COM 66737P900 399 551 SH Call DFND 1 0 551 0
NORTHWEST BIOTHERAPEUTICS INC COM 66737P950 628 868 SH Put DFND 1 0 868 0
NOVAVAX INC COM 670002104 1,139 251,500 SH   DFND 1 0 251,500 0
NOVAVAX INC COM 670002954 3,595 7,935 SH Put DFND 1 0 7,935 0
OCERA THERAPEUTICS INC COM 67552A108 641 60,726 SH   DFND 1 0 60,726 0
OMEROS CORP COM 682143102 241 20,000 SH   DFND 1 0 20,000 0
ONCOGENEX PHARMACEUTICALS INC COM 68230A906 641 545 SH Call DFND 1 0 545 0
ONCOTHYREON INC COM 682324908 152 511 SH Call DFND 1 0 511 0
OPHTHOTECH CORP COM 683745103 570 15,944 SH   DFND 1 0 15,944 0
OPHTHOTECH CORP COM 683745953 1,430 400 SH Put DFND 1 0 400 0
OPKO HEALTH INC COM 68375N103 7,747 831,237 SH   DFND 1 0 831,237 0
OPKO HEALTH INC COM 68375N903 18,735 20,102 SH Call DFND 1 0 20,102 0
OPKO HEALTH INC COM 68375N953 21,648 23,227 SH Put DFND 1 0 23,227 0
OREXIGEN THERAPEUTICS INC COM 686164104 291 44,784 SH   DFND 1 0 44,784 0
OREXIGEN THERAPEUTICS INC COM 686164954 896 1,379 SH Put DFND 1 0 1,379 0
OVASCIENCE INC COM 69014Q101 3,195 357,354 SH   DFND 1 0 357,354 0
OXYGEN BIOTHERAPEUTICS INC COM 69207P308 11,770 2,120,754 SH   DFND 1 0 2,120,754 0
OXYGEN BIOTHERAPEUTICS INC COM 69207P908 152 274 SH Call DFND 1 0 274 0
PACIFIC ETHANOL INC COM 69423U955 797 512 SH Put DFND 1 0 512 0
PEREGRINE PHARMACEUTICALS INC COM 713661304 6,017 238,409 SH   DFND 1 0 238,409 0
PFIZER INC COM 717081903 13,815 4,301 SH Call DFND 1 0 4,301 0
PFIZER INC COM 717081953 2,088 650 SH Put DFND 1 0 650 0
PHARMACYCLICS INC COM 716933906 15,033 1,500 SH Call DFND 1 0 1,500 0
PHARMACYCLICS INC COM 716933956 15,324 1,529 SH Put DFND 1 0 1,529 0
PLURISTEM THERAPEUTICS INC COM 72940R102 938 253,383 SH   DFND 1 0 253,383 0
PLURISTEM THERAPEUTICS INC COM 72940R952 3,553 9,603 SH Put DFND 1 0 9,603 0
PRANA BIOTECHNOLOGY LTD ADR 739727105 48 17,300 SH   DFND 1 0 17,300 0
PRANA BIOTECHNOLOGY LTD ADR 739727905 838 2,994 SH Call DFND 1 0 2,994 0
PRANA BIOTECHNOLOGY LTD ADR 739727955 62 222 SH Put DFND 1 0 222 0
PROGENICS PHARMACEUTICALS COM 743187106 2,118 517,794 SH   DFND 1 0 517,794 0
PROGENICS PHARMACEUTICALS COM 743187906 324 794 SH Call DFND 1 0 794 0
PROGENICS PHARMACEUTICALS COM 743187956 122 298 SH Put DFND 1 0 298 0
PROTHENA CORPORATION PLC SHS G72800908 862 225 SH Call DFND 1 0 225 0
PROTHENA CORPORATION PLC SHS G72800958 479 125 SH Put DFND 1 0 125 0
PSIVIDA CORP COM 74440J901 41 100 SH Call DFND 1 0 100 0
PSIVIDA CORP COM 74440J951 262 640 SH Put DFND 1 0 640 0
PUMA BIOTECHNOLOGY INC COM 74587V907 5,332 512 SH Call DFND 1 0 512 0
PUMA BIOTECHNOLOGY INC COM 74587V957 2,822 271 SH Put DFND 1 0 271 0
RECRO PHARMA INC COM 75629F109 1,647 227,793 SH   DFND 1 0 227,793 0
REGENERON PHARMACEUTICALS COM 75886F107 5,162 17,191 SH   DFND 1 0 17,191 0
REGENERON PHARMACEUTICALS COM 75886F907 36,514 1,216 SH Call DFND 1 0 1,216 0
REGENERON PHARMACEUTICALS COM 75886F957 39,006 1,299 SH Put DFND 1 0 1,299 0
REPROS THERAPEUTICS INC COM 76028H959 5,980 3,371 SH Put DFND 1 0 3,371 0
ROCKWELL MEDICAL INC COM 774374952 7,155 5,652 SH Put DFND 1 0 5,652 0
SALIX PHARMACEUTICALS LTD COM 795435106 225 2,170 SH   DFND 1 0 2,170 0
SALIX PHARMACEUTICALS LTD COM 795435956 1,533 148 SH Put DFND 1 0 148 0
SANGAMO BIOSCIENCES INC COM 800677106 3,205 177,265 SH   DFND 1 0 177,265 0
SANGAMO BIOSCIENCES INC COM 800677906 18,098 10,010 SH Call DFND 1 0 10,010 0
SAREPTA THERAPEUTICS INC COM 803607100 8,461 352,100 SH   DFND 1 0 352,100 0
SAREPTA THERAPEUTICS INC COM 803607900 843 351 SH Call DFND 1 0 351 0
SAREPTA THERAPEUTICS INC COM 803607950 9,756 4,060 SH Put DFND 1 0 4,060 0
SEATTLE GENETICS INC COM 812578902 16,907 3,711 SH Call DFND 1 0 3,711 0
SEATTLE GENETICS INC COM 812578952 15,932 3,497 SH Put DFND 1 0 3,497 0
SEMLER SCIENTIFIC INC COM 81684M104 1,664 318,198 SH   DFND 1 0 318,198 0
SPDR S&P 500 ETF TR UNIT 78462F103 25,026 1,338 SH Put DFND 1 0 1,338 0
SPDR SERIES TRUST TR 78464A870 6,233 43,745 SH   DFND 1 0 43,745 0
SPDR SERIES TRUST TR 78464A950 28,581 2,006 SH Put DFND 1 0 2,006 0
SUNESIS PHARMACEUTICALS INC COM 867328901 2,075 3,139 SH Call DFND 1 0 3,139 0
SUNESIS PHARMACEUTICALS INC COM 867328951 541 818 SH Put DFND 1 0 818 0
SYNAGEVA BIOPHARMA CORP COM 87159A103 1,123 13,538 SH   DFND 1 0 13,538 0
SYNAGEVA BIOPHARMA CORP COM 87159A953 11,043 1,331 SH Put DFND 1 0 1,331 0
SYNERGY PHARMACEUTICALS WAR 871639308 718 377,908 SH   DFND 1 0 377,908 0
TEKMIRA PHARMACEUTICALS CORP COM 87911B909 967 450 SH Call DFND 1 0 450 0
TESARO INC COM 881569107 2,904 98,500 SH   DFND 1 0 98,500 0
TESARO INC COM 881569907 413 140 SH Call DFND 1 0 140 0
TEVA PHARMACEUTICAL INDUSTRIES LTD ADR 881624209 19,273 364,741 SH   DFND 1 0 364,741 0
TEVA PHARMACEUTICAL INDUSTRIES LTD ADR 881624909 80,275 15,192 SH Call DFND 1 0 15,192 0
TEVA PHARMACEUTICAL INDUSTRIES LTD ADR 881624959 123,820 23,433 SH Put DFND 1 0 23,433 0
THERAVANCE INC COM 88338T104 1,068 34,531 SH   DFND 1 0 34,531 0
THERAVANCE INC COM 88338T954 1,661 537 SH Put DFND 1 0 537 0
THERMO FISHER SCIENTIFIC INC COM 883556102 4,645 38,630 SH   DFND 1 0 38,630 0
THERMO FISHER SCIENTIFIC INC COM 883556902 13,226 1,100 SH Call DFND 1 0 1,100 0
TONIX PHARMACEUTICALS HOLDIN COM 890260201 2,863 275,000 SH   DFND 1 0 275,000 0
TROVAGENE INC COM 897238309 115 20,000 SH   DFND 1 0 20,000 0
UNIQURE B.V. SHS N90064101 5,505 354,000 SH   DFND 1 0 354,000 0
UNITED THERAPEUTICS CORP COM 91307C902 4,796 510 SH Call DFND 1 0 510 0
UNITED THERAPEUTICS CORP COM 91307C952 2,040 217 SH Put DFND 1 0 217 0
VERTEX PHARMACEUTICALS INC COM 92532F900 169,728 24,000 SH Call DFND 1 0 24,000 0
VERTEX PHARMACEUTICALS INC COM 92532F950 41,909 5,926 SH Put DFND 1 0 5,926 0
VIVUS INC COM 928551100 131 22,032 SH   DFND 1 0 22,032 0
VIVUS INC COM 928551950 112 189 SH Put DFND 1 0 189 0
XOMA CORP COM 98419J107 858 164,728 SH   DFND 1 0 164,728 0
XOMA CORP COM 98419J907 559 1,073 SH Call DFND 1 0 1,073 0
XOMA CORP COM 98419J957 564 1,082 SH Put DFND 1 0 1,082 0
ZIOPHARM ONCOLOGY INC COM 98973P101 506 110,573 SH   DFND 1 0 110,573 0
ZIOPHARM ONCOLOGY INC COM 98973P901 316 690 SH Call DFND 1 0 690 0
ZIOPHARM ONCOLOGY INC COM 98973P951 667 1,457 SH Put DFND 1 0 1,457 0